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| 1 | Additively manufactured biodegradable porous magnesium implants for elimination of implant-related infections:An in vitro and in vivo study显示文摘Magnesium(Mg)alloys that have both antibacterial and osteogenic properties are suitable candidates for orthopedic implants.However,the fabrication of ideal Mg implants suitable for bone repair remains challenging because it requires implants with interconnected pore structures and personalized geometric shapes.In this study,we fabricated a porous 3D-printed Mg-Nd-Zn-Zr(denoted as JDBM)implant with suitable mechanical properties using selective laser melting technology.The 3D-printed JDBM implant exhibited cytocompatibility in MC3T3-E1 and RAW267.4 cells and excellent osteoinductivity in vitro.Furthermore,the implant demonstrated excellent antibacterial ratios of 90.0% and 92.1% for methicillin-resistant S.aureus(MRSA)and Escherichia coli,respectively.The 3D-printed JDBM implant prevented MRSA-induced implant-related infection in a rabbit model and showed good in vivo biocompatibility based on the results of histological evaluation,blood tests,and Mg2+deposition detection.In addition,enhanced inflammatory response and TNF-α secretion were observed at the bone-implant interface of the 3D-printed JDBM implants during the early implantation stage.The high Mg^(2+)environment produced by the degradation of 3D-printed JDBM implants could promote M1 phenotype of macrophages(Tnf,iNOS,Ccl3,Ccl4,Ccl5,Cxcl10,and Cxcl2),and enhance the phagocytic ability of macrophages.The enhanced immunoregulatory effect generated by relatively fast Mg^(2+)release and implant degradation during the early implantation stage is a potential antibacterial mechanism of Mg-based implant.Our findings indicate that 3D-printed porous JDBM implants,having both antibacterial property and osteoinductivity,hold potential for future orthopedic applications. | Kai Xie Nanqing Wang Yu Guo Shuang Zhao Jia Tan Lei Wang Guoyuan Li Junxiang Wu Yangzi Yang Wenyu Xu Juan Chen Wenbo Jiang Penghuai Fu Yongqiang Hao | 2022 | Bioactive Materials2022，7，2： | 8 |
| 2 | Two-dimensional optical spatial differentiation and high-contrast imaging显示文摘Optical analog signal processing technology has been widely studied and applied in a variety of science and engineering fields, with the advantages of overcoming the low-speed and high-power consumption associated with its digital counterparts. Much attention has been given to emerging metasurface technology in the field of optical imaging and processing systems. Here, we demonstrate, for the first time, broadband two-dimensional spatial differentiation and high-contrast edge imaging based on a dielectric metasurface across the whole visible spectrum. This edge detection method works for both intensity and phase objects simply by inserting the metasurface into a commercial optical microscope. This highly efficient metasurface performing a basic optical differentiation operation opens up new opportunities in applications of fast,compactible and power-efficient ultrathin devices for data processing and biological imaging. | Junxiao Zhou Haoliang Qian Junxiang Zhao Min Tang Qianyi Wu Ming Lei Hailu Luo Shuangchun Wen Shaochen Chen Zhaowei Liu | 2021 | National Science Review2021，8，6： | 6 |
| 3 | Application of Contact Graph Routing in Satellite Delay Tolerant Networks显示文摘Satellite networks have many inherent advantages over terrestrial networks and have become an important part of the global network infrastructure.Routing aimed at satellite networks has become a hot and challenging research topic.Satellite networks,which are special kind of Delay Tolerant Networks(DTN),can also adopt the routing solutions of DTN.Among the many routing proposals,Contact Graph Routing(CGR) is an excellent candidate,since it is designed particularly for use in highly deterministic space networks.The applicability of CGR in satellite networks is evaluated by utilizing the space oriented DTN gateway model based on OPNET(Optimized Network Engineering Tool).Link failures are solved with neighbor discovery mechanism and route recomputation.Earth observation scenario is used in the simulations to investigate CGR's performance.The results show that the CGR performances are better in terms of effectively utilizing satellite networks resources to calculate continuous route path and alternative route can be successfully calculated under link failures by utilizing fault tolerance scheme. | ZHU Laitao LI Yong ZHANG Junxiang WU Jing TAI Xiao ZHOU Jianguo | 2015 | 空间科学学报2015，35，1： | 5 |
| 4 | Serum semaphorin 4C as a diagnostic biomarker in breast cancer:A multicenter retrospective study显示文摘Background:To date,there is no approved blood-based biomarker for breast cancer detection.Herein,we aimed to assess semaphorin 4C(SEMA4C),a pivotal protein involved in breast cancer progression,as a serum diagnostic biomarker.Methods:We included 6,213 consecutive inpatients from Tongji Hospital,Qilu Hospital,and Hubei Cancer Hospital.Training cohort and two validation cohorts were introduced for diagnostic exploration and validation.A pan-cancer cohort was used to independently explore the diagnostic potential of SEMA4C among solid tumors.Breast cancer patients who underwent mass excision prior to modified radical mastectomy were also analyzed.We hypothesized that increased pretreatment serum SEMA4C levels,measured using optimized in-house enzymelinked immunosorbent assay kits,could detect breast cancer.The endpoints were diagnostic performance,including area under the receiver operating characteristic curve(AUC),sensitivity,and specificity.Post-surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM classification.There was no restriction on disease stage for eligibilities.Results:We included 2667 inpatients with breast lesions,2378 patients with other solid tumors,and 1168 healthy participants.Specifically,118 patients with breast cancer were diagnosed with stage 0(5.71%),620 with stage I(30.00%),966 with stage II(46.73%),217 with stage III(10.50%),and 8 with stage IV(0.39%).Patients with breast cancer had significantly higher serum SEMA4C levels than benign breast tumor patients and normal controls(P<0.001).Elevated serum SEMA4C levels had AUC of 0.920(95%confidence interval[CI]:0.900–0.941)and 0.932(95%CI:0.911–0.953)for breast cancer detection in the two validation cohorts.The AUCs for detecting early-stage breast cancer(n=366)and ductal carcinoma in situ(n=85)were 0.931(95%CI:0.916–0.946)and 0.879(95%CI:0.832–0.925),respectively.Serum SEMA4C levels significantly decreased after surgery,and the reduction was more striking after modified radical mastectomy,compared with mass excision(P<0.001).The positive rate of enhanced serum SEMA4C levels was 84.77%for breast cancer and below 20.75%for the other 14 solid tumors.Conclusions:Serum SEMA4C demonstrated promising potential as a candidate biomarker for breast cancer diagnosis.However,validation in prospective settings and by other study groups is warranted. | Ya Wang Long Qiao Jie Yang Xiong Li Yaqi Duan Jiahao Liu Shaoqi Chen Huayi Li Dan Liu Tian Fang Jingjing Ma Xiaoting Li Fei Ye Junxiang Wan Juncheng Wei Qin Xu Ensong Guo Ping Jin Mingfu Wu Lin Zhang Yun Xia Yaqun Wu Jun Shao Yaojun Feng Qing Zhang Zongyuan Yang Gang Chen Qinghua Zhang Xingrui Li Shixuan Wang Junbo Hu Xiaoyun Wang Mona P.Tan Kazuaki Takabe Beihua Kong Qifeng Yang Ding Ma Qinglei Gao | 2021 | Cancer Communications2021，41，12： | 3 |
| 5 | Impacts of landscape structure on surface urban heat islands: A case study of Shanghai, China显示文摘 | Junxiang Li Conghe Song Lu Cao Feige Zhu Xianlei Meng Jianguo Wu | 2011 | Remote Sensing of Environment2011，，12： | 2 |
| 6 | Reliable sensors based on graphene textile with negative resistance variation in three dimensions显示文摘The weft-knitted reduced graphene oxide(r-GO)textile that is made up of many conductive r-GO coated fibers was successfully prepared dependent on the electrospray deposition technique.Interestingly,the r-GO textile presents negative resistance variation not only in axial direction as the pressure increases but also in transverse direction as the lateral stretch increases which makes it has the advantage to fabricate the reliable sensors based on strain-resistance effect.The transverse-strain and pressure sensors based on the r-GO textiles all show the excellent sensing characteristics such as high sensitivity,reliability,and good durability,etc.The maximum gauge factors(GF)of the transverse-sensor are 27.1 and 153.5 in the x-and/-direction,respectively.And the practical detection range can up to 40%in the x-direction and 35%in the y-direction,respectively.The r-GO textile pressure sensor also shows high sensitivity for a broad pressure range that with a GF up to 716.8 kPa-1 for less than 4.5 kPa region and still has more sensitive pressure sensing characteristics even the pressure goes up to 14 kPa.Based on those good performances of r-GO textile sensors,its potential applications in human body states monitoring have been studied. | Wenpeng Han Yijun Wu He Gong Linxin Liu Junxiang Yan Mengfei Li Yunze Long Guozhen Shen | 2021 | Nano Research2021，14，8： | 2 |
| 7 | Impacts of landscape structure on surface urban heat islands: A case study of Shanghai, China显示文摘 | Junxiang Li Conghe Song Lu Cao Feige Zhu Xianlei Meng Jianguo Wu | 2011 | Remote Sensing of Environment2011，，12： | 1 |
| 8 | Beyond fundamental resonance mode:high-order multi-band ALN PMUT for in vivo photoacoustic imaging显示文摘This paper reports on an aluminum nitride(AlN)piezoelectric micromachined ultrasound transducer(PMUT)array for photoacoustic(PA)imaging,where the high-order resonance modes of the PMUT are utilized to improve imaging resolution.A flexural vibration mode(FVM)PMUT is fabricated and applied in a photoacoustic imaging(PAI)system.Specifically,the microelectromechanical system(MEMS)-based PMUT is suitable for PA endoscopic imaging of blood vessels and bronchi due to its miniature size and high sensitivity.More importantly,AlN is a nontoxic material,which makes it harmless for biomedical applications.In the PAI system,the AlN PMUT array is used to detect PA signals,and the acousto–mechanical response is designed and optimized at the PMUT’s fundamental resonance.In this work,we focus on the high-order resonance performance of the PMUT PAI beyond the fundamental resonance.The acoustic and electrical responses of the PMUT’s high-order resonance modes are characterized and analyzed.The fundamental and three high-order resonance bandwidths are 2.2,8.8,18.5,and 48.2 kHz.Compared with the resolution at the fundamental resonance mode,the resolutions at third-and fourth-order resonance modes increase by 38.7%and 76.9%in a phantom experiment.The high-order resonance modes of the AlN PMUT sensor array provide higher central frequency and wider bandwidth for PA signal detection,which increase the resolution of PAI compared to the PMUT working at the fundamental resonance mode. | Junxiang Cai Yiyun Wang Daohuai Jiang Songsong Zhang Yuandong Alex Gu Liang Lou Fei Gao Tao Wu | 2022 | Microsystems & Nanoengineering2022，8，6： | 1 |
| 9 | Neurogenic differentiation of human umbilical cord mesenchymal stem cells on aligned electrospun polypyrrole/ polylactide composite nanofibers with electrical stimulation显示文摘 | Junfeng ZHOU Liang CHENG Xiaodan SUN Xiumei WANG ShouhongJIN Junxiang LI Qiong WU | 2016 | Frontiers of Materials Science2016，10，3： | 1 |
| 10 | Quantifying the speed, growth modes, and landscape pattern changes of urbanization: A hierarchical patch dynamics approach显示文摘 | Li Cheng Li Junxiang Wu Jianguo | 2013 | Landscape Ecology2013，28，10： | 1 |
| 11 | Strapdown inertial navigation system algorithms based on dual quatemions显示文摘 | Wu Yuanxin Hu Xiaoping Hu Dewen Li Tao Lian Junxiang | 2005 | IEEE Transactions on Aerospace and Electronic Syetems2005，41，1： | 1 |
| 12 | Association of the genetic polymorphism of EPHX1 and EPHX2 with the susceptibility to chronic benzene poisoning显示文摘The aim of this study was to explore the association of the genetic polymorphism of EPHX1 and EPHX2 with the susceptibility to chronic benzene poisoning(CBP).A case-control study of 268 patients with CBP and 268 healthy workers matched by age and sex,all of whom were occupationally exposed to benzene,was conducted.The single nucleotide polymorphisms(SNPs,rs2854451,rs3738047,rs2234922 and rs1051741)of EPHX1 gene and the SNP(rs751141)of EPHX2 gene were tested by the TaqMan PCR method.In the subjects carrying the genotype of EPHX1 rs3738047 GG,the risk of CBP was decreased in the individuals simultaneously carrying EPHX1 rs2234922 G(P=0.02).Alternatively,in the subjects carrying the genotype of EPHX1 rs2234922 AA,the risk of CBP was increased in the individuals simultaneously carrying the allele of EPHX2 rs751141A(P=0.03).It was also found that there were potential interactions between alcohol consumption and the polymorphism of EPHX1 rs1051741(x_(H)^(2)=5.28,P=0.02)or rs2234922(x_(H)^(2)=6.71,P=0.01).Compared to individuals with EPHX1 rs1051741 CC or rs2234922 AA genotype in the drinkers,the risk of CBP in those carrying genotypes of EPHX1 rs1051741 CT+TT or rs2234922 AG+GG was decreased,respectively(P=0.04,P<0.01).Haplotype analysis of polymorphisms in EPHX1 showed that the risk of CBP was increased in the subjects with haplotype 2(rs2854451-A,rs3738047-G,rs2234922-A,rs1051741-C)or haplotype 4(rs2854451-G,rs3738047-A,rs2234922-G,rs1051741-T),but decreased in those with haplotype 6(rs2854451-G,rs3738047-G,rs2234922-G,rs1051741-T)or haplotype 10(rs2854451-A,rs3738047-A,rs2234922-G,rs1051741-T),respectively.Logistic regression analysis revealed that smoking might play a role in modifying the risk of CBP(OR=0.313,95%CI:0.123–0.794,P=0.015).The genetic polymorphism in EPHX1 may be associated with the risk of CBP in the Chinese occupational population and further research is needed for the association between the genetic polymorphism in EPHX2 and the susceptibility to CBP. | SUN Pin ZHANG Zhongbin WU Fen WAN Junxiang JIN Xibeng XIA Zhaolin | 2007 | Frontiers of Medicine2007，1，3： | 1 |
| 13 | ILIDViz:An incremental learning-based visual analysis system for network anomaly detection显示文摘Background With the development of information technology,there is a significant increase in the number of network traffic logs mixed with various types of cyberattacks.Traditional intrusion detection systems(IDSs)are limited in detecting new inconstant patterns and identifying malicious traffic traces in real time.Therefore,there is an urgent need to implement more effective intrusion detection technologies to protect computer security.Methods In this study,we designed a hybrid IDS by combining our incremental learning model(KANSOINN)and active learning to learn new log patterns and detect various network anomalies in real time.Conclusions Experimental results on the NSLKDD dataset showed that KAN-SOINN can be continuously improved and effectively detect malicious logs.Meanwhile,comparative experiments proved that using a hybrid query strategy in active learning can improve the model learning efficiency. | Xuefei TIAN Zhiyuan WU Junxiang CAO Shengtao CHEN Xiaoju DONG | 2023 | Virtual Reality & Intelligent Hardware2023，5，6： | 0 |
| 14 | Growth hormone promotes the reconstruction of injured axons in the hypothalamo-neurohypophyseal system显示文摘Previous studies have shown that growth hormone can regulate hypothalamic energy metabolism, stress, and hormone release. Therefore, growth hormone has great potential for treating hypothalamic injury. In this study, we established a specific hypothalamic axon injury model by inducing hypothalamic pituitary stalk electric lesions in male mice. We then treated mice by intraperitoneal administration of growth hormone. Our results showed that growth hormone increased the expression of insulin-like growth factor 1 and its receptors, and promoted the survival of hypothalamic neurons, axonal regeneration, and vascular reconstruction from the median eminence through the posterior pituitary. Altogether, this alleviated hypothalamic injury-caused central diabetes insipidus and anxiety. These results suggest that growth hormone can promote axonal reconstruction after hypothalamic injury by regulating the growth hormone-insulin-like growth factor 1 axis. | Kai Li Zhanpeng Feng Zhiwei Xiong Jun Pan Mingfeng Zhou Weizhao Li Yichao Ou Guangsen Wu Mengjie Che Haodong Gong Junjie Peng Xingqin Wang Songtao Qi Junxiang Peng | 2024 | Neural Regeneration Research2024，19，10： | 0 |
| 15 | Accelerated fracture healing by osteogenic Ti45Nb implants through the PI3K–Akt signaling pathway显示文摘The key to managing fracture is to achieve stable internal fixation,and currently,biologically and mechanically appropriate internal fixation devices are urgently needed.With excellent biocompatibility and corrosion resistance,titanium–niobium alloys have the potential to become a new generation of internal fixation materials for fractures.However,the role and mechanism of titanium–niobium alloys on promoting fracture healing are still undefined.Therefore,in this study,we systematically evaluated the bone-enabling properties of Ti45Nb via in vivo and in vitro experiments.In vitro,we found that Ti45Nb has an excellent ability to promote MC3T3-E1 cell adhesion and proliferation without obvious cytotoxicity.Alkaline phosphatase(ALP)activity and alizarin red staining and semiquantitative analysis showed that Ti45Nb enhanced the osteogenic differentiation of MC3T3-E1 cells compared to the Ti6Al4V control.In the polymerase chain reaction experiment,the expression of osteogenic genes in the Ti45Nb group,such as ALP,osteopontin(OPN),osteocalcin(OCN),type 1 collagen(Col-1)and runt-related transcription factor-2(Runx2),was significantly higher than that in the control group.Meanwhile,in the western blot experiment,the expression of osteogenic-related proteins in the Ti45Nb group was significantly increased,and the expression of PI3K–Akt-related proteins was also higher,which indicated that Ti45Nb might promote fracture healing by activating the PI3K–Akt signaling pathway.In vivo,we found that Ti45Nb implants accelerated fracture healing compared to Ti6Al4V,and the biosafety of Ti45Nb was confirmed by histological evaluation.Furthermore,immunohistochemical staining confirmed that Ti45Nb may promote osteogenesis by upregulating the PI3K/Akt signaling pathway.Our study demonstrated that Ti45Nb exerts an excellent ability to promote fracture healing as well as enhance osteoblast differentiation by activating the PI3K/Akt signaling pathway,and its good biosafety has been confirmed,which indicates its clinical translation potential. | Jia Tan Jiaxin Li Zhaoyang Ran Junxiang Wu Dinghao Luo Bojun Cao Liang Deng Xiaoping Li Wenbo Jiang Kai Xie Lei Wang Yongqiang Hao | 2023 | Bio-Design and Manufacturing2023，6，6： | 0 |
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