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| 1 | 2016 Chinese expert consensus and guidelines for the diagnosis and treatment of papillary thyroid microcarcinoma显示文摘The incidence of papillary thyroid carcinoma(PTC)has exponentially increased in recent years.Papillary thyroid microcarcinoma(PTMC)accounts for the majority of the reported cases of PTC.The debates and crucial issues in PTMC management have received researchers'attention.To further improve the clinical management of PTMC in China, | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Li Gao Zhuming Guo Tao Huang Xiaoming Huang Xiaoming Li Yansong Lin Qinjiang Liu Xin Ni Yi Pan Jianwu Qin Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Daiwei Zhao Naisong Zhang ShengZhang Ying Zheng Jingqiang Zhu Dapeng Li Xiangqian Zheng 无 | 2017 | Cancer Biology & Medicine2017，14，3： | 23 |
| 2 | A critical epitope in CD147 facilitates memory CD4^(+) T-cell hyper-activation in rheumatoid arthritis显示文摘The abnormal activation of CD4^(+)CD45RO+memory T(Tm)cells plays an important role in the pathogenesis of rheumatoid arthritis(RA).Previous studies have shown that CD147 participates in T-cell activation.However,it remains unclear whether CD147 is involved in abnormal Tm-cell activation in RA patients.In this study,we demonstrated that CD147 was predominantly upregulated in Tm cells derived from RA patients.The anti-CD147 mAb 5A12 specifically inhibited Tm-cell activation and proliferation and further restrained osteoclastogenesis.Using a structural–functional approach,we depicted the interface between 5A12 and CD147.This allowed us to identify two critical residues,Lys63 and Asp65,as potential targets for RA treatment,as the double mutation K63A/D65A inhibited Tm-cell activation,mimicking the neutralization by 5A12.This study provides not only a theoretical basis for a“CD147-Tm/Osteoclast-RA chain”for the potential prevention and treatment of RA or other T-cell-mediated autoimmune diseases but also a new target for related drug design and development. | Na Guo Sheng Ye Kui Zhang Xiaoling Yu Hongyong Cui Xiangmin Yang Peng lin Minghua Lv Jinlin Miao Yang Zhang Qing Han Rongguang Zhang Zhinan Chen Ping Zhu | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 3 | Investigation on interface of NiFeCr/NiFe/Ta films with high magnetic field sensitivity显示文摘NiFeCr/NiFe/Ta films with excellent performance were prepared by magnetron sputtering system.The anisotropic magetoresistance (AMR) value (ΔR/R) and magnetic filed sensitivity (Sv,Sv=[d(ΔR/R)/dH]max.) for the 12 nm NiFe film deposited on NiFeCr buffer layer were 3.66% and 1.42×10-4%·T-1,respectively.The higher Sv of the film is close to that of a spin valve (SV).The microstructure analysis shows that the NiFeCr buffer layer has adopted the same structure with the same interplanar distance as the NiFe layer,inducing a strong NiFe (111) texture,and that the NiFeCr/NiFe interface is quite smooth,leading to a high degree of specular reflection of conduction electrons.Both increase the ΔR and reduce the R in the film,which lead to the high ΔR/R.Clean substrate surfaces are critical for preparation of high performance NiFeCr/NiFe/Ta films,and sputter cleaning or pre-deposition of 5 nm amorphous Al2O3 layer in the deposition chamber can provide the re-quired clean substrate surfaces for the growth of the buffer layer. | Sheng, Shu Li, Wei Li, Minghua Yu, Guanghua | 2012 | Rare Metals2012，31，1： | 6 |
| 4 | Advances and prospects of PVDF based polymer electrolytes显示文摘Exploring highly foldable batteries with no safety hazard is a crucial task for the realization of portable,wearable,and implantable electric devices.Given these concerns,developing solid-state batteries is one of the most promising routes to achieve this aspiration.Because of the excellent flexibility and processability,polyvinylidene fluoride(PVDF) based electrolytes possess great potential to pack high energy density flexible batteries,however,suffers the various intrinsic shortcomings such as inferior ionic conductivity,a high degree of crystallinity,and lack of reactive groups.Clearing the progress of the present state and concluding the specific challenges faced by PVDF based electrolytes will help to develop PVDF based polymer batteries.In this review,we summarize the recent progress of gel polymer electrolytes and all solid polymer electrolytes based on PVDF.The ion transport mechanisms and preparation methods of PVDF based electrolytes are briefly introduced.Meanwhile,the current design principle and properties of electrolytes are highlighted and systematically discussed.Some peculiar modified strategies performed in lithium-sulfur batteries and lithium-oxygen batteries are also included.Finally,this review describes the challenges and prospects of some solid-state electrolytes to provide strategies for manufacturing high-performance PVDF electrolytes aimed at practical application with flexible requirements. | Yixin Wu Yu Li Yang Wang Qian Liu Qingguo Chen Minghua Chen | 2022 | Journal of Energy Chemistry2022，31，1： | 5 |
| 5 | miR-137 and miR-491 Negatively Regulate Dopamine Transporter Expression and Function in Neural Cells显示文摘The dopamine transporter(DAT) is involved in the regulation of extracellular dopamine levels.A 40-bp variable-number tandem repeat(VNTR) polymorphism in the 3'-untranslated region(3'UTR) of the DAT has been reported to be associated with various phenotypes that are involved in the aberrant regulation of dopaminergic neurotransmission.In the present study,we found that miR-137 and miR-491 caused a marked reduction of DAT expression,thereby influencing neuronal dopamine transport.Moreover,the regulation of miR-137 and miR-491 on this transport disappeared after the DAT was silenced.The miR-491 seed region that is located on the VNTR sequence in the 3'UTR of the DAT and the regulatory effect of miR-491 on the DAT depended on the VNTR copy-number.These data indicate that miR-137 and miR-491 regulate DAT expression and dopamine transport at the posttranscriptional level,suggesting that microRNA may be targeted for the treatment of diseases associated with DAT dysfunction. | Xiaojian Jia Feng Wang Ying Han XuewenGeng Minghua Li Yu Shi Lin Lu Yun Chen | 2016 | Neuroscience Bulletin2016，32，6： | 5 |
| 6 | An improved surface-plasmonic nanobeam cavity for higher Q and smaller V显示文摘We demonstrate a high-Q hybrid surface-plasmon-polariton-photonic crystal(SP3C) nanobeam cavity.The proposed cavities are analyzed numerically using the three-dimensional finite difference time domain(3D-FDTD) method.The results show that a Q-factor of 2076 and a modal volume V of 0.16(/2n) 3 can be achieved in a 50 nm silica-gap hybrid SP3C nanobeam cavity when it operates at telecommunications wavelengths and at room temperature.V can be further reduced to 0.02(/2n) 3 when the silica thickness decreases to 10 nm,which leads to a Q/V ratio that is 11 times that of the corresponding plasmonic-photonic nanobeam cavity(without silica).The ultrahigh Q/V ratio originates from the low-loss nature and deep sub-wavelength confinement of the hybrid plasmonic waveguide,as well as the mode gap effect used to reduce the radiation loss.The proposed structure is fully compatible with semiconductor fabrication techniques and could lead to a wide range of applications. | YU Ping QI Biao XU Chao HU Ting JIANG XiaoQing WANG MingHua YANG JianYi | 2012 | Chinese Science Bulletin2012，57，25： | 4 |
| 7 | Research of high speed optical switch based on compound semiconductor显示文摘High-speed optical switch and its array are the crucial components of all-optical switching system.This paper presents the analytical model of a total-internal-reflection(TIR) optical switch.By employing the carrier injection effect in GaAs and the GaAs/AlGaAs double heterojunction structure,the X-junction TIR switch and the Mach-Zehnder interference(MZI) switch are demonstrated at 1.55 μm.The measured results show that the extinction ratio of both switches exceeds 20 dB.The switching speed reaches the scale of 10 ns. | WANG MingHua QI Wei YU Hui JIANG XiaoQing YANG JianYi | 2009 | Chinese Science Bulletin2009，54，20： | 4 |
| 8 | 2017 Chinese expert consensus on the clinical application ofserum marker for thyroid cancer显示文摘In recent years, the clinical incidence of thyroid cancer has been increasing year by year, and its risk assessment and clinical management methods have also been accordingly modified and constantly improved. There are great differences between the clinical diagnostic and therapeutic modes and disease management of thyroid cancer employed by various medical institutions in China, particularly with regard to the clinical application of serum marker of thyroid cancer. To this end, the China Anti-Cancer Association Thyroid Cancer Specialized Committee Chinese Association of Thyroid Oncology organized this compilation of ExpertConsensus on Clinical Application of Serum Marker of Thyroid Cancer to help and impel relevant clinical institutions and professionals to standardize clinical diagnosis, treatment, and long-term management of thyroid cancer, and to properly utilize the serum marker for scientific auxiliary clinical diagnosis and assessment of thyroid cancer before and after operation. | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Wei Cui Li Gao Zairong Gao Lin Guo Zhuming Guo Tao Huang Xiaoming Huang Yansong Lin Qinjiang Liu Xin Ni Jianwu Qin Li Ren Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Bin Zhang DaiweiZhao Ying Zheng Jingqiang Zhu Xiangqian Zheng 无 | 2018 | Cancer Biology & Medicine2018，15，4： | 3 |
| 9 | Modification of magnetic properties in SmCo films by controlling crystallization and phase transition显示文摘A series of Cr/SmCo/Cr films with high Sm concentration(37.7at%) were prepared by magnetron sputtering.Effects of SmCo thickness,annealing temperature,and annealing time on magnetic properties and crystal structure were carefully studied.Results show that crystallization degree and phase transition in the films can be controlled by the SmCo thickness and optimized by properly increasing the annealing temperature and extending the annealing time.Finally,a SmCo film with high magnetic properties and low MEI was constructed. | FENG Chun LINing LI Shuai HUO QianMing LI MingHua ZHAN Qian LI BaoHe JIANG Yong YU GuangHua | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，10： | 3 |
| 10 | Enhanced bioactivity and interfacial bonding strength of Ti3Zr2Sn3Mo25Nb alloy through graded porosity and surface bioactivation显示文摘The gradient porous Ti3Zr2Sn3Mo25Nb(TLM)alloy rods were fabricated through sintering the alloyed powder to a solid core.The porous sample was then modified by a Micro Arc Oxidation(MAO)treatment in an electrolyte containing calcium and phosphate,a hydrothermal treatment enabled secondary microporous hydroxyapatite(HA)coating,and a further bone morphogenetic protein-2(BMP-2)loading treatment through immersion and freeze-drying.The treatment led to an orderly secondary microporous coating containing HA nano-particles and evenly distributed BMP-2 in the porous coatings.As a result,osteoblasts could adhere and grow well on the coatings with a high cell adhesion rate and cell functional activity.The in-situ shear testing indicated that the interfacial strength had been enhanced significantly.Improvement of the bond formation and osseointegration with the titanium implant is attributed to increased surface area for the cell to attach,creating voids for the cell to grow in,and activating titanium surface by introducing bioactive ingredients such as HA and BMP-2. | Sen Yu Zhe Yu Dagang Guo Hui Zhu Minghua Zhang Jianye Han Zhentao Yu Yemin Cao Gui Wang | 2022 | Journal of Materials Science & Technology2022，，5： | 3 |
| 11 | The structure and mechanical property of silane-graftedpolyethylene/SiO_(2) nanocomposite fiber rope显示文摘The effect of vinyltrimethoxysilane(VTMS)graft and SiO_(2) on the structure and mechanical properties of silane-grafted-polyethylene/SiO_(2)(VTMS-g-PE/SiO_(2))nanocomposite fibers and ropes was studied.Scanning electron microscopy(SEM),Fourier transfer infrared(FT-IR),differential scanning calorimetry analysis(DSC)and tensile mechanical tests were performed to characterize the morphology,thermal and mechanical properties of nanocomposite fibers and ropes.The results revealed that the SiO_(2) nanoparticles were well dispersed throughout the polymeric matrix.With increasing SiO_(2) content,T_(m),the melt peak width and X_(c),degree of crystallinity,of VTMS-g-PE/SiO_(2) nanocomposite fibers increased.The breaking load and breaking strength of the nanocomposite fiber ropes were remarkably improved compared to pure PE fiber ropes and elongation at break was also decreased. | Wenwen Yu Jiangao Shi Lumin Wang Xiaoxue Chen Minghua Min Lei Wang Yongli Liu | 2017 | Aquaculture and Fisheries2017，2，1： | 2 |
| 12 | Multi-antenna synchronized global navigation satellite system receiver and its advantages in high-precision positioning applications显示文摘 | Danan DONG Wen CHEN Miaomiao CAI Feng ZHOU Minghua WANG Chao YU Zhengqi ZHENG Yuanfei WANG | 2016 | Frontiers of Earth Science2016，10，4： | 2 |
| 13 | Electro-Fenton method for the removal of methyl red in an efficient electrochemical system显示文摘 | Minghua Zhou Qinghong Yu Lecheng Lei | 2007 | Separation and Purification Technology2007，57，2： | 1 |
| 14 | The property and microstructure study of Polyimide/Nano-TiO 2 Hybrid Films with sandwich structures显示文摘 | Xiaoxu Liu Jinghua Yin Yunan Kong Minghua Chen Yu Feng Zhonghua Wu Bo Su Qingquan Lei | 2013 | Thin Solid Films2013，，： | 1 |
| 15 | 显示文摘 | Yu Minghua Gu Guoman Meng Weidong | 2007 | Applied Surface Science2007，253，7： | 1 |
| 16 | Microstructure and dielectric property study of Polyimide/BaTiO 3 nanocomposite films显示文摘 | Minghua Chen Jinghua Yin Xiaoxu Liu Yu Feng Bo Su Qingquan Lei | 2013 | Thin Solid Films2013，，： | 1 |
| 17 | Electro-Fenton method for the removal of methyl red in anefficient electrochemical system 显示文摘 | Minghua Zhou Qinghong Yu Lecheng Lei | 2007 | Separation and Purification Technology2007，57，： | 1 |
| 18 | Preparation,Characterization and Photocatalytic Activity of in Situ N,S-codoped TiO2 Powders显示文摘 | Zhou Minghua | 2006 | J Mol Catal A2006，246，： | 1 |
| 19 | Hyperspectral image unmixing algorithm based on endmember-constrained nonnegative matrix factorization显示文摘 | Yan ZHAO Zhen ZHOU Donghui WANG Yicheng HUANG Minghua YU | 2016 | Frontiers of Optoelectronics2016，9，4： | 1 |
| 20 | Micro-nano structure poly(ether sulfones)/poly(ethyleneimine) nanofibrous affinity membranes for adsorption of anionic dyes and heavy metal ions in aqueous solution显示文摘 | Minghua Min Lingdi Shen Guishan Hong Meifang Zhu Yu Zhang Xuefen Wang Yanmo Chen Benjamin S. Hsiao | 2012 | Chemical Engineering Journal2012，，： | 1 |
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