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| 1 | Down-staging depth score to predict outcomes in locally advanced rectal cancer achieving ypl stage after neoadjuvant chemo-radiotherapy versus de novo stage pl cohort:A propensity score-matched analysis显示文摘Objective:Prognosis of patients with locally advanced rectal cancer(LARC)but achieving yp T1–2N0 stage after neoadjuvant concurrent chemo-radiotherapy(CRT)has been shown to be favorable.This study aims to determine whether the long-term outcome of yp T1–2N0 cases can be comparable to that of p T1–2N0 cohort that received definitive surgery for early disease.Method:From January 2008 to December 2013,449 consecutive patients with rectal cancer were treated and their outcome maintained in a database.Patients with LARC underwent total mesorectal excision(TME)surgery at4–8 weeks after completion of CRT,and those achieving stage yp I were identified as a group.As a comparison,stage p I group pertains to patients whose initially limited disease was not upstaged after TME surgery alone.After propensity score matching(PSM),comparisons of local regional control(LC),distant metastasis-free survival(DMFS),disease-free survival(DFS)and overall survival(OS)were performed using Kaplan-Meier analysis and log-rank test between yp I and p I groups.Down-staging depth score(DDS),a novel method of evaluating CRT response,was used for subset analysis.Results:Of the 449 patients,168 matched cases were generated for analysis.Five-year LC,DMFS,DFS and OS for stage p I vs.yp I groups were 96.7%vs.96.4%(P=0.796),92.7%vs.73.6%(P=0.025),91.2%vs.73.6%(P=0.080)and 93.1%vs.72.3%(P=0.040),respectively.In the DDS-favorable subset of the yp I group,LC,DMFS,DFS and OS resulted in no significant differences in comparison with the p I group(P=0.384,0.368,0.277 and0.458,respectively).Conclusions:LC was comparable in both groups;however,distant metastasis developed more frequently in down-staged LARC than de novo early stage cases,reflecting the need to improve the efficacy of systemic treatment despite excellent pathologic response.DDS can be an indicator to identify a subset of the yp I group whose longterm oncologic outcomes are as good as those of stage p I cohort. | Ning Li Jing Jin Jing Yu Shuai Li Yuan Tang Hua Ren Wenyang Liu Shulian Wang Yueping Liu Yongwen Song Hui Fang Zihao Yu Yexiong Li | 2018 | Chinese Journal of Cancer Research2018，30，3： | 4 |
| 2 | Ice-wedge Pseudomorphs Showing Climatic Change Since the Late Pleistocene in the Source Area of the Yellow River, Northeast Tibet显示文摘The source area of the Yellow River is located in the northeastern Tibetan Plateau, and is a high-elevation region with the annual mean temperature of-3.9℃. The ice-wedge pseudomorphs discovered in this region are recognized as two types.One was found in sandy gravel beds of the second terrace of the Yellow River. This ice-wedge pseudomorph is characterized by higher ratio of breadth/depth, and are 1~1.4 m wide and about 1 m deep. The bottom border of the ice-wedge pseudomorph is round arc in section. Another discovered in the pedestal of the second terrace has lower ratio of width/depth, and is 0.3~1.0 m wide and 1~2 m deep. Its bottom border is sharp. Based on the TL dating, the former was formed at the middle Holocene (5.69±0.43 ka BP and 5.43±0.41 ka BP),that is, the Megathermal, and the latter was formed at the late Last Glacial Maximum (13.49± 1.43 ka BP).Additionally, the thawing-freezing folders discovered in the late Late Pleistocene proluvium are 39.83±3.84 ka BP in age. The study on the ice-wedge pseudomorphs showed that the air temperature was lowered by up to 6~7 ℃ in the source area of the Yellow River when the ice-wedge pseudomorphs and thawing-freezing folds developed. | CHENG Jie ZHANG Xujiao TIAN Mingzhong YU Wenyang YU Jiangkuan TANG Dexiang YUE Jianwei | 2005 | Journal of Mountain Science2005，2，3： | 3 |
| 3 | Unstruc- tured finite volume method for water impact on a rigid body显示文摘 | YU Yan MING Pingjian DUAN Wenyang | 2014 | Journal of hydrodynanfics2014，26，4： | 1 |
| 4 | Key Technology of intelligent and on-demand Data Service in Multi- space agency显示文摘 | Wenyang Yu Guoqing Li Jibo Xie | 2010 | Ninth International Conference on Grid and Cloud Computing2010，，： | 1 |
| 5 | Flood monitoring based on spatial information grid显示文摘 | Li Guoqing Zhang Qian Yu Wenyang | 2009 | Eighth International Conference on Grid and Cooperative Computing2009，，： | 1 |
| 6 | Down-staging depth score could be a survival predictor for locally advanced gastric cancer patients after preoperative chemoradiotherapy显示文摘Objective:The predictive effect of preoperative chemoradiotherapy(CRT)is low and difficult in guiding individualized treatment.We examined a surrogate endpoint for long-term outcomes in locally advanced gastric cancer patients after preoperative CRT.Methods:From April 2012 to April 2019,95 patients with locally advanced gastric cancer who received preoperative concurrent CRT and who were enrolled in three prospective studies were included.All patients were stage T_(3/4) N_(+).Local control,distant metastasis-free survival(DMFS),disease-free survival(DFS)and overall survival(OS)were evaluated.Clinicopathological factors related to long-term prognosis were analyzed using univariate and multivariate analyses.The down-staging depth score(DDS),which is a novel method of evaluating CRT response,was used to predict long-term outcomes.Results:The median follow-up period for survivors was 30 months.The area under the curve(AUC)of the receiver operating characteristic(ROC)curve predicted by the DDS was 0.728,which was better than the pathological complete response(pCR),histological response and ypN0.Decision curve analysis further affirmed that DDS had the largest net benefit.The DDS cut-off value was 4.pCR and ypN0 were associated with OS(P=0.026 and 0.049).Surgery and DDS are correlated with DMFS,DFS and OS(surgery:P=0.001,<0.001 and<0.001,respectively;and DDS:P=0.009,0.013 and 0.032,respectively).Multivariate analysis showed that DDS was an independent prognostic factor of DFS(P=0.021).Conclusions:DDS is a simple,short-term indicator that was a better surrogate endpoint than pCR,histological response and ypN0 for DFS. | Ning Li Xin Wang Yuan Tang Dongbin Zhao Yihebali Chi Lin Yang Liming Jiang Jun Jiang Jinming Shi Wenyang Liu Hua Ren Hui Fang Yu Tang Bo Chen Ningning Lu Hao Jing Shunan Qi Shulian Wang Yueping Liu Yongwen Song Yexiong Li Jing Jin | 2021 | Chinese Journal of Cancer Research2021，33，4： | 1 |
| 7 | Model Tests on the Effect of Dip Angles on Flow Behavior of Liquefied Sand显示文摘The flow behavior of liquefied sand is reported using a self-developed testing system that enables the flow processes of liquefied sand to be studied at different slopes of the soil layers.The test device is mainly composed of a vibrating table,a transparent model box and a high-speed video monitoring camera.The tests replicated the horizontal and sloping flows of saturated sand in the model box,which can be tilted to various angles to study the flow characteristics of liquefied sand.The high-speed video monitoring camera captured and recorded the processes within the flowing sand.With increasing downslope,the strain,strain rate,duration time,and sand flow distance increased.The results of our experiment indicate that when selecting sites for engineering structures,the surface downslopes should be taken into account if liquefiable soils are present.Finally,some suggestions regarding site assessment and structural design for sites prone to liquefaction were presented. | Wenyang Li Yu Huang | 2023 | Journal of Earth Science2023，34，2： | 0 |
| 8 | Requirement-driven remote sensing metadata planning and online acquisition method for large-scale heterogeneous data显示文摘Remote sensing data acquisition is one of the most essential processes in the field of Earth observation.However,traditional methods to acquire data do not satisfy the requirements of current applications because large-scale data processing is required.To address this issue,this paper proposes a data acquisition framework that carries out remote sensing metadata planning and then realizes the online acquisition of large amounts of data.Firstly,this paper establishes a unified metadata cataloging model and realizes the catalog of metadata in a local database.Secondly,a coverage calculation model is presented,which can show users the data coverage information in a selected geographical region under the data requirements of a specific application.Finally,according to the data retrieval results and the coverage calcula-tion,a machine-to-machine interface is provided to acquire target remote sensing data.Experiments were conducted to verify the availability and practicality of the proposed frame-work,and the results show the strengths and powerful capabilities of our framework by overcoming deficiencies in traditional methods.It also achieved the online automatic acquisi-tion of large-scale heterogeneous remote sensing data,which can provide guidance for remote sensing data acquisition strategies. | Shuang Wang Guoqing Li Wenyang Yu Yue Ma | 2022 | Geo-Spatial Information Science2022，25，2： | 0 |
| 9 | Elimination of the yellow pigment gene PSY-E2 tightly linked to the Fusarium head blight resistance gene Fhb7 from Thinopyrum ponticum显示文摘Fhb7 is a major gene that was transferred from Thinopyrum ponticum to chromosome 7D of wheat(Triticum aestivum)and confers resistance to both Fusarium head blight(FHB)and Fusarium crown rot(FCR).However,Fhb7 is tightly linked to the PSY-E2 gene,which causes yellow flour,limiting its application in breeding.To break this linkage,marker K-PSY was developed for tagging PSY-E2 and used with Fhb7 markers to identify recombination between the two genes.Screening 21,000 BC1F2 backcross progeny(Chinese Spring ph1bph1b*2/SDAU 2028)revealed two Fhb7^(+)wheat-Tp7el_(2)L lines,Shannong 2–16and Shannong 16–1,that carry a desired truncated Fhb7^(+)translocation segment without PSY-E2.The two lines show levels of resistance to FHB and FCR similar to those of the original translocation line SDAU 2028,but have white flour.To facilitate Fhb7 use in wheat breeding,STS markers were developed and used to isolate Fhb7 on a truncated Tp7el_(2) translocation segment.Near-isogenic lines carrying the Fhb7^(+)segment were generated in the backgrounds of three commercial cultivars,and Fhb7^(+)lines showed increased FHB and FCR resistance without yield penalty.The breakage of the tight linkage between Fhb7 and PSY-E2 via homoeologous recombination provides genetic resources for improvement of wheat resistance to FHB and FCR and permit the large-scale deployment of Fhb7 in breeding using marker-assisted selection. | Xuefeng Li Dong Li Yu Xuan Ziming He Lanfei Zhao Yongchao Hao Wenyang Ge Shoushen Xu Bingqian Hou Biao Wang Jun Guo Wenwen Liu Mingzhu Li Yi Han Cunyao Bo Yinguang Bao Zengjun Qi Steven S.Xu Guihua Bai Hongwei Wang Lingrang Kong | 2023 | The Crop Journal2023，11，3： | 0 |
| 10 | Benefit of rituximab maintenance is associated with Follicular Lymphoma International Prognostic Index in patients with follicular lymphoma显示文摘Rituximab maintenance(RM)prolongs the progression-free survival(PFS)of responding patients with follicular lymphoma(FL),but the maintenance efficacy in different Follicular Lymphoma International Prognostic Index(FLIPI)risk group is still confusing.We performed a retrospective analysis of the effect of RM treatments in patients with FL responding to induction therapy based on their FLIPI risk assessment carried out prior to treatment.We identified 93 patients between 2013 and 2019 who received RM every 3 months for≥4 doses(RM group),and 60 patients who did not accept RM or received rituximab less than 4 doses(control group).After a median follow-up of 39 months,neither median overall survival(OS)nor PFS was reached for the entire population.The PFS was significantly prolonged in the RM group compared to the control group(median PFS NA vs 83.1 months,P=.00027).When the population was divided into the 3 FLIPI risk groups,the PFS differed significantly(4-year PFS rates,97.5%vs 88.8%vs 72.3%,P=.01)according to group.There was no significant difference in PFS for FLIPI low-risk patients with RM compared to the control group(4-year PFS rates,100%vs 93.8%,P=.23).However,the PFS of the RM group was significantly prolonged for FLIPI intermediate-risk(4-year PFS rates,100%vs 70.3%,P=.00077)and high-risk patients(4-year PFS rates,86.7%vs 57.1%,P=.023).These data suggest that standard RM significantly prolongs the PFS of patients assigned to intermediate-and high-risk FLIPI groups but not to low-risk FLIPI group,and pending larger-scale studies to validate. | Ru Li Tingyu Wang Rui Lyv Yi Wang Ying Yu Yuting Yan Qi Sun Wenjie Xiong Wei Liu Weiwei Sui Wenyang Huang Huijun Wang Chengwen Li Jun Wang Dehui Zou Gang An Jianxiang Wang Lugui Qiu Shuhua Yi | 2023 | Blood Science2023，5，2： | 0 |
| 11 | Seasonal change of circulating leptin associated with testicular activities of the wild ground squirrels(Citellus dauricus)显示文摘The purpose of this study was to explore the variations in the circulating leptin concentrations of the wild ground squirrels in relation to seasonal changes in testicular activities.Hematoxylin-eosin staining showed all types of elongated spermatids and spermatogenic cells existed in the testis in April,while the primary spermatocytes and spermatogonia were most advanced stages of germ cells in June.In addition,the primary spermatocytes,secondary spermatocytes,and spermatogonia were most advanced stages of germ cells in September.The highest circulating leptin concentration was consistent with the maximum body weight results from accumulation of adipose tissue in September.The mRNA expression level of leptin receptor(Ob-R)and STAT3 was lowest in June,raised in September,and remained increased in April.Ob-R and STAT3 were stronger staining in the Leydig cells in July.Moreover,the concentrations of testosterone(T)showed the maximum values in April,the minimum values in June,and significant increases in September.Furthermore,it is worth noting that the levels of T increased with the mRNA levels of Ob-R,STAT3,StAR,and testicular steroidogenic enzymes(3β-HSD,P450c17,and P450scc).Moreover,RNA-seq analyses of testis during the different periods showed that a total of 4209 genes were differ-entially expressed genes(DEGs);further analysis revealed that DEGs related with the Jak/STAT pathways and reproduction were altered.Taken together,the results suggested that the leptin regulated testicular function through the Jak/STAT pathways and testicular steroidogenic factor expressions. | Wenyang YU Sijie FAN Xi WANG Jueyu ZHU Zhengrong YUAN Yingying HAN Haolin ZHANG Qiang WENG | 2023 | Integrative Zoology2023，18，1： | 0 |
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