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| 1 | Ethnic Differences in Preterm Birth Risks for Pregnant Women with Thyroid Dysfunction or Autoimmunity:A Meta-analysis显示文摘Objective Abnormal maternal thyroid function is associated with preterm birth.However,this association stays dubious in relevant individual studies for ethnic difference reasons and lack of direct supporting data.This study aimed to evaluate the relationship between preterm birth and thyroid dysfunction or autoimmunity based on ethnic differences.Methods Relevant studies were identified through searches of MEDLINE,Excerpta Medica,Wan Fang,China Biological Medicine disc,and China National Knowledge Infrastructure from inception to June 15,2016.Original articles in which an incidence or prevalence of thyroid dysfunction or autoimmunity before second trimester of pregnancy could be extracted were included.Results Thirty-two unique studies were included for the final meta-analysis.Patients involved were divided into two groups:Group 1(G1) and Group 2(G2) comprising of Asian and Caucasian populations,respectively.Positive thyroid antibodies were associated with the occurrence of preterm birth in both G1 [odds ratio(OR):3.62,95% confidence interval(CI):2.83-4.65] and G2(OR:1.35,95% CI:1.17-1.56);hypothyroidism,only in G2(OR:1.20,CI:1.09-1.33);and subclinical hypothyroidism or hypothyroxinemia,in neither group.Conclusion Thyroid autoimmunity may be a more favorable factor leading to preterm birth among pregnant women of different ethnicities,compared with thyroid dysfunction. | LI Min WANG Shao Wei WU Feng Li SHI Jin YU Pu Lin PENG Xiu Ling SUN Liang | 2016 | Biomedical and Environmental Sciences2016，29，10： | 5 |
| 2 | Malnutrition Increases the Risk of Mortality in Hospitalized Lung Cancer Patients显示文摘Background The Global Leadership Initiative on Malnutrition(GLIM)recently developed a new set of diagnostic criteria for identifying patients with malnutrition.Because the GLIM criteria were only introduced a little over 3 years ago,additional validation and reliability testing are needed in a variety of populations.Methods We performed an observational,multicenter cohort study.From July 2013 to October 2018,lung cancer patients were recruited from the Daping Hospital of Army Medical University and the First Hospital of Jilin University as part of the INSCOC project.Previously-established cut-off values for the calf circumference(CC,male<30 cm,female<29.5 cm)were applied as the reduced muscal mass of phenotypic criteria to establish the GLIM diagnosis.Multivariate Cox regression analyses were performed to analyze the association between the GLIM criteria and survival.Results A total of 1219 patients with lung cancer were studied as subjects.Their age was 58.81±9.92 years old,and 820 were male and 399 were female.According to the GLIM diagnostic criteria using the CC as a muscle mass measurement,303 patients(24.9%)were categorized as malnourished,142 patients(23.1%)in the adult group(18≤age<60)and 161 patients(26.7%)in the older group(age≥60 years).The patients with malnutrition had a higher incidence of anemia than the nourished patients(P=0.012).The QLQ-C30 score and KPS score indicating that the malnourished patients had a consistently worse quality of life compared to the nourished group(all P<0.001).The median survival of the malnutrition group was 42(95%CI:34-50)months,which was much shorter than the 62(95%CI:57-66)months in the nourished group(P<0.001).In the adult group,the median survival decreased from 65(95%CI:55-72)months in nourished group to 34(95%CI:25-48)months in the patients with malnutrition(P<0.001).In the older group,it decreased from 61(95%CI:55-67)months to 48(95%CI:39-59)months(P=0.001).A Cox regression analysis showed that GLIM-diagnosed malnutrition was associated with an increased risk of death among adult group(HR=1.670,95%CI:1.29-2.16),older group(HR=1.332,95%CI:1.05-1.69)and overall(HR=1.453,95%CI:1.22-1.72).Conclusion All of these results demonstrate that GLIM-diagnosed malnutrition is associated with a poorer survival for all lung cancer patients,independent of age. | Fei Fei Chong Liang Yu Yin Jie Liu Na Li Jing Guo Yang Fan Meng Yuan Zhang Ling Zhang Xiu Mei He Hong Mei Zhang Mu Li Shi Wei Li Hong Xia Xu | 2022 | Journal of Nutritional Oncology2022，7，1： | 4 |
| 3 | Optimal Waist Circumference Cut-off values for Identifying Metabolic Risk Factors in Middle-aged and Elderly Subjects in Shandong Province of China显示文摘Objective To study the optimal waist circumference(WC) cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of China. Methods A total of 2 873 men and 5 559 women were included in this cross-sectional study. Metabolic syndrome(MetS) was diagnosed according to the definition of Chinese Diabetes Society in 2004. The relation between WC and MetS was analyzed by multivariate logistic regression analysis. The optimal WC cut-off values were identified using the area under the ROC curve and the different diagnostic criteria for central obesity were compared. Results The WC was the risk factor for MetS independent of BMI, blood glucose, blood lipid, and blood pressure. The optimal WC cut-off value was 83.8 cm and 91.1 cm for identifying MetS in women and men, respectively. Compared with 80 cm and 85 cm for women and men, 85 cm and 90 cm had a higher Youden index for identifying all metabolic risk factors and MetS in women and men. Conclusion The appropriate WC cut-off value is 85 cm and 90 cm for identifying central obesity and MetS in women and men in Shandong Province of China. | HOU Xin Guo WANG Chuan MA Ze Qiang YANG Wei Fang WANG Ji Xiang LI Cheng Qiao WANG Yu Lian LIU Shu Min Hu Xiu Ping ZHANG Xiu Ping JIANG Mei WANG Wei Qing NING Guang ZHENG Hui Zhen MA Ai Xia SUN Yu SONG Jun LIN Peng LIANG Kai LIU Fu Qiang LI Wen Juan XIAO Juan GONG Lei WANG Mei Jian LIU Ji Dong YAN Fei YANG Jun Peng WANG Ling Shu TIAN Meng ZHAO Ru Xing JIANG Ling CHEN Li | 2014 | Biomedical and Environmental Sciences2014，27，5： | 3 |
| 4 | Synthesis of N-methylene phosphonic chitosan(NMPCS)and its potential as gene carder显示文摘N-Methylene phosphoulc chitosan (NMPCS),an amphiphilic macromolecule with powerful chelating ability of Ca^(2+) ions,was synthesized and characterized.The physicochemical properties of NMPCS and the interactions between NMPCS and plasmid DNA were investigated by FTIR,^(13)C NMR,X-ray,agarose gel electrophorcsis retardation assay,atomic force microscopy (AFM) and circular dichroism (CD).The results suggest that at charge ratio 2:1 or above,DNA could be completely entrapped and spherical complexes with mean size of 80-210 nm were formed.Taking HeLa as host cell,luciferase expression mediated by NMPCS improved about 100 times compared to the expression mediated by chitosan. | Dun Wan Zhu Jin Gen Bo Hai Ling Zhang Wen Guang Liu Xi Gang Leng Cun Xian Song Yu Ji Yin Li Ping Song Lan Xia Liu Lin Mei Xiu Lan Li Yang Zhang Kang De Yao | 2007 | Chinese Chemical Letters2007，18，11： | 3 |
| 5 | Emergence of fatalPRRSV variants; unpar alleled outbreaks of atypical PRRS in China andmolecular dissection of the unique hallmark显示文摘 | Tian ke gong Yu xiu ling Zhao tie zhu | 2007 | PLos ONE2007，2，6： | 1 |
| 6 | Synthesis of NiFe_2O_4 Powders Well Defined in Size and Morphologies显示文摘The uniform NiFe2O4 powders with different particle size and morphologies (octahedral, cubic and spherical) have been prepared from different precursors via hydrothermal process. The nanocrystallines derived from precursor B in the weak alkali solution (pH≤10) are superparamagnetic. | Yu Ting ZHAO*, De Hong CHEN, Dai Rong CHEN, Xiu Ling JIAO Department of Chemistry, Shandong University, Jinan 250100 | 2002 | Chinese Chemical Letters2002，13，4： | 1 |
| 7 | Pathogenic Pseudorabies Virus, China, 2012显示文摘 | Yu XIU LING ZHOU ZHI HU DONG MEI | 2014 | Emerg Infect Dis2014，20，： | 1 |
| 8 | Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark显示文摘 | TIAN Ke-gong YU Xiu ling ZHAO Tie-zhu | 2007 | PloS ONE2007，2，6： | 1 |
| 9 | Two Side Chain β-CD Polysiloxanes Used as New Stationary Phase for Chiral Separation by HRGC显示文摘Two new stationary phases : (Ⅰ) [bikis(2,6-di-O-pentyl-3-O-hex-6O-pentyl-3-O-methyl)-β-CD-polysiloxane] and (Ⅱ) [heptkis(2,6-di-O-methyl-3-O-hex-6-enyl)-β-CD-polysiloxane] were synthesized and successfully used for GC separation of chiral isomers.The possess high column efficiency and exhibit fine chiral separation ability. | Han Bang ZHANG Yun LING Ruo Nong FU Yu Xiu WEN(Department of Chemical Engineering. Beijing Institute of Technology. Beijing 100081) | 1997 | Chinese Chemical Letters1997，8，2： | 1 |
| 10 | Rapid Detection of Rifampin-resistant Clinical Isolates of Mycobacterium tuberculosis by Reverse Dot Blot Hybridization显示文摘Objective A PCR-reverse dot blot hybridization(RDBH) assay was developed for rapid detection of rpo B gene mutations in ‘hot mutation region' of Mycobacterium tuberculosis(M. tuberculosis). Methods 12 oligonucleotide probes based on the wild-type and mutant genotype rpoB sequences of M. tuberculosis were designed to screen the most frequent wild-type and mutant genotypes for diagnosing RIF resistance. 300 M. tuberculosis clinical isolates were detected by RDBH, conventional drug-susceptibility testing(DST) and DNA sequencing to evaluate the RDBH assay. Results The sensitivity and specificity of the RDBH assay were 91.2%(165/181) and 98.3%(117/119), respectively, as compared to DST. When compared with DNA sequencing, the accuracy, positive predictive value(PPV) and negative predictive value(NPV) of the RDBH assay were 97.7%(293/300), 98.2%(164/167), and 97.0%(129/133), respectively. Furthermore, the results indicated that the most common mutations were in codons 531(48.6%), 526(25.4%), 516(8.8%), and 511(6.6%), and the combinative mutation rate was 15(8.3%). One and two strains of insertion and deletion were found among all strains, respectively. Conclusion Our findings demonstrate that the RDBH assay is a rapid, simple and sensitive method for diagnosing RIF-resistant tuberculosis. | GUO Qian YU Yan ZHU Yan Ling ZHAO Xiu Qin LIU Zhi Guang ZHANG Yuan Yuan LI Gui Lian WEI Jian Hao WU Yi Mou WAN Kang Lin | 2015 | Biomedical and Environmental Sciences2015，28，1： | 1 |
| 11 | Extremely low genetic diversity indicating the endangered status of ranodon sibiri- cus ( Amphibia : Caudata) and implications for phylogeography 显示文摘 | Shao Yu Chen Yi Jun Zhang Xiu Ling Wang | 2012 | PLoS ONE2012，7，33： | 1 |
| 12 | Distribution of Microbiota in Fine Particulate Matter Particles in Guangzhou, China显示文摘Objective High PM2.5 concentration is the main feature of increasing haze in developing states,but information on its microbial composition remains very limited.This study aimed to determine the composition of microbiota in PM2.5 in Guangzhou,a city located in the tropics in China.Methods In Guangzhou,from March 5th to 10th,2016,PM2.5 was collected in middle volume air samplers for 23 h daily.The 16 S rDNA V4 region of the PM2.5 sample extracted DNA was investigated using high-throughput sequence.Results Among the Guangzhou samples,Proteobacteria,Bacteroidetes,Firmicutes,Cyanobacteria,and Actinobacteria were the dominant microbiota accounting for more than 90%of the total microbiota,and Stenotrophomonas was the dominant gram-negative bacteria,accounting for 21.30%–23.57%.We examined the difference in bacterial distribution of PM2.5 between Beijing and Guangzhou at the genus level;Stenotrophomonas was found in both studies,but Escherichia was only detected in Guangzhou.Conclusion In conclusion,the diversity and specificity of microbial components in Guangzhou PM2.5 were studied,which may provide a basis for future pathogenicity research in the tropics. | DONG Shi Rui HAN Ya Jing WU Jing ZENG Cheng Li ZHU Ke Hui CHEN Xiao Jing LIU Yu Mei ZOU Xiao Qian ZHENG Shao Ling WEN Zi Hao LIU Dan Dan WANG Yao HUANG Xiu Xia DU Xiu Ben HAO Jian Lei WANG Huan Yu GUO Shu JING Chun Xia YANG Guang | 2020 | Biomedical and Environmental Sciences2020，33，5： | 1 |
| 13 | An Alternating Direction Method of Multipliers for MCP-penalized Regression with High-dimensional Data显示文摘 | Yue Yong SHI Yu Ling JIAO Yong Xiu CAO Yan Yan LIU | 2018 | Acta Mathematica Sinica,English Series2018，34，12： | 1 |
| 14 | Clinical Biobanks, from the World to China显示文摘The 2009 annual special issue of Time Magazine on March 23rd summarized the‘10 Ideas Changing the World Right Now’,in which‘Biobank’had been listed as the eighth.Biobank or biorepository has been developed since last century.Tissue banks represented the early type of clinical biobanks and mainly concentrated on clinical usage such as transplantation at the beginning.The first | JI Xu ZHAO Xiu Mei JIANG Jing Jing YIN Ling GUO Yu Cheng | 2014 | Biomedical and Environmental Sciences2014，27，6： | 1 |
| 15 | Synthesis and Structure of Vanadium-barium Complex of 2,4,6-Tripicolinato with 20-Member Macrocyclic Cavities显示文摘A new heteronuclear complex, dimer [(2-OH2)2Ba2(H2O)4][VO2(tpa)]24H2O (tpa: 2,4,6-tripicolinate trianion), was synthesized and structurally determined by X-ray diffraction technique where all hydrogen atoms have been located directly. The coordination geometry of V(V) ion is a distorted trigonal bipyrimid and that of Ba(II) ion is a capped square antiprism. One 2-O bridging bond and two hydrogen bonds act between the coordination geometries. A 1-D extended porous construction containing 20-member cavities is observed in the crystal. | Yu Xia DIAO, Yang TIAN, Si Hui ZHAN, Wen Xing ZHANG*,Xiu Ling JIAO, Dai Rong CHEN School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100 | 2003 | Chinese Chemical Letters2003，14，7： | 0 |
| 16 | Synthesis of Monodisperse α-Fe_2O_3 Particles in Short Periods显示文摘Monodisperse a-Fe2O3 particles with different particle size (ca. 62010 nm or 604 nm) have been successfully prepared by hydrothermal method in short periods. In this process, the crystal-growing inhibitor (DBS) favored the formation of monodisperse nanoparticles. | Yu Ting ZHAO, De Hong CHEN, Dai Rong CHEN*, Xiu Ling JIAO Department of Chemistry, Shandong University, Jinan 250100 | 2003 | Chinese Chemical Letters2003，14，3： | 0 |
| 17 | Convex PBW-type Lyndon Bases and Restricted Two-parameter Quantum Group of Type F_(4)显示文摘The convex PBW-type Lyndon basis for two-parameter quantum group U_(r,s)(F_(4))is given.Assume thatrs^(-1)is a primitive l-th root of unity with l odd,then the restricted quantum group u_(r,s)(F_(4))as a quotient of U_(r,s)(F_(4))is pointed,and of a Drinfel’d double structure under a certain condition.All of Hopf isomorphisms of u_(r,s)(F_(4))are determined,and the necessary and sufficient condition for u_(r,s)(F_(4))to be a ribbon Hopf algebra is singled out by describing the left and right integrals. | Xiao Yu CHEN Nai Hong HU Xiu Ling WANG | 2023 | Acta Mathematica Sinica,English Series2023，39，6： | 0 |
| 18 | Genomic characterization reveals distinctmutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract显示文摘Background:Neuroendocrine carcinomas of the gastrointestinal tract(GINECs)remain a disease of grim prognosis with limited therapeutic options.Their molecular characteristics are still undefined.This study aimed to explore the underlying genetic basis and heterogeneity of GI-NECs.Methods:Comprehensive genomic analysis using whole-exome sequencing was performed on 143 formalin-fixed,paraffin-embedded samples of surgically resected GI-NEC with a thorough histological evaluation.Mutational signatures,somatic mutations,and copy number aberrations were analyzed and compared across anatomic locations and histological subtypes.Survival analysis was conducted to identify the independent factors.Results:In total,143GI-NECswere examined:the stomach,87 cases(60.8%);the esophagus,29 cases(20.3%);the colorectum,20 cases(14.0%);and the small intestine,7 cases(4.9%).Eighty-three(58.0%)and 60(42.0%)cases were subclassified into small cell and large cell subtypes,respectively.GI-NECs showed distinct genetic alterations from their lung counterparts and non-neuroendocrine carcinomas in the same locations.Obvious heterogeneity of mutational signatures,somatic mutations,and copy number variations was revealed across anatomic locations rather than histological subtypes.Except for tumor protein p53(TP53)and retinoblastoma 1(RB1),the most frequently mutated genes in the stomach,esophagus,colorectum,and small intestine were low-density lipoprotein receptor-related protein 1B(LRP1B),notch receptor 1(NOTCH1),adenomatosis polyposis coli(APC),catenin beta 1(CTNNB1),respectively.Mutations in the WNT-β-catenin,NOTCH and erythroblastic leukemia viral oncogene B(ERBB)pathwayswere prevalently identified in gastric,esophageal,and colorectalNECs,respectively.Importantly,104(72.7%)GI-NECs harbored putative clinically relevant alterations,and non-gastric location and RB1 bi-allelic inactivation with copy number alterations were identified as two independent poor prognostic factors.Furthermore,we found that tumor cells in GI-NECs first gain clonal mutations in TP53,RB1,NOTCH1 and APC,followed by subsequent wholegenome doubling(WGD)and post-WGD clonal mutations in LRP1B,CUB and Sushi multiple domains 3(CSMD3),FAT tumor suppressor homolog 4(FAT4)and erb-b2 receptor tyrosine kinase 4(ERBB4),and finally develop subclonal mutations.Conclusions:GI-NECs harbor distinct genomic landscapes and demonstrate significant genetic heterogeneity across different anatomic locations.Moreover,potentially actionable alterations and prognostic factors were revealed for GI-NECs. | Huanwen Wu Zicheng Yu Yueping Liu Lei Guo Lianghong Teng Lingchuan Guo Li Liang Jing Wang Jie Gao Ruiyu Li Ling Yang Xiu Nie Dan Su Zhiyong Liang | 2022 | Cancer Communications2022，42，12： | 0 |
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