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| 1 | Short-term Load Prediction of Integrated Energy System with Wavelet Neural Network Model Based on Improved Particle Swarm Optimization and Chaos Optimization Algorithm显示文摘To improve energy efficiency and protect the environment,the integrated energy system(IES)becomes a significant direction of energy structure adjustment.This paper innovatively proposes a wavelet neural network(WNN)model optimized by the improved particle swarm optimization(IPSO)and chaos optimization algorithm(COA)for short-term load prediction of IES.The proposed model overcomes the disadvantages of the slow convergence and the tendency to fall into the local optimum in traditional WNN models.First,the Pearson correlation coefficient is employed to select the key influencing factors of load prediction.Then,the traditional particle swarm optimization(PSO)is improved by the dynamic particle inertia weight.To jump out of the local optimum,the COA is employed to search for individual optimal particles in IPSO.In the iteration,the parameters of WNN are continually optimized by IPSO-COA.Meanwhile,the feedback link is added to the proposed model,where the output error is adopted to modify the prediction results.Finally,the proposed model is employed for load prediction.The experimental simulation verifies that the proposed model significantly improves the prediction accuracy and operation efficiency compared with the artificial neural network(ANN),WNN,and PSO-WNN. | Leijiao Ge Yuanliang Li Jun Yan Yuqian Wang Na Zhang | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，6： | 11 |
| 2 | Evaluation of the situational awareness effects for smart distribution networks under the novel design of indicator framework and hybrid weighting method显示文摘As a key application of smart grid technologies,the smart distribution network(SDN)is expected to have a high diversity of equipment and complexity of operation patterns.Situational awareness(SA),which aims to provide a critical visibility of the SDN,will enable a significant assurance for stable SDN operations.However,the lack of systematic evaluation through the three stages of perception,comprehensive,and prediction may prevent the SA technique from effectively achieving the performance necessary to monitor and respond to events in SDN.To analyze the feasibility and effectiveness of the SA technique for the SDN,a comprehensive evaluation framework with specific performance indicators and systematic weighting methods is proposed in this paper.Besides,to implement the indicator framework while addressing the key issues of human expert scoring ambiguity and the lack of data in specific SDN areas,an improved interval-based analytic hierarchy process-based subjective weighting and a multi-objective programming method-based objective weighting are developed to evaluate the SDN SA performance.In addition,a case study in a real distribution network of Tianjin,China is conducted whose outcomes verify the practicality and effectiveness of the proposed SA technique for SDN operating security. | Leijiao GE Yuanliang LI Suxuan LI Jiebei ZHU Jun YAN | 2021 | Frontiers in Energy2021，15，1： | 9 |
| 3 | Optimal design and verification of temporal and spatial filters using second-order cone programming approach显示文摘Temporal filters and spatial filters are widely used in many areas of signal processing. A number of optimal design criteria to these problems are available in the literature. Various computational techniques are also presented to optimize these criteria chosen. There are many drawbacks in these methods. In this paper, we introduce a unified framework for optimal design of temporal and spatial filters. Most of the optimal design problems of FIR filters and beamformers are included in the framework. It is shown that all the design problems can be reformulated as convex optimization form as the second-order cone programming (SOCP) and solved efficiently via the well-established interior point methods. The main advantage of our SOCP approach as compared with earlier approaches is that it can include most of the existing methods as its special cases, which leads to more flexible designs. Furthermore, the SOCP approach can optimize multiple required performance measures, which is the drawback of earlier approaches. The SOCP approach is also developed to optimally design temporal and spatial two-dimensional filter and spatial matrix filter. Numerical results demonstrate the effectiveness of the proposed approach. | YAN Shefeng MA Yuanliang | 2006 | Science in China(Series F)2006，49，2： | 6 |
| 4 | Matched field noise suppression: Principle with application to towed hydrophone line array显示文摘Discrete noise source suppression in underwa-ter acoustic channel has attracted great attention in recent years. The paper proposes a new principle for dealing with the problem. This new principle is called matched field noise suppression (MFNS). Based on a previous work of the au-thors group, a full understanding about how a discrete noise source shows effects on the performance of a towed hydro-phone line array has been obtained. In light of that finding, MFNS is proposed, which explores and utilizes the charac-teristics of the noise transmission channel to achieve much greater suppression of the noise in comparison with existing approaches. MFNS combines the concept of matched field processing (MFP) and optimal sensor array processing (OSAP) together to suppress the discrete noise source and to maintain an optimal beam for receiving far-field wanted plane wave signals. A MFNS beam-former is deduced in constraint with signal plane-wave response being unit and noise matched field response being zero. A closed-form solution of the weight vec-tor for the beam-former is given. Computer simulation results agree well to the theoretical analysis. | MA Yuanliang YAN Shefeng YANG Kunde | 2003 | Chinese Science Bulletin2003，48，12： | 4 |
| 5 | Applying artificial intelligence for cancer immunotherapy显示文摘Artificial intelligence(AI)is a general term that refers to the use of a machine to imitate intelligent behavior for performing complex tasks with minimal human intervention,such as machine learning;this technology is revolutionizing and reshaping medicine.AI has considerable potential to perfect health-care systems in areas such as diagnostics,risk analysis,health information administration,lifestyle supervision,and virtual health assistance.In terms of immunotherapy,AI has been applied to the prediction of immunotherapy responses based on immune signatures,medical imaging and histological analysis.These features could also be highly useful in the management of cancer immunotherapy given their ever-increasing performance in improving diagnostic accuracy,optimizing treatment planning,predicting outcomes of care and reducing human resource costs.In this review,we present the details of AI and the current progression and state of the art in employing AI for cancer immunotherapy.Furthermore,we discuss the challenges,opportunities and corresponding strategies in applying the technology for widespread clinical deployment.Finally,we summarize the impact of AI on cancer immunotherapy and provide our perspectives about underlying applications of AI in the future. | Zhijie Xu Xiang Wang Shuangshuang Zeng Xinxin Ren Yuanliang Yan Zhicheng Gong | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 2 |
| 6 | Robust supergain beamforming for circular array via second-order cone programming显示文摘 | YAN Shefeng MA Yuanliang | 2005 | Applied Acoustics (S0003-682X)2005，66，9： | 1 |
| 7 | Immunopotentiating effects of four Chinese herbal polysaccharides administered vaccination in chickens显示文摘 | Qiu Yan Hu Yuanliang Cui Baoan | 2007 | Poultry Science2007，86，12： | 1 |
| 8 | Robust supergain beamforming for circular array via second-order cone programming 显示文摘 | Yan Shefeng Ma Yuanliang | 2005 | Applied Acoustics2005，66，9： | 1 |
| 9 | Robust supergain beamforming for circular array via second-order cone programming显示文摘 | YAN Shefeng MA Yuanliang | 2005 | Applied Acoustics2005，66，9： | 1 |
| 10 | Optimal array pattern synthesis with desired magnitude response显示文摘 | Yan Shefeng Ma Yuanliang Yang Kunde | 2004 | Sonar Detection Systems I2004，14，11： | 1 |
| 11 | The implication of pyroptosis in cancer immunology:Current advances and prospects显示文摘Pyroptosis is a regulated cell death pathway involved in numerous human diseases,especially malignant tumors.Recent studies have identified multiple pyroptosis-associated signaling molecules,like caspases,gasdermin family and inflammasomes.In addition,increasing in vitro and in vivo studies have shown the significant linkage between pyroptosis and immune regulation of cancers.Pyroptosis-associated biomarkers regulate the infiltration of tumor immune cells,such as CD4^(+) and CD8^(+) T cells,thus strengthening the sensitivity to therapeutic strategies.In this review,we explained the relationship between pyroptosis and cancer immunology and focused on the significance of pyroptosis in immune regulation.We also proposed the future application of pyroptosis-associated biomarkers in basic research and clinical practices to address malignant behaviors.Exploration of the underlying mechanisms and biological functions of pyroptosis is critical for immune response and cancer immunotherapy. | Wei Liu Jinwu Peng Muzhang Xiao Yuan Cai Bi Peng Wenqin Zhang Jianbo Li Fanhua Kang Qianhui Hong Qiuju Liang Yuanliang Yan Zhijie Xu | 2023 | Genes & Diseases2023，10，6： | 0 |
| 12 | Intra-heterogeneity in transcription and chemoresistant property of leukemia-initiating cells in murine Setd2^(-/-) acutemyeloid leukemia显示文摘Background:Heterogeneity of leukemia-initiating cells(LICs)is a major obstacle in acute myeloid leukemia(AML)therapy.Accumulated evidence indicates that the coexistence of multiple types of LICs with different pathogenicity in the same individual is a common feature in AML.However,the functional heterogeneity including the drug response of coexistent LICs remains unclear.Therefore,this study aimed to clarify the intra-heterogeneity in LICs that can help predict leukemia behavior and develop more effective treatments.Methods:Spleen cells from the primary Setd2^(-/-)-AML mouse were transplanted into C57BL/6 recipient mice to generate a transplantable model.Flow cytometry was used to analyze the immunophenotype of the leukemic mice.Whole-genome sequencing was conducted to detect secondary hits responsible for leukemia transformation.A serial transplantation assay was used to determine the self-renewal potential of Setd2^(-/-)-AML cells.A limiting-dilution assay was performed to identify the LIC frequency in different subsets of leukemia cells.Bulk and single-cell RNA sequencing were performed to analyze the transcriptional heterogeneity of LICs.Small molecular inhibitor screening and in vivo drug treatment were employed to clarify the difference in drug response between the different subsets of LICs.Results:In this study,we observed an aged Setd2^(-/-)mouse developing AML with co-mutation of Nras^(G12S) and Braf^(K520E).Further investigation identified two types of LICs residing in the c-Kit^(+)B220^(+)Mac-1^(-)and c-Kit^(+)B220^(+)Mac-1^(+)subsets,respectively.In vivo transplantation assay disclosed the heterogeneity in differentiation between the coexistent LICs.Besides,an intrinsic doxorubicinresistant transcriptional signature was uncovered in c-Kit^(+)B220^(+)Mac-1^(+)cells.Indeed,doxorubicin plus cytarabine(DA),the standard chemotherapeutic regimen used in AML treatment,could specifically kill c-Kit^(+)B220^(+)Mac-1^(−)cells,but it hardly affected c-Kit^(+)B220^(+)Mac-1^(+)cells.Transcriptome analysis unveiled a higher activation of RAS downstream signaling pathways in c-Kit^(+)B220^(+)Mac-1^(+)cells than in c-Kit^(+)B220^(+)Mac-1^(-)cells.Combined treatmentwithDAand RAS pathway inhibitors killed both c-Kit^(+)B220^(+)Mac-1^(−)and c-Kit^(+)B220^(+)Mac-1^(+)cells and attenuated disease progression.Conclusions:This study identified two cell subsets enriched for LICs inmurine Setd2^(-/-)-AML and disclosed the transcriptional and functional heterogeneity of LICs,revealing that the coexistence of different types of LICs in thismodel brings about diverse drug response. | Jiachun Song Longting Du Ping Liu Fuhui Wang Bo Zhang Yinyin Xie Jing Lu Yi Jin Yan Zhou Gang Lv Jianmin Zhang Saijuan Chen Zhu Chen Xiaojian Sun Yuanliang Zhang Qiuhua Huang | 2021 | Cancer Communications2021，41，9： | 0 |
| 13 | In-flight deformation measurement for high-aspect-ratio wing based on 3D speckle correlation显示文摘In order to get an effective solution of the in-flight wing deformation measurement for high-wing aircrafts with high-aspect-ratio,a method based on three-dimensional(3D)speckle correlation technique is proposed.Firstly,an in-flight wing deformation measurement system with two sets of conjugate cameras is designed based on structural characteristics and test requirements of high-wing aircrafts with large-aspect-ratio.Secondly,the in-flight wing deformation measurement method based on 3D speckle correlation technique is introduced including three aspects:measuring system and wing datum calibration,speckle image matching and 3D reconstruction,and wing deformation analysis.Fi-nally,ground simulation test of dynamic deformation measurement of a scaled model wing and flight test of dynamic deformation measurement of a large transport wing are carried out.The test results show that the measuring accuracy of single point coordinate in ground simulation test is better than 0.1 mm/m,in the airborne vibration environment,the static single-point positioning accuracy is bet-ter than 5 mm,and the in-flight wing deformation measurement data is well received by the flight test engineers.This method can satisfy the requirements of stability,reliability,high precision,non-con-tact and full-field measurement for dynamic deformation measurement of aircraft wing with high-as-pect-ratio. | 张兴国 HU Binghua WANG Yuanliang YAN Hui MA Xiaodong GE Quanbo | 2023 | High Technology Letters2023，29，3： | 0 |
| 14 | Multivariate Two-stage Adaptive-stacking Prediction of Regional Integrated Energy System显示文摘To reduce environmental pollution and improve the efficiency of cascaded energy utilization, regional integrated energy system(RIES) has received extensive attention. An accurate multi-energy load prediction is significant for RIES as it enables stakeholders to make effective decisions for carbon peaking and carbon neutrality goals. To this end, this paper proposes a multivariate two-stage adaptive-stacking prediction(M2ASP) framework. First, a preprocessing module based on ensemble learning is proposed. The input data are preprocessed to provide a reliable database for M2ASP, and highly correlated input variables of multi-energy load prediction are determined. Then, the load prediction results of four predictors are adaptively combined in the first stage of M2ASP to enhance generalization ability. Predictor hyper-parameters and intermediate data sets of M2ASP are trained with a metaheuristic method named collaborative atomic chaotic search(CACS) to achieve the adaptive staking of M2ASP. Finally, a prediction correction of the peak load consumption period is conducted in the second stage of M2ASP. The case studies indicate that the proposed framework has higher prediction accuracy, generalization ability, and stability than other benchmark prediction models. | Leijiao Ge Yuanliang Li Jan Yan Yuanliang Li Jiaan Zhang Xiaohui Li | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，5： | 0 |
| 15 | Profiling the Bisecting N-acetylglucosamine Modification in Amniotic Membrane via Mass Spectrometry显示文摘Bisecting N-acetylglucosamine(GlcNAc),a GlcNAc linked to the coreβ-mannose residue via aβ1,4 linkage,is a special type of N-glycosylation that has been reported to be involved in various biological processes,such as cell adhesion and fetal development.This N-glycan structure is abundant in human trophoblasts,which is postulated to be resistant to natural killer cellmediated cytotoxicity,enabling a mother to nourish a fetus without rejection.In this study,we hypothesized that the human amniotic membrane,which serves as the last barrier for the fetus,may also express bisected-type glycans.To test this hypothesis,glycomic analysis of the human amniotic membrane was performed,and bisected N-glycans were detected.Furthermore,our proteomic data,which have been previously employed to explore human missing proteins,were analyzed and the presence of bisecting GlcNAc-modified peptides was confirmed.A total of 41glycoproteins with 43 glycopeptides were found to possess a bisecting GlcNAc,and 25 of these glycoproteins were reported to exhibit this type of modification for the first time.These results provide insights into the potential roles of bisecting GlcNAc modification in the human amniotic membrane,and can be beneficial to functional studies on glycoproteins with bisecting GlcNAc modifications and functional studies on immune suppression in human placenta. | Qiushi Chen Yuanliang Zhang Keren Zhang Jie Liu Huozhen Pan Xinran Wang Siqi Li Dandan Hu Zhilong Lin Yun Zhao Guixue Hou Feng Guan Hong Li Siqi Liu Yan Ren | 2022 | Genomics, Proteomics & Bioinformatics2022，20，4： | 0 |
| 16 | CGG repeat expansion in LOC642361/NUTM2B-AS1 typically presents as oculopharyngodistal myopathy显示文摘CGG repeat expansions in LOC642361/NUTM2B-AS1 have recently been identified as a cause of oculopharyngeal myopathy with leukoencephalopathy.However,since only three patients from a single family were reported,it remains unknown whether their clinicopathological features are typical for CGG repeat expansions in LOC642361/NUTM2B-AS1.Here,using repeat-primed-polymerase chain reaction and long-read sequencing,we identify 12 individuals from 3 unrelated families with CGG repeat expansions in LOC642361/NUTM2B-AS1,typically presenting with oculopharyngodistal myopathy.The CGG repeat expansions range from 161 to 669 repeat units.Most of the patients present with ptosis,restricted eye movements,dysphagia,dysarthria,and diffuse limb muscle weakness.Only one patient shows T2-weighted hyperintensity in the cerebellar white matter surrounding the deep cerebellar nuclei on brain magnetic resonance imaging.Muscle biopsies from three patients show a myopathic pattern and rimmed vacuoles.Analyses of muscle biopsies suggest that CGG repeat expansions in LOC642361/NUTM2B-AS1 may deleteriously affect aggrephagic capacity,suggesting that RNA toxicity and mitochondrial dysfunction may contribute to pathogenesis.Our study thus expands the phenotypic spectrum for the CGG repeat expansion of LOC642361/NUTM2B-AS1 and indicates that this genetic variant typically manifests as oculopharyngodistal myopathy with chronic myopathic changes with rimmed vacuoles and filamentous intranuclear inclusions in muscle fibers. | Yan Shi Chunyan Cao Yiheng Zeng Yuanliang Ding Long Chen Fuze Zheng Xuejiao Chen Fanggui Zhou Xiefeng Yang Jinjing Li Liuqing Xu Guorong Xu Minting Lin Hiroyuki Ishiura Shoji Tsuji Ning Wang Zhiqiang Wang Wan-Jin Chen Kang Yang | 2024 | Journal of Genetics and Genomics2024，51，2： | 0 |
| 17 | CRABP2 regulates infiltration of cancer-associated fibroblasts and immune response in melanoma显示文摘Finding biomarkers for immunotherapy is an urgent issue in cancer treatment.Cellular retinoic acid-binding protein 2(CRABP2)is a controversial factor in the occurrence and development of human tumors.However,there is limited research on the relationship between CRABP2 and immunotherapy response.This study found that negative correlations of CRABP2 and immune checkpoint markers(PD-1,PD-L1,and CTLA-4)were observed in breast invasive carcinoma(BRCA),skin cutaneous melanoma(SKCM),stomach adenocarcinoma(STAD)and testicular germ cell tumors(TGCT).In particular,in SKCM patients who were treated with PD-1 inhibitors,high levels of CRABP2 predicted poor prognosis.Additionally,CRABP2 expression was elevated in cancer-associated fibroblasts(CAFs)at the single-cell level.The expression of CRABP2 was positively correlated with markers of CAFs,such as MFAP5,PDPN,ITGA11,PDGFRα/βand THY1 in SKCM.To validate the tumor-promoting effect of CRABP2 in vivo,SKCM xenograft mice models with CRABP2 overexpression have been constructed.These models showed an increase in tumor weight and volume.Enrichment analysis indicated that CRABP2 may be involved in immunerelated pathways of SKCM,such as extracellular matrix(ECM)receptor interaction and epithelial-mesenchymal transition(EMT).The study suggests that CRABP2 may regulate immunotherapy in SKCM patients by influencing infiltration of CAFs.In conclusion,this study provides new insights into the role of CRABP2 in immunotherapy response.The findings suggest that CRABP2 may be a promising biomarker for PD-1 inhibitors in SKCM patients.Further research is needed to confirm these findings and to explore the clinical implications of CRABP2 in immunotherapy. | SHUANGSHUANG ZENG XI CHEN QIAOLI YI ABHIMANYU THAKUR HUI YANG YUANLIANG YAN SHAO LIU | 2024 | Oncology Research2024，32，2： | 0 |
| 18 | Dynamic m6A-ncRNAs association and their impact on cancer pathogenesis, immune regulation and therapeutic response显示文摘Several types of modifications have been proven to participate in the metabolism and processing of different RNA types,including non-coding RNAs(ncRNAs).N-6-methyladenosine(m6A)is a dynamic and reversible RNA modification that is closely involved in the ncRNA homeostasis,and serves as a crucial regulator for multiple cancer-associated signaling pathways.The ncRNAs usually regulate the epigenetic modification,mRNA transcription and other biological processes,displaying enormous roles in human cancers.In this review,we summarized the significant implications of m6A-ncRNA interaction in various types of cancers.In particular,the interplay between m6A and ncRNAs in cancer pathogenesis and therapeutic resistance are being widely recognized.We also discussed the relevance of m6A-ncRNA interaction in immune regulation,followed by the interference on cancer immunotherapeutic procedures.In addition,we briefly highlighted the computation tools that could identify the accurate features of m6A methylome among ncRNAs.In summary,this review would pave the way for a better understanding of the biological functions of m6A-ncRNA crosstalk in cancer research and treatment. | Yuanliang Yan Jinwu Peng Qiuju Liang Xinxin Ren Yuan Cai Bi Peng Xi Chen Xiang Wang Qiaoli Yi Zhijie Xu | 2023 | Genes & Diseases2023，10，1： | 0 |
| 19 | Field Control Efficacy of Three Fungicides against Eucalyptus Purple Blotch显示文摘[Objective] The paper was to explore safe fungicides with high efficiency and long persistence against eucalyptus purple blotch. [Method]10%Difenoconazole WG,500 g /L thiophanate-methyl SC and 50% carbendazim WP were evaluated through experiment in forest,and clear water was used as CK. [Result]Three fungicides all had relatively good control effect against eucalyptus purple blotch. Most eucalyptus trees were able to restore growth and sprout new shoots after continuous three times of administration with the interval of 10 d. 10% Difenoconazole WG possessed the best control effect against eucalyptus purple blotch,with the disease index of 25. 24 and the control effect of 40. 24%; followed by 500 g /L thiophanate-methyl SC 600 times dilution,with the disease index of 27. 09 and the control effect of 35. 87%; 50% carbendazim WP 500 times dilution had the poorest control effect,with the disease index of 32. 21 and the control effect of23. 74%. The disease index of CK was 42. 24. [Conclusion]The above fungicides were safe to eucalyptus,and could be used to control eucalyptus purple blotch. | Tian Yan Chen Guifang Yang Yuanliang Li Guo | 2014 | Plant Diseases and Pests2014，5，3： | 0 |
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