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| 1 | Study on Agricultural Intellectual Property Protection and High-Quality Development of Traditional Chinese Medicine of Ginseng显示文摘Agricultural intellectual property has the functions of carrying forward agricultural cultural heritage,encouraging agricultural scientific and technological innovation,cultivating the brand of agricultural products and so on. The protection and application of agricultural intellectual property rights can enhance the vitality,innovation and competitiveness of agricultural economy,and promote the strategy of high-quality agricultural development and rural revitalization. Ginseng is a traditional medicinal variety with superior characteristics in Northeast China,and it is one of the most famous ' three treasures' in Northeast China. This paper introduces ginseng( Panax ginseng C. A. Mey.) and its medicinal value,analyzes the traditional knowledge,biological genetic resources,new plant varieties,patents,geographical indications,trademarks and other agricultural intellectual property resources of ginseng,studies the traditional Chinese medicine GAP certification and certification of ' Three Agricultural Products' and the construction of the dominant area of agricultural product( Fusong ginseng) with Chinese characteristics,and explores the rural revitalization strategy and traditional Chinese medicine development strategy,ginseng agricultural intellectual property protection and high quality development strategy. | Yuanpeng SUN Zhe WU Xueqin SIMA Yanling SUN Zheng CHENG | 2019 | Asian Agricultural Research2019，11，6： | 7 |
| 2 | Intellectual Property Protection and High Quality Development of Radix Glycyrrhizae for Treatment of COVID-19显示文摘Radix Glycyrrhizae is the dominant native medicinal material variety in the north and northwestern medicinal materials producing areas.It is a main Chinese medicine of effective TCM drugs and formulas for the treatment of new coronavirus disease(COVID-19).This paper introduces the medicinal value of Radix Glycyrrhizae,involving the labeling,cultural heritage,and creative intellectual property rights of the Chinese medicinal materials,analyzes the poverty-stricken areas that are ecologically suitable for Radix Glycyrrhizae cultivation,and the superior counties and production bases of the Chinese medicinal materials.Besides,mainly from the aspects of perfect intellectual property rights,the establishment of authentic medicinal material production bases,and the construction of quality control systems,etc.,it discusses the rural revitalization strategy and the development strategy of traditional Chinese medicine(TCM),agricultural intellectual property protection and high-quality development strategy of Radix Glycyrrhizae. | Yuanpeng SUN Yanling SUN Zheng CHENG Yusi LIU Zhe WU | 2020 | Asian Agricultural Research2020，12，5： | 6 |
| 3 | Rape Breeding and Its Intellectual Property Protection in China显示文摘Rape is the third largest oil crop in the world and the first one in China.The national average rapeseed yield is only 2077.5 kg/hm^(2),and the rapeseed oil yield is 894 kg/hm^(2).This paper introduced the main types,germplasm resources,breeding bases and breeding progress of Chinese rape,and studied its high-quality varieties,breeding patents and new varieties of agricultural plants.We analyzed the main problems such as serious loss of germplasm resources in Brassica campestris L.and Brassica juncea(L.)Czern.et Coss and weak'agricultural chip'in rape field,and put forward strategies such as strengthening the protection of rape germplasm resources,encouraging the development of'agricultural chip'in rape industry clusters with national advantages and characteristics,and strengthening the protection of agricultural intellectual property rights. | Li GAO Leying WU Yamin PENG Yuanpeng SUN Jin ZENG Zhiguo SUN | 2023 | Agricultural Biotechnology2023，12，3： | 4 |
| 4 | Geographical Indication Intellectual Property Protection and Regional Public Brand Construction of Rape Industry in China显示文摘As China s largest oil crop,rape occupies a central position in ensuring the safety of China s cooking oil supply.This paper introduced China s rapeseed industry from the rape type,rapeseed production,planting area,national rapeseed production protected area,rape national dominant characteristic industrial clusters,and rapeseed industry,etc.Besides,from the aspects of geographical indication products,geographical indication trademarks,and geographical indications of agricultural products,this paper discussed the intellectual property protection of geographical indications of rape,rapeseed,and rapeseed oil in China.It analyzed the main problems such as the lag in the formulation of relevant standards for geographical indications and the low use of special signs for geographical indications,and finally came up with recommendations including building a public brand of geographical indications and expanding foreign exchanges of geographical indications. | Li GAO Yamin PENG Leying WU Jin ZENG Yuanpeng SUN Zhiguo SUN | 2023 | Asian Agricultural Research2023，15，6： | 4 |
| 5 | National Protection Zone for Rapeseed Production and Industrial Cluster of Rape in Hubei Province显示文摘Hubei Province is the main winter rapeseed producing area in China,and has the national advantage and characteristic industrial cluster of rape.The protection zone for the production of important agricultural products of rapeseed in Hubei Province also ranks first as that in Hunan Province.This paper studied the winter rape industry,the important agricultural product production protection zone of rapeseed,the provincial double-low high-quality rape protection zone and the industrial cluster of rape in Jianghan Plain in Hubei Province,and analyzed the main problems existing in the development of rapeseed production protection zone and industrial cluster of rape.Finally,it came up with strategies including promoting national rape varieties,overcoming the problem of rape'agricultural chip',promoting the'rice+rape'rotation model,and strengthening the protection of intellectual property rights of brand marks. | Li GAO Yamin PENG Leying WU Jin ZENG Yuanpeng SUN Zhiguo SUN | 2023 | Asian Agricultural Research2023，15，9： | 3 |
| 6 | Study on the Inheritance,Innovation and Development of Scutellaria baicalensis Georgi in the Treatment of COVID-19显示文摘The discovery of highly effective medicine'Qingfei Paidu Decoction'for COVID-19 is a new era gift of traditional Chinese medicine to the world.The traditional Chinese medicine Scutellaria baicalensis Georgi,as a medicinal plant in the family of Labiatae,is the dominant variety of genuine medicinal material in North China.It is the leading traditional Chinese medicine in the advantageous area of agricultural products with Chinese characteristics in Shangdang of Changzhi City,and it is one of the 21 herbal medicines in the new national prescription'Qingfei Paidu Decoction'for the rapid and effective treatment of COVID-19.This paper introduces S.baicalensis Georgi and its traditional Chinese medicine GAP base,ecologically suitable planting county and medicinal value in poor areas,and studies the intellectual property resources related to S.baicalensis Georgi,such as traditional knowledge,biological genetic resources,patents,new plant varieties,geographical indications,and trademarks.This paper mainly discusses the inheritance essence,innovation and high-quality development strategy of S.baicalensis Georgi under the rural revitalization strategy and traditional Chinese medicine development strategy from the aspects of intellectual property rights,important agricultural cultural heritage,advantageous areas of characteristic agricultural products and so on. | Yuanpeng SUN Yusi LIU Zheng CHENG Zhe WU Yanling SUN | 2020 | Medicinal Plant2020，11，4： | 3 |
| 7 | Protection of Intellectual Property and Authenticity of Chinese Herbal Medicine Chrysanthemum morifolium显示文摘This paper first introduced Chrysanthemum morifolium Ramat. and its medicinal value. Then, it studied agricultural intellectual property resources such as geographical indications, trademarks, patents, new plant varieties, biological genetic resources, and traditional knowledge related to C. morifolium . Finally, it summarized poverty-stricken areas ecologically suitable for planting C. morifolium , analyzed the GAP certification of C. morifolium , pollution-free agricultural product certification, green food certification, and organic food certification, and discussed the strategies for C. morifolium intellectual property protection and authenticity protection in the context of TCM development strategy and rural revitalization strategy. | Yuanpeng SUN Yanling SUN Xueqin SIMA Zhe WU Zheng CHENG | 2019 | Medicinal Plant2019，10，4： | 2 |
| 8 | Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2显示文摘Dear Editor To date,tens of millions of people have been infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),causing the outbreak of the respiratory disease named the coronavirus disease 2019(COVID-19).As a newly emerged member of the coronavirus family,SARS-CoV-2 is an enveloped positive-strand RNA virus,which has probably the largest genome(approximately 30 kb)among all RNA viruses.The nucleocapsid(N)protein of SARS-CoV-2 is mainly responsible for recognizing and wrapping viral RNA into helically symmetric structures(Malik,2020). | Dan Zhao Weifan Xu Xiaofan Zhang Xiaoting Wang Yiyue Ge Enming Yuan Yuanpeng Xiong Shenyang Wu Shuya Li Nian Wu Tingzhong Tian Xiaolong Feng Hantao Shu Peng Lang Jingxin Li Fengcai Zhu Xiaokun Shen Haitao Li Pilong Li Jianyang Zeng | 2021 | Protein & Cell2021，12，9： | 1 |
| 9 | N-polar InGaN nanowires: breaking the efficiency bottleneck of nano and micro LEDs显示文摘The efficiency of conventional quantum well light-emitting diodes(LEDs) decreases drastically with reducing areal size. Here we show that such a critical size scaling issue of LEDs can be addressed by utilizing N-polar In Ga N nanowires. We studied the epitaxy and performance characteristics of N-polar In Ga N nanowire LEDs grown on sapphire substrate by plasma-assisted molecular beam epitaxy. A maximum external quantum efficiency-11% was measured for LEDs with lateral dimensions as small as 750 nm directly on wafer without any packaging. The effect of electron overflow and Auger recombination on the device performance is also studied. This work provides a viable approach for achieving high-efficiency nano and micro LEDs that were not previously possible. | Xianhe Liu Yi Sun Yakshita Malhotra Ayush Pandey Ping Wang Yuanpeng Wu Kai Sun Zetian Mi | 2022 | Photonics Research2022，10，2： | 1 |
| 10 | The development and application of genome editing technology in ruminants: a review显示文摘Transgenic ruminants are a valuable resource for both animal breeding and biomedical research.The development of transgenic breeding is proceeding slowly,because it suffers from low efficiency of gene transfer and possible safety problems from uncontrolled random integration.However,new breeding methods combined with genome editing and somatic cell nuclear transfer or microinjection can offer an economic and efficient way to produce gene-edited ruminants,which can serve as bioreactors or have improved disease resistance,animal welfare and product quality.Recent advances in precise genome editing technologies,especially clustered regularly interspaced short palindromic repeat(CRISPR)/Cas9 nucleases,are enabling the systematic development of gene-edited ruminant production.This review covers the development of gene-edited ruminants,the particulars of site-specific engineered nucleases and the state of the art and new insights into practical applications and social acceptance of genome editing technology in ruminants.It is concluded that the production of gene-edited ruminants is feasible and through improvements in genome editing technology it is possible to help feed the world. | Mengke YUAN Yuanpeng GAO Jing HAN Teng WU Jingcheng ZHANG Yongke WEI Yong ZHANG | 2020 | Frontiers of Agricultural Science and Engineering2020，7，2： | 1 |
| 11 | Synthesis andCharacterization of UV-Curable Waterborne Polyurethane Acry-late Possessing Perfluorooctanoate Side-Chains 显示文摘 | LiuTuo Pan Xuemei Wu Yuanpeng | 2012 | J PolymRes2012，19，2： | 1 |
| 12 | A facile approach to Fe 3 O 4 @Au nanoparticles with magnetic recyclable catalytic properties显示文摘 | Yuanpeng Wu Tao Zhang Zhaohui Zheng Xiaobin Ding Yuxing Peng | 2009 | Materials Research Bulletin2009，，4： | 1 |
| 13 | Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling显示文摘Nicotine is the principal alkaloid of tobacco often manufactured into cigarettes and belongs to a highly addictive class of drugs.Nicotine attenuates the neuroinflammation induced by microglial activation.However,the molecular target(s)underlying anti-inflammatory action of nicotine has not been fully understood.Considering the psychoactive substances morphine,cocaine,and methamphetamine act as xenobiotic-associated molecular patterns and can be specifically sensed by the innate immune receptor Toll-like receptor 4(TLR4),here we sought to delineate whether nicotine and/or its metabolite cotinine may be recognized by the innate immune system via myeloid differentiation protein 2(MD2). | Hongyuan Li Yinghua Peng Cong Lin Xiaozheng Zhang Tianshu Zhang Yibo Wang Yuanpeng Li Siru Wu Hongshuang Wang Mark RHutchinson Linda RWatkins Xiaohui Wang | 2021 | The Innovation2021，2，2： | 0 |
| 14 | A novel clinical model for risk prediction and stratification of new-onset diabetes mellitus after distal pancreatectomy显示文摘Background:The incidence of new-onset diabetes mellitus(NODM)after distal pancreatectomy(DP)remains high.Few studies have focused on NODM in patients with pancreatic benign or low-grade malignant lesions(PBLML).This study aimed to develop and validate an effective clinical model for risk prediction and stratification of NODM after DP in patients with PBLML.Methods:A follow-up survey was conducted to investigate NODM in patients without preoperative DM who underwent DP.Four hundred and forty-eight patients from Peking Union Medical College Hospital(PUMCH)and 178 from Guangdong Provincial People’s Hospital(GDPH)met the inclusion criteria.They constituted the training cohort and the validation cohort,respectively.Univariate and multivariate Cox regression,as well as least absolute shrinkage and selection operator(LASSO)analyses,were used to identify the independent risk factors.The nomogram was constructed and verified.Concordance index(C-index),receiver operating characteristic(ROC)curve,calibration curves,and decision curve analysis(DCA)were applied to assess its predictive performance and clinical utility.Accordingly,the optimal cut-off point was determined by maximally selected rank statistics method,and the cumulative risk curves for the high-and low-risk populations were plotted to evaluate the discrimination ability of the nomogram.Results:The median follow-up duration was 42.8 months in the PUMCH cohort and 42.9 months in the GDPH cohort.The postoperative cumulative 5-year incidences of DM were 29.1%and 22.1%,respectively.Age,body mass index(BMI),length of pancreatic resection,intraoperative blood loss,and concomitant splenectomy were significant risk factors.The nomogram demonstrated significant predictive utility for post-pancreatectomy DM.The C-indexes of the nomogram were 0.739 and 0.719 in the training and validation cohorts,respectively.ROC curves demonstrated the predictive accuracy of the nomogram,and the calibration curves revealed that prediction results were in general agreement with the actual results.The considerable clinical applicability of the nomogram was certified by DCA.The optimal cut-off point for Background:The incidence of new-onset diabetes mellitus(NODM)after distal pancreatectomy(DP)remains high.Few studies have focused on NODM in patients with pancreatic benign or low-grade malignant lesions(PBLML).This study aimed to develop and validate an effective clinical model for risk prediction and stratification of NODM after DP in patients with PBLML.Methods:A follow-up survey was conducted to investigate NODM in patients without preoperative DM who underwent DP.Four hundred and forty-eight patients from Peking Union Medical College Hospital(PUMCH)and 178 from Guangdong Provincial People’s Hospital(GDPH)met the inclusion criteria.They constituted the training cohort and the validation cohort,respectively.Univariate and multivariate Cox regression,as well as least absolute shrinkage and selection operator(LASSO)analyses,were used to identify the independent risk factors.The nomogram was constructed and verified.Concordance index(C-index),receiver operating characteristic(ROC)curve,calibration curves,and decision curve analysis(DCA)were applied to assess its predictive performance and clinical utility.Accordingly,the optimal cut-off point was determined by maximally selected rank statistics method,and the cumulative risk curves for the high-and low-risk populations were plotted to evaluate the discrimination ability of the nomogram.Results:The median follow-up duration was 42.8 months in the PUMCH cohort and 42.9 months in the GDPH cohort.The postoperative cumulative 5-year incidences of DM were 29.1%and 22.1%,respectively.Age,body mass index(BMI),length of pancreatic resection,intraoperative blood loss,and concomitant splenectomy were significant risk factors.The nomogram demonstrated significant predictive utility for post-pancreatectomy DM.The C-indexes of the nomogram were 0.739 and 0.719 in the training and validation cohorts,respectively.ROC curves demonstrated the predictive accuracy of the nomogram,and the calibration curves revealed that prediction results were in general agreement with the actual results.The considerable clinical applicability of the nomogram was certified by DCA.The optimal cut-off point for risk prediction value was 2.88, and the cumulative risk curves of each cohort showed significant differences between the high- and low-risk groups. Conclusions: The nomogram could predict and identify the NODM risk population, and provide guidance to physicians in monitoring and controlling blood glucose levels in PBLML patients after DP. | Zhihong Chen Ning Shi Cheng Xing Yiping Zou Yuanpeng Zhang Zhenrong Chen Fan Wu Haosheng Jin Rufu Chen Menghua Dai | 2023 | Hepatobiliary Surgery and Nutrition2023，12，6： | 0 |
| 15 | InGaN micro-light-emitting diodes monolithically grown on Si:achieving ultra-stable operation through polarization and strain engineering显示文摘Micro or submicron scale light-emitting diodes(μLEDs)have been extensively studied recently as the next-generation display technology.It is desired that μLEDs exhibit high stability and efficiency,submicron pixel size,and potential monolithic integration with Si-based complementary metal-oxide-semiconductor(CMOS)electronics.Achieving such uLEDs,however,has remained a daunting challenge.The polar nature of Ill-nitrides causes severe wavelength/color instability with varying carrier concentrations in the active region.The etching-induced surface damages and poor material quality of high indium composition InGaN quantum wells(QWs)severely deteriorate the performance of uLEDs,particularly those emitting in the green/red wavelength.Here we report,for the first time,μLEDs grown directly on Si with submicron lateral dimensions.The μLEDs feature ultra-stable,bright green emission with negligible quantum-confined Stark effect(QCSE).Detailed elemental mapping and numerical calculations show that the QCSE is screened by introducing polarization doping in the active region,which consists of InGaN/AlGaN QWs surrounded by an AlGaN/GaN shell with a negative Al composition gradient along the c-axis.In comparison with conventional GaN barriers,AlGaN barriers are shown to effectively compensate for the tensile strain within the active region,which significantly reduces the strain distribution and results in enhanced indium incorporation without compromising the material quality.This study provides new insights and a viable path for the design,fabrication,and integration of high-performance μLEDs on Si for a broad range of applications in on-chip optical communication and emerging augmented reality/mixed reality devices,and so on. | Yuanpeng Wu Yixin Xiao Ishtiaque Navid Kai Sun Yakshita Malhotra Ping Wang Ding Wang Yuanxiang Xu Ayush Pandey Maddaka Reddeppa Walter Shin Jiangnan Liu Jungwook Min Zetian Mi | 2022 | Light(Science & Applications)2022，11，10： | 0 |
| 16 | Talcum-doped composite separator with superior wettability and heatproof properties for high-rate lithium metal batteries显示文摘Separator is supposed to own outstanding thermal stability,superior wettability and electrolyte uptake,which is essential for developing high-rate and safe lithium metal batteries(LMBs).However,commercial polyolefin separators possess poor wettability and limited electrolyte uptake.For addressing this issue,we put forward a composite separator to implement above functions by doping layered-silicate(talcum)into polyvinylidene fluoride(PVDF).With significant improvement of electrolyte absorption benefiting from the strong adsorption energy values(-1.64-1.70 eV)between talcum and the electrolyte in lithium metal batteries,PVDF/Talcum(PVDF/TM)composite separator owns a small contact angle and superior electrolyte uptake.PVDF/TM composite separator with 10 wt%talcum(T-10)owns a tiny contact angle of 8°,while those of polypropylene(PP)and PVDF are 48°and 20°with commercial electrolyte.Moreover,the addition of thermotolerant talcum endows the T-10 composite separator with great thermostability,whose thermal shrinkage is only 5.39%at 150°C for 0.5 h.The cell with LiFeO4cathode and the T-10 composite separator reaches 91.7 m Ah/g in discharge capacity at 4.8 m A/cm^(2)(10 C),far superior to that with pure PVDF separator(56.3 m Ah/g)and PP(51.4 m Ah/g). | Mengqiu Yang Yuanpeng Ji Yunfa Dong Botao Yuan Liwei Dong Yuanpeng Liu Sue Hao Chunhui Yang Xiaoqiang Wu Qingquan Kong Jiecai Han Weidong He | 2023 | Chinese Chemical Letters2023，34，1： | 0 |
| 17 | Effects of substrate types on the transformation of heavy metal speciation and bioavailability in an anaerobic digestion system显示文摘Chemical speciation can fundamentally affect the potential toxicity and bioavailability of heavy metals.The transformation of heavy metal speciation and change of bioavailability were investigated in an anaerobic digestion(AD)system using four different substrates(pig manure(PM),cattle manure(CAM),chicken manure(CHM)and rice straw(RS)).The results obtained indicated that the total contents of heavy metals in PM,CHM and GAM were higher than in RS and decreased in the order Zn>Cu>Ni>Pb>As>Cd in all substrates.Moreover,the speciation with the largest proportion for each heavy metal was the same both in the different substrates and the biogas residues.Among them,Zn,Ni,Cd and As were mainly in the reducible fraction(F2),while Cu was mainly in the oxidizable fraction(F3)and Pb occurred predominantly in the residual fraction(F4).Our results further indicated that the AD process had a greater effect on the speciation of heavy metals in CHM and PM,but less on CAM and RS.The rates of change in bioavailability followed the order PM>CHM>CAM>RS.Changes in organic matter,humic acid or local metal ion environment as a result of AD were inferred as likely mechanisms leading to the transformation of heavy metal speciation.These results enhanced our understanding of the behavior of heavy metals in AD and provided a new perspective for the treatment and disposal of the substrates. | Xiarong Zheng Kuanhuai Wu Pengju Sun Siyu Zhouyang Yuanpeng Wang Haitao Wang Yanmei Zheng Qingbiao Li | 2021 | Journal of Environmental Sciences2021，33，3： | 0 |
| 18 | High-performance fiber strain sensor of carbon nanotube/thermoplastic polyurethane@styrene butadiene styrene with a double percolated structure显示文摘In this work,a high-performance fiber strain sensor is fabricated by constructing a double percolated structure,consisting of carbon nanotube(CNT)/thermoplastic polyurethane(TPU)continuous phase and styrene butadiene styrene(SBS)phase,incompatible with TPU(CNT/TPU@SBS).Compared with other similar fiber strain sensor systems without double percolated structure,the CNT/TPU@SBS sensor achieves a lower percolation threshold(0.38 wt.%)and higher electrical conductivity.The conductivity of 1%-CNT/TPU@SBS(4.12×10^(-3) S·m^(-1))is two orders of magnitude higher than that of 1%-CNT/TPU(3.17×10^(-5) S·m^(-1))at the same CNT loading of 1 wt.%.Due to double percolated structure,the 1%-CNT/TPU@SBS sensor exhibits a wide strain detection range(0.2%-100%)and an ultra-high sensitivity(maximum gauge factor(GF)is 32411 at 100%strain).Besides,the 1%-CNT/TPU@SBS sensor shows a high linearity(R^(2)=0.97)at 0%-20%strain,relatively fast response time(214 ms),and stability(500 loading/unloading cycles).The designed sensor can efficiently monitor physiological signals and movements and identify load distribution after being woven into a sensor array,showing broad application prospects in wearable electronics. | Dong XIANG Libing LIU Xiaoyu CHEN Yuanpeng WU Menghan WANG Jie ZHANG Chunxia ZHAO Hui LI Zhenyu LI Ping WANG Yuntao LI | 2022 | Frontiers of Materials Science2022，16，1： | 0 |
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