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| 1 | IL-37b suppresses T cell priming by modulating dendritic cell maturation and cytokine production via dampening ERK/NF-κB/S6K signalings显示文摘Interleukin 37b (IL-37b ) 在压制有免疫力的回答起一个关键作用,部分由 modulating 树枝状的房间(DC ) 的功能。然而,精确机制大部分仍然是未知的。这里,我们在回答由 DC 导致了的 DC 成熟和 T 房间上调查了 IL-37b 的效果,并且探索了深奥发信号的小径。它被发现那 IL-37b 下面调整在 vitro 的 DC 上的 co-stimulatory 分子 CD80 和 CD86 的表情。同时,支持 inflammatory cytokines 的表情例如 TNF-6, 和 IL-6,被压制,当时 T 房间的表示禁止的 cytokine TGF- 在 IL-37b-treated DC 被增加。另外, T 房间上的 DC 的激活效果被 IL-37b 损害。我们进一步表明细胞外的调整单人赛的 kinase (英皇家空军之阶级最低之兵) ,原子 factor-B (NF-B ) ,和表明小径的 mTOR-S6K 涉及 IL-37b 导致的 DC 的抑制。这被化学禁止者的同样镇压的效果在 DC 在 IL-6 和 TNF- 的表情上对 NF-B,英皇家空军之阶级最低之兵,和 S6K 证实。在结论,这些结果证明 IL-37b 由在英皇家空军之阶级最低之兵, NF-B,和基于 S6K 的禁止的发信号小径包含在 T 房间 priming 压制了 DC 成熟和 immunostimulatory 能力。 | Wantong Wu Weiqiang Wang Yun Wang Wenwen Li Gang Yu Zhonglong Li Chunmin Fang Yue Shen Zhina Sun Ling Han Juan Yu Lijun Fang Song Chen Kui Dong Zhongchao Han Hanzhi Liu Yuechen Luo Xiaoming Feng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
| 2 | Loss of Lkb1 impairs Treg function and stability to aggravate graft-versus-host disease after bone marrow transplantation显示文摘Accumulating evidence suggests that a reduction in the number of Foxp3^(+) regulatory T cells(Tregs)contributes to the pathogenesis of acute graft-versus-host disease(aGVHD),which is a major adverse complication that can occur after allogeneic hematopoietic stem cell transplantation(allo-HSCT).However,the precise features and mechanism underlying the defects in Tregs remain largely unknown.In this study,we demonstrated that Tregs were more dramatically decreased in bone marrow compared with those in peripheral blood from aGVHD patients and that bone marrow Treg defects were negatively associated with hematopoietic reconstitution.Tregs from aGVHD patients exhibited multiple defects,including the instability of Foxp3 expression,especially in response to IL-12,impaired suppressor function,decreased migratory capacity,and increased apoptosis.Transcriptional profiling revealed the downregulation of Lkb1,a previously identified critical regulator of murine Treg identity and metabolism,and murine Lkb1-regulated genes in Tregs from aGVHD patients.Foxp3 expression in human Tregs could be decreased and increased by the knockdown and overexpression of the Lkb1 gene,respectively.Furthermore,a loss-of-function assay in an aGVHD murine model confirmed that Lkb1 deficiency could impair Tregs and aggravate disease severity.These findings reveal that Lkb1 downregulation contributes to multiple defects in Tregs in human aGVHD and highlight the Lkb1-related pathways that could serve as therapeutic targets that may potentially be manipulated to mitigate aGVHD. | Xiuhua Su Qianqian Wang Wei Guo Xiaolei Pei Qing Niu Maolan Liu Yuanyuan Liu Song Chen Sizhou Feng Yi He Donglin Yang Rongli Zhang Qiaoling Ma Weihua Zhai Aiming Pang Jialin Wei Yong Huang Yuechen Luo Mingzhe Han Xiaoming Feng Erlie Jiang | 2020 | Cellular & Molecular Immunology2020，17，5： | 3 |
| 3 | Benign paroxysmal vertigo of childhood:diagnostic val-ue of vestibular test and high stimulus rate auditory brain-stem response test显示文摘 | Daogong Zhang Zhaomin Fan Yuechen Han | 2012 | Int J Pediatr Otorhinolaryngol2012，76，1： | 1 |
| 4 | Effects of nitrogen fertilizer on root-shoot characteristics,grain yield and nitrogen use efficiency of different maize varieties in North China Plain显示文摘Excessive nitrogen(N)fertilizer application in crop production has resulted in a series of environmental issues in North China Plain(NCP).Breeding N-efficient maize varieties is one of the effective strategies to improve the N use efficiency of maize and reduce environmental pollution.This study designed an experiment for two maize varieties(‘Xian-Yu 335’[XY335]and‘Hua-Nong 138’[HN138])with three N-level treatments(0 kg/hm^(2),180 kg/hm^(2),300 kg/hm^(2),i.e.N0,N180,N300).The aim of the study was to determine the response characteristics of maize canopy structure,root morphology,and anatomical structure,as well as N uptake and utilization of N fertilizer.Results showed that grain yield,N use efficiency,and N harvest index of XY335 were higher 5.20%-13.68%,11.86%-19.11%,and 6.07%-3.33%than those of HN138,respectively.Compared with HN138,XY335 had a higher leaf area index and photosynthetic nitrogen-use efficiency.The root length,root length density,root absorption area,root absorption area,and root active absorption area of XY335 in each period were higher than that of HN138.The proportion of RCA of XY335 was significantly higher than that of HN138,which was 14.64%higher on average.In the future breeding process,the high N and low N double-high-efficiency varieties should pay more attention to the improvement of root cortex aeration tissue. | Xiangling Li Liu Pan Rui Wang Yiping Zuo Jian Wang Jinling Han Yuechen Zhang Baozhong Yin | 2022 | International Journal of Agricultural and Biological Engineering2022，15，5： | 0 |
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