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| 1 | MicroRNA-125b-5p inhibits proliferation and promotes adipogenic differentiation in 3T3-L1 preadipocytes显示文摘以前的证据显示了 microRNA-125b (miR-125b ) 家庭戏在癌症房间生长,开发,区别,和 apoptosis 的规定的重要角色。然而,他们是否贡献 adipocyte 区别的过程,仍然保持不清楚。在现在的学习,我们表明表示 miR-125b-5p 铺平, miR-125b 家庭的一个成员,在进成熟 adipocyte 的 3T3-L1 preadipocyte 的区别期间是戏剧性地起来调整的。进 3T3-L1 房间的 miR-125b-5p 的补充支持了由增加的类脂化合物微滴和 adipocyte 特定的分子的标记的 mRNA 层次证实了的 adipogenic 区别,包括 peroxisome 激活 proliferators 的受体, CCAAT/enhancer-binding 蛋白质,丰满的酸绑定的蛋白质 4,并且脂蛋白脂肪分解酵素,并且由 triglyceride 累积。CCK-8 试金证明 miR-125b-5p 补充显著地禁止了房间增长。流动 cytometry 分析证明 miR-125b-5p 象 mRNA 和 G1/S-related 基因的蛋白质表示一样损害了 G1/S 阶段转变,例如 Cyclin D2, Cyclin D3,和 CDK4。不过,它没在 apoptosis 上有效果。由目标基因预言,另外,我们证明 smad4 可以是在鼠标 3T3-L1 preadipocytes 的 miR-125b-5p 的一个潜在的目标,为一些 miR-125b-5p 的函数的财务。一起拿,这些数据显示 miR-125b-5p 可以在 adipocyte 区别用作一个重要积极管理者,至少部分通过下面调整的 smad4。 | Dan Ouyang Yaqiong Ye Dongguang Guo Xiaofang Yu Jian Chen Junjie Qi Xiaotong Tan Yuan Zhang Yongjiang Ma Yugu Li | 2015 | Acta Biochimica et Biophysica Sinica2015,47,5: | 9 |
| 2 | MiR-181a-5p regulates 3T3-L1 cell adipogenesis by targeting Smad7 and Tcf7I2显示文摘 | Dan Ouyang Lifeng Xu Lihua zhang Dongguang Guo Xiaotong Tan Xiaofang Yu Junjie Qi Yaqiong Ye Qihong Liu Yongjiang Ma Yugu Li | 2016 | Acta Biochimica et Biophysica Sinica2016,48,11: | 9 |
| 3 | MicroRNAs expression profiles in adipose tissues and liver from sex-linked dwarf and normal chickens显示文摘 | Yaqiong Ye Li Deng Meile Liang Lifeng Xu Lihua Zhang Yongjiang Ma Yugu Li | 2014 | Acta Biochimica et Biophysica Sinica2014,46,8: | 4 |
| 4 | MicroRNA-195a-5p inhibits mouse medullary thymic epithelial cells proliferation by directly targeting Smad7显示文摘MiR-195 在在肿瘤的不同类型禁止房间增长被含有。它是否贡献 thymic 的过程上皮的房间(侦探) 增长仍然保持不清楚。在这研究,我们发现 miR-195a-5p 在从变老的老鼠孤立的侦探是高度起来调整的。进一步的实验证明 miR-195a-5p 模仿禁止的 transfection 老鼠的增长髓的 thymic 第 1 行上皮的房间(MTEC1 ) ,而在 MTEC1 的 miR-195a-5p 禁止者的 transfection 有相反的效果。另外, miR-195a-5p 没在 MTEC1 apoptosis 上有明显的效果。而且, Smad7,转变生长因素小径的一个否定管理者,被酶试金作为 miR-195a-5p 的一个直接目标证实。一起拿,我们的结果显示 miR-195a-5p 禁止 MTEC1 增长,至少部分地,经由 Smad7 的下面规定。 | Dongguang Guo Yaqiong Ye Junjie Qi Lifeng Xu Lihua Zhang Xiaolong Tan Zhigang Tan Xiaofang Yu Yuan Zhang Yongjiang Ma Yugu Li | 2016 | Acta Biochimica et Biophysica Sinica2016,48,3: | 3 |
| 5 | MicroRNA-181a-5p enhances cell proliferation in medullary thymic epithelial cells via regulating TGF-β signaling显示文摘在从不同年龄的老鼠的胸腺纸巾的 miRNAs 的表示侧面在我们的以前的学习被表明了。在 miRNA 表达式侧面的综合分析以后,我们证明 miR-181a-5p 的表达式显著地在 thymic 被减少从 10- 的上皮的房间(侦探) 到 19-month-old 鼠标当与那相比在从 1-month-old 的侦探由量的反向的 transcriptase 聚合酶的鼠标锁住反应时。我们在侦探假设了那 miR-181a-5p 可能通过调整一些基因或发信号的小径与年龄相关的胸腺复杂物被联系。测试这个假设,老鼠髓的 thymic 上皮的房间(MTEC1 ) 被使用。有 miR-181a-5p 的 Transfection 模仿支持了 MTEC1 房间的增长,但是没影响 apoptosis。效果被颠倒 miR-181a-5p 的表示什么时候在 MTEC1 房间被压制。而且,转变生长因素贝它受体(Tgfbr1 ) 我被酶试金作为 miR-181a-5p 的一个直接目标证实。而且,它被发现 miR-181a-5p 的那 overexpression 下面调整 Smad3 的 phosphorylation 并且堵住了发信号的转变生长因素贝它的激活。不过,一相反地,关联在 Tgfbr1 的表示之间被观察,在侦探的 miR-181a-5p 源于不同年龄的老鼠。一起,我们提供 miR-181a-5p 可以是在侦探,和表示的增长的一个重要内长的管理者的证据在侦探的 miR-181a-5p 的层次可以与年龄相关的胸腺复杂物被联系。 | Dongguang Guo Yaqiong Ye Junjie Qi Lihua Zhang Lifeng Xu Xiaotong Tan Xiaofang Yu Qihong Liu Jilong Liu Yuan Zhang Yongjiang Ma Yugu Li | 2016 | Acta Biochimica et Biophysica Sinica2016,48,9: | 2 |
| 6 | Analysis of the risk factors for traeheostomy in traumatic cervical spinal cord injury 显示文摘 | Yugue I Okada S Ueta T | 2012 | Spine (Phila Pa 1976)2012,37,: | 1 |
| 7 | Deltamethrin induces delayed apoptosis and altered expression of p53 and bax in rat brain显示文摘 | Aiguo Wu Yugu Liu | 2000 | Envirl Toxicol and Pharmacol2000,8,3: | 1 |
| 8 | Analysis of the risk factors for severity of neurologic status in 216 patients with thoracolumbar and lumbar burst fractures显示文摘 | Yugue I Aono K Shiba K | 2011 | Spine (Phila Pa 1976)2011,36,19: | 1 |
| 9 | Analysis of the risk factors for severity of neurologic status in 216 patients with thoracolumbar and lumbar burst fractures显示文摘 | Yugue I Aono K Shiba K | 2011 | Spine2011,36,19: | 1 |
| 10 | Age and sex differences in microRNAs expression during the process of thymus aging显示文摘偏导性的胸腺复杂物和 microRNAs 的重要性(miRNAs,米尔) 在 modulating 的表示胸腺发展在许多研究被报导了。然而,男性和女性怎么在胸腺复杂物以那么多方法不同,仍然保持不清楚。探讨这个问题,我们在未经治疗的 3-month-old 和 12-month-old 调查了 miRNA 表达式侧面雌、雄的鼠标胸腺。结果证明 7 和 18 miRNAs 分别地被定义为性特定、年龄特定的 miRNAs。miR-181c-5p, miR-20b-5p, miR-98b-5p, miR-329-3p, miR-341-5p,和 miR-2137 的表示由量的聚合酶链反应在老鼠胸腺显示出重要年龄差别。miR-2137 的高表达式层次在鼠标 thymic 被检测上皮的房间并且逐渐地在胸腺老化的进程期间增加了。偏导女性的 miRNAs 的 MiR-27b-3p 和 miR-378a-3p 在 vivo 在老鼠胸腺作为性应答、雌激素应答的 miRNAs 被证实。他们的潜在的目标基因和小径被联机软件识别。性特定、年龄特定的 miRNA 表示的可能的规定角色在胸腺老化的过程期间被讨论。我们的结果建议这些 miRNAs 可以是为性特定、年龄特定的胸腺老化和复杂物的学习的潜在的 biomarkers。 | Dongguang Guo Yaqiong Ye Junjie Qi Xiaotong Tan Yuan Zhang Yongjiang Ma Yugu Li | 2017 | Acta Biochimica et Biophysica Sinica2017,49,5: | 1 |
| 11 | Analysis of Differentially Expressed Genes and Signaling Pathways Related to Intramuscular Fat Deposition in Skeletal Muscle of Sex-Linked Dwarf Chickens显示文摘 | Yaqiong Ye Shumao Lin Heping Mu Xiaohong Tang Yangdan Ou Jian Chen Yongjiang Ma Yugu Li Isao Usui | 2014 | BioMed Research International2014,,: | 1 |
| 12 | Analysis of the risk factors for severity of neurologic status in 216 patients with thoracolumbar and lumbar burst fractures 显示文摘 | Yugue I Aono K Shiba K | 2011 | Spine (Phila Pa 1976)2011,36,19: | 1 |
| 13 | Analysis of the Risk Factors for Tracheostomy in Traumatic Cervical Spinal Cord Injury显示文摘 | Yugué I Okada S Ueta T | | 0,,1976: | 1 |
| 14 | Analysis of the risk factors for severity of neurologic status in 216 patients with thoracolumbar and lumbar bursffractares 显示文摘 | Yugue I Aono K Shiba K | 2011 | Spine2011,36,19: | 1 |
| 15 | Analysis of the Risk Factors for Severity of Neurologic Status in 216 Patients With Thoracolumbar and Lumbar Burst Fractures显示文摘 | Yugue I Aono K Shiba K | | 0,,1976: | 1 |
| 16 | Analysis of the risk fac- tors for severity of neurologic status in 216 patients with thoracolumbar and lumbar burst fractures显示文摘 | Yugue I Aono K Shiba K | 2011 | Spine(Phila Pa 1976)2011,36,19: | 1 |
| 17 | Analysis of the risk factors for severity of neurologic status in 216 patients with thoraco- lumbar and lumbar burst fractures 显示文摘 | Yugue I Aono K Shiba K | 2011 | Spine (Phila Pa 1976)2011,36,19: | 1 |
| 18 | Structure,defects,and microwave dielectric properties of Al-doped and Al/Nd co-doped Ba_(4)Nd_(9.33)Ti_(18)O_(54)ceramics显示文摘Low-loss tungsten–bronze microwave dielectric ceramics are dielectric materials with potential application value for miniaturized dielectric filters and antennas in the fifth-generation(5G)communication technology.In this work,a novel Al/Nd co-doping method of Ba_(4)Nd_(9.33)Ti_(18)O_(54)(BNT)ceramics with a chemical formula of Ba_(4)Nd_(9.33+z/3)Ti_(18−z)Al_(z)O_(54)(BNT–AN,0≤z≤2)was proposed to improve the dielectric properties through structural and defect modulation.Together with Al-doped ceramics(Ba_(4)Nd_(9.33)Ti_(18−z)Al_(4z/3)O_(54),BNT–A,0≤z≤2)for comparison,the ceramics were prepared by a solid state method.It is found that Al/Nd co-doping method has a significant effect on improving the dielectric properties compared with Al doping.As the doping amount z increased,the relative dielectric constant(εr)and the temperature coefficient of resonant frequency(τf)of the ceramics decreased,and the Q×f values of the ceramics obviously increased when z≤1.5.Excellent microwave dielectric properties ofεr=72.2,Q×f=16,480 GHz,andτf=+14.3 ppm/℃were achieved in BNT–AN ceramics with z=1.25.Raman spectroscopy and thermally stimulated depolarization current(TSDC)technique were firstly combined to analyze the structures and defects in microwave dielectric ceramics.It is shown that the improvement on Q×f values was originated from the decrease in the strength of the A-site cation vibration and the concentration of oxygen vacancies(VO××),demonstrating the effect and mechanism underlying for structural and defect modulation on the performance improvement of microwave dielectric ceramics. | Weijia GUO Zhiyu MA Yu LUO Yugu CHEN Zhenxing YUE Longtu LI | 2022 | Journal of Advanced Ceramics2022,11,4: | 1 |
| 19 | A new clinical evaluation for hysterical paralysis显示文摘 | Yugué I Shiba K Ueta T | 2004 | Spine2004,29,17: | 1 |
| 20 | Effects of chitooligosaccharides on rabbit neutrophils in vitro 显示文摘 | Jiangli Dou Chengyu Tan Yugu ang Du | 2007 | Carbohydrate Polymers2007,69,2: | 1 |