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| 1 | Knockdown of SLC39A7 inhibits cell growth and induces apoptosis in human colorectal cancer cells显示文摘 | Nengquan Sheng Li Yan Weiqiang You Gewen Tan Jianfeng Gong Hongqi Chen Yi Yang Landian Hu Zhigang Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，10： | 4 |
| 2 | Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study显示文摘 | Qiujin Shen Jia Fan Xin-Rong Yang Yexiong Tan Weifeng Zhao Yang Xu Ning Wang Yongdong Niu Zheng Wu Jian Zhou Shuang-Jian Qiu Ying-Hong Shi Bin Yu Ning Tang Wei Chu Min Wang Jinhua Wu Zhigang Zhang Shengli Yang Jianren Gu Hongyang Wang Wenxin Qin | 2012 | Lancet Oncology2012，，8： | 4 |
| 3 | Numerical study on the evolution of the shock-accelerated SF_6 interface:Influence of the interface shape显示文摘The early phases of the shock interaction process on two-dimensional interfaces with different shapes are numerically investigated in this study,which are closely related to the shock refraction and reflection,vorticity production and transport.The numerical method employs an adaptive unstructured quadrilateral mesh,which can capture the wave pattern and interface evolution very well.Simulations are carried out under the conditions of an incident shock Mach number of 1.2 and the light/heavy (air/SF 6) interface.Five different shapes are considered in the simulations:rectangle,ellipse,diamond and two kinds of triangle.The results show that the interfacial shapes can influence the wave patterns particularly on the shape and evolution of refracted shock waves.The generation and the distribution of vorticity on the interfaces with five different shapes also have dissimilarities.The circulation deposition on five interfaces is quantitatively investigated and compared with theoretical model.A good agreement is found between the numerical results and the predictions by the theoretical model.Some characteristic scales of the interface are tracked.Under the influence of nonlinear-acoustic effect and vorticity effect,the interfaces present different evolution modes. | FAN MeiRu ZHAI ZhiGang SI Ting LUO XiSheng ZOU LiYong TAN DuoWang | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，2： | 4 |
| 4 | Peniazaphilones A—I,Produced by Co-culturing of Mangrove Endophytic Fungi,Penicillium sclerotiorum THSH-4 and Penicillium sclerotiorum ZJHJJ-18显示文摘Co-culturing the mangrove endophytic fungus Penicillium sclerotiorum THSH-4 with Penicillium sclerotiorum ZJHJJ-18 in PDB medium resulted in the production of nine new azaphilones derivatives,peniazaphilones A—I(1-9),and six known azaphilones derivatives(10-15).Their structures were elucidated by analysis of detailed spectroscopic data,single-crystal X-ray diffraction,ECD spectra,^(13)C NMR calculation and DP4+analysis.It is noteworthy that compound 1 with an isoquinoline quinone moiety,was isolated from natural source for the first time.Besides,compound 2 is the third reported phenylhydrazone derivative from fungi.In the bioactivity assays,compounds 1,12,14 and 15(IC_(50)=4.71-17.64μmol/L)exhibited potent inhibition of LPS-induced NO release from RAW264.7 without obvious cytotoxicity within 50μmol/L compared to the positive control indomethacin(IC_(50)=35.27μmol/L).Moreover,compounds 1 and 13 displayed moderate to strong cytotoxicity to A549 and MDA-MB-435,with IC_(50) values in the range of 6.84-14.63μmol/L.Together compound 1 showed moderate broad-spectrum antibacterial activity. | Wencong Yang Jie Yuan Qi Tan Yan Chen Yujia Zhu Hongming Jiang Ge Zou Zhenming Zang Bo Wang Zhigang She | 2021 | Chinese Journal of Chemistry2021，39，12： | 3 |
| 5 | A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer显示文摘Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,respectively.Patients who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer. | Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg Naohiro Ishii Angela Toss Mona PTan Mathew A Cherian Erwei Song | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 6 | MicroRNA-195a-5p inhibits mouse medullary thymic epithelial cells proliferation by directly targeting Smad7显示文摘MiR-195 在在肿瘤的不同类型禁止房间增长被含有。它是否贡献 thymic 的过程上皮的房间(侦探) 增长仍然保持不清楚。在这研究,我们发现 miR-195a-5p 在从变老的老鼠孤立的侦探是高度起来调整的。进一步的实验证明 miR-195a-5p 模仿禁止的 transfection 老鼠的增长髓的 thymic 第 1 行上皮的房间(MTEC1 ) ,而在 MTEC1 的 miR-195a-5p 禁止者的 transfection 有相反的效果。另外, miR-195a-5p 没在 MTEC1 apoptosis 上有明显的效果。而且, Smad7,转变生长因素小径的一个否定管理者,被酶试金作为 miR-195a-5p 的一个直接目标证实。一起拿,我们的结果显示 miR-195a-5p 禁止 MTEC1 增长,至少部分地,经由 Smad7 的下面规定。 | Dongguang Guo Yaqiong Ye Junjie Qi Lifeng Xu Lihua Zhang Xiaolong Tan Zhigang Tan Xiaofang Yu Yuan Zhang Yongjiang Ma Yugu Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，3： | 3 |
| 7 | Continuous determination of bath carbon content on 150 t BOF by off-gas analyzer 显示文摘 | Hu Zhigang He Ping Tan Mingxiang | 2003 | Journal of University of Scienee and Technology Beijing2003，10，6： | 1 |
| 8 | The First High-quality Reference Genome of Sika Deer Provides Insights into High-tannin Adaptation显示文摘Sika deer are known to prefer oak leaves,which are rich in tannins and toxic to most mammals;however,the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear.In identifying the mechanism responsible for the tolerance of a highly toxic diet,we have made a major advancement by explaining the genome of sika deer.We generated the first high-quality,chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments.Comparative genome analyses showed that the UGT and CYP gene families are functionally involved in the adaptation of sika deer to high-tannin food,especially the expansion of the UGT family 2 subfamily B of UGT genes.The first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for understanding evolutionary events and tannin adaptation.Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals. | Xiumei Xing Cheng Ai Tianjiao Wang Yang Li Huitao Liu Pengfei Hu Guiwu Wang Huamiao Liu Hongliang Wang Ranran Zhang Junjun Zheng Xiaobo Wang Lei Wang Yuxiao Chang Qian Qian Jinghua Yu Lixin Tang Shigang Wu Xiujuan Shao Alun Li Peng Cui Wei Zhan Sheng Zhao Zhichao Wu Xiqun Shao Yimeng Dong Min Rong Yihong Tan Xuezhe Cui Shuzhuo Chang Xingchao Song Tongao Yang Limin Sun Yan Ju Pei Zhao Huanhuan Fan Ying Liu Xinhui Wang Wanyun Yang Min Yang Tao Wei Shanshan Song Jiaping Xu Zhigang Yue Qiqi Liang Chunyi Li Jue Ruan Fuhe Yang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，1： | 1 |
| 9 | Design and Fabrication of Biodegradable Fluorescein-Labelled Nanospheres 显示文摘 | Li Yang Tan Ying Ning Zhigang | 2011 | Carbohydr Polym2011，86，： | 1 |
| 10 | Breast Cancer Awareness and Association with Frequency of Screening Among Women—China,2020显示文摘Summary What is already known about this topic?Breast cancer awareness plays a crucial role in promoting screening attendance,enabling early detection,and improving survival rates associated with breast cancer.Nevertheless,a persistent issue is the low public awareness of breast cancer warning signs and risk factors. | Heling Bao Liyuan Liu Shu Cong Fei Wang Lixiang Yu Liwen Fang Xuening Duan Feng Tan Zhigang Yu Linhong Wang | 2023 | China CDC weekly2023，5，15： | 0 |
| 11 | Influence of ground effect on flow field structure and aerodynamic noise of high-speed trains显示文摘The simulation of the ground effect has always been a technical difficulty in wind tunnel tests of high-speed trains.In this paper,large eddy simulation and the curl acoustic integral equation were used to simulate the flow-acoustic field results of high-speed trains under four ground simulation systems(GSSs):“moving ground+rotating wheel”,“stationary ground+rotating wheel”,“moving ground+stationary wheel”,and“stationary ground+stationary wheel”.By comparing the fluid-acoustic field results of the four GSSs,the influence laws of different GSSs on the flow field structure,aero-acoustic source,and far-field radiation noise characteristics were investigated,providing guidance for the acoustic wind tunnel testing of high-speed trains.The calculation results of the aerodynamic noise of a 350 km/h high-speed train show that the moving ground and rotating wheel affect mainly the aero-acoustic performance under the train bottom.The influence of the rotating wheel on the equivalent sound source power of the whole vehicle was not more than 5%,but that of the moving ground slip was more than 15%.The average influence of the rotating wheel on the sound pressure level radiated by the whole vehicle was 0.3 dBA,while that of the moving ground was 1.8 dBA. | Xiaoming TAN Linli GONG Xiaohong ZHANG Zhigang YANG | 2024 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2024，25，2： | 0 |
| 12 | Downregulation of myosin Ⅵ reduced cell growth and increased apoptosis in human colorectal cancer显示文摘Colorectal 癌症(CRC ) 是世界范围的第三最通常诊断的癌症,与在最后十年稳定地增加的死亡。肌浆球蛋白 VI (MYO6 ) 表示被发现在人的癌房间类型的一些类型被提高,建议它可以是为诊断和后续的敏感 biomarker。在这研究,我们首先使用了 Oncomine 数据库在 CRC 纸巾探索 MYO6 的表示,然后构造了指向 MYO6 基因的 RNA 干扰的 plasmid。在指向 MYO6 进 SW1116 房间的 lentivirus 的 transfection 以后,房间生存能力和增长与 3-(4,5-Dimethylthiazol-2-yl ) 被测量 -2,5-diphenyltetrazolium 溴化物和殖民地形成试金。房间周期分发是由流动 cytometry 的 assayed, apoptosis 被 Annexin V 评估。MYO6 表示被量的即时聚合酶链反应和西方的污点分析检测。MYO6 mRNA 是在用公共 Oncomine microarray 数据集的数据采矿的 CRC 纸巾的 upregulated,这被发现。MYO6 的弄空显著地禁止了房间增长和殖民地形成。另外, MYO6 击倒稍微在 G0/G1 阶段逮捕了房间周期,但是显著地随 apoptotic 房间的增加增加了房间的 sub-G1 阶段的比例。这些结果建议 MYO6 可以支持房间生长并且可以为 CRC 的 anticancer 治疗被用作一个潜在的目标。 | Weiqiang You Gewen Tan Nengquan Sheng Jianfeng Gong Jun Yan Di Chen Huizhen Zhang Zhigang Wang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 0 |
| 13 | A large-sized basal ankylopollexian from East Asia, shedding light on early biogeographic history of Iguanodontia显示文摘A presumably mostly quadrupedal ankylopollexian iguanodontian, Bayannurosaurus perfectus gen. et sp.nov., is reported here, and is represented by an excellently well-preserved skeleton from the Lower Cretaceous Bayingebi Formation of Inner Mongolia, China. The diagnosis of the taxon includes several autapomorphies, notably a dorsally directed, strap-like posterodorsal process of the jugal and a horizontally oriented preacetabular process of the ilium. The nearly complete caudal series retains eight posterior-most caudals with procoelous, trapezoidal centra in dorsal view, and the last three caudals are fully fused. The discovery of B. perfectus opens a critical new window on the early evolution and intercontinental dispersal of Iguanodontia. The skeleton displays a transitional morphology between nonhadrosauriform ankylopollexians and Hadrosauriformes. A phylogenetic analysis indicates that Bayannurosaurus is positioned higher on the tree than Hypselospinus, but below Ouranosaurus just outside of Hadrosauriformes. The tree topology of Iguanodontia with temporal and spatial constraints reveals a possible biogeographic scenario supported by the statistical dispersal-vicariance analysis: around the J/K boundary, non-hadrosauriform ankylopollexians experienced multiple dispersal events from Europe to Asia, accompanying the coeval fall of the global sea level. | Xing Xu Qingwei Tan Yilong Gao Zhiqiang Bao Zhigang Yin Bin Guo Junyou Wang Lin Tan Yuguang Zhang Hai Xing | 2018 | Science Bulletin2018，63，9： | 0 |
| 14 | Scalable Data Assignment Algorithm of Parallel I/O for Distributed Heterogeneous Computing显示文摘 | ZENG Biqing CHEN Zhigang TAN Lu XIONG Ce | 2005 | 通讯和计算机(中英文版)2005，2，3： | 0 |
| 15 | A 640×640 ISFET array for detecting cell metabolism显示文摘Ion sensitive field effect transistor(ISFET)devices are highly accurate,convenient,fast and low-cost in the detection of ions and biological macromolecules,such as DNA molecules,antibodies,enzymatic substrates and cellular metabolites.For high-throughput cell metabolism detection,we successfully designed a very large-scale biomedical sensing application specific integrated circuit(ASIC)with a 640×640 ISFET array.The circuit design is highly integrated by compressing the size of a pixel to 7.4×7.4μm^(2)and arranging the layout of even and odd columns in an interdigital pattern to maximize the utilization of space.The chip can operate at a speed of 2.083M pixels/s and the dynamic process of the fluid flow on the surface of the array was monitored through ion imaging.The pH sensitivity is 33±4 mV/pH and the drift rate is 0.06 mV/min after 5 h,indicating the stability and robustness of the chip.Moreover,the chip was applied to monitor pH changes in CaSki cells metabolism,with pH shifting from 8.04 to 7.40 on average.This platform has the potential for continuous and parallel monitoring of cell metabolism in single-cell culture arrays. | Ling Yang Yizheng Huang Zhigang Song Manqing Tan Yude Yu Zhao Li | 2023 | Journal of Semiconductors2023，44，2： | 0 |
| 16 | Corrigendum to:MicroRNA-195a-5p inhibits mouse medullary thymic epithelial cells proliferation by directly targeting Smad7显示文摘Acta Biochimica et Biophysica Sinica,2016,48(3),290-297,http://gffzzd3cc09b8251d45dfsp9ubv0xqqp0o60uk.ffgz.tsg.suse.edu.cn/10.1093/abbs/gmv136 In the originally published version of this article,Figure ID on page 293 is the incorrect figure.We have replaced it with the correct figure.The authors apologize for this error. | Dongguang Guo Yaqiong Ye Junjie Qi Lifeng Xu Lihua Zhang Xiaotong Tan Zhigang Tan Xiaofang Yu Yuan Zhang Yongjiang Ma Yugu Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 0 |
| 17 | Multi-scale attention encoder for street-to-aerial image geo-localization显示文摘The goal of street-to-aerial cross-view image geo-localization is to determine the location of the query street-view image by retrieving the aerial-view image from the same place.The drastic viewpoint and appearance gap between the aerial-view and the street-view images brings a huge challenge against this task.In this paper,we propose a novel multiscale attention encoder to capture the multiscale contextual information of the aerial/street-view images.To bridge the domain gap between these two view images,we first use an inverse polar transform to make the street-view images approximately aligned with the aerial-view images.Then,the explored multiscale attention encoder is applied to convert the image into feature representation with the guidance of the learnt multiscale information.Finally,we propose a novel global mining strategy to enable the network to pay more attention to hard negative exemplars.Experiments on standard benchmark datasets show that our approach obtains 81.39%top-1 recall rate on the CVUSA dataset and 71.52%on the CVACT dataset,achieving the state-of-the-art performance and outperforming most of the existing methods significantly. | Songlian Li Zhigang Tu Yujin Chen Tan Yu | 2023 | CAAI Transactions on Intelligence Technology2023，8，1： | 0 |
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