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| 1 | Antitumor agents. Part 218: Cappamensin A, a new In vitro anticancer principle, from Capparis sikkimensis显示文摘 | Jiu-Hong Wu Fang-Rong Chang Ken-ichiro Hayashi Hiroaki Shiraki Chih-Chuang Liaw Yuka Nakanishi Kenneth F. Bastow Donglei Yu Ih-Sheng Chen Kuo-Hsiung Lee | 2003 | Bioorganic & Medicinal Chemistry Letters2003，，13： | 1 |
| 2 | Causes of vertical transmission of hepatitis B virus under the at‐risk prevention strategy in Japan显示文摘 | Yuka Torii Hiroshi Kimura Kazuhiko Hayashi Michio Suzuki Jun‐ichi Kawada Seiji Kojima Yoshiaki Katano Hidemi Goto Yoshinori Ito | 2013 | Microbiol Immunol2013，，2： | 1 |
| 3 | Delayed postprandial metabolism of triglyceride-rich lipoproteins in obese young men compared to lean young men显示文摘 | Yuka Nabeno-Kaeriyama Yoshiko Fukuchi Sanae Hayashi Tomoko Kimura Akira Tanaka Michitaka Naito | 2010 | Clinica Chimica Acta2010，，21： | 1 |
| 4 | Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy显示文摘 | Yuka Ikegame Kentaro Yamashita Shin-Ichiro Hayashi Hiroshi Mizuno Masahiro Tawada Fukka You Kiyofumi Yamada Yoshitaka Tanaka Yusuke Egashira Shigeru Nakashima Shin-Ichi Yoshimura Toru Iwama | 2011 | Cytotherapy2011，，6： | 1 |
| 5 | Design and synthesis of a new polymer-supported Evans-type oxazolidinone: an efficient chiral auxiliary in the solid-phase asymmetric alkylation reactions显示文摘 | Tomoya Kotake Yoshio Hayashi S. Rajesh Yoshie Mukai Yuka Takiguchi Tooru Kimura Yoshiaki Kiso | 2005 | Tetrahedron2005，，15： | 1 |
| 6 | Interleukin-10 or tumor necrosis factor-α polymorphisms and the natural course of hepatitis C virus infection in a hyperendemic area of Japan显示文摘 | Kazunori Kusumoto Hirofumi Uto Katsuhiro Hayashi Yuka Takahama Hiroyuki Nakao Robert Suruki Sherri O. Stuver Akio Ido Hirohito Tsubouchi | 2006 | Cytokine2006，，1： | 1 |
| 7 | Direct-acting antivirals for hepatitis C virus-infected patients with hepatocellular carcinoma显示文摘BACKGROUND Hepatocellular carcinoma(HCC)in hepatitis C virus(HCV)-infected patients has a high risk of recurrence.Although eradication of HCV is expected to reduce this risk,the risk in patients with a history of HCC may be high after treatment with direct-acting antivirals(DAAs).AIM To determine the risk factors for HCC recurrence in patients with HCV and a history of HCC.METHODS The risk of HCC recurrence in patients with a history of HCC and/or of HCC occurrence in patients without a history of HCC after DAA therapy was retrospectively analyzed in 311 HCV patients treated at our institution and several neighboring hospitals.The frequency and predictors of HCC recurrence/occurrence after DAA treatment were included in these analyses.The clinical course of HCC before and after DAA treatment was also evaluated.RESULTS HCV patients with a history of HCC were older and had greater progression of liver fibrosis and diabetes than patients without a history of HCC.Median recurrence-free survival(RFS)was 1092 d in patients with a history of HCC,and post-DAA HCC recurrence/occurrence was observed in 29 patients(53.7%)with and 5(1.9%)without a history of HCC over 6 years(P<0.001).RFS in patients with a history of HCC did not differ significantly before and after DAA treatment.The frequency of HCC recurrence/occurrence in patients with a history of HCC was lower after than before DAA treatment.Multivariate analysis showed that the incidence rate of HCC recurrence/occurrence before DAA treatment was the only independent predictor of HCC recurrence/occurrence after DAA treatment.Liver function was well preserved and clinical course was good in patients with HCC recurrence/occurrence after DAA therapy.CONCLUSION DAA therapy in patients infected with HCV is also effective in patients with a history of HCC.Curative treatment for HCC is desirable before DAA therapy.The frequency of HCC recurrence/occurrence before DAA therapy was associated with a significantly increased risk of HCC recurrence after DAA therapy.Careful observation after DAA therapy is required in patients with a history of HCC. | Kazuto Tajiri Hiroyuki Ito Kengo Kawai Yoshiro Kashii Yuka Hayashi Aiko Murayama Masami Minemura Terumi Takahara Yukihiro Shimizu Ichiro Yasuda | 2022 | World Journal of Hepatology2022，14，6： | 0 |
| 8 | 选举令安倍得以推行其对战后新日本的构想显示文摘日本选民赋予首相安倍晋三领导的执政联盟以压倒性胜利,从而使他能够更加自由地推行其雄心勃勃的经济增长计划和强硬的外交政策.预计这次选举胜利将对日本经济和全球金融市场构成影响.
在历经数年的领导人频繁更迭以及立法瘫痪之后,目前几乎可以肯定,日本将进入一个政治稳定的时代.周日(7月21日)的选举令执政党自民党及其执政联盟小党伙伴获得了对国会上院半数以上席位的控制,而去年12月的胜利令他们掌控了下院 这就结束了'扭曲国会'现象,即政府的分裂.在过去二十多年的大部分时间里,'扭曲国会'时不时地对日本领导层形成牵制. | Yuka Hayashi Toko Sekiguchi George Nishiyama 沈丹琳 | 2013 | 英语文摘2013，，9： | 0 |
| 9 | Surgery for pancreatic tumors in the midst of COVID-19 pandemic显示文摘The spread of the new coronavirus(COVID-19)infection in 2020 has had a significant impact on the treatment of cancer worldwide.During the COVID-19 pandemic,the biggest challenge for pancreatic surgeons is the difficulty in providing oncological care.In this review article,from the standpoint of surgeons,we explain the concept of triaging of patients with pancreatic tumors under the COVID-19 pandemic,and the actual impact of COVID-19 on the treatment of patients with pancreatic tumors.The most vital points in selecting the best therapeutic approach for patients with pancreatic tumors during this pandemic are(1)Oncologists need to tailor the treatment plan based on the COVID-19 phase,tumor malignant potential,and patients’comorbidities;and(2)Optimal treatment for pancreatic cancer should be planned according to the condition of each patient and tumor resectability based on national comprehensive cancer network resectability criteria.To choose the best therapeutic approach for patients with pancreatic tumors during this pandemic,we need to tailor the treatment plan based on elective surgery acuity scale(ESAS).Newly established ESAS for pancreatic tumor and flowchart indicating the treatment strategy of pancreatic cancer,are feasible to overcome this situation. | Hiroyuki Kato Yukio Asano Satoshi Arakawa Masahiro Ito Norihiko Kawabe Masahiro Shimura Chihiro Hayashi Takayuki Ochi Hironobu Yasuoka Takahiko Higashiguchi Yuka Kondo Hidetoshi Nagata Akihiko Horiguchi | 2021 | World Journal of Clinical Cases2021，9，18： | 0 |
| 10 | Rapid transformation of branched pancreatic duct-derived intraductal tubulopapillary neoplasm into an invasive carcinoma: A case report显示文摘BACKGROUND Intraductal tubulopapillary neoplasm(ITPN)is a rare disease accounting for approximately 3%of all intraductal pancreatic tumors,with intraductal papillary mucinous neoplasm(IPMN)being one of the most common differential diagnoses.Both ITPN and IPMN display slow growth.A branched pancreatic duct type is commonly observed in IPMN,whereas ITPN derived from the branched pancreatic duct has been reported in a limited number of cases;hence,its pathogenesis remains unclear.CASE SUMMARY Here,we present the case of a patient with ITPN localized in a branched pancreatic duct,with poorly controlled irritable bowel syndrome.A contrastenhanced computed tomography scan of the abdomen incidentally revealed a 5-mm oligemic nodule-like change in the body of the pancreas.Endoscopic ultrasound(EUS)indicated a 10-mm hypoechoic mass without any cystic structures that had grown within 2 mo.EUS-guided fine needle aspiration was performed for definitive diagnosis,and the findings suggested ductal papillary carcinoma.Distal pancreatectomy was performed,and the tumor was pathologically diagnosed as ITPN with an invasive cancerous component,pT3N1aM0,pStage IIB(International Cancer Control,8^(th) edition).The patient underwent treatment with postoperative adjuvant chemotherapy(S-1 monotherapy);however,relapse was observed 1 year and 10 mo after surgical resection,and subsequent treatment involving a combination of chemotherapy and radiotherapy was administered.Maintenance therapy has since facilitated a stable disease state.CONCLUSION Regardless of the microscopic size of the neoplasm,early diagnosis of ITPN with EUS-guided fine needle aspiration and surgical resection are crucial. | Kenta Yamamoto Yutaka Takada Takuya Kobayashi Ryo Ito Yuka Ikeda Shogo Ota Kanna Adachi YukariShimada Motohito Hayashi Toshinao Itani Satsuki Asai Kojiro Nakamura | 2023 | World Journal of Clinical Oncology2023，14，12： | 0 |
| 11 | 日本开启新时代显示文摘导读:8月30日,日本最大的在野党民主党在第45届众议院选举中大获全胜,结束了自民党独霸政坛54年的局面。人心思变促成了这一日本战后历史性的变革。人们以选票表明了对日本政治决策方式和官僚体制的否定,对重振日本经济的期待。尽管对鸠山由纪夫能否兑现民主党变革日本政治、经济的诺言,日本人“一半期待,一半不安”,但日本国内政治生态的改变,亦会引发东亚政治生态的变数。 | Yuka Hayashi 李凤芹 | 2009 | 英语文摘2009，，10： | 0 |
| 12 | 亚股反弹难掩美经济衰退阴云显示文摘在美国联邦储备委员会(Fed)22日出人意料地宣布大幅减息的决定后,亚洲股市23日展开反弹。不过,股市的强劲表现并未给大型机构投资者带来多少喜悦,他们担心经济萧条的阴云会令美国消费者捂紧钱袋,不再踊跃购买亚洲出口商品。 | Laura Santini James T. Areddy Yuka Hayashi | 2008 | 海外经济评论2008，，6： | 0 |
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