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| 1 | L_-glutamine provides acid resistance for Escherichia coil through enzymatic release of ammonia显示文摘 | Peilon Lu | 2013 | Cell Research2013，23，5： | 23 |
| 2 | Prolonged manganese exposure induces severe deficits in lifespan,development and reproduction possibly by altering oxidative stress response in Caenorhabditis elegans显示文摘We examined the possible multiple defects induced by acute and prolonged exposure to high levels of manganese(Mn) solution by monitoring the endpoints of lifespan,development,reproduction,and stress response.Our data suggest that acute exposure(6 h) to Mn did not cause severe defects of life span,development,and reproduction,similarly,no significant defect could be found in animals exposed to a low concentration of Mn(2.5 μmol/L) for 48 h.In contrast,prolonged exposure(48 h) to high Mn concentrations(75 and 200 μmol/L) resulted in significant defects of life span,development,and reproduction,as well as the increase of the percentage of population with hsp-16.2::gfp expression indicating the obvious induction of stress responses in exposed animals.Moreover,prolonged exposure(48 h) to high concentrations(75 and 200 μmol/L) of Mn decreased the expression levels of antioxidant genes of sod-1,sod-2,sod-3,and sod-4 compared to control.Therefore,prolonged exposure to high concentrations of Mn will induce the severe defects of life span,development,and reproduction in nematodes possibly by affecting the stress response and expression of antioxidant genes in Caenorhabditis elegans. | XIAO Jing | 2009 | Journal of Environmental Sciences2009，21，6： | 13 |
| 3 | Characteristics of Pegmatite-Related Fluids and Significance to Ore-Forming Processes in the Zhaxikang Pb-Zn-Sb Polymetallic Deposit,Tibet,China显示文摘The Zhaxikang Pb-Zn-Sb polymetallic deposit is one of the most important deposits in the newly recognized southern Tibet antimony-gold metallogenic belt.Compared to the porphyry deposits in the Gangdese belt,much less researches have addressed these deposits,and the genesis of the Zhaxikang deposit is still controversial.Based on field investigation,petrographic,microthermometric,Laser Raman Microprobe(LRM) and SEM/EDS analyses of fluid,melt-fluid,melt and solid inclusions in quartz and beryl from pegmatite,this paper documents the characteristics and the evolution of primary magmatic fluid which was genetically related to greisenization,pegmatitization,and silification in the area.The results show that the primary magmatic fluids were derived from unmixing between melt and fluid and underwent a phase separation process soon after the exsolution.The primary magmatic fluids are of low salinity,high temperature,and can be approximated by the H_2O-NaCl-CO_2 system.The presence of Mn-Fe carbonate in melt-fluid inclusions and a Zn-bearing mineral(gahnite) trapped in beryl and in inclusions from pegmatite indicates high Mn,Fe,and Zn concentrations in the parent magma and magmatic fluids,and implies a genetic link between pegmatite and Pb-Zn-Sb mineralization.High B and F concentrations in the parent magma largely lower the solidus of the magma and lead to late fluid exsolution,thus the primary magmatic fluids related to pegmatite have much lower temperature than those in most porphyry systems.Boiling of the primary magmatic fluids leads to high-salinity and high-temperature fluids which have high capacity to transport Pb,Zn and Sb.The decrease in temperature and mixing with fluids from other sources may have caused the precipitation of Pb-Zn-Sn(Au) minerals in the distal fault systems surrounding the causative intrusion. | XIE Yuling WANG Bogong LI Yingxu LI Guangming DONG Suiliang GUO Xiang WANG Lei | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 6 |
| 4 | Recent Advances in Atmospheric Ionization Mass Spectrometry:Developments and Applications显示文摘Over the past 15 years,ambient ionization mass spectrometry has rapidly developed,greatly expanding the applications of single-cell analysis,food and agricultural,envi-ronmental,chemical analysis,biomedical analysis,mass spectrometry imaging,among other areas.Real time mass spectrometry evaluations of living sample,such as in vivo direct analysis for single cell,clinical applications,metabolic monitoring of living species and transient intermediates in organic reactions,have demonstrated the power and potential significance of ambient ionization mass spectrometry.Here-in,we want to introduce a partial of our works atmospheric ionization mass spec-trometry,related to ambient ionization mass spectrometry. | Yuling Li Yuqi Cao Yinlong Guo | 2020 | Chinese Journal of Chemistry2020，38，1： | 5 |
| 5 | Abnormal Brain Structure and Function in First-Episode Childhood- and Adolescence-Onset Schizophrenia: Association with Clinical Symptoms显示文摘Dear Editor,Schizophrenia is one of the most complicated and serious psychiatric disorders, and patients often show markedly disrupted structural and functional abnormalities during resting-state imaging scans of the brain. Patients with firstepisode childhood- and adolescence-onset schizophrenia (CAOS) refers to individuals under the age of 18 years whose first episode of illness had occurred before they were 13 years old [1]. The symptoms are similar to adultonset schizophrenia-auditory hallucinations or language deficits and abnormal cognition. However, CAOS patients often present with more severe psychotic symptoms and have a worse prognosis and treatment effect [2]. | Yanhong Xia Dan Lv Yinghui Liang Haisan Zhang Keyang Pei Rongrong Shao Yali Li Yan Zhang Yuling Li Jinghua Guo Luxian Lv Suqin Guo | 2019 | Neuroscience Bulletin2019，35，3： | 4 |
| 6 | The “1-3-7” Approach to Malaria Surveillance and Response--Henan Province, China, 2012−2018显示文摘What is already known about this topic?The“1-3-7”approach to malaria surveillance and response was a key measure for malaria elimination in China and was first introduced into the World Health Organization(WHO)as an international guideline for malaria surveillance and response in 2018.What is added by this report?The“1-3-7”approach was well implemented in Henan Province from 2012−2018.Over this study period,a total of 1,294 malaria cases were detected and reported,and all cases were diagnosed and reported within 1 day with 99.23%(1,284/1,294)of cases were investigated within 3 days.In addition,93.7%(1,212/1,294)of foci were investigated and vector control was implemented within 7 days at all residual non-active foci to prevent further spread.What are the implications for public health practice?The“1-3-7”controlling pattern would be an effective and approachable method for implementation especially in malaria-eliminating countries and regions,but the interval from symptom onset to diagnosis cannot be ignored.Thus,the roles and responsibilities that all actors involved in the health sector must be specified too. | Qunqun Zhang Ying Liu Yabo Hu Yuling Zhao Chengyun Yang Dan Qian Ruimin Zhou Suhua Li Zhou Guan Deling Lu Hongwei Zhang Wanshen Guo | 2020 | China CDC weekly2020，2，17： | 3 |
| 7 | Condensation of STM is critical for shoot meristem maintenance and salt tolerance in Arabidopsis显示文摘The shoot meristem generates the entire shoot system and is precisely maintained throughout the life cycle under various environmental challenges.In this study,we identified a prion-like domain(PrD)in the key shoot meristem regulator SHOOT MERISTEMLESS(STM),which distinguishes STM from other related KNOX1 proteins.We demonstrated that PrD stimulates STM to form nuclear condensates,which are required for maintaining the shoot meristem.STM nuclear condensate formation is stabilized by selected PrD-containing STM-interacting BELL proteins in vitro and in vivo.Moreover,condensation of STM promotes its interaction with the Mediator complex subunit MED8 and thereby enhances its transcriptional activity.Thus,condensate formation emerges as a novel regulatory mechanism of shoot meristem functions.Furthermore,we found that the formation of STM condensates is enhanced upon salt stress,which allows enhanced salt tolerance and increased shoot branching.Our findings highlight that the transcription factor partitioning plays an important role in cell fate determination and might also act as a tunable environmental acclimation mechanism. | Xiuwei Cao Qingwei Du Yahe Guo Ying Wang Yuling Jiao | 2023 | Molecular Plant2023，16，9： | 2 |
| 8 | Effects of 2, 4-Dichlorophenoxy Acetic Acid andLight on Growth of Gerbera (Gerbera jamesoniicv. Daxueju) Callus显示文摘This study was conducted to determine effects of 2,4-dichlorophenoxy acetic acid(2,4-D) and light on growth of gerbera(Gerbera jamesonii cv. Daxueju) callus. Callus was induced from both petiole and leaf explants of gerbera on Murashige and Skoog medium supplemented with 3% sucrose and various concentrations of 2,4-D and placed under light and dark. Callus induction percentage, callus size and callus fresh and dry weights were efficiently higher when using petiole as explant. MS medium supplemented with 1.5 mg/L 2,4-D showed the highest callus induction percentage of 96.70%. Callus induced under light had larger weight mass. It was indicated that 1.5 mg/L 2,4-D and light could promote growth of gerbera callus from petiole explant. | Esther Mabafokeng MOHLAKOLA Chunzhen CHENG Yuling LIN Rongfang GUO Kyaw Thu MIN Yukun CHEN Zhongxiong LAI | 2017 | Agricultural Science & Technology2017，18，3： | 2 |
| 9 | RNA modifications:importance in immune cell biology and related diseases显示文摘RNA modifications have become hot topics recently.By influencing RNA processes,including generation,transportation,function,and metabolization,they act as critical regulators of cell biology.The immune cell abnormality in human diseases is also a research focus and progressing rapidly these years.Studies have demonstrated that RNA modifications participate in the multiple biological processes of immune cells,including development,differentiation,activation,migration,and polarization,thereby modulating the immune responses and are involved in some immune related diseases.In this review,we present existing knowledge of the biological functions and underlying mechanisms of RNA modifications,including N6-methyladenosine(m^(6)A),5-methylcytosine(m^(5)C),N1-methyladenosine(m1 A),N7-methylguanosine(m^(7)G),N4-acetylcytosine(ac^(4)C),pseudouridine(Ψ),uridylation,and adenosine-to-inosine(A-to-I)RNA editing,and summarize their critical roles in immune cell biology.Via regulating the biological processes of immune cells,RNA modifications can participate in the pathogenesis of immune related diseases,such as cancers,infection,inflammatory and autoimmune diseases.We further highlight the challenges and future directions based on the existing knowledge.All in all,this review will provide helpful knowledge as well as novel ideas for the researchers in this area. | Lian Cui Rui Ma Jiangluyi Cai Chunyuan Guo Zeyu Chen Lingling Yao Yuanyuan Wang Rui Fan Xin Wang Yuling Shi | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 2 |
| 10 | RNA Methylome Reveals the m^(6)A-mediated Regulation of Flavor Metabolites in Tea Leaves under Solar-withering显示文摘The epitranscriptomic mark N6-methyladenosine(m^(6)A),which is the predominant internal modification in RNA,is important for plant responses to diverse stresses.Multiple environmental stresses caused by the tea-withering process can greatly influence the accumulation of specialized metabolites and the formation of tea flavor.However,the effects of the m^(6)A-mediated regulatory mechanism on flavor-related metabolic pathways in tea leaves remain relatively uncharacterized.We performed an integrated RNA methylome and transcriptome analysis to explore the m^(6)Amediated regulatory mechanism and its effects on flavonoid and terpenoid metabolism in tea(Camellia sinensis)leaves under solar-withering conditions.Dynamic changes in global m^(6)A level in tea leaves were mainly controlled by two m^(6)A erasers(CsALKBH4A and CsALKBH4B)during solar-withering treatments.Differentially methylated peak-associated genes following solarwithering treatments with different shading rates were assigned to terpenoid biosynthesis and spliceosome pathways.Further analyses indicated that CsALKBH4-driven RNA demethylation can directly affect the accumulation of volatile terpenoids by mediating the stability and abundance of terpenoid biosynthesis-related transcripts and also indirectly influence the flavonoid,catechin,and theaflavin contents by triggering alternative splicing-mediated regulation.Our findings revealed a novel layer of epitranscriptomic gene regulation in tea flavor-related metabolic pathways and established a link between the m^(6)A-mediated regulatory mechanism and the formation of tea flavor under solar-withering conditions. | Chen Zhu Shuting Zhang Chengzhe Zhou Caiyun Tian Biying Shi Kai Xu Linjie Huang Yun Sun Yuling Lin Zhongxiong Lai Yuqiong Guo | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 2 |
| 11 | Multi-task MIML learning for pre-course student performance prediction显示文摘In higher education,the initial studying period of each course plays a crucial role for students,and seriously influences the subsequent learning activities.However,given the large size of a course’s students at universities,it has become impossible for teachers to keep track of the performance of individual students.In this circumstance,an academic early warning system is desirable,which automatically detects students with difficulties in learning(i.e.,at-risk students)prior to a course starting.However,previous studies are not well suited to this purpose for two reasons:1)they have mainly concentrated on e-learning platforms,e.g.,massive open online courses(MOOCs),and relied on the data about students’online activities,which is hardly accessed in traditional teaching scenarios;and 2)they have only made performance prediction when a course is in progress or even close to the end.In this paper,for traditional classroom-teaching scenarios,we investigate the task of pre-course student performance prediction,which refers to detecting at-risk students for each course before its commencement.To better represent a student sample and utilize the correlations among courses,we cast the problem as a multi-instance multi-label(MIML)problem.Besides,given the problem of data scarcity,we propose a novel multi-task learning method,i.e.,MIML-Circle,to predict the performance of students from different specialties in a unified framework.Extensive experiments are conducted on five real-world datasets,and the results demonstrate the superiority of our approach over the state-of-the-art methods. | Yuling Ma Chaoran Cui Jun Yu Jie Guo Gongping Yang Yilong Yin | 2020 | Frontiers of Computer Science2020，14，5： | 1 |
| 12 | Induction of reproductive deficits in nematode Caenorhabditis elegans exposed to metals at different developmental stages 显示文摘 | GUO Yuling YANG Yiehao WANG Dayong | 2009 | Reproductive Toxicology2009，28，1： | 1 |
| 13 | Phase relations of R-T-M temary system, crystal structure and magnetic properties of R(T,M)13 compounds (R = Light rare earth; T = Co, Fe; M = Al, Si) ( Ⅰ ) 显示文摘 | Liang Jingkui Rao Guanghui Tang Weihua Zhao Yanming Guo Yongquan Yan Xiaohua Zhang Yuling Cheng Xiangrong Xie Sishen Yu Yude Tian Jinghua Cheng Xiaolong Liang Jingmei | 1996 | Progress in Natural Science1996，6，6： | 1 |
| 14 | Synthesizing, microstructure and microhardness distribution of Ti–Si–C–N/TiCN composite coating on Ti–6Al–4V by laser cladding显示文摘 | Yuling Yang Na Guo Jinfeng Li | 2012 | Surface & Coatings Technology2012，，： | 1 |
| 15 | Increase in root density induced by coronatine improves maize drought resistance in North China显示文摘Drought stress caused by insufficient irrigation or precipitation impairs agricultural production worldwide.In this study,a two-year field experiment was conducted to investigate the effect of coronatine(COR),a functional analog of jasmonic acid(JA),on maize drought resistance.The experiment included two water treatments(rainfed and irrigation),four COR concentrations(mock,0μmol L^(-1);A1,0.1μmol L^(-1);A2,1μmol L^(-1);A3,10μmol L^(-1))and two maize genotypes(Fumin 985(FM985),a drought-resistant cultivar and Xianyu 335(XY335),a drought-sensitive cultivar).Spraying 1μmol L^(-1)COR at seedling stage increased surface root density and size,including root dry matter by 12.6%,projected root area by 19.0%,average root density by 51.9%,and thus root bleeding sap by 28.2%under drought conditions.COR application also increased leaf area and SPAD values,a result attributed to improvement of the root system and increases in abscisic acid(ABA),JA,and salicylic acid(SA)contents.The improvement of leaves and roots laid the foundation for increasing plant height and dry matter accumulation.COR application reduced anthesis and silking interval,increasing kernel number per ear.COR treatment at 1μmol L^(-1)increased the yield of XY335 and FM985 by 7.9%and 11.0%,respectively.Correlation and path analysis showed that grain yields were correlated with root dry weight and projected root area,increasing maize drought resistance mainly via leaf area index and dry matter accumulation.Overall,COR increased maize drought resistance mainly by increasing root dry weight and root area,with 1μmol L-^(-1)COR as an optimal concentration. | Yuling Guo Guanmin Huang Qing Guo Chuanxi Peng Yingru Liu Mingcai Zhang Zhaohu Li Yuyi Zhou Liusheng Duan | 2023 | The Crop Journal2023，11，1： | 1 |
| 16 | Plant G proteins interact with endoplasmic reticulum luminal protein receptors to regulate endoplasmic reticulum retrieval显示文摘Maintaining endoplasmic reticulum(ER) homeostasis is essential for the production of biomolecules.ER retrieval, i.e., the retrograde transport of compounds from the Golgi to the ER, is one of the pathways that ensures ER homeostasis. However, the mechanisms underlying the regulation of ER retrieval in plants remain largely unknown. Plant ERD2-like proteins(ERD2 s) were recently suggested to function as ER luminal protein receptors that mediate ER retrieval. Here, we demonstrate that heterotrimeric G protein signaling is involved in ERD2-mediated ER retrieval. We show that ERD2 s interact with the heterotrimeric G protein Ga and Ggsubunits at the Golgi. Silencing of Ga, Gb, or Gg increased the retention of ER luminal proteins. Furthermore,overexpression of Ga, Gb, or Gg caused ER luminal proteins to escape from the ER, as did the co-silencing of ERD2 a and ERD2 b. These results suggest that G proteins interact with ER luminal protein receptors to regulate ER retrieval. | Shanshan Wang Ke Xie Guoyong Xu Huarui Zhou Qiang Guo Jingyi Wu Zengwei Liao Na Liu Yan Wang Yule Liu | 2018 | Journal of Integrative Plant Biology2018，60，7： | 1 |
| 17 | VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance显示文摘Radiotherapy remains the mainstay for treatment of various types of human cancer;however,the clinical efficacy is often limited by radioresistance,in which the underlying mechanism is largely unknown.Here,using esophageal squamous cell carcinoma(ESCC)as a model,we demonstrate that guanine nucleotide exchange factor 2(VAV2),which is overexpressed in most human cancers,plays an important role in primary and secondary radioresistance.We have discovered for the first time that VAV2 is required for the Ku70/Ku80 complex formation and participates in non-homologous end joining repair of DNA damages caused by ionizing radiation. | Weiling Liu Chuanwang Miao Shaosen Zhang Yachen Liu Xiangjie Niu Yiyi Xi Wenjia Guo Jiahui Chu Ai Lin Hongjin Liu Xinyu Yang Xinjie Chen Ce Zhong Yuling Ma Yuqian Wang Shihao Zhu Shuning Liu Wen Tan Dongxin Lin Chen Wu | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 18 | Effects of Micronutrient Niacin on Treatment Efficiency of Textile Wastewater显示文摘纺织品废水作为 mostdifficultly 要对待的废水之一众所周知。纺织品废水处理效率上的烟碱酸的效果被 1.0 mg 中心点L~的连续增加学习(-1)烟碱酸,水样品的物理、化学的索引例如货到付款,氨和脱氢酶活动,与标准方法每天被分析,并且在废水处理性能的明显的改进被完成。Theexact 结果显示出那:(1 ) 烟碱酸能与是的移动率 signifcantly 改进 COD 移动效率控制系统的至于那些的 1.31 次;(2 ) 在这个试验性的条件下面,烟碱酸的增加没几乎在氨的移动上有效果;(3 ) 烟碱酸的增加能在 130% 改进脱氢酶的活动。它证明纺织品废水处理系统的生物处理性能能可能通过微量元素烟碱酸补充被优化。 | LIANG Wei HU Hongying GU Xin CHE Yuling WANG Hui GUO Yufeng SONG Yudong | 2006 | Wuhan University Journal of Natural Sciences2006，11，3： | 1 |
| 19 | A crosstalk between auxin and brassinosteroid regulates leaf shape by modulating growth anisotropy显示文摘Leaf shape is highly variable within and among plant species,ranging from slender to oval shaped.This is largely determined by the proximodistal axis of growth.However,little is known about how proximal–distal growth is controlled to determine leaf shape.Here,we show that Arabidopsis leaf and sepal proximodistal growth is tuned by two phytohormones.Two class A AUXIN RESPONSE FACTORs(ARFs),ARF6 and ARF8,activate the transcription of DWARF4,which encodes a key brassinosteroid(BR)biosynthetic enzyme.At the cellular level,the phytohormones promote more directional cell expansion along the proximodistal axis,as well as final cell sizes.BRs promote the demethyl-esterification of cell wall pectins,leading to isotropic in-plane cell wall loosening.Notably,numerical simulation showed that isotropic cell wall loosening could lead to directional cell and organ growth along the proximodistal axis.Taken together,we show that auxin acts through biosynthesis of BRs to determine cell wall mechanics and directional cell growth to generate leaves of variable roundness. | Yuanyuan Xiong Binbin Wu Fei Du Xiaolu Guo Caihuan Tian Jinrong Hu Shouqin Lii Mian Long Lei Zhang Ying Wang Yuling Jiao | 2021 | Molecular Plant2021，14，6： | 1 |
| 20 | Immature tassel culture of Zea diploperennis and Zea diploperennis-Zea may shybrid:Plantregeneration,rapid propagation,and isozyme analysi 显示文摘 | Guo Xiaocai Zhang Yuling | 1989 | Genetic Manipulation in Plants1989，5，2： | 1 |
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