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| 1 | Glycosyltransferases:Mining,engineering and applications in biosynthesis of glycosylated plant natural products显示文摘UDP-Glycosyltransferases(UGTs)catalyze the transfer of nucleotide-activated sugars to specific acceptors,among which the GT1 family enzymes are well-known for their function in biosynthesis of natural product glycosides.Elucidating GT function represents necessary step in metabolic engineering of aglycone glycosylation to produce drug leads,cosmetics,nutrients and sweeteners.In this review,we systematically summarize the phylogenetic distribution and catalytic diversity of plant GTs.We also discuss recent progress in the identifi-cation of novel GT candidates for synthesis of plant natural products(PNPs)using multi-omics technology and deep learning predicted models.We also highlight recent advances in rational design and directed evolution engineering strategies for new or improved GT functions.Finally,we cover recent breakthroughs in the appli-cation of GTs for microbial biosynthesis of some representative glycosylated PNPs,including flavonoid glycosides(fisetin 3-O-glycosides,astragalin,scutellarein 7-O-glucoside),terpenoid glycosides(rebaudioside A,ginseno-sides)and polyketide glycosides(salidroside,polydatin). | Bo He Xue Bai Yumeng Tan Wentao Xie Yan Feng Guang-Yu Yang | 2022 | Synthetic and Systems Biotechnology2022，7，1： | 2 |
| 2 | Distributed time-varying formation control with uncertainties based on an event-triggered mechanism显示文摘This paper investigates the distributed time-varying formation(TVF)problems for general linear multi-agent systems(MASs)subject to matched bounded uncertainties based on an adaptive event-triggered mechanism.A TVF protocol was designed with an event-triggered mechanism by introducing adaptive weights into the formation control protocol and triggering condition,and the large chattering phenomenon was avoided by theσ-modification adaptive law.According to the Lyapunov stability theory,proof has been established that the MASs in the presence of uncertainties can realize the expected formation that satisfies the given feasible condition.Finally,an example is provided to verify the effectiveness of the proposed algorithm. | Xiaoduo LI Yumeng BAI Xiwang DONG Qingdong LI Zhang REN | 2021 | Science China(Information Sciences)2021，64，3： | 1 |
| 3 | An inactivated recombinant rabies virus chimerically expressed RBD induces humoral and cellular immunity against SARS-CoV-2 and RABV显示文摘Many studies suggest that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)can infect various animals and transmit among animals,and even to humans,posing a threat to humans and animals.There is an urgent need to develop inexpensive and efficient animal vaccines to prevent and control coronavirus disease 2019(COVID-19)in animals.Rabies virus(RABV)is another important zoonotic pathogen that infects almost all warmblooded animals and poses a great public health threat.The present study constructed two recombinant chimeric viruses expressing the S1 and RBD proteins of the SARS-CoV-2 Wuhan01 strain based on a reverse genetic system of the RABV SRV9 strain and evaluated their immunogenicity in mice,cats and dogs.The results showed that both inactivated recombinant viruses induced durable neutralizing antibodies against SARS-CoV-2 and RABV and a strong cellular immune response in mice.Notably,inactivated SRV-nCoV-RBD induced earlier antibody production than SRV-nCoV-S1,which was maintained at high levels for longer periods.Inactivated SRV-nCoV-RBD induced neutralizing antibodies against both SARS-CoV-2 and RABV in cats and dogs,with a relatively broadspectrum cross-neutralization capability against the SARS-CoV-2 pseudoviruses including Alpha,Beta,Gamma,Delta,and Omicron,showing potential to be used as a safe bivalent vaccine candidate against COVID-19 and rabies in animals. | Haili Zhang Hongli Jin Feihu Yan Yumeng Song Jiaxin Dai Cuicui Jiao Yujie Bai Jingxuan Sun Di Liu Shen Wang Mengyao Zhang Jilong Lu Jingbo Huang Pei Huang Yuanyuan Li Xianzhu Xia Hualei Wang | 2023 | Virologica Sinica2023，38，2： | 0 |
| 4 | 磷不是内蒙古温带典型草原地上净初级生产力的主要限制因素显示文摘磷是植物生长所必需的营养元素,然而,温带典型草原地上净初级生产力(ANPP)是否受到磷的限制仍存在争议。为探讨磷添加在自然条件和氮添加条件下对温带典型草原ANPP和不同功能群植物地上生物量的影响,本研究利用位于内蒙古温带典型草原的中国科学院植物研究所多伦恢复生态学试验示范研究站的16年氮磷添加实验平台,对植物群落ANPP、禾草和杂类草地上生物量以及土壤有效氮、磷含量进行了连续5年(2016–2020)的测量。研究结果表明,在自然条件下添加磷对ANPP和禾草、杂类草的地上生物量没有显著影响。而在添加氮的条件下,添加磷显著增加了ANPP和杂类草的地上生物量。线性回归分析的结果表明,ANPP与土壤速效磷浓度无显著相关,而与土壤速效氮浓度呈显著正相关。这些结果表明,磷不是内蒙古温带典型草原初级生产力的主要限制因素,但在添加氮的条件下添加磷可以提高温带典型草原的ANPP并改变植物群落组成。本研究为指导温带典型草原的管理提供了有价值的信息。 | Yumeng Guo Meng Zhou Jun Sheng Yujia Yuan Guangyuan Yuan Wen-Hao Zhang Wenming Bai | 2023 | Journal of Plant Ecology2023，16，4： | 0 |
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