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| 1 | Dynamic downscaling of near-surface air temperature at the basin scale using WRF-a case study in the Heihe River Basin, China显示文摘一般发行量模型(GCM ) 的空间决定太粗糙,不能代表地区性的气候变化在地区性,为许多环境建模和影响评价要求的盆,和本地规模。天气研究和预报模型(WRF ) 是一下一代,充分可压缩,有运行时刻的 Euler 非静水力学的 mesoscale 预报模型静水力学的选择。这个模型在从一公里的规模为 downscaling 天气和气候是有用的到几千公里,并且为导出也为水文学模拟要求的气象学的参数是有用的。这篇论文的目的是验证由中国气象学的管理(CMA ) 车站的每日的观察数据,并且由模仿 5 km/1 h 空气温度的 WRF 时时,在原处,分水岭的数据结盟了遥感勘测试验性的研究工程。每日的确认证明 WRF 模拟与观察数据有好同意;R ^ 啜在 WRF 模拟和每个车站之间的 2 ^ 是超过 0.93;为每个车站的 meanbias 错误(MBE ) 绝对是不到 | Xiaoduo PAN Xin Li Xiaokang SHI Xujun HAN Lihui LUO Liangxu WANG | 2012 | Frontiers of Earth Science2012，6，3： | 24 |
| 2 | QTG-Seq Accelerates QTL Fine Mapping through QTL Partitioning and Whole-Genome Sequencing of Bulked Segregant Samples显示文摘Deciphering the genetic mechanisms underlying agronomic traits is of great importance for crop improvement. Most of these traits are controlled by multiple quantitative trait loci (QTLs), and identifying the underlying genes by conventional QTL fine-mapping is time-consuming and labor-intensive. Here, we devised a new method, named quantitative trait gene sequencing (QTG-seq), to accelerate QTL fine-mapping. QTGseq combines QTL partitioning to convert a quantitative trait into a near-qualitative trait, sequencing of bulked segregant pools from a large segregating population, and the use of a robust new algorithm for identifying candidate genes. Using QTG-seq, we fine-mapped a plant-height QTL in maize (Zea mays L.), qPH7, to a 300-kb genomic interval and verified that a gene encoding an NF-YC transcription factor was the functional gene. Functional analysis suggested that qPH7-encoding protein might influence plant height by interacting with a CO-like protein and an AP2 domain-containing protein. Selection footprint ana卜 ysis indicated that qPH7 was subject to strong selection during maize improvement. In summary, QTG-seq provides an efficient method for QTL fine-mapping in the era of “big data'. | Hongwei Zhang Xi Wang Qingchun Pan Pei Li Yunjun Liu Xiaoduo Lu Wanshun Zhong Minqi Li Linqian Han Juan Li Pingxi Wang Dongdong Li Yan Liu Qing Li Fang Yang Yuan-Ming Zhang Guoying Wang Lin Li | 2019 | Molecular Plant2019，12，3： | 13 |
| 3 | Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders显示文摘孤独性光谱混乱(ASD ) 是有异构的病原学的许多人的神经病学的混乱。E3 ubiquitin (Ub ) 的活动过度 ligase UBE3A,不完全地源自 15q11-q13 拷贝数字变化,为世界范围的 ASD 盒子的 1%-3% 的报道,而是内在的机制遗体描绘了。这里,我们报导 ALDH1A2 的功能, retinoic 酸(RA ) 的限制率的酶合成,被 UBE3A 否定地以一种 ubiquitylation 依赖的方式调整。过多的 UBE3A 剂量被发现损害调停 RA 的 neuronal homeostatic synaptic 粘性。象 ASD 一样症状被 overexpressing UBE3A 在前额的外皮或由一个 ALDH1A 对手的管理在老鼠概括,而 RA 补充显著地减轻了过多的 UBE3A 导致剂量的象 ASD 一样显型。由识别在 ASD 作为内在的机制发信号的减少的 RA,显型连接了到 UBE3A 活动过度,我们的调查结果介绍 ASD 病原学的新远景并且对这逐渐地流行的疾病便于治疗学的开发的一个模式。 | Xingxing Xu Chuanyin Li Xiaobo Gao Kun Xia Hui Guo Yali Li ZijianHao Lei Zhang Daming Gao Chenfan Xu Huatai Xu Zhi-Qi Xiong Zilong Qiu Ling Mei Xiaoduo Xie Kangcheng Ruan Ronggui Hu | 2018 | Cell Research2018，28，1： | 13 |
| 4 | Toward an improved data stewardship and service for environmental and ecological science data in West China显示文摘Sharing of scientific data can help scientific research to flourish and facilitate more widespread use of scientific data for the benefit of society.The Environmental and Ecological Science Data Center for West China(WestDC),sponsored by the National Natural Science Foundation of China(NSFC),aims to collect,manage,integrate,and disseminate environmental and ecological data from western China.It also aims to provide a long-term data service for multidisciplinary research within NSFC’s‘‘Environment and Ecology of West China Research Plan’’(NSFC West Plan).An integrated platform has been developed by the WestDC,and this has the function of data sharing,acting as a knowledge repository.Major data sets developed by the WestDC include basic geographic data,the regionalization of global data set for China,scientific data for cold and arid regions in China,scientific data for the cryosphere in countries that neighbor China,data relating to the inland river basins in northwestern China,and data submitted by the NSFC West Plan projects.In compliance with the‘‘full and open’’data sharing policy,most data in the WestDC can be accessed online.Highlights include detailed data documentation,the integration of data with bibliographic knowledge,data publishing,and data reference. | Xin Li Zhuotong Nan Guodong Cheng Yongjian Ding Lizong Wu Liangxu Wang Jian Wang Youhua Ran Hongxing Li Xiaoduo Pan Zhongming Zhu | 2011 | International Journal of Digital Earth2011，4，4： | 11 |
| 5 | Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress显示文摘在细胞的 ubiquitin (Ub ) 的改变动态平衡,作为 Ub 知道强调,展示并且影响处于多重条件的细胞的回答,然而,内在的机制不完全地被理解。这里,我们报导 autophagy 受体 p62/sequestosome-1 与结合酶, UBE2D2 和 UBE2D3 的 E2 Ub 交往。内长的 p62 在 Ub 动态平衡的 upregulation 期间经历 E2 依赖的 ubiquitylation,一个条件作为 Ub + 应力称为,那对由 bortezomib 的 Ub overexpression,热吃惊或延长 proteasomal 抑制内在,化学疗法的药。p62 的 Ubiquitylation 破坏 p62 的 UBA 领域的 dimerization,解放它的能力认出为选择 autophagy 的 polyubiquitylated 货物。我们进一步证明这机制可能为在 Ub + 压力条件之上的 autophagy 激活是批评的。机制的描述和在察觉到 Ub 应力并且控制选择 autophagy 的 p62 的规章的角色能帮助理解并且调制细胞的回答到许多内长、环境的挑战,潜在地对 autophagy 相关的病为治疗学的策略的发展打开一条新大街。 | Hong Peng Jiao Yang Guangyi Li Qing You Wen Han Tianrang Li Darning Gao Xiaoduo Xie Byung-Hoon Lee Juan Du Jian Hou Tao Zhang Hai Rao Ying Huang Qinrun Li Rong Zeng Lijian Hui Hongyan Wang Qin Xia Xuemin Zhang Yongning He Masaaki Komatsu Ivan Dikic Daniel Finley Ronggui Hu | 2017 | Cell Research2017，27，5： | 9 |
| 6 | Validation of WRF model on simulating forcing data for Heihe River Basin显示文摘The research of coupling WRF(Weather Research and Forecasting Model)with a land surface model is enhanced to explore the interaction of the atmosphere and land surface;however,regional applicability of WRF model is questioned.In order to do the validation of WRF model on simulating forcing data for the Heihe River Basin,daily meteorological observation data from 15 sta-tions of CMA(China Meteorological Administration)and hourly meteorological observation data from seven sites of WATER(Watershed Airborne Telemetry Experimental Research)are used to compare with WRF simulations,with a time range of a whole year for 2008.Results show that the average MBE(Mean Bias Error)of daily 2-m surface temperature,surface pressure,2-m rela-tive humidity and 10-m wind speed were-0.19 °C,-4.49 hPa,4.08% and 0.92 m/s,the average RMSE(Root Mean Square Error)of them were 2.11 °C,5.37 hPa,9.55% and 1.73 m/s,and the average R(correlation coefficient)of them were 0.99,0.98,0.80 and 0.55,respectively.The average MBE of hourly 2-m surface temperature,surface pressure,2-m relative humidity,10-m wind speed,downward shortwave radiation and downward longwave were-0.16 °C,-6.62 hPa,-5.14%,0.26 m/s,33.0 W/m2 and-6.44 W/m2,the average RMSE of them were 2.62 °C,17.10 hPa,20.71%,2.46 m/s,152.9 W/m2 and 53.5 W/m2,and the average R of them were 0.96,0.97,0.70,0.26,0.91 and 0.60,respectively.Thus,the following conclusions were obtained:(1)regardless of daily or hourly validation,WRF model simulations of 2-m surface temperature,surface pressure and relative humidity are more reliable,especially for 2-m surface air temperature and surface pressure,the values of MBE were small and R were more than 0.96;(2)the WRF simulating downward shortwave radiation was relatively good,the average R between WRF simulation and hourly observation data was above 0.9,and the average R of downward longwave radiation was 0.6;(3)both wind speed and rainfall simulated from WRF model did not agree well with observation data. | XiaoDuo Pan Xin Li | 2011 | Research in Cold and Arid Regions2011，3，4： | 9 |
| 7 | Regulation of Leaf Angle by Auricle Development n Maize显示文摘 | Fanying Kong Tingting Zhang Jisheng Liu Siqi Heng Qingbiao Shi Haisen Zhang Zeli Wang Lei Ge Pinghua Li Xiaoduo Lu Gang Li | 2017 | Molecular Plant2017，10，3： | 5 |
| 8 | Evaluation with low-dose dual-phase helical computed tomography of patients with thyroid lesions显示文摘 | Li Lin Wang Yong Zhao Yanfeng Zou Shuangmei Lin Meng Yu Xiaoduo Tang Wei Zhou Chunwu Luo Dehong | 2014 | Chinese Medical Journal2014，，22： | 3 |
| 9 | Integration of high-throughput phenotyping,GWAS,and predictive models reveals the genetic architecture of plant height in maize显示文摘Plant height(PH)is an essential trait in maize(Zea mays)that is tightly associated with planting density,biomass,lodging resistance,and grain yield in the field.Dissecting the dynamics of maize plant architecture will be beneficial for ideotype-based maize breeding and prediction,as the genetic basis controlling PH in maize remains largely unknown.In this study,we developed an automated high-throughput phenotyping platform(HTP)to systematically and noninvasively quantify 77 image-based traits(i-traits)and 20 field traits(f-traits)for 228 maize inbred lines across all developmental stages.Time-resolved i-traits with novel digital phenotypes and complex correlations with agronomic traits were characterized to reveal the dynamics of maize growth.An i-trait-based genome-wide association study identified 4945 traitassociated SNPs,2603 genetic loci,and 1974 corresponding candidate genes.We found that rapid growth of maize plants occurs mainly at two developmental stages,stage 2(S2)to S3 and S5 to S6,accounting for the final PH indicators.By integrating the PH-association network with the transcriptome profiles of specific internodes,we revealed 13 hub genes that may play vital roles during rapid growth.The candidate genes and novel i-traits identified at multiple growth stages may be used as potential indicators for final PH in maize.One candidate gene,ZmVATE,was functionally validated and shown to regulate PH-related traits in maize using genetic mutation.Furthermore,machine learning was used to build predictive models for final PH based on i-traits,and their performancewas assessed across developmental stages.Moderate,strong,and very strong correlations between predictions and experimental datasets were achieved from the early S4(tenth-leaf)stage.Colletively,our study provides a valuable tool for dissecting the spatiotemporal formation of specific internodes and the genetic architecture of PH,as well as resources and predictive models that are useful for molecular design breeding and predicting maize varieties with ideal plant architectures. | Weixuan Wang Weijun Guo Liang Le Jia Yu Yue Wu Dongwei Li Yifan Wang Huan Wang Xiaoduo Lu Hong Qiao Xiaofeng Gu Jian Tian Chunyi Zhang Li Pu | 2023 | Molecular Plant2023，16，2： | 1 |
| 10 | Separation of two constituents from purple sweet potato by combination of silica gel column and high-speed counter-current chromatography显示文摘 | Kai He Xiaoli Ye Xuegang Li Hongying Chen Lujiang Yuan Yafei Deng Xin Chen Xiaoduo Li | 2011 | Journal of Chromatography B2011，，： | 1 |
| 11 | Distributed time-varying formation control with uncertainties based on an event-triggered mechanism显示文摘This paper investigates the distributed time-varying formation(TVF)problems for general linear multi-agent systems(MASs)subject to matched bounded uncertainties based on an adaptive event-triggered mechanism.A TVF protocol was designed with an event-triggered mechanism by introducing adaptive weights into the formation control protocol and triggering condition,and the large chattering phenomenon was avoided by theσ-modification adaptive law.According to the Lyapunov stability theory,proof has been established that the MASs in the presence of uncertainties can realize the expected formation that satisfies the given feasible condition.Finally,an example is provided to verify the effectiveness of the proposed algorithm. | Xiaoduo LI Yumeng BAI Xiwang DONG Qingdong LI Zhang REN | 2021 | Science China(Information Sciences)2021，64，3： | 1 |
| 12 | Occurrence and characterization of selected organochlorine contaminants in outdoor dust collected from Xinxiang, a fast developing city in North China显示文摘 | Yongfang Li Zhongzhi Yang Xiaoduo Kong Guangjie He | 2012 | Environmental Monitoring and Assessment2012，，5： | 1 |
| 13 | Microglia activation in the offspring of prenatal Poly I:C exposed rats:a PET imaging and immunohistochemistry study显示文摘Background The well-known | Xue Li Xin Tian Luxian Lv Gangrui Hei Xufeng Huang Xiaoduo Fan Jinming Zhang Jianjiang Zhang Lijuan Pang Xueqin Song | 2018 | General Psychiatry2018，31，4： | 1 |
| 14 | Heterogeneous sea-level rises along coastal zones and small islands显示文摘Coastal zones and many small islands are highly susceptible to sea-level rise(SLR). Coastal zones have a large exposed population and integrated high-value assets, and islands provide diverse ecosystem services to millions of people worldwide. The coastal zones and small islands affected by SLR are likely to suffer from submergence, flooding and erosion in the future. However, very few studies have addressed the heterogeneity in SLR changes and the potential risk to coastal zones and small islands. Here we used the mean sea level(MSL) derived from satellite altimetry data to analyse the trends and accelerations of SLRs along global coastal zones and small islands. We found that except for the Antarctic coastal zone, the annual MSL within 50 km of the coasts presented an increasing trend of 3.09 ± 0.13 mm a^-1 but a decreasing acceleration of -0.02 ± 0.02 mm a^-2 from 1993 to 2017. The highest coastal MSL trend of3.85 ± 0.60 mm a^-1 appeared in Oceania, and the lowest trend of 2.32 ± 0.37 mm a^-1 occured in North America. Africa, North America and South America showed acceleration trends, and Eurasia, Australia and Oceania had deceleration trends. Further, MSLs around global small islands reflected an increasing trend with a rate of 3.01 ± 0.16 mm a^-1 but a negative acceleration of -0.02 ± 0.02 mm a^-2. Regional heterogeneity in the trends and accelerations of MSLs along the coasts and small islands suggests that stakeholders should take discriminating precautions to cope with future disadvantageous impacts of the SLR. | Guoshuai Li Xin Li Tandong Yao Tao Che Hong Yang Mingguo Ma Haipeng Zhao Xiaoduo Pan | 2019 | Science Bulletin2019，64，11： | 0 |
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