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| 1 | On-chip plasmonic spin-Hall nanograting for simultaneously detecting phase and polarization singularities显示文摘Phase and polarization singularities are important degrees of freedom for electromagnetic field manipulation.Detecting these singularities is essential for modern optics,but it is still a challenge,especially in integrated optical systems.In this paper,we propose an on-chip plasmonic spin-Hall nanograting structure that simultaneously detects both the polarization and phase singularities of the incident cylindrical vortex vector beam(CVVB).The nanograting is symmetry-breaking with different periods for the upper and lower parts,which enables the unidirectional excitation of the surface plasmon polariton depending on the topological charge of the incident optical vortex beam.Additionally,spin-Hall meta-slits are integrated onto the grating so that the structure has a chiral response for polarization detection.We demonstrate theoretically and experimentally that the designed structure fully discriminates both the topological charges and polarization states of the incident beam simultaneously.The proposed structure has great potential in compact integrated photonic circuits. | Fu Feng Guangyuan Si Changjun Min Xiaocong Yuan Michael Somekh | 2020 | Light(Science & Applications)2020，9，1： | 11 |
| 2 | Targeting polarized phenotype of microglia via IL6/JAK2/ STAT3 signaling to reduce NSCLC brain metastasis显示文摘Tumor-associated macrophages have emerged as crucial factors for metastases.Microglia are indispensable components of the brain microenvironment and play vital roles in brain metastasis(BM).However,the underlying mechanism of how activated microglia promote brain metastasis of non-small cell lung cancer(NSCLC)remains elusive. | Yu Jin Yalin Kang Minghuan Wang Bili Wu Beibei Su Han Yin Yang Tang Qianxia Li Wenjie Wei Qi Mei Guangyuan Hu Veronika Lukacs-Kornek Jian Li Kongming Wu Xianglin Yuan Wei Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 3 |
| 3 | Ectopic expression of BdCIPK31 confers enhanced low-temperature tolerance in transgenic tobacco plants显示文摘Calcineurin 象 B 一样蛋白质(CBL ) , Ca 2+ 传感器,和它的交往的蛋白质 kinases (CIPK ) 在植物反应起必要作用强调。然而,很少研究在低温度的反应集中了于 CIPK 的功能。在现在的学习, BdCIPK31,在 Brachypodium distachyon 的寒冷应答的 CIPK,被发现参予低温度的反应。BdCIPK31 的宫外的表示在转基因的烟草授与冷忍耐。进一步的分析显示 BdCIPK31 的那个表达式在低温度的处理下面在转基因的植物改进了 ROS 解毒和 omsoprotectant 生合成,建议 BdCIPK31 在到导致寒冷的氧化、渗透的压力的植物改编断然工作。而且, BdCIPK31 能 upregulate 在寒冷下面的一些代表性的压力相关的基因的表情强调。在结论,这些调查结果建议 BdCIPK31 在植物寒冷反应断然工作。 | Qingchen Luo Qiuhui Wei Ruibin Wang Yang Zhang Fan Zhang Yuan He Guangxiao Yang Guangyuan He | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 3 |
| 4 | TaASR1 , a transcription factor gene in wheat, confers drought stress tolerance in transgenic tobacco显示文摘 | WEI HU CHAO HUANG XIAOMIN DENG SHIYI ZHOU LIHONG CHEN YIN LI CHENG WANG ZHANBING MA QIANQIAN YUAN YAN WANG RUI CAI XIAOYU LIANG GUANGXIAO YANG GUANGYUAN HE | 2013 | Plant Cell Environ2013，，8： | 1 |
| 5 | Nanostructured sul- fur cathodes 显示文摘 | Yang Yuan Zheng Guangyuan Cui Yi | 2013 | Chemical Society Reviews2013，42，7： | 1 |
| 6 | Nanostructured sul- fur cathodes 显示文摘 | Yang Yuan Zheng Guangyuan Cui Yi | 2013 | Chemical Society Reviews2013，42，： | 1 |
| 7 | Hollow carbon nanofiber-encapsulated sulfur cathodes for high specific capacity rechargeable lithium batteries显示文摘 | Zheng Guangyuan Yang Yuan Cha Judy J | 2011 | Nano Letters2011，11，10： | 1 |
| 8 | A low-energy ion spectrometer with half-space entrance for three-axis stabilized spacecraft显示文摘A low-energy ion spectrometer(LEIS) for use aboard three-axis stabilized spacecraft has been developed to measure ion energy per charge distribution in three-dimensional space with good energy-, angular-and temporal-resolutions. For the standard top-hat electrostatic analyzer used widely in space plasma detection, three-axis stabilized spacecraft makes it difficult to obtain complete coverage of all possible ion arrival directions. We have designed angular scanning deflectors supplementing to a cylindrically symmetric top-hat electrostatic analyzer to provide a half-space field of view as 360°×90°(–45°–+45°), and fabricated the LEIS flight model for detecting magnetospheric ions in geosynchronous orbit. The performance of this payload has been evaluated in detail by a series of simulation and environmental tests, and the payload has also been calibrated through laboratory experiments using a low-energy ion source. The results show that capabilities of the LEIS payload are in accordance with the requirements of a magnetospheric mission. | HU RenXiang SHAN Xu YUAN GuangYuan WANG ShuWen ZHANG WeiHang QI Wei CAO Zhe LI YiRen CHEN ManMing YANG XiaoPing WANG Bo SHAO SiPei LI Feng ZHONG XiaoQing FAN Dan HAO XinJun FENG ChangQing SU ZhenPeng SHEN ChengLong LI Xin DAI GuYue QIU BingLin PAN ZongHao LIU Kai XU ChunKai LIU ShuBin AN Qi ZHANG TieLong WANG YuMing CHEN XiangJun | 2019 | Science China(Technological Sciences)2019，62，6： | 1 |
| 9 | Nanostructured sulfur cathodes显示文摘 | YANG Yuan ZHENG Guangyuan CUI Yi | 2013 | Chemical Society Reviews2013，42，： | 1 |
| 10 | Associations between Single-Nucleotide Polymorphisms in the PI3K–PTEN–AKT–mTOR Pathway and Increased Risk of Brain Metastasis in Patients with Non–Small Cell Lung Cancer显示文摘 | Qianxia Li Ju Yang Qianqian Yu Huanlei Wu Bo Liu Huihua Xiong Guangyuan Hu Jing Zhao Xianglin Yuan Zhongxing Liao | 2013 | Clinical Cancer Research2013，，22： | 1 |
| 11 | Hollow carbon nanofiber-encapsulated sulfur cathodes for high specific capacity rechargeable lithium batteries显示文摘 | ZHENG Guangyuan YANG Yuan CHA J J | 2011 | Nano Letters2011，11，： | 1 |
| 12 | Fractal characterization of pore structure and its influence on CH_(4) adsorption and seepage capacity of low-rank coals显示文摘The pore structures of coal can directly affect the adsorption and seepage capacity of coalbed methane(CBM),which therefore is an important influence on CBM exploration and development.In this study,the pore structures of low-rank coals from the Middle Jurassic Xishanyao Formation in the southern Junggar Basin were analyzed,and the fractal dimensions(D1,D2,D3 and D4 corresponding to pore sizes of 0-5 nm,5-100 nm,100-1000 nm and 1000-20000 nm,respectively)were calculated to quantitatively describe these coal pore structures.The results show that Xishanyao coal is characterized by open pore morphology,good pore connectivity and well-developed seepage pores and microfractures,which is beneficial to CBM seepage.The D1 and D2 can be used to characterize the pore surface and structure of adsorption pores respectively.The D3 and D4 can be used to represent the pore structure of seepage pores.Compared with adsorption pores,the structure of seepage pores is more affected by the change of coal rank.The D1 is better than D2 in characterizing the methane adsorption capacity.When D1>2.2,D1 is positively correlated with Langmuir volume(VL)and negatively correlated with Langmuir pressure(PL),while D2 shows a weak opposite trend.The coals with the higher D1 and lower D2 are associated with a higher VL,indicating the coal reservoir with more complex pore surfaces and simpler pore structures has stronger methane adsorption capacity.D4 is better than D3 in characterizing the methane seepage capacity.The porosity and permeability of coal reservoirs increase with the increase of D4,while D3 displays an opposite trend,which is mainly related to the well-developed microfractures.The well-developed fracture system enhances the seepage capacity of the Xishanyao coal reservoir.This study reveals the fractal characteristics of pore structure and its significant influence on adsorption and seepage capacity of low-rank coal. | Guangyuan MU Haihai HOU Jiaqiang ZHANG Yue TANG Ya-nan LI Bin SUN Yong LI Tim JONES Yuan YUAN Longyi SHAO | 2022 | Frontiers of Earth Science2022，16，4： | 0 |
| 13 | Seroprevalence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in patients with cancer and the impact of anti-tumor treatment on antibodies显示文摘Objective The aim of this study was to examine the seroprevalence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)among patients with cancer and followed up changes in SARS-CoV-2-specific antibodies to explore the impact of anti-tumor treatment in patients.Methods Patients with cancer who visited the Outpatient Clinic of Oncology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China between March 9 and April 30,2020 were enrolled in this retrospective cohort study.SARS-CoV-2 immunoglobulin(Ig)G,IgM,and viral load at various time points during the disease course were determined.Results We examined the serological results of 779 patients with cancer.The overall seroprevalence(IgG-positive or IgM-positive)rate of SARS-CoV-2 was 3.4%.The probability of seropositivity was significantly higher in patients with gastric cancer than in those without gastric cancer(odds ratio:6.349,95%confidence interval:2.191–18.396).Follow-up data showed that SARS-CoV-2 IgM and IgG levels decreased and the polymerase chain reaction test result remained negative in seropositive patients with cancer.Conclusion This study investigated the seroprevalence of SARS-CoV-2 in coronavirus disease(COVID-19)-positive patients with cancer in Wuhan,China.The seropositivity in patients with cancer was lower than or similar to that in the general population.Irrespective of anti-tumor therapy,the levels of SARS-CoV-2 antibodies decreased in these patients.More studies are needed to better understand the impact of anti-tumor therapy on change in the levels of SARS-CoV-2 antibodies. | Bili Wu Bo Liu Xueyan Jiang Ye Yuan Wan Qin Kai Qin Qi Mei Li Zhang Huilan Zhang Guangyuan Hu Xianglin Yuan | 2021 | Oncology and Translational Medicine2021，7，3： | 0 |
| 14 | Outcomes of palliative local treatment in metastatic colorectal cancer patients receiving chemotherapy plus bevacizumab显示文摘Objective The aim of this study was to assess the value of palliative local treatment of incurable metastatic lesions in colorectal cancer(CRC) patients receiving chemotherapy plus bevacizumab.Methods Data of 105 patients with histologically confirmed synchronous or metachronous metastatic CRC who received bevacizumab treatment from January 1, 2011 to January 31, 2017 were retrospectively reviewed. Sixteen(15%) patients who were treated with bevacizumab for less than 4 cycles were excluded, and finally, 89(85%) patients were enrolled. Among them, 33(37%) patients who received palliative local treatment were categorized into the palliative local treatment group, and the remaining 56(63%) patients were categorized into the chemotherapy plus bevacizumab group. The primary endpoint was overall survival(OS), which was calculated using Kaplan-Meier survival analyses. Factors possibly influencing survival were evaluated by univariate and multivariate analyses. Adverse events(AEs) were graded according to Common Terminology Criteria for Adverse Events, version 4.0. Grades 1–2 and 3–4 AEs of the two groups were compared and analyzed using the Fisher's exact test and χ~2 analysis.Results The median follow-up period was 20.4 months, ranging from 1 to 60 months. The median OS in the palliative local treatment group was 36.3 months(95% CI, 33.5–39.2), and that in the chemotherapy plus bevacizumab group was 20.5 months(95% CI, 17.6–23.4). Both the univariate(HR 0.13, 95% CI, 0.05–0.30, P < 0.001) and multivariate(HR 0.16, 95% CI, 0.07–0.39, P < 0.001) analyses showed that the addition of palliative local treatment could prolong survival compared with chemotherapy plus bevacizumab alone. There were no significant differences in the rates of common chemotherapy-or bevacizumab-related AEs between the two groups.Conclusion These findings suggest palliative local treatment is an effective and safe method for treating patients with incurable metastatic CRC receiving chemotherapy plus bevacizumab. | Ben Zhao Lu Wang Qianqian Yu Guangyuan Hu Hong Qiu Mingsheng Zhang Li Sun Ping Peng Xianglin Yuan | 2018 | Oncology and Translational Medicine2018，4，3： | 0 |
| 15 | Impacts of China's Emergence on the World Economy: A Value Chain Perspective显示文摘This paper sheds light on the demand-side impact of China’s emergence on the world economy from a value chain perspective. A measure linking final demand with value-added in the context of global value chains is developed. Data from the World Input-Output Database is used to analyze foreign value-added induced by final demand in China. It is found that foreign value-added to meet final demand in China increases over time except during 2008–2009, proving that China has a significant power to shape the world economy through its final demand. Besides, it is found that about88% of foreign value-added is absorbed in China through intermediate imports. In addition, how and to what extend the final demand in China contributes to other countries’ GDP growth is investigated.Results show that continuous increase in foreign value-added absorbed in China becomes a ballooning source of economic growth, and final demand in China is rather a remedy in aftermath of the global recession during 2008–2009. Finally, it is found that the increase in foreign value-added absorbed in China is due not only to the surge in final demand but also to bullwhip effect along global value chains. | Guangyuan XING Aolin LENG Zongxian FENG Yuan ZHANG | 2022 | Journal of Systems Science and Information2022，10，6： | 0 |
| 16 | 磷不是内蒙古温带典型草原地上净初级生产力的主要限制因素显示文摘磷是植物生长所必需的营养元素,然而,温带典型草原地上净初级生产力(ANPP)是否受到磷的限制仍存在争议。为探讨磷添加在自然条件和氮添加条件下对温带典型草原ANPP和不同功能群植物地上生物量的影响,本研究利用位于内蒙古温带典型草原的中国科学院植物研究所多伦恢复生态学试验示范研究站的16年氮磷添加实验平台,对植物群落ANPP、禾草和杂类草地上生物量以及土壤有效氮、磷含量进行了连续5年(2016–2020)的测量。研究结果表明,在自然条件下添加磷对ANPP和禾草、杂类草的地上生物量没有显著影响。而在添加氮的条件下,添加磷显著增加了ANPP和杂类草的地上生物量。线性回归分析的结果表明,ANPP与土壤速效磷浓度无显著相关,而与土壤速效氮浓度呈显著正相关。这些结果表明,磷不是内蒙古温带典型草原初级生产力的主要限制因素,但在添加氮的条件下添加磷可以提高温带典型草原的ANPP并改变植物群落组成。本研究为指导温带典型草原的管理提供了有价值的信息。 | Yumeng Guo Meng Zhou Jun Sheng Yujia Yuan Guangyuan Yuan Wen-Hao Zhang Wenming Bai | 2023 | Journal of Plant Ecology2023，16，4： | 0 |
| 17 | Effects of hypoxia inducible factor-1alpha siRNA on theinvasion of human Hela cells and expression of relatedproteins显示文摘The effects of hypoxia on the invasion and the related protein expression of Hela cells and the role of hypoxia inducible factor-1α(HIF-1α)were investigated.The Hela cells were divided into three groups,namely,H0(non-transfected Hela cells),H1(pGenesil-1 empty plasmid-transfected Hela cells),and H2(HIF-1α-shRNA plasmid-transfected Hela cells),and were cultured under hypoxia(1%O2)and normoxia for 48 h.The expression of HIF-1α,E-cadherin,β-catenin,and actin was detected using Western blot.The scratch test and the invasion assay were applied to examine the invasion in each group.The expression of HIF-1α,E-cadherin,andβ-catenin in tumor grafts was assayed immunohistochemically.Western blot results revealed that the bands of HIF-1α,E-cadherin,β-catenin,and actin proteins were detected in the H0 and H1 groups under hypoxia for 48 h.The expression of E-cadherin,β-catenin,and actin was detected in the H2 group under hypoxia for 48 h,and normoxia.In the H0,H1,and H2 groups under normoxia,and the H2 group under hypoxia for 48 h,no expression of HIF-1αwas detectable.The scratch test showed that the invasive ability in the H2 group was significantly alleviated.Immunohistochemi-cally,it was found that there was a significant difference in the expression of HIF-1α,E-cadherin,andβ-catenin between the H1 and H2 groups(P<0.05),but the difference was not significant between the H0 and H1 groups.It was concluded that the effects of hypoxia on the invasion of human cervical cancer Hela cells and the expression of related proteins(E-cadherin,β-catenin,and actin)depend on HIF-1α. | Bin YANG Xianglin YUAN Yanmei ZOU Qingsong XI Guoxian LONG Qiang FU Guangyuan HU | 2009 | Frontiers of Medicine2009，3，3： | 0 |
| 18 | 2D-polyimide film sensitized monolayer MoS_(2) phototransistor enabled near-infrared photodetection显示文摘Two-dimensional(2D)transition metal dichalcogenides(TMDCs)-based heterostructures open the door to fabricate various promising hybrid photodetectors,while it is still a challenge to achieve excellent and stable near-infrared(NIR)photoresponse.Here,a MoS_(2)–2DPI(2D-polyimide(2DPI))heterojunction-based phototransistor(HPT)was fabricated.Near-infrared photodetection with excellent performance has been realized.This HPT exhibited a photoresponsivity of 390.5 A/W,a specific detectivity of 5.10×10^(12)Jones,a photogain 1.04×10^(5),and a photoresponse rise and decay time of 400 and 430 ms(λ=900 nm,P=16.2μW/cm^(2)),respectively.It also shows a broadband wavelength response from 405 to 1,020 nm.This superior performance could be attributed to the strong near-infrared absorption and the type-II(staggered)band alignment which ensures efficient charge transfer from 2DPI to MoS_(2).The face-to-face spatial configuration of MoS_(2)–2DPI heterostructures ensures efficient transfer of photoinduced carriers through the interface,electron and holes can be separated due to the large band offsets.This work presents a significant step for the manipulation of high-performance NIR photodetector of twodimensional covalent organic polymer-sensitized monolayer TMDCs. | Qingqing Luo Guangyuan Feng Yaru Song Enbing Zhang Jiangyan Yuan Dejuan Fa Qisheng Sun Shengbin Lei Wenping Hu | 2022 | Nano Research2022，15，9： | 0 |
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