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| 1 | Rational Design and Application of an Indolium-Derived Heptamethine Cyanine with Record-Long Second Near-Infrared Emission显示文摘Heptamethine cyanine dyes,typified by indocyanine green,have been extensively employed as bioimaging indicators and theranostic agents.Significant efforts have been made to develop functional heptamethine cyanine dyes with outstanding bioimaging and theranostic utilities.In this work,we rationally designed and successfully developed a novel indolium-like heptamethine cyanine dye by installing indolium-derived polycyclic aromatic hydrocarbons on the terminal ends of a conjugated polyene backbone.This dye showed excellent photostability and showed bright fluorescent emission in the second near-infrared(NIR-Ⅱ)window with a peak at approximately 1120 nm.Such long wavelength emission prompted a superior bioimaging resolution in vivo.In particular,this NIR-Ⅱ dye had the remarkable capability of marking the blood vessels of the hindlimbs,abdomens,and brains of mice.More significantly,this dye involved a typical indolium-like heptamethine skeleton and exhibited two strong absorption bands in the 700–1300 nm NIR range,which endowed it with an intrinsic tumor-targeting capability and a high photothermal conversion efficiency(up to 68.2%),serving for the photothermal therapy of tumors under the guidance of NIR-Ⅱ fluorescence imaging.This work provides an efficient design strategy for achieving indolium-like heptamethine cyanine dyes with further NIR-Ⅱ emission. | Xiaoxie Ma Yurou Huang Syed Ali Abbas Abedi Heejeong Kim Tan Teck Boon Davin Xiaogang Liu Wen-Chao Yang Yao Sun Sheng Hua Liu Jun Yin Juyoung Yoon Guang-Fu Yang | 2022 | CCS Chemistry2022，4，6： | 2 |
| 2 | Engineering core–shell Co_(9)S_(8)/Co nanoparticles on reduced graphene oxide: Efficient bifunctional Mott–Schottky electrocatalysts in neutral rechargeable Zn–Air batteries显示文摘It is significant for the rational construction of the high–efficient bifunctional electrocatalysts for in–depth understandings of how to improve the electron transfer and ion/oxygen transport in catalyzing oxygen reduction reaction and oxygen evolution reaction(ORR and OER),but still full of vital challenges.Herein,we synthesize the novel“three–in–one”catalyst that engineers core–shell Mott–Schottky Co_(9)S_(8)/Co heterostructure on the defective reduced graphene oxide(Co_(9)S_(8)/Co–rGO).The Co_(9)S_(8)/Co–rGO catalyst exhibits abundant Mott–Schottky heterogeneous–interfaces,the well–defined core–shell nanostructure as well as the defective carbon architecture,which provide the multiple guarantees for enhancing the electron transfer and ion/oxygen transport,thus boosting the catalytic ORR and OER activities in neutral electrolyte.As expected,the integrated core–shell Mott–Schottky Co_(9)S_(8)/Co–rGO catalyst delivers the most robust and efficient rechargeable ZABs performance in neutral solution electrolytes accompanied with a power density of 59.5 mW cm^(-2) and superior cycling stability at 5 mA cm^(-2) over 200 h.This work not only emphasizes the rational designing of the high–efficient bifunctional oxygen catalysts from the fundamental understanding of accelerating the electron transfer and ion/oxygen transport,but also sheds light on the practical application prospects in more friendly environmentally neutral rechargeable ZABs. | Xingkun Wang Guangming Zhan Yurou Wang Yan Zhang Jian Zhou Ren Xu Huiyu Gai Huanlei Wang Heqing Jiang Minghua Huang | 2022 | Journal of Energy Chemistry2022，31，5： | 2 |
| 3 | Phyllanthi Fructus:A modal medicinal and food homologous item in quality evaluation显示文摘Phyllanthi Fructus is a highly unique medicine and food homologous item,which exhibits distinctive flavor,notable nutritional value,and abundant pharmacological activity.It has enormous potential in the creation of health products and pharmaceuticals.However,due to the unique laws of quality formation and transfer of Phyllanthi Fructus,its appearance,shape,chemical compositions,nutrients,and sensory flavors are frequently greatly influenced by botanical resources,the processing and storage conditions.As a result,the current quality evaluation model is difficult to meet the needs of Phyllanthi Fructus as a medicine and food homologous item in the development of diversified products.This paper constructs the hierarchical utilization mode of Phyllanthi Fructus based on its unique quality formation and transmission laws,explores the quality evaluation model for food-oriented use and medicinal-oriented use,respectively,and systematically describes the quality evaluation idea under diversified application scenarios.This paper aims to serve as a reference for the construction of a quality evaluation model suitable for the medicine and food homologous item of Phyllanthi Fructus. | Gefei Li Yurou Jiang Dingkun Zhang Li Han Taigang Mo Sanhu Fan Haozhou Huang Junzhi Lin | 2023 | Chinese Herbal Medicines2023，15，3： | 0 |
| 4 | Heptamethine cyanines in bioorthogonal chemistry显示文摘Due to their excellent fluorescence properties and biological function,cyanine dyes have been widely applied in biological imaging.Heptamethine cyanine(Cy7)dyes,as a type of classic near-infrared(NIR)fluorescent dyes,are considered as one of the effective fluorescent tools in the living organisms due to their good biocompatibility and very low background interference.Bioorthogonal reactions performed in living cells and tissues have developed by leaps and bounds in recent years.The NIR fluorescent labeling technique involving cyanine has attracted widespread attention.This review summarizes their recent application in the field of bioorthogonal imaging,mainly concluding Cy7-type dyes,labeling strategy,bioimaging application,etc.We expect this work can provide some helps for the studies of NIR bioorthogonal reaction in vivo. | Yuanyuan Liao Yuting Liang Yurou Huang Xiaoyan Zeng Tian He Jun Yin | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
| 5 | Recent progress on fluorescent probes for viruses显示文摘Viruses are ubiquitous in human life. Some viruses can be used as vectors of genetic engineering and specific pesticides. Other viruses trigger a variety of diseases in humans, animals and plants, resulting in high infection rates and mortality. Therefore, convenient, accurate and rapid detection of viruses is of great significance for the diagnosis and treatment of subsequent diseases. In contrast to traditional methods of detection, which rely on time-consuming and complex techniques such as polymerase chain reaction (PCR), fluorescent probes and imaging methods generate real-time results, with high specificity, and have been widely used in viral detection. In this review, the application of viral fluorescent probes in analyzing the molecular structure, detection and biological imaging is discussed. In particular, we categorized the probes based on their specificity for human and plant viruses, reviewing the latest findings and analyzing their limitations. The potential of fluorescent molecular probes in the treatment of viral disease and environmental analysis, and their possible combinations with protein and immune technology are discussed. | Siyang Shen Weilin Xu Jianxiang Lu Shuhui Wang Yurou Huang Xiaoyan Zeng Weimin Xiao Jun Yin | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
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