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| 1 | Side Effects of Large-Scale Assessments in Education显示文摘Purpose:In line with a recent call for side effects research in education,this article aims to synthesize the major concerns that have been raised in the literature concerning large-scale assessments(LSAs)in education.Design/Approach/Methods:The researchers endeavored to complete a deep review of the literature on LSAs to synthesize the reported side effects.The review was synthesized thematically to understand and report the consequences of the ongoing push for the use of LSA in education.Findings:Thematic analysis indicated overarching side effects of LSA in education.We discuss why negative side effects exist and present evidence of the most commonly observed side effects of LSA in education,including distorting education,exacerbating inequity and injustice,demoralization of professionals,ethical corruption,and stifling of innovation in education.Originality/Value:While concerns about the use and misuse of LSA in education are not new and have been discussed widely in the literature,rarely have they been discussed as inherent qualities and consequences of LSAs that can do harm to education. | Trina E.Emler Yong Zhao Jiayi Deng Danqing Yin Yurou Wang | 2019 | ECNU Review of Education2019，2，3： | 2 |
| 2 | Target identification of natural medicine with chemical proteomics approach:probe synthesis,target fishing and protein identification显示文摘Natural products are an important source of new drugs for the treatment of various diseases.However,developing natural productbased new medicines through random moiety modification is a lengthy and costly process,due in part to the difficulties associated with comprehensively understanding the mechanism of action and the side effects.Identifying the protein targets of natural products is an effective strategy,but most medicines interact with multiple protein targets,which complicate this process.In recent years,an increasing number of researchers have begun to screen the target proteins of natural products with chemical proteomics approaches,which can provide a more comprehensive array of the protein targets of active small molecules in an unbiased manner.Typically,chemical proteomics experiments for target identification consist of two key steps:(1)chemical probe design and synthesis and(2)target fishing and identification.In recent decades,five different types of chemical proteomic probes and their respective target fishing methods have been developed to screen targets of molecules with different structures,and a variety of protein identification approaches have been invented.Presently,we will classify these chemical proteomics approaches,the application scopes and characteristics of the different types of chemical probes,the different protein identification methods,and the advantages and disadvantages of these strategies. | Xiao Chen Yutong Wang Nan Ma Jing Tian Yurou Shao Bo Zhu Yin Kwan Wong Zhen Liang Chang Zou Jigang Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 3 | Engineering core–shell Co_(9)S_(8)/Co nanoparticles on reduced graphene oxide: Efficient bifunctional Mott–Schottky electrocatalysts in neutral rechargeable Zn–Air batteries显示文摘It is significant for the rational construction of the high–efficient bifunctional electrocatalysts for in–depth understandings of how to improve the electron transfer and ion/oxygen transport in catalyzing oxygen reduction reaction and oxygen evolution reaction(ORR and OER),but still full of vital challenges.Herein,we synthesize the novel“three–in–one”catalyst that engineers core–shell Mott–Schottky Co_(9)S_(8)/Co heterostructure on the defective reduced graphene oxide(Co_(9)S_(8)/Co–rGO).The Co_(9)S_(8)/Co–rGO catalyst exhibits abundant Mott–Schottky heterogeneous–interfaces,the well–defined core–shell nanostructure as well as the defective carbon architecture,which provide the multiple guarantees for enhancing the electron transfer and ion/oxygen transport,thus boosting the catalytic ORR and OER activities in neutral electrolyte.As expected,the integrated core–shell Mott–Schottky Co_(9)S_(8)/Co–rGO catalyst delivers the most robust and efficient rechargeable ZABs performance in neutral solution electrolytes accompanied with a power density of 59.5 mW cm^(-2) and superior cycling stability at 5 mA cm^(-2) over 200 h.This work not only emphasizes the rational designing of the high–efficient bifunctional oxygen catalysts from the fundamental understanding of accelerating the electron transfer and ion/oxygen transport,but also sheds light on the practical application prospects in more friendly environmentally neutral rechargeable ZABs. | Xingkun Wang Guangming Zhan Yurou Wang Yan Zhang Jian Zhou Ren Xu Huiyu Gai Huanlei Wang Heqing Jiang Minghua Huang | 2022 | Journal of Energy Chemistry2022，31，5： | 2 |
| 4 | Lanthanide-Doped Nanoparticles with Near-Infrared-to- Near-Infrared Luminescence for Bioimaging显示文摘Lanthanide (行,或稀土元素) 做的 nanoparticles 为他们的突出的光性质是著名的并且广泛地为生物应用被使用了,特别在生物试金和医药成像。最近,广泛的注意近红外线(NIR ) 波长范围戏剧性地为它的快反馈,高空间的分辨率和深织物穿入增加了。纸巾在这个区域有最小的吸收度。当很多优秀评论基于 lanthanide 盖住生物医学的成像的各种各样的方面时做的 nanoparticles,没有评论,系统地与 lanthanide 总结 NIR-to-NIR 成像做的 nanoparticles。在这评论,我们在成像基于 lanthanide 做了的 NIR-to-NIR 的最近的发展集中 nanoparticles,并且在它讨论挑战和机会。 | Yurong Wei Xiangdong Yang Yurou Ma Shengfu Wang Quan Yuan | 2016 | Chinese Journal of Chemistry2016，34，6： | 1 |
| 5 | Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport显示文摘Dear Editor,As one of the critical sphingolipid metabolites in eukaryotes,sphingosine-1-phosphate(S1P)acts as a bioactive lipid mediator in the immune and vascular systems.S1P prompts its physiological roles through two mechanisms,binding to its intracellular targets or extracellular secretion.Intracellular S1P promotes cellular proliferation,whereas plasma S1P facilitates immune cell trafficking,regulates angiogenesis,and helps to maintain vascular integrity.1 Due to the amphipathic property,S1P cannot diffuse freely but has to be transported across the cell membrane through active transport.1 In the past two decades,several S1P transporters have been identified,including two major facilitator superfamily(MFS)members:Spinster homolog 2(Spns2)and Mfsd2b,and some ATP-binding cassette family transporters.Among these transporters,Spns2 is the first identified and the most extensively studied.2 Here,we reported two cryo-electron microscopy(EM)structures of human Spns2 in inward-open conformations bound to S1P or inhibitor 16d. | Bin Pang Leiye Yu Tong Li Haizhan Jiao Xiaomei Wu Jinxin Wang Ruiping He Yurou Zhang Juan Wang Hongli Hu Wei Dai Li Chen Ruobing Ren | 2024 | Cell Research2024，34，2： | 0 |
| 6 | Earth-abundant magnetite with carbon coatings as reversible cathodes for stretchable zinc-ion batteries显示文摘Earth-abundant magnetite(Fe_(3)O_(4))as cathode materials in aqueous zinc-ion batteries(ZIBs)is limited by its very low capacity and poor cycling.Here,a combined strategy based on carbon coating and electrolyte optimization is adopted to improve the performance of Fe_(3)O_(4).The Zn-Fe_(3)O_(4)@C batteries display specific capacities of 93 mAh g^(−1) and 81%capacity retention after 200 cycles.Such performance is attributed to the enhanced electrical conductivity and structural stability of Fe_(3)O_(4)@C nanocomposites with suppressed iron dissolution.Experimental analysis reveals that the charge storage is contributed by diffusion-limited redox reactions and surface-controlled pseudocapacitance.A stretchable Zn-Fe_(3)O_(4)@C battery is further fabricated,showing stable performance when it is bent or stretched.Fe_(3)O_(4) is a promising cathode material for cost-effective,safe,sustainable and wearable energy supplies. | Zhao Wang Yurou Wang Guoqi Wang Wei Wu Jian Zhu | 2021 | Journal of Energy Chemistry2021，30，11： | 0 |
| 7 | Two-Dimensional Cathode Materials for Aqueous Rechargeable Zinc-Ion Batteries显示文摘Rechargeable aqueous zinc-ion batteries(ZIBs)featuring low cost,superior performance,and environmental benignity have attracted dramatic atten-tion as a promising alternative energy storage system to lithium-ion batteries.Nevertheless,the development of ZIBs is still hindered by the limited selection of cathode materials due to the large solvation sheath and charge density of Zn^(2+).Two-dimensional(2D)materials have attracted extraor-dinary attention owing to the unique layered structure bonded by weak van der Waals'forces,which makes them promising host materials for Zn^(2+)intercalation/de-intercalation.In this review,the synthesis and properties of 2D materials for cathodes in ZIBs are discussed.Meanwhile,various re-ports on 2D materials as ZIBs cathodes are summarized.Three key strategies to elicit improved Zn2+storage abilities:defect engineering,hetero-structure engineering,and interlayer engineering,are highlighted.Finally,this review ends with perspectives relating to the challenges and opportu-nities of 2D materials-based ZIBs. | Yurou Wang Jun Yin Jian Zhu | 2022 | Chinese Journal of Chemistry2022，40，8： | 0 |
| 8 | Recent progress on fluorescent probes for viruses显示文摘Viruses are ubiquitous in human life. Some viruses can be used as vectors of genetic engineering and specific pesticides. Other viruses trigger a variety of diseases in humans, animals and plants, resulting in high infection rates and mortality. Therefore, convenient, accurate and rapid detection of viruses is of great significance for the diagnosis and treatment of subsequent diseases. In contrast to traditional methods of detection, which rely on time-consuming and complex techniques such as polymerase chain reaction (PCR), fluorescent probes and imaging methods generate real-time results, with high specificity, and have been widely used in viral detection. In this review, the application of viral fluorescent probes in analyzing the molecular structure, detection and biological imaging is discussed. In particular, we categorized the probes based on their specificity for human and plant viruses, reviewing the latest findings and analyzing their limitations. The potential of fluorescent molecular probes in the treatment of viral disease and environmental analysis, and their possible combinations with protein and immune technology are discussed. | Siyang Shen Weilin Xu Jianxiang Lu Shuhui Wang Yurou Huang Xiaoyan Zeng Weimin Xiao Jun Yin | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
| 9 | Detection and quantitative analysis of tumor-associated tertiary lymphoid structures显示文摘Tumor-associated tertiary lymphoid structures(TLSs)are ectopic lymphoid formations within tumor tissue,with mainly B and T cell populations forming the organic aggregates.The presence of TLSs in tumors has been strongly associated with patient responsiveness to immunotherapy regimens and improving tumor prognosis.Researchers have been motivated to actively explore TLSs due to their bright clinical application prospects.Various studies have attempted to decipher TLSs regarding their formation mechanism,structural composition,induction generation,predictive markers,and clinical utilization.Meanwhile,the scientific approaches to qualitative and quantitative descriptions are crucial for TLS studies.In terms of detection,hematoxylin and eosin(H&E),multiplex immunohistochemistry(mIHC),multiplex immunofluorescence(mIF),and 12-chemokine gene signature have been the top approved methods.However,no standard methods exist for the quantitative analysis of TLSs,such as absolute TLS count,analysis of TLS constituent cells,structural features,TLS spatial location,density,and maturity.This study reviews the latest research progress on TLS detection and quantification,proposes new directions for TLS assessment,and addresses issues for the quantitative application of TLSs in the clinic. | Man YANG Yurou CHE Kezhen LI Zengyi FANG Simin LI Mei WANG Yiyao ZHANG Zhu XU Liping LUO Chuan WU Xin LAI Weidong WANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，9： | 0 |
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