|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | No expenditure difference among patients with liver cancer at stageⅠ-ⅣV:Findings from a multicenter cross-sectional study in China显示文摘Objective:The number of liver cancer patients in China accounts for more than half of the world.However,China currently lacks national,multicenter economic burden data,and meanwhile,measuring the differences among different subgroups will be informative to formulate corresponding policies in liver cancer control.Thus,the aim of the study was to measure the economic burden of liver cancer by various subgroups.Methods:A hospital-based,multicenter and cross-sectional survey was conducted during 2012・2014,covering 39 hospitals and 21 project sites in 13 provinces across China.The questionnaire covers clinical information,sociology,expenditure,and related variables.All expenditure data were reported in Chinese Yuan(CNY)using 2014 values.Results:A total of 2,223 liver cancer patients were enrolled,of whom 59.61%were late-stage cases(III-IV),and 53.8%were hepatocellular carcinoma.The average total expenditure per liver cancer patient was estimated as 53,220 CNY,including 48,612 CNY of medical expenditures(91.3%)and 4,608 CNY of non-medical expenditures(8.7%).The average total expenditures in stage I,H,m and stage IV were 52,817 CNY,50,877 CNY,50,678 CNY and 54,089 CNY(P>0.05),respectively.Non-medical expenditures including additional meals,additional nutrition care,transportation,accommodation and hired informal nursing were 1,453 CNY,839 CNY,946 CNY,679 CNY and 200 CNY,respectively.The one-year out-of-pocket expenditure of a newly diagnosed patient was 24,953 CNY,and 77.2%of the patients suffered an unmanageable financial burden.Multivariate analysis showed that overall expenditure differed in almost all subgroups(P<0.05),except for sex,clinical stage,and pathologic type.Conclusions:There was no difference in treatment expenditure for liver cancer patients at different clinical stages,which suggests that maintaining efforts on treatment efficacy improvement is important but not enough.To fiirtherly reduce the overall economic burden from liver cancer,more effort should be given to primary and secondary prevention strategies. | Haike Lei Lin Lei Jufang Shi Yongzhong Wu Ling Liang Huiyao Huang Mei He Fangzhou Bai Maomao Cao Hui Qiu Yuting Wang Chengcheng Liu Jia Du Hong Wang Yan Zhang Mengdi Cao Ji Peng Ni Li Chunfeng Qu Min Dai Wanqing Chen Jie He | 2020 | Chinese Journal of Cancer Research2020，32，4： | 7 |
| 2 | Aeroelastic optimization design for wing with maneuver load uncertainties显示文摘An aeroelastic optimization design methodology for air vehicle considering the uncertainties in maneuver load conditions is presented and applied to a structural design process of low-aspect-ratio wing. An aerodynamic load correction model is developed and used to predict the critical load conditions with the perturbations of theoretical linear aerodynamic forces and experimental aerodynamic forces from wind-tunnel test, when concerning the uncertainties in use of theoretical linear and experimental aerodynamic forces. Three objective functions of critical loads are defined. The load evaluations for three wing sections are investigated in four characteristic maneuvers, and the most critical load conditions are confirmed by using the sequential quadratic programming method. On this basis, the aeroelastic optimization design employing the genetic-gradient hybrid algorithm is conducted, in which the objective is to minimize structural mass subject to the constraints of stress, deformation and flutter speed. The resulting optimal structure is heavier than the one simply based on the theoretical linear or experimental aerodynamic forces. However, it is more robust when encountering the critical load conditions in actual flight due to the consideration of uncertainties in aerodynamic forces in the early design phase, thereby, the risk of structural redesign can be reduced. | YANG Chao, XIAO ZhiPeng*, WAN ZhiQiang, YAN De & DAI YuTing School of Aeronautic Science and Engineering, Beihang University, Beijing 100191, China | 2010 | Science China(Technological Sciences)2010，53，11： | 6 |
| 3 | Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblasti显示文摘B-cell precursor acute lymphoblastic leukemia(BCP-ALL)is characterized by genetic alterations with high heterogeneity.Precise subtypes with distinct genomic and/or gene expression patterns have been recently revealed using high-throughput sequencing technology.Most of these profiles are associated with recurrent non-overlapping rearrangements or hotspot point mutations that are analogous to the established subtypes,such as DUX4 rearrangements,MEF2D rearrangements,ZNF384/ZNF362 rearrangements,NUTM1 rearrangements,BCL2/MYC and/or BCL6 rearrangements,ETV6-RUNX1-like gene expression,PAX5alt(diverse PAX5 alterations,including rearrangements,intragenic amplifications,or mutations),and hotspot mutations PAX5(p.Pro80Arg)with biallelic PAX5 alterations,IKZF1(p.Asn159Tyr),and ZEB2(p.His1038Arg).These molecular subtypes could be classified by gene expression patterns with RNA-seq technology.Refined molecular classification greatly improved the treatment strategy.Multiagent therapy regimens,including target inhibitors(e.g.,imatinib),immunomodulators,monoclonal antibodies,and chimeric antigen receptor T-cell(CAR-T)therapy,are transforming the clinical practice from chemotherapy drugs to personalized medicine in the field of risk-directed disease management.We provide an update on our knowledge of emerging molecular subtypes and therapeutic targets in BCP-ALL. | Jianfeng Li Yuting Dai Liang Wu Ming Zhang Wen Ouyang Jinyan Huang Saijuan Chen | 2021 | Frontiers of Medicine2021，15，3： | 6 |
| 4 | Methods and advances in the study of aeroelasticity with uncertainties显示文摘Uncertainties denote the operators which describe data error, numerical error and model error in the mathematical methods. The study of aeroelasticity with uncertainty embedded in the subsystems, such as the uncertainty in the modeling of structures and aerodynamics, has been a hot topic in the last decades. In this paper, advances of the analysis and design in aeroelasticity with uncertainty are summarized in detail. According to the non-probabilistic or probabilistic uncertainty, the developments of theories, methods and experiments with application to both robust and probabilistic aeroelasticity analysis are presented, respectively. In addition, the advances in aeroelastic design considering either probabilistic or non-probabilistic uncertainties are introduced along with aeroelastic analysis. This review focuses on the robust aeroelasticity study based on the structured singular value method, namely the l method. It covers the numerical calculation algorithm of the structured singular value, uncertainty model construction, robust aeroelastic stability analysis algorithms, uncertainty level verification, and robust flutter boundary prediction in the flight test, etc. The key results and conclusions are explored. Finally, several promising problems on aeroelasticity with uncertainty are proposed for future investigation. | Dai Yuting Yang Chao | 2014 | Chinese Journal of Aeronautics2014，27，3： | 5 |
| 5 | Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies显示文摘Social hierarchies emerged during evolution,and social rank influences behavior and health of individuals.However,the evolutionary mechanisms of social hierarchy are still unknown in amniotes.Here we developed a new method and performed a genome-wide screening for identifying regions with accelerated evolution in the ancestral lineage of placental mammals,where mammalian social hierarchies might have initially evolved.Then functional analyses were conducted for the most accelerated region designated as placental-accelerated sequence 1(PAS1,P=3.15 × 10^-18).Multiple pieces of evidence show that PAS1 is an enhancer of the transcription factor gene Lhx2 involved in brain development.PAS1s isolated from various amniotes showed different c/s-regulatory activity in vitro,and affected the expression of Lhx2 differently in the nervous system of mouse embryos.PAS1 knock-out mice lack social stratification.PAS1 knock-in mouse models demonstrate that PAS1s determine the social dominance and subordinate of adult mice,and that social ranks could even be turned over by mutated PAS1.All homozygous mutant mice had normal huddled sleeping behavior,motor coordination and strength.Therefore,PAS1-Lhx2 modulates social hierarchies and is essential for establishing social stratification in amniotes,and positive Darwinian selection on PAS1 plays pivotal roles in the occurrence of mammalian social hierarchies. | Yuting Wang Guangyi Dai Zhili Gu Guopeng Liu Ke Tang Yi-Hsuan Pan Yujie Chen Xin Lin Nan Wu Haoshan Chen Su Feng Shou Qiu Hongduo Sun Qian Li Chuan Xu Yanan Mao Yong Edward Zhang Philipp Khaitovich Yan-Ling Wang Qunxiu Liu Jing-Dong Jackie Han Zhen Shao Gang Wei Chun Xu Naihe Jing Haipeng Li | 2020 | Cell Research2020，30，5： | 4 |
| 6 | Dynamic response analysis under atmospheric disturbances for helicopters based on elastic blades显示文摘A flight dynamics model based on elastic blades for helicopters is developed.Modal shape analysis is used to describe the rotating elastic blades for the purpose of reducing the elastic degrees of freedom for blades.The analytical result is employed to predict the rotor forces and moments.The equilibrium equation of the flight dynamics model is then constructed for the elastic motion for blades and the rigid motion for other parts.The nonlinear equation is further simplified,and the gradient descent algorithm is adopted to implement the trim simulation.The trim analysis shows that the effect of blade elasticity on the accuracy of rotor forces and moments is apparent at high speed,and the proposed method presents good accuracy for trim performance.The timedomain response is realized by a combination of the Newmark method and the adaptive RungeKutta method.The helicopter control responses of collective pitch show that the response accuracy of the model at a yaw-and-pitch attitude is improved.Finally,the influence of blade elasticity on the helicopter dynamic response in low-altitude wind shear is investigated.An increase in blade elasticity reduces the oscillation amplitude of the yaw angle and the vertical speed by more than 70%.Compared with a rigid blade,an elastic blade reduces the vibration frequency of the angular velocity and results in a fast return of the helicopter to its stable flight. | Tong Liu Yuting Dai Guanxin Hong Linpeng Wang | 2017 | Chinese Journal of Aeronautics2017，30，2： | 4 |
| 7 | High-temperature phase transition behavior and magnetocaloric effect in a sub-rapidly solidified La–Fe–Si plate produced by centrifugal casting显示文摘A sub-rapidly solidified La Fe_(11.6)Si_(1.4)plate was fabricated directly from liquid by centrifugal casting method.The phase constitution,microstructure and magnetocaloric effect were investigated using backscatter scanning electron microscopy,X-ray diffraction,differential scanning calorimetry and physical property measurement system.When the plate was annealed at 1373 K,1 phase was formed by a solid-state peritectoid reaction.A first-order magnetic phase transition occurred in the vicinity of188 K,and the effective refrigeration capacities reached 203.5 J/kg and 209.7 J/kg in plates annealed for1 h and 3 h,respectively,under a magnetic field change of 3 T.It is suggested that centrifugal casting may become a new approach to prepare high-performance La–Fe–Si magnetocaloric plates for practical applications,which could largely accelerate the formation of 1 phase during high-temperature heat-treatment process due to refined and homogeneous honeycombed microstructure. | Zhishuai Xu Yuting Dai Yue Fang Zhiping Luo Ke Han Changjiang Song Qijie Zhai Hongxing Zheng | 2018 | Journal of Materials Science & Technology2018，34，8： | 4 |
| 8 | A Detection-Switching-Assisted DCF Mechanism for Simulcast WLAN-over-Fiber Based Distributed Antenna Systems显示文摘Distributed antenna systems(DASs) using Radio-over-fiber(Ro F) links is a promising candidate to provide flexible coverage and high data rates. For simulcast Wireless local-area network(WLAN) use in Ro F systems, the stations covered by different Remote antenna units(RAUs) contend for the wireless medium using Media access control(MAC) mechanism. Severe inter-RAU hidden nodes problem will happen due to the stations in different RAUs cannot detect each other very well. In order to alleviate this inter-RAU collision problem, a promising detection-switching-assisted Distributed coordination function(DCF) mechanism is presented using in the uplink. The control delay issues of the proposed mechanism are also discussed in this paper. | FAN Yuting LI Jianqiang XU Kun DAI Yitang | 2017 | Chinese Journal of Electronics2017，26，4： | 3 |
| 9 | A male-ABCD algorithm for hepatocellular carcinoma risk prediction in HBs Ag carriers显示文摘Objective: Hepatocellular carcinoma(HCC) development among hepatitis B surface antigen(HBs Ag) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We aimed to construct a risk-stratified HCC prediction model for HBs Ag-positive male adults.Methods: HBs Ag-positive males of 35-69 years old(N=6,153) were included from a multi-center populationbased liver cancer screening study. Randomly, three centers were set as training, the other three centers as validation. Within 2 years since initiation, we administrated at least two rounds of HCC screening using Bultrasonography and α-fetoprotein(AFP). We used logistic regression models to determine potential risk factors,built and examined the operating characteristics of a point-based algorithm for HCC risk prediction.Results: With 2 years of follow-up, 302 HCC cases were diagnosed. A male-ABCD algorithm was constructed including participant's age, blood levels of GGT(γ-glutamyl-transpeptidase), counts of platelets, white cells,concentration of DCP(des-γ-carboxy-prothrombin) and AFP, with scores ranging from 0 to 18.3. The area under receiver operating characteristic was 0.91(0.90-0.93), larger than existing models. At 1.5 points of risk score,26.10% of the participants in training cohort and 14.94% in validation cohort were recognized at low risk, with sensitivity of identifying HCC remained 100%. At 2.5 points, 46.51% of the participants in training cohort and 33.68% in validation cohort were recognized at low risk with 99.06% and 97.78% of sensitivity, respectively. At 4.5 points, only 20.86% of participants in training cohort and 23.73% in validation cohort were recognized at high risk,with positive prediction value of 22.85% and 12.35%, respectively.Conclusions: Male-ABCD algorithm identified individual's risk for HCC occurrence within short term for their HCC precision surveillance. | Yuting Wang Minjie Wang He Li Kun Chen Hongmei Zeng Xinyu Bi Zheng Zhu Yuchen Jiao Yong Wang Jian Zhu Hui Zhao Xiang Liu Chunyun Dai Chunsun Fan Can Zhao Deyin Guo Hong Zhao Jianguo Zhou Dongmei Wang Zhiyuan Wu Xinming Zhao Wei Cui Xuehong Zhang Jianqiang Cai Wanqing Chen Chunfeng Qu | 2021 | Chinese Journal of Cancer Research2021，33，3： | 3 |
| 10 | DDIT4 mediates the proliferation-promotive effect of IL-34 in human monocytic leukemia cells显示文摘Interleukin 34(IL-34)is a cytokine that shares the receptor with colony-stimulating factor 1(CSF-1).IL-34 is involved in a broad range of pathologic processes including cancer.We previously demonstrated that IL-34 promoted the proliferation and colony formation of human acute monocytic leukemia(AMoL)cells.However,the mechanism has not been elucidated.Here,by analyzing the gene profiles of Molm13 and THP1 cells overexpressing IL-34(Molm13-IL-34 and THP1-IL-34),upregulation of the DNA damageinducible transcript 4(DDIT4)was detected in both series.Knockdown of DDIT4 effectively inhibited the proliferation,promoted apoptosis and colony formation in Molm13-IL-34 and THP1-IL-34 cells.Our results suggest that DDIT4 mediates the proliferationpromotive effect of IL-34 whereas does not mediate the promotive effect of IL-34 on colony formation in AMoL cells. | Xiaoqian Lv Yuting Hu Lina Wang Dongyue Zhang Hao Wang Yibo Dai Xiaoxi Cui Guoguang Zheng | 2021 | Blood Science2021，3，2： | 2 |
| 11 | Porous hybrid scaffold strategy for the realization of lightweight,highly efficient microwave absorbing materials显示文摘Exploring an advanced and efficient electromagnetic(EM) wave absorbing material by improving dielectric loss capacity and adjusting impendence matching is crucial yet challenging. Herein, the bacterial cellulose(BC) derived carbon aerogel(CA) with a robust nanofibrous network was used as a conductive loss scaffold to dissipate EM waves effectively, and the Zn O microparticles with excellent dielectric properties and low electrical conductivity were decorated on the scaffold to adjust dielectric parameters and impedance matching adequately. By using different zinc precursors, the tunable size and morphologies of Zn O crystals were obtained due to the growth rate of different crystallographic, including flowerlike, nanorod like, and cauliflower-like morphologies, which is beneficial to strong multiple reflections,intensive interfacial polarization, better impendence matching, as well as excellent maintenance of the hierarchical structure. Owing to the appropriate impendence matching and the considerable EM wave dissipation, the CA@ZnO composites achieve a superior EM absorbing performance with a broad effective absorbing bandwidth(whole X band) and a minimum reflection coefficient(-53.3 d B). This work paves a new way for developing lightweight and highly efficient EM absorbing materials comprising the carbon scaffold and semiconductor microparticles. | Meng Zhu Yuting Lei Heng Wu Luo Kong Hailong Xu Xuanxuan Yan Yongjian Xu Lei Dai | 2022 | Journal of Materials Science & Technology2022，，34： | 2 |
| 12 | Quadrupole-Linear Ion Trap Tandem Mass Spectrometry System for Clinical Biomarker Analysis显示文摘The accurate and efficient measurement of small molecule disease markers for clinical diagnosis is of great importance.In this study,a quadrupole-linear ion trap(Q-LIT)tandem mass spectrometer was designed and built in our laboratory.Target precursor ions were first selected in the quadrupole,and then injected,trapped,and fragmented simultaneously in the linear ion trap(LIT)to reduce the space charge effect,enrich the target product ions,and promote sensitivity.The targeted analytes were measured with selected reaction monitoring using a positive scan mode with electrospray ionization(ESI).Ions with a mass-to-charge ratio(m/z)ranging from 195 to 2022 were demonstrated.When scanning at 1218amu.s^(-1),unit resolution and an accuracy of higher than m/z 0.28 was obtained for m/z up to 2000.The dimensionless Mathieu parameter(q)value used in this study was 0.40 for collision-induced dissociation(CID),which was activated by resonance excitation.And an overall CID efficiency of 64%was achieved(activation time,50 ms).Guanidinoacetic acid(GAA)and creatine(CRE)were used as model compounds for small molecule clinical biomarkers.The limits of quantification were 1.0 and 0.2 nmol.L^(-1)for GAA and CRE,respectively.A total of 77 actual samples were successfully analyzed by the home-built ESI-Q-LIT tandem mass spectrometry system.The developed method can reduce matrix interference,minimize space charge effects,and avoid the chromatographic separation of complex samples to simplify the pretreatment process.This novel Q-LIT system is expected to be a good candidate for the determination of biomarkers in clinical diagnosis and therapeutics. | Xiang Fang Jie Xie Shiying Chu You Jiang Yuting An Chang Li Xiaoyun Gong Rui Zhai Zejian Huang Chunling Qiu Xinhua Dai | 2022 | Engineering2022，，9： | 1 |
| 13 | Identification and robust limit-cycle-oscillation analysis of uncertain aeroelastic system显示文摘Model uncertainty directly affects the accuracy of robust flutter and limit-cycle-oscillation (LCO) analysis. Using a data-based method, the bounds of an uncertain block-oriented aeroelastic system with nonlinearity are obtained in the time domain. Then robust LCO analysis of the identified model set is performed. First, the proper orthonormal basis is constructed based on the on-line dynamic poles of the aeroelastic system. Accordingly, the identification problem of uncertain model is converted to a nonlinear optimization of the upper and lower bounds for uncertain parameters estimation. By replacing the identified memoryless nonlinear operators by its related sinusoidal-input describing function, the Linear Fractional Transformation (LFT) technique is applied to the modeling process. Finally, the structured singular value (μ) method is applied to robust LCO analysis. An example of a two-degree wing section is carried out to validate the framework above. Results indicate that the dynamic characteristics and model uncertainties of the aeroelastic system can be depicted by the identified uncertain model set. The robust LCO magnitude of pitch angle for the identified uncertain model is lower than that of the nominal model at the same velocity. This method can be applied to robust flutter and LCO prediction. | DAI YuTing WU ZhiGang YANG Chao | 2011 | Science China(Technological Sciences)2011，54，7： | 1 |
| 14 | Stall flutter prediction based on multi-layer GRU neural network显示文摘The modeling of dynamic stall aerodynamics is essential to stall flutter, due to the flow separation in a large-amplitude pitching oscillation process. A newly neural network based Reduced Order Model(ROM) framework for predicting the aerodynamic forces of an airfoil undergoing large-amplitude pitching oscillation at various velocities is presented in this work. First, the dynamic stall aerodynamics is calculated by solving RANS equations and the transitional SST-γ model. Afterwards, the stall flutter bifurcation behavior is calculated by the above CFD solver coupled with structural dynamic equation. The critical flutter speed and limit-cycle oscillation amplitudes are consistent with those obtained by experiments. A newly multi-layer Gated Recurrent Unit(GRU) neural network based ROM is constructed to accelerate the calculation of aerodynamic forces. The training and validation process are carried out upon the unsteady aerodynamic data obtained by the proposed CFD method. The well-trained ROM is then coupled with the structure equation at a specific velocity, the Limit-Cycle Oscillation(LCO) of stall flutter under this flow condition is predicted precisely and more quickly. In order to predict both the critical flutter velocity and LCO amplitudes after bifurcation at different velocities, a new ROM with GRU neural network considering the variation of flow velocities is developed. The stall flutter results predicted by ROM agree well with the CFD ones at different velocities. Finally, a brief sensitivity analysis of two structural parameters of ROM is carried out. It infers the potential of the presented modeling method to depict the nonlinearity of dynamic stall and stall flutter phenomenon. | Yuting DAI Haoran RONG You WU Chao YANG Yuntao XU | 2023 | Chinese Journal of Aeronautics2023，36，1： | 1 |
| 15 | Effect of caffeic acid derivatives on polychlorinated biphenyls induced hepatotoxicity in male mice显示文摘Chronic exposure to coplanar polychlorinated biphenyls(PCBs),a potent inducer of toxic reactive oxygen species(ROS),in the environment and food can cause liver diseases.It remains unknown whether caffeic acid derivatives(CADs) exerted protective effect on PCB-induced hepatotoxicity.We sought to evaluate the activities of 3CADs on PCB169-induced oxidative stress and DNA damage in the liver.Male ICR mice were administered with1 μmol/mL PCB169 at 5 mL/kg body weight for 2 weeks.The mice were given CADs by gastric gavage for 3weeks.We found that PCB169 decreased the growth rate and reduced the levels of superoxide dismutase(SOD),glutathione(GSH) and GSH peroxidase(GPx).It increased the liver weight,malondialdehyde(MDA)and 8-hydroxy-2'-deoxyguanosine(8-OHdG) levels and CYPlAl activity in the liver tissues and plasma of mice(P<0.05).Pretreatment of mice with CADs restored the above parameters to normal levels.There was a synergistic protective effect between CADs in preventing MDA and 8-OHdG formation and inducing CYPlAl and phase II metabolism enzyme(SOD,GPx) activities(P<0.05).In conclusion,PCB169 induced hepatotoxicity and pretreatment with CADs had synergistic protective effects on liver damage. | Ruirui Li Shuyuan Cao Jinfeng Dai Li Wang Lei Li Yubang Wang Wenqin Yin Yuting Ye | 2014 | The Journal of Biomedical Research2014，28，5： | 1 |
| 16 | Dedifferentiated human umbilical cord mesenchymal stem cell reprogramming of endogenous hSDF-1a expression participates in neural restoration in hypoxic-ischemic brain damagerats显示文摘The transplantation of human umbilical cord mesenchymal stem cells(hUC-MSCs)can promote hypoxic-ischemic brain damage(HIBD)nerve repair,but finding suitable seed cells to optimize transplantation and improve treatment efficiency is an urgent problem to be solved.In this study,we induced hUC-MSCs into dedifferentiated hUC-MSCs(De-hUC-MSCs),and the morphology,stem cell surface markers,proliferation and tri-directional differentiation ability of the De-hUC-MSCs and hUC-MSCs were detected.A whole-gene chip was utilized for genome cluster,gene ontology and KEGG pathway analyses of differentially expressed genes.De-hUC-MSCs were transplanted into HIBD rats,and behavioral experiments and immunofluorescence assays were used to assess the therapeutic effect.A lentivirus vector for human stromal cell-derived factor-1(hSDF-1a)was constructed,and the role of hSDF-1a in the neuroprotective effect and mechanism of De-hUC-MSCs was verified.De-hUC-MSCs displayed similar cell morphology,stem cell surface marker expression,cell proliferation and even three-dimensional differentiation ability as hUC-MSCs but exhibited greater treatment potential in vivo.The reprogramming mechanism of hSDF-1a participated in the dedifferentiation process.By successfully constructing a stable hSDF-1a cell line,we found that De-hUC-MSCs might participate in nerve repair through the hSDF-1a/CXCR4/PI3K/Akt pathway.De-hUC-MSCs reprogramming of endogenous hSDF-1a expression may mediate the hSDF-1a/CXCR4/PI3K/Akt pathway involved in nerve repair in HIBD rats. | Zhou Xiaoqin Liu Jia Dai Mengjie Gu Jialu Bi Yang Wang Yuting Hu Huajian Liu Bo Zhang Xiaojun Li Zhongyue Chen Jie Li Tingyu Zhan Xue | 2021 | Genes & Diseases2021，8，3： | 1 |
| 17 | Climate technology transfer in BRI era:needs,priorities,and barriers from receivers’perspective显示文摘Technology is an instrument to build BRI relationships,mitigate the environmental and climate impacts of BRI projects,as well as to enhance environmental sustainability in the regions.This study aims to reposition China in global climate technology transfer in BRI era and to obtain initial knowledge on needs,priorities,and barriers from the receivers’perspective.Focus group method with aid of questionnaire survey and follow-up face-to-face interviews was adopted to capture the major issues directly expressed by receivers from these countries.A total of 63 valid questionnaires were collected,and 13 respondents were face-to-face interviewed.The results confirmed that energy and agriculture were the most prioritized sectors for mitigation and adaptation in the developing countries alongside OBOR.The prioritized technologies for mitigation included cogeneration,solar photovoltaic,and biomass/biogas electricity.Irrigation,conservation agriculture,and soil management were prioritized for adaptation in agricultural sector,and water recycling and reuse,source water protection,and urban drainage management in water resource sector.Technology cost during installation and operation was stressed as the most important factor constraining the application and diffusion of climate technologies.But communication including language,information,and ways of communication,was also identified as an important factor.This implied that the conventional climate technology transfer need adapt to changing contexts of BRI and be complemented with innovative approaches involving multi-actors in different phases of climate technology development.Due to the limited representativeness of the sample,the results can hardly be generalized to all the countries,but raised interesting topics for future researches. | Minpeng Chen Lei Zhang Fei Teng Jingjing Dai Zhuang Li Ziqi Wang Yuting Li | 2020 | Ecosystem Health and Sustainability2020，6，1： | 1 |
| 18 | Frustrated Lewis pairs in situ formation in B-based porous aromatic frameworks for efficient o-phenylenediamine cyclization显示文摘Benzimidazoles are very important chemical materials in the pharmaceutical industry,and the most common synthetic route is cyclization of o-phenylenediamine with carbon sources,in which utilization of inexpensive and abundant CO_(2)as C1 source is very impressive.Porous aromatic frameworks(PAFs)with highly desired skeletons have attracted great attentions in gas capture and catalysis.Herein,B-based PAF-165 and PAF-166 are designed and synthesized via Friedel-Crafts alkylation reaction,which present high surface areas as well as high stability.Benefiting from the abundant electron-deficient B centers,both PAFs exhibit excellent selective CO_(2)adsorption abilities.The presence of sterically hindered B units in PAFs can act as Lewis acid active sites for the frustrated Lewis pairs(FLPs)in situ formation with ophenylenediamine,thus promoting the synthesis of benzimidazole.The optimal reaction conditions for o-phenylenediamine cyclization with PAF catalysts are explored,and the reaction mechanism is also proposed.This work provides feasible ideas for incorporating FLPs within porous materials as reusable heterogeneous catalysts for CO_(2)capture and conversion. | Anqi Dai Shulin Li Tienan Wang Yuting Yang Yuyang Tian Xiaofei Jing Guangshan Zhu | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
| 19 | USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia显示文摘T-cell acute lymphoblastic leukemia(T-ALL)is a highly aggressive leukemia that is primarily caused by aberrant activation of the NOTCH1 signaling pathway.Recent studies have revealed that posttranslational modifications,such as ubiquitination,regulate NOTCH1 stability,activity,and localization.However,the specific deubiquitinase that affects NOTCH1 protein stability remains unestablished.Here,we report that ubiquitin-specific protease 7(USP7)can stabilize NOTCH1.USP7 deubiquitinated NOTCH1 in vivo and in vitro,whereas knockdown of USP7 increased the ubiquitination of NOTCH1.USP7 interacted with NOTCH1 protein in T-ALL cells,and the MATH and UBL domains of USP7 were responsible for this interaction.Depletion of USP7 significantly suppressed the proliferation of T-ALL cells in vitro and in vivo,accompanied by downregulation of the NOTCH1 protein level.Similarly,pharmacologic inhibition of USP7 led to apoptosis of T-ALL cells.More importantly,we found that USP7 was significantly upregulated in human T-ALL cell lines and patient samples,and a USP7 inhibitor exhibited cell cytotoxicity toward primary T-ALL cells,indicating the clinical relevance of these findings.Overall,our results demonstrate that USP7 is a novel deubiquitinase that stabilizes NOTCH1.Therefore,USP7 may be a promising therapeutic target in the currently incurable T-ALL. | Huizhuang Shan Xiangyun Li Xinhua Xiao Yuting Dai Jinyan Huang Junjun Song Meng Liu Li Yang Hu Lei Yin Tong Li Zhou Hanzhang Xu Yingli Wu | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 0 |
| 20 | Control Effect of UAV Low Volume Spray Technology on Thrips and Tomato Spotted Wilt Virus in Tobacco Field显示文摘[Objectives]The paper was to explore the influence of unmanned aerial vehicle(UAV)low volume spray technology on the control effect of viruliferous thrips and tomato spotted wilt virus(TSWV)under different pesticide concentrations,and to explore the effective control nodes and methods of thrips and TSWV.[Methods]According to the occurrence characteristics of thrips and TSWV,the field control effects of 4 pesticides on thrips and TSWV were tested by UAV with the thrips number and disease index as indicators,following the principle of regional and periodic control trials.[Results]In the groups of UAV and artificial prevention and control,4 agents were used alternatively,including 1%emamectin benzoate ME,1.7%abamectin imidacloprid ME,5%emamectin benzoate WDG,and 30%pyriproxyfen dinotefuran SL.There was no significant difference in the control effect of thrips and TSWV among treatment 1(recommended dosage of UAV agent),treatment 2(reduction of recommended dosage of UAV agent by 25%)and treatment 4(recommended dosage of artificial control agent),and the control effects on thrips were more than 83.16%in the 3 treatments.The disease index of TSWV in the 3 treatments decreased from 8.64±1.37 in the blank control group to less than 3,which reached the prevention and control threshold.But treatment 3(reduction of recommended dosage of UAV agent by 50%)did not reach the prevention and control threshold.The disease index of TSWV in the blank control area increased with the increase of the number of live nymphs of thrips,and there was a significant positive correlation,with good fitness.[Conclusions]UAV has a significant impact on the control effect of thrips and TSWV under different pesticide concentrations.In the actual flight control application,it is recommended that the amount of the pesticides is about 3/4 and not less than 1/2 of that of the artificial application.The control area should be extended to 100 m of the ridge of the tobacco field,and UAV is used periodically to control thrips and TSWV for 5 times from pre-transplanting stage to pre-squaring stage of flue-cured tobacco.The control effect is significantly different from the traditional artificial application. | Zefan LIU Dean XIE Jiabao HAN Yanfen XIE Li MA Siyuan GAO Ruiqi PENG Yuting ZHAO Xiangze FU Wengang CHENG Yonghong FENG Yan ZHANG Huaping ZHANG Ying HUANG Leijie DAI Lanfeng WANG | 2023 | Plant Diseases and Pests2023，14，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员