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| 1 | Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment显示文摘The Hedgehog(HH) signaling pathway plays important roles in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment(TME). Aberrant HH signaling activation may accelerate the growth of gastrointestinal tumors and lead to tumor immune tolerance and drug resistance.The interaction between HH signaling and the TME is intimately involved in these processes, for example, tumor growth, tumor immune tolerance, inflammation, and drug resistance. Evidence indicates that inflammatory factors in the TME, such as interleukin 6(IL-6) and interferon-g(IFN-g), macrophages, and T cell-dependent immune responses, play a vital role in tumor growth by affecting the HH signaling pathway. Moreover, inhibition of proliferating cancer-associated fibroblasts(CAFs) and inflammatory factors can normalize the TME by suppressing HH signaling. Furthermore, aberrant HH signaling activation is favorable to both the proliferation of cancer stem cells(CSCs) and the drug resistance of gastrointestinal tumors. This review discusses the current understanding of the role and mechanism of aberrant HH signaling activation in gastrointestinal carcinogenesis, the gastrointestinal TME,tumor immune tolerance and drug resistance and highlights the underlying therapeutic opportunities. | Jinghui Zhang Jiajun Fan Xian Zeng Mingming Nie Jingyun Luan Yichen Wang Dianwen Ju Kai Yin | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 5 |
| 2 | Polyethyleneimine modified AuPd@PdAu alloy nanocrystals as advanced electrocatalysts towards the oxygen reduction reaction显示文摘Designing the low cost, active, durable, and alcohol-tolerant cathode catalysts towards the oxygen reduction reaction(ORR) is significant for the large-scale commercialization of direct alcohol fuel cells.Recently, Pd-based nanocrystals have attracted attention as Pt-alternative cathode catalysts towards the ORR in the alkaline electrolyte. Unfortunately, the pristine Pd-based nanocrystals lack the selectivity towards the ORR due to their inherent activity for the alcohol molecule oxidation reaction in the alkaline electrolyte. In this work, polyethyleneimine(PEI) modified Au Pd alloy nanocrystals with Au-rich Au Pd alloy cores and Pd-rich Pd Au alloy shells(AuPd@PdAu-PEI) are successfully synthesized using a traditional chemical reduction method in presence of PEI. The rotating disk electrode(RDE) technique is applied to evaluate the ORR performance of AuPd@PdAu-PEI nanocrystals. Compared with commercial Pd black,AuPd@PdAu-PEI nanocrystals show significantly enhanced activity and durability towards the ORR, and simultaneously exhibit particular alcohol tolerance towards the ORR in the alkaline electrolyte. | Qi Xue Guangrui Xu Rundong Mao Huimin Liu Jinghui Zeng Jiaxing Jiang Yu Chen | 2017 | Journal of Energy Chemistry2017，26，6： | 5 |
| 3 | Increasing prevalence of antibiotic resistance genes in manured agricultural soils in northern China显示文摘Land application of manure tends to result in the dissemination of antibiotic resistance in the environment.In this study,the influence of long-term manure application on the enrichment of antibiotic resistance genes(ARGs)and mobile genetic elements(MGEs)in agricultural soils was investigated.All the analyzed eight ARGs(tetA,tetW,tetX,sull,sulll,ermF,aac(6')-Ib-cr and blaTEM)and two MGEs(intJJ and Tn916/1545)were detected in both the manured and control soils,with relative abundances ranging from 10^-6 to 10^-2 Compared with the control soil,the relative abundances of ARGs and MGEs in manured soils were enriched 1.0-18.1 fold and 0.6-69.1 fold,respectively.High-throughput sequencing analysis suggested that at the phylum level,the bacteria carrying intll and ermF might be mainly affiliated with Proteobacteria and Bacteroides,respectively.The dominant genera carrying intll and ermF cow\d be Pseudomonas and Bacteroides,independent of manure application.Correlation analysis revealed that ARGs had strong links with soil physicochemical properties(TC,TN,and OM),heavy metals(Cu,Zn and Pb)and MGEs,indicating that the profile and spread of ARGs might be driven by the combined impacts of multiple factors.In contrast,soil pH and C/N exhibited no significant relationships with ARGs.Our findings provide evidence that long-term manure application could enhance the prevalence and stimulate the propagation of antibiotic resistance in agricultural soils. | Nan Wu Weiyu Zhang Shiyu Xie Ming Zeng Haixue Liu Jinghui Yang Xinyuan Liu Fan Yang | 2020 | Frontiers of Environmental Science & Engineering2020，14，1： | 3 |
| 4 | Ionically cross-linked chitosan microspheres for controlled release of bioactive nerve growth factor显示文摘 | Wen Zeng Jinghui Huang Xueyu Hu Wei Xiao Mengyao Rong Zhi Yuan Zhuojing Luo | 2011 | International Journal of Pharmaceutics2011，，2： | 1 |
| 5 | A new promising phosphor, Na3La2(BO3)3: Ln ( Ln=Eu, Tb) 显示文摘 | Li Zhihua Zeng Jinghui Zhang Guochun | 2005 | Joumal of Solid State Chemistry2005，178，12： | 1 |
| 6 | Preparation of nickel nanopowders in ethanol-water system (EWS)显示文摘 | Zheng Huagui Liang Jiahe Zeng Jinghui | 2001 | Mater Res Bull2001，，36： | 1 |
| 7 | Pressure-con- trolled fabrication of stibnite nanorods by the solvothermal decomposition of a simple single-source precursor 显示文摘 | Yang Jian Zeng Jinghui Yu Shuhong | 2000 | Chemistry of Materials2000，12，10： | 1 |
| 8 | Solvothermal synthesis of the ternary semiconductor AInSz (A=Na, K) nanocrystal at low temperature显示文摘 | Zheng Rongbo Zeng Jinghui Qian Yitai | 2003 | Materials Chemistry and Physics2003，82，1： | 1 |
| 9 | Ionically cross-linked chitosan microspheres for controlled released of bioactive nerve growth factor显示文摘 | ZENG Wen HUANG Jinghui HU Xueyu | 2011 | International Journal of Pharmaeeutics2011，421，2： | 1 |
| 10 | Experimental study on the vitrification and xenotransplantation of human ovarian tissue显示文摘Background:Cryopreservation of ovarian tissue is a promising method for preserving fertility.Transmission electron microscopy(TEM)is an evaluation system for cryo-injury during the cooling and warming process which is very laborious and needs to be optimized.Objective:In this study,we evaluated that serum 17β-oestradiol(E2)may be used as an indicator of vitrified ovarian tissue.Methods:Immunodeficient nude mice were used as hosts for xenografting of vitrified-warmed human ovarian tissues.A total of 54 mice were divided into two group:vitrified ovarian xenotransplant(VOX)group(n?45)and non-transplant control group(n?9).The transplanted mice were grouped into vitrified/warmed grafted-4 weeks(VOX-4w,n?15),vitrified/warmed grafted-6weeks(VOX-6w n?15)and vitrified/warmed grafted-12 weeks(VOX-12w n?15)according to the time after transplantation.The viable and functional recovery of grafted ovarian tissue was assessed by light microscopy,transmission electron microscopy,and hormone(E2)assays.Results:Serum E2 concentration was significantly higher in VOX-6w(group(21.07 pg/ml)than that of VOX-12w group(15.59 pg/ml).VOX-12w group showed a lower value(12.61 pg/ml)for E2 concentration.The trend for E2 concentration was consistent with the morphological identification of the grafts.Conclusion:In vivo serum hormone E2 released by cortical biopsies can be used as a functional marker for xenotransplanted vitrified-warmed human ovarian tissue reserve. | Jinghui Zhao Yuping Ge Jingyi Li Yucui Zeng Guoyi Dong Liping Zeng Juanjuan Dai Hui Du Mumin Shao Xuewen Yu Huan Li Fang He Zhouchun Shang Chun Wang Gabor Vajt Huiru Tang Ruifang Wu Yutao Du | 2022 | Gynecology and Obstetrics Clinical Medicine2022，2，1： | 1 |
| 11 | Ethanolthermal synthesis to γ-CuI nanocrystals at low temperature显示文摘 | Liu Yuanfang Zhan Jinhua Zeng Jinghui | 2001 | Journal of materials science letters2001，，20： | 1 |
| 12 | Ionically cross-linked chitosan microspheres for controlled released of bioactive nerve growth factor显示文摘 | ZENG WEN HUANG JINGHUI HU XUEYU | 2011 | International Jouenal of Phar- maceutics2011，421，2： | 1 |
| 13 | Preparation of nickel nanopowders in ethanol-water system (EWS)显示文摘 | Zheng Huagui Liang Jiahe Zeng Jinghui | 2001 | Materials Research Bulletin2001，36，56： | 1 |
| 14 | 显示文摘 | Zheng Huagui Zeng Jinghui Liang Jiahe | 1999 | Acta Metallurgica Sinica1999，35，8： | 1 |
| 15 | Preparation of nickel nanopowders in ethanol-water system(EWS)显示文摘 | ZHENG Huagui LIANG Jiahe ZENG Jinghui | 2001 | Material Research Bulletin2001，36，56： | 1 |
| 16 | Controlled hydrothermal synthesis of thin single-crystal tellurium nanobelts and nanotubes显示文摘 | MO Maosong ZENG Jinghui LIU Xianming | 2002 | Adv Mater2002，14，22： | 1 |
| 17 | Optimal Motion Planning of the Space Manipulator for Minimum Reaction Torque to Satellite显示文摘For the problem of free⁃floating space robot(FFSR)that the motion of manipulator will cause a large disturbance to the attitude of satellite,a path planning method based on hp⁃adaptive Gauss pseudospectral method(hp⁃AGPM)is proposed in this paper.In this method,the minimum reaction torque acting on satellite is taken as the objective function,and the number of segments and the order of polynomial in each segment are determined adaptively to improve the accuracy and the efficiency of the solution.At the same time,the theoretical convergence of the designed method is innovatively proved to ensure that the solution of the discretized nonlinear programming(NLP)problem is the optimal solution to the original optimal problem.The simulation results of a planar two degree⁃of⁃freedom(2⁃DOF)space manipulator show that the proposed path planning method is more effective than the resolved acceleration control(RAC)method and the control variable parameterization(CVP)method,and is better than other pseudospectral methods both in computation speed and the number of collocation points. | Zhiqiang Xu Xiangxin Zeng Jinghui Li Zhaoyan Jia | 2022 | Journal of Harbin Institute of Technology(New Series)2022，29，2： | 0 |
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