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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome显示文摘Hutchinson-Gilford 早衰症候群(HGPS ) 和沃纳症候群(WS ) 是二最好描绘的人的 progeroid 症候群。HGPS 被一个点变化在 lamin A (LMNA ) 基因引起,导致截断的蛋白质 productprogerin 的生产。WS 被变化在 WRN 基因引起,编码 loss-of-function RecQ DNA helicase。这里,由基因编辑,我们创造了 isogenic 人的胚胎的干细胞(转换字符) 与异质接合(G608G/+) 或同型结合(G608G/G608G ) LMNA 变化和 biallelic WRN 大美人为为 HGPS 和 WS 致病建模,分别地。当转换字符和 endothelial 房间(EC ) 没介绍早熟的老朽的任何特征时, HGPS 间充质、 WS 间充质的干细胞(MSC ) 与不同动力学显示出联系老化的显型。当 HGPS-MSCs 展出了迟了发作的尖锐早衰 characterisitcs 时, WS-MSCs 有早发作的温和早衰显型。一起拿,我们的学习比较并且形成对照不同病理 underpinning 二早衰混乱,并且提供可靠干细胞为病理学、生理的老化识别新治疗学的策略的基于的模型。 | Zeming Wu Weiqi Zhang Moshi Song Wei Wang Gang Wei Wei Li Jinghui Lei Yu Huang Yanmei Sang Piu Chan Chang Chen Jing Qu Keiichiro Suzuki Juan Carlos Izpisua Belmonte Guang-Hui Liu | 2018 | Protein & Cell2018，9，4： | 15 |
| 3 | Comparative studies on histological and ultra-structure of the pituitary of different ploidy level fishes显示文摘The histological and ultra-structure of the pituitary in diploid red crucian carp(Carassius auratus red var.),triploid crucian carp and allotetraploid hybrids within and after the breeding season were comparatively studied.The result showed that there were six endocrine cell types in the pituitary of these three kinds of fishes,and there was an obvious difference in cell size among different ploidy level fishes.As for the same type of pituitary cells,the cell size was increased gradually with the in- creasing ploidy level.In the breeding season,the allotetraploid hybrids had higher proportion of go- nadotropin cells(GTH)than triploids,and the triploids had higher proportion of GTH than diploids.The results were related to the earlier sexual maturity of allotetraploid hybrids and sterility of triploid cru- cian carp.On the other hand,among the three kinds of fishes,the proportion of somatotropin(STH) cells in triploids crucian carp was the highest,whereas that in allotetraploid hybrids was the lowest. The results might be connected with the faster growth rate of triploids and slower growth rate of al- lotetraploid hybrids.In addition,in GTH cells of meso-adenohypophysis after the breeding season, there were many endocrine particles in triploids,while those endocrine particles were released from the cells in allotetraploids and diploids.This result showed that the sterility of triploid crucian carp might be related to the hormone which was not released from the GTH cells.In a word,the present study indicated that the differences in the structure of pituitary among different ploidy level fishes contributed to their difference in the growth rate and gonadal development. | LONG Yu LIU Shaojun HUANG Weiren ZHANG Jian SUN Yuandong ZHANG Chun CHEN Song LIU Jinghui LIU Yun | 2006 | Science China(Life Sciences)2006，49，5： | 13 |
| 4 | Effects of grassland management on the community structure, aboveground biomass and stability of a temperate steppe in Inner Mongolia, China显示文摘Plant community structure responds strongly to anthropogenic disturbances, which greatly influence community stability. The changes in community structure, aboveground biomass(AGB), biodiversity and community stability associated with different management practices were studied with a three-year field investigation in a temperate steppe of Inner Mongolia, China. The species richness, Shannon-Wiener index, evenness, plant functional type abundance, AGB, temporal community stability, summed covariance, scaling coefficient and dominant species stability were compared among areas subjected to long-term reservation(R), long-term grazing(G), mowing since enclosure in 2008(M) and grazing enclosure since 2008(E). Site R had higher perennial grass abundance and lower species richness than sites G, M and E, although the AGB was not significantly different among the four sites. The species structure varied from a single dominant species at site R to multiple dominant species at sites G, M and E. The long-term reservation grassland had lower biodiversity but higher stability, whereas the enclosed grassland with/without mowing had higher biodiversity but lower stability. Different stability mechanisms, such as the compensatory dynamics, mean-variance scaling and dominant species stability were examined. Results showed that community stability was most closely related to the relative stability of the dominant species, which supports the biomass ratio hypothesis proposed by Grime. | ZHANG Jinghui HUANG Yongmei CHEN Huiying GONG Jirui QI Yu YANG Fei LI Engui | 2016 | Journal of Arid Land2016，8，3： | 6 |
| 5 | Mex3a promotes oncogenesis through the RAP1/MAPK signaling pathway in colorectal cancer and is inhibited by hsa-miR-6887-3p显示文摘Background:Although Mex3 RNA-binding family member A(Mex3a)has demonstrated an important role in multiple cancers,its role and regulatory mechanism in CRC is unclear.In this study,we aimed to investigate the role and clinical significance of Mex3a in CRC and to explore its underlying mechanism.Methods:Western blotting and quantitative real-time polymerase chain reaction(qRT-PCR)were performed to detect the expression levels of genes.5-Ethynyl-2’-deoxyuridine(EDU)and transwell assays were utilized to examine CRC cell proliferation and metastatic ability.The R software was used to do hierarchical clustering analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis.Overexpression and rescue experiments which included U0126,a specific mitogen activated protein kinase kinase/extracellular regulated protein kinase(MEK/ERK)inhibitor,and PX-478,a hypoxia-inducible factor 1 subunit alpha(HIF-1α)inhibitor,were used to study the molecularmechanisms of Mex3a in CRC cells.Co-immunoprecipitation(Co-IP)assay was performed to detect the interaction between two proteins.Bioinformatics analysis including available public database and Starbase software(starbase.sysu.edu.cn)were used to evaluate the expression and prognostic significance of genes.TargetScan(www.targetscan.org)and the miRDB(mirdb.org)website were used to predict the combination site between microRNA and target mRNA.BALB/c nude micewere used to study the function of Mex3a and hsa-miR-6887-3p in vivo.Results:Clinicopathological and immunohistochemical(IHC)studies of 101 CRC tissues and 79 normal tissues demonstrated that Mex3a was a significant prognostic factor for overall survival(OS)in CRC patients.Mex3a knockdown substantially inhibited the migration,invasion,and proliferation of CRC cells.Transcriptome analysis and mechanism verification showed that Mex3a regulated the RAP1 GTPase activating protein(RAP1GAP)/MEK/ERK/HIF-1αpathway.Furthermore,RAP1GAP was identified to interact with Mex3a in Co-IP experiments.Bioinformatics and dual-luciferase reporter experiments revealed that hsa-miR-6887-3p could bind to the 3’-untranslated regions(3’-UTR)of the Mex3amRNA.hsa-miR-6887-3p downregulated Mex3a expression and inhibited the tumorigenesis of CRC both in vitro and in vivo.Conclusions:Our study demonstrated that the hsa-miR-6887-3p/Mex3a/RAP1GAP signaling axis was a key regulator of CRC and Mex3a has the potential to be a new diagnostic marker and treatment target for CRC. | Haixia Li Jinghui Liang Jiang Wang Jingyi Han Shuang Li Kai Huang Chuanyong Liu | 2021 | Cancer Communications2021，41，6： | 5 |
| 6 | Aerodynamic characteristics of rigid coaxial rotor by wind tunnel test and numerical calculation显示文摘Focusing on aerodynamic characteristics of rigid coaxial rotor of a high-speed helicopter in hover and forward flight, a wind tunnel test is conducted in the 8 m ? 6 m low-speed straightflow wind tunnel of China Aerodynamics Research and Development Center. In the experiment,a 4 m diameter composite model rigid coaxial rotor is designed and manufactured, and firstorder flapping frequency ratio of the blade is 1.796 to ensure sufficient stiffness at the blade root.Rotor aerodynamic performance is measured under hovering and high advance ratio conditions.Also, the numerical method is used to calculate aerodynamic characteristics in typical states of the rigid coaxial rotor for analysis purpose. The rotor lift-drag ratio and lateral lift offset in the experiment are emphatically analyzed for the rigid coaxial rotor. The results indicate that in forward flight condition, the rotor lift-drag ratio first increases and then decreases with the increment of advance ratio and lift offset. When advance ratio remains constant, with the increment of lift offset, the lift-drag ratio of rigid coaxial rotor first increases and then decreases. | Jinghui DENG Feng FAN Ping'an LIU Shuilin HUANG Yongfeng LIN | 2019 | Chinese Journal of Aeronautics2019，32，3： | 5 |
| 7 | The effect of erythropoietin to the proliferation of cancer cell lines显示文摘对客观调查了红细胞生成素(EPO ) 是否将支持人的癌症房间线 MCF-7, Panc-1 和 HepG2 的增长以便决定 EPO 是否将结果更坏的预后到有恶性病的病人。我们由 MTT 试金检验了禁止的生长或 EPO 的宣传效果到 MCF-7, Panc-1 和 HepG2 的方法。然后,我们检验了与 EPO 并且没有由 FCM 的 EPO 有教养的那些癌症房间线的房间周期。结果在那里显示出的结果不是禁止的重要生长或到 MCF-7, Panc-1 和 HepG2 的 EPO 的宣传效果。与 EPO 有教养的那些癌症房间线的房间周期也有不重要对没有 EPO 有教养的那些癌症房间线的不同。EPO 没有提升,这被结束的结论完成到癌症房间线的增长,并且也许不结果更坏的预后到有恶性病的病人。 | Wenshan He Tao Huang Jinghua Ren Jinghui Zhang | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，6： | 3 |
| 8 | Influence of ultrasonic treatment on the characteristics of epoxy resin and the interfacial property of its carbon fiber composites显示文摘 | Huang Yudong Liu Li Qiu Jinghui | 2002 | Composites Science and Technology2002，62，16： | 1 |
| 9 | Ionically cross-linked chitosan microspheres for controlled release of bioactive nerve growth factor显示文摘 | Wen Zeng Jinghui Huang Xueyu Hu Wei Xiao Mengyao Rong Zhi Yuan Zhuojing Luo | 2011 | International Journal of Pharmaceutics2011，，2： | 1 |
| 10 | Traumatic brain injury induced by exposure to blast overpressure via ear canal显示文摘Exposure to explosive shockwave often leads to blast-induced traumatic brain injury in military and civilian populations.Unprotected ears are most often damaged following exposure to blasts.Although there is an association between tympanic membrane perforation and TBI in blast exposure victims,little is known about how and to what extent blast energy is transmitted to the central nervous system via the external ear canal.The present study investigated whether exposure to blasts directed through the ear canal causes brain injury in LongEvans rats.Animals were exposed to a single blast(0–30 pounds per square inch(psi))through the ear canal,and brain injury was evaluated by histological and behavioral outcomes at multiple time-points.Blast exposure not only caused tympanic membrane perforation but also produced substantial neuropathological changes in the brain,including increased expression of c-Fos,induction of a profound chronic neuroinflammatory response,and apoptosis of neurons.The blast-induced injury was not limited only to the brainstem most proximal to the source of the blast,but also affected the forebrain including the hippocampus,amygdala and the habenula,which are all involved in cognitive functions.Indeed,the animals exhibited long-term neurological deficits,including signs of anxiety in open field tests 2 months following blast exposure,and impaired learning and memory in an 8-arm maze 12 months following blast exposure.These results suggest that the unprotected ear canal provides a locus for blast waves to cause TBI.This study was approved by the Institutional Animal Care and Use Committee at the University of Mississippi Medical Center(Animal protocol#0932 E,approval date:September 30,2016 and 0932 F,approval date:September 27,2019). | Yang Ou Brad AClifton Jinghui Li David Sandlin Na Li Li Wu Chunming Zhang Tianwen Chen Jun Huang Yue Yu Jerome Allison Fan Fan Richard JRoman James Shaffery Wu Zhou Yi Pang Hong Zhu | 2022 | Neural Regeneration Research2022，17，1： | 1 |
| 11 | Safe Navigation for UAV-Enabled Data Dissemination by Deep Reinforcement Learning in Unknown Environments显示文摘Unmanned aerial vehicles(UAVs) are increasingly considered in safe autonomous navigation systems to explore unknown environments where UAVs are equipped with multiple sensors to perceive the surroundings. However, how to achieve UAVenabled data dissemination and also ensure safe navigation synchronously is a new challenge. In this paper, our goal is minimizing the whole weighted sum of the UAV’s task completion time while satisfying the data transmission task requirement and the UAV’s feasible flight region constraints. However, it is unable to be solved via standard optimization methods mainly on account of lacking a tractable and accurate system model in practice. To overcome this tough issue,we propose a new solution approach by utilizing the most advanced dueling double deep Q network(dueling DDQN) with multi-step learning. Specifically, to improve the algorithm, the extra labels are added to the primitive states. Simulation results indicate the validity and performance superiority of the proposed algorithm under different data thresholds compared with two other benchmarks. | Fei Huang Guangxia Li Shiwei Tian Jin Chen Guangteng Fan Jinghui Chang | 2022 | China Communications2022，19，1： | 1 |
| 12 | Joining of C r/SiC composite to Ti 'alloy using composite filler materials显示文摘 | Xiong Jinghui Huang Jihua Wang Zhiping | 2009 | Materials Science and T-hnology2009，25，： | 1 |
| 13 | Clinical application of massively parallel sequencing‐based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11 105 pregnancies with mixed risk factors显示文摘 | Shan Dan Wei Wang Jinghui Ren Yali Li Hua Hu Zhengfeng Xu Tze Kin Lau Jianhong Xie Weihua Zhao Hefeng Huang Jiansheng Xie Luming Sun Xiaohong Zhang Weipeng Wang Shixiu Liao Rong Qiang Jiangxia Cao Qiufang Zhang Yulin Zhou Haiyan Zhu Mei Zhong Yi Guo Linhu | 2012 | Prenat Diagn2012，，13： | 1 |
| 14 | Method of Generating Strategic Guidance Information for Driving Evacuation Flows to Approach Safety-Based System Optimal Dynamic Flows: Case Study of a Large Stadium显示文摘In previous evacuation flow planning, a system optimal dynamic traffic assignment(SODTA) did not consider the exogenous costs caused by potential traffic accidents. A traffic accident,which might occur as a result of traffic congestion, will impact an evacuation process because of accidentrelated delays experienced by the downstream vehicles. This paper establishes a safety-based SO-DTA linear programming model in which the generalized system cost incorporates both the travel time and the accident-related delay. The goal is to minimize the generalized system cost under the cell transmission setup. Furthermore, the authors provide strategic guidance information that considers both the objective of the decision maker and the route choice behavior of the evacuees. Mathematically,the authors propose an unconstrained non-linear programming model aimed at minimizing the gap between the safety-based flows and the stochastic real-world evacuation flows, to provide strategic travel time information to be published on variable message signs(VMS). In the case study, the authors found that the safety-based SO-DTA model can reduce congestion and improve the evacuation efficiency; the stochastic real-world evacuation flows, guided by strategic information, can approach the safety-based flows. | REN Gang HUANG Zhengfeng LU Lili HUA Jingyi WANG Jinghui | 2015 | Journal of Systems Science & Complexity2015，28，3： | 1 |
| 15 | Navigation for UAV Pair-Supported Relaying in Unknown IoT Systems with Deep Reinforcement Learning显示文摘Unmanned aerial vehicles(UAVs) have recently been regarded as a promising technology in Internet of things(IoT). UAVs functioned as intermediate relay nodes are capable of establishing uninterrupted and high-quality communication links between remotely deployed IoT devices and the destination. Multiple UAVs are required to be deployed due to their limited onboard energy. We study a UAV pair-supported relaying in unknown IoT systems, which consists of transmitter and receiver. Our goal is that transmitter gathers the data from each device then transfers the information to receiver,and receiver finally transmits the information to the destination, while meeting the constraint that the amount of information received from each device reaches a certain threshold. This is an optimization problem with highly coupled variables, such as trajectories of transmitter and receiver. On account of no prior knowledge of the environment, a dueling double deep Q network(dueling DDQN) algorithm is proposed to solve the problem.Whether it is in the phase of transmitter’s receiving information or the phase of transmitter’s forwarding information to receiver, the effectiveness and superiority of the proposed algorithm is demonstrated by extensive simulationsin in comparison to some base schemes under different scenarios. | HUANG Fei LI Guangxia WANG Haichao TIAN Shiwei YANG Yang CHANG Jinghui | 2022 | Chinese Journal of Electronics2022，31，3： | 1 |
| 16 | Ionically cross-linked chitosan microspheres for controlled released of bioactive nerve growth factor显示文摘 | ZENG Wen HUANG Jinghui HU Xueyu | 2011 | International Journal of Pharmaeeutics2011，421，2： | 1 |
| 17 | Electrical stimulation accelerates nerve regeneration and functional recovery in delayed peripheral nerve injury in rats显示文摘 | Jinghui Huang Yongguang Zhang Lei Lu Xueyu Hu Zhuojing Luo | 2013 | Eur J Neurosci2013，，12： | 1 |
| 18 | Sim- plified method of designing FIR filter with controllable center frequency 显示文摘 | Huang Xiangdong Chu Jinghui Lu Wei | 2010 | Transactions of 77anjin University2010，16，4： | 1 |
| 19 | Clinical application of massively parallel sequencing‐based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11 105 pregnancies with mixed risk factors显示文摘 | Shan Dan Wei Wang Jinghui Ren Yali Li Hua Hu Zhengfeng Xu Tze Kin Lau Jianhong Xie Weihua Zhao Hefeng Huang Jiansheng Xie Luming Sun Xiaohong Zhang Weipeng Wang Shixiu Liao Rong Qiang Jiangxia Cao Qiufang Zhang Yulin Zhou Haiyan Zhu Mei Zhong Yi Guo Linhu | 2012 | Prenat Diagn2012，，13： | 1 |
| 20 | Ionically cross-linked chitosan microspheres for controlled released of bioactive nerve growth factor显示文摘 | ZENG WEN HUANG JINGHUI HU XUEYU | 2011 | International Jouenal of Phar- maceutics2011，421，2： | 1 |
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