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| 1 | Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)显示文摘Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence.Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology.The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM. | Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong Chen Xing Chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu Feng Qing-Jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-Ying Liao Hong Luo Zheng-Ren Liu Jing-Hua Lu Bin Luo Xiao-Peng Ma Jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-Ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-Jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-Peng Zhang Sheng-Chu Zhang Dai-Wei Zhao Xiang-Min Zheng Le-Wei Zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu | 2022 | Military Medical Research2022，9，4： | 13 |
| 2 | Venetoclax联合低剂量阿糖胞苷治疗不耐受强化化疗的初治急性髓系白血病患者:一项Ⅲ期随机、安慰剂对照试验中中国队列结果显示文摘目的:探讨Venetoclax联合低剂量阿糖胞苷(LDAC)在不能耐受强化诱导化疗的中国急性髓系白血病(AML)患者中的疗效及安全性。方法:一项Ⅲ期随机、双盲安慰剂对照试验(VIALE-C)中中国队列的结果。在本项国际临床试验中,入组了不适合接受强化化疗、新诊断为AML的18岁或以上的成人患者。在全球范围内,患者(211例)按2∶1的比例随机分配接受Venetoclax+LDAC或安慰剂+LDAC(28 d为1个周期),在第1~10天接受LDAC。主要研究终点为总生存(OS);次要研究终点包括缓解率、无事件生存期及不良事件(AE)。结果:入组15例中国患者(Venetoclax组9例;安慰剂组6例)。中位年龄为72(61~86)岁。与安慰剂组相比,Venetoclax组的死亡风险下降38%(HR=0.62,95%CI 0.12~3.07)。对延长6个月随访进行的计划外分析显示,Venetoclax组的中位OS时间为9.0个月,安慰剂组为4.1个月。完全缓解(CR)率与血细胞计数未完全恢复的CR(CRi)率分别为33%(3/9)和0(0/6)。最常见的非血液学AE(Venetoclax组与安慰剂组)为低钾血症(5/9和4/6)、呕吐(4/9和3/6)、便秘(2/9和4/6)和低白蛋白血症(1/9和4/6)。结论:Venetoclax联合LDAC在中国患者中表现出有意义的疗效和可管理的安全性特征,这与在全球VIALE-C人群中的观察结果一致,使其成为不适合接受强化化疗的新诊断AML患者的一个重要治疗选择。 | 胡豫 金洁 张钰 胡建达 李军民 魏旭东 高素君 Zha Jiuhong Jiang Qi Wu Jun Wellington Mendes Andrew H.Wei 王建祥 | 2021 | 中华血液学杂志2021，42，4： | 7 |
| 3 | Mitochondrial aldehyde dehydrogenase(ALDH2)rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer’s disease via inhibition of ACSL4-dependent ferroptosis显示文摘Alzheimer’s disease(AD)is associated with high incidence of cardiovascular events but the mechanism remains elusive.Our previous study reveals a tight correlation between cardiac dysfunction and low mitochondrial aldehyde dehydrogenase(ALDH2)activity in elderly AD patients.In the present study we investigated the effect of ALDH2 overexpression on cardiac function in APP/PS1 mouse model of AD.Global ALDH2 transgenic mice were crossed with APP/PS1 mutant mice to generate the ALDH2-APP/PS1 mutant mice.Cognitive function,cardiac contractile,and morphological properties were assessed.We showed that APP/PS1 mice displayed significant cognitive deficit in Morris water maze test,myocardial ultrastructural,geometric(cardiac atrophy,interstitial fibrosis)and functional(reduced fractional shortening and cardiomyocyte contraction)anomalies along with oxidative stress,apoptosis,and inflammation in myocardium.ALDH2 transgene significantly attenuated or mitigated these anomalies.We also noted the markedly elevated levels of lipid peroxidation,the essential lipid peroxidation enzyme acyl-CoA synthetase long-chain family member 4(ACSL4),the transcriptional regulator for ACLS4 special protein 1(SP1)and ferroptosis,evidenced by elevated NCOA4,decreased GPx4,and SLC7A11 in myocardium of APP/PS1 mutant mice;these effects were nullified by ALDH2 transgene.In cardiomyocytes isolated from WT mice and in H9C2 myoblasts in vitro,application of Aβ(20μM)decreased cell survival,compromised cardiomyocyte contractile function,and induced lipid peroxidation;ALDH2 transgene or activator Alda-1 rescued Aβ-induced deteriorating effects.ALDH2-induced protection against Aβ-induced lipid peroxidation was mimicked by the SP1 inhibitor tolfenamic acid(TA)or the ACSL4 inhibitor triacsin C(TC),and mitigated by the lipid peroxidation inducer 5-hydroxyeicosatetraenoic acid(5-HETE)or the ferroptosis inducer erastin.These results demonstrate an essential role for ALDH2 in AD-induced cardiac anomalies through regulation of lipid peroxidation and ferroptosis. | Zhi-yun Zhu Yan-dong Liu Yan Gong Wei Jin Elena Topchiy Subat Turdi Yue-feng Gao Bruce Culver Shu-yi Wang Wei Ge Wen-liang Zha Jun Ren Zhao-hui Pei Xing Qin | 2022 | Acta Pharmacologica Sinica2022，43，1： | 6 |
| 4 | COMPARISON OF GRANULAR MATERIAL BEHAVIOUR UNDER DRAINED TRIAXIAL AND PLANE STRAIN CONDITIONS USING 3D DEM SIMULATIONS显示文摘Three dimensional (3D) DEM (discrete element method) simulations of drained triaxial compression and plane strain tests are presented for both dense and loose assemblies of polydisperse spheres using a periodic cell. In the work reported, drained tests were modelled by deforming the samples under constant mean stress conditions. The drained behaviour is shown to be qualitatively similar to published physical experimental results. The Bishop's formula for the estimation of the intermediate principal stress is evaluated. The existence of critical density is shown to be independent of initial packing densities and strain conditions. Different failure criteria have been compared based on the DEM simulation results, and the Lade criterion is found to be the most appropriate one. A new microscopic fabric parameter is introduced to give insight to structural anisotropy under general 3D fabric conditions. It is found that two parameters characterize the evolution of the stress and fabric respectively independent of strain conditions. | Guobin Gong Xiaoxiong Zha Jun Wei | 2012 | Acta Mechanica Solida Sinica2012，25，2： | 6 |
| 5 | Who will win the future of display technologies?显示文摘In recent years,China and other countries have invested heavily in the research and manufacturing capacity of display technology.Meanwhile,different display technology scenarios,ranging from traditional LCD (liquid crystal display) to rapidly expanding OLED (organic light-emitting diode) and emerging QLED (quantum-dot light-emitting diode),are competing for market dominance.Amidst the trivium strife,OLED,backed by | hepeng jia Xiuqi Huang Liangsheng Liao Xiaogang Peng Jun Xu Dongyuan Zha | 2018 | National Science Review2018，5，3： | 5 |
| 6 | Effect of Working Position on Vertical Motion Straightness of Open Hydrostatic Guideways in Grinding Machine显示文摘Hydrostatic guideways have various applications in precision machine tools due to their high motion accuracy. The analysis of motion straightness in hydrostatic guideways is generally ignoring the external load on the slider. A variation force also exists, caused by the different working positions, together with the dead load of the slider and that of other auxiliary devices. The effect of working position on vertical motion straightness is investigated based on the equivalent static model, considering the error averaging effort of pressured oil film in open hydrostatic guideways. Open hydrostatic guideways in LGF1000 are analyzed with this approach. The theoretical results show that the slider has maximum vertical motion straightness when the working position is closer the guiderail of Y axis. The vertical motion straightness reaches a minimum value as the working position is located at the center of the two guiderails on the Y axis. The difference between the maximum and minimum vertical motion straightness is 34.7%. The smaller vertical motion straightness is attributed to the smaller spacing of the two pads centers, along the Y direction. The experimental results show that the vertical motion straightness is 4.15 μm/1200 mm, when the working position is located in the middle of the X beam, and 5.08 μm/1200 mm, when the working position is approaching the Y guiderails, denoting an increase of 18.3%. The changing trends of the measured results validate the correctness of the theoretical model. The research work can be used to reveal the variation law of accuracy of the open hydrostatic guideways, under different working positions, to predict the machining precision, and provides the basis for an error compensation strategy for gantry type grinding machines. | ZHA JUn WANG Zhiwei XUE Fei CHEN Yaolong | 2017 | Chinese Journal of Mechanical Engineering2017，30，1： | 5 |
| 7 | Differential temporal expression of matrix metalloproteinases following sciatic nerve crush显示文摘We previously performed transcriptome sequencing and found that genes for matrix metalloproteinases(MMPs),such as MMP7 and 12,seem to be highly upregulated following peripheral nerve injury,and may be involved in nerve repair.In the present study,we systematically determined the expression levels of MMPs and their regulators at 1,4,7 and 14 days after sciatic nerve crush injury.The number of differentially expressed genes was elevated at 4 and 7 days after injury,but decreased at 14 days after injury.Among the differentially expressed genes,those most up-regulated showed fold changes of more than 214,while those most down-regulated exhibited fold changes of more than 2-10.Gene sequencing showed that,at all time points after injury,a variety of MMP genes in the 'Inhibition of MMPs' pathway were up-regulated,and their inhibitor genes were down-regulated.Expression of key up-and down-regulated genes was verified by quantitative real-time polymerase chain reaction analysis and found to be consistent with transcriptome sequencing.These results suggest that MMP-related genes are strongly involved in the process of peripheral nerve regeneration. | Jing Qin Guang-bin Zha Jun Yu Hong-hong Zhang Sheng Yi | 2016 | Neural Regeneration Research2016，11，7： | 5 |
| 8 | Synthesis of a kind of geminal imidazolium ionic liquid with long aliphatic chains显示文摘与长烃组,一起的新奇 geminal imidazolium ionic 液体 1,4 二度(3-tetradecylimidazolium-1-yl ) 钢瓶煤气溴化物被综合,一个有效综合方法详细地被介绍。它的结构被英尺红外决定,(1 ) H NMR 和元素的分析。 | Yun Sheng Ding Min Zha Jun Zhang Seng Shan Wang | 2007 | Chinese Chemical Letters2007，18，1： | 5 |
| 9 | Optical properties and chemical composition of PM_(2.5) in Shanghai in the spring of 2012显示文摘The semi-diurnal mean aerosol mass concentration, chemical composition, and optical properties of PM2.5were investigated in Shanghai during the spring of 2012. Slight pollution was observed during the study period. The average PM2.5 concentration was 64.11 土 22.83(xg/m3. The mean coefficients of extinction,scattering, and absorption at 532 nm were 125.9 士 78.5,91.1 士 56.3,and 34.9 士 23.6 Mm-1, respectively. A relatively low mean single scattering albedo at 532 nm(0.73 士 0.04) and low level of elemental carbon(EC,2.67 士 1.96 |xg/m3) suggested that the light absorption was enhanced due to the internal mixing of the EC.Sulfate contributed the most to aerosol light scattering in Shanghai. The chemical composition of PM2.5was dominated by particulate organic matter, sulfate, nitrate, ammonium, and EC. Anthropogenic sources made a significant contribution to the emission and loading of the particulate pollutants. A relatively good correlation between the aerosol chemical composition and the cloud condensation nuclei(CCN) activation indicated that aerosol chemistry is an important factor that influences the saturated hygroscopicity and growth of the aerosol. | Guanghan Huang Tiantao Cheng Renjian Zhang Jun Tao Chunpeng Leng Yunwei Zhang Shuping Zha Deqin Zhang Xiang Li Chunyang Xu | 2014 | Particuology2014，12，2： | 4 |
| 10 | Mutation analysis in a Chinese family with multiple endocrine neoplasia type 1显示文摘(MEN1 ) 背景多重内分泌的瘤形成类型 1 是被肿瘤 suppressor 基因 MEN1 的 germline 变化引起的正染色体的主导的癌症症候群。这研究试图在中国家谱 withMEN1 识别变化。有 MEN1 的一个大中国家庭被收集的方法。所有编码区域和他们 MEN1 基因的邻近的序列被放大并且定序。在这个家庭,的结果在 exon 的异质接合的 cytosine 插入 10 (c.1546_1547insC ) 导致 MEN1 的一个框架移动变化在 proband 和他的家庭的另外的二个受苦的成员被发现。这个变化在 intron 被连接到新奇单个核苷酸多型性(SNP ) 3 (IVS3+18C > T ) 。结论在 exon 的变化 10 MEN1 基因力量与 MEN1 导致甲状旁腺的增生和垂体腺瘤和 cosegregate 的开发症候群。新发现 IVS3+18C 的意义 > MEN1 的 T 需要进一步的调查。 | ZHA Bing-bing LIANG Wang LIU Jun CHENG Juan HONG Xiao-wu LIU Jing LI Yi-ming MA Duan | 2010 | Chinese Medical Journal2010，，5： | 3 |
| 11 | Selective electrocatalytic CO2 reduction enabled by SnO2 nanoclusters显示文摘The development of high-performance electrocatalysts holds the decisive key to the electrochemical CO2 reduction toward value-added products. Formic acid or formate is a desirable reduction product, but its selective production is often challenging. Tin based-materials have attracted great attention for formate production, and yet their performances are far from satisfactory. In this study, we reported the preparation of SnO2 nanoclusters from the controlled self-polymerization of dopamine together with SnO32-, followed by the mild-temperature calcination. The final product consisted of large primary particles that were further made of small secondary SnO2 nanocrystals. When evaluated as the electrocatalyst for CO2 reduction in 0.5 M NaHCO3, our material exhibited impressive activity, selectivity and stability for the selective CO2 reduction to formate. A peak formate Faradaic efficiency of^73% and large partial current density of 16.3 mA/cm2 was achieved at -0.92 V versus reversible hydrogen electrode. | Hui Yang Yang Huang Jun Deng Yunling Wu Na Han Chenyang Zha Leigang Li Yanguang Li | 2019 | Journal of Energy Chemistry2019，28，10： | 3 |
| 12 | Presence of high nitryl chloride in Asian coastal environment and its impact on atmospheric photochemistry显示文摘Nitryl chloride(ClNO2)is a product of nocturnal halogen activation of nitrogen oxides and has potential to impact atmospheric photochemistry.Here we report the first observation result of ClNO2in an Asian environment.The measurements were made with a thermal decomposition chemical ionization mass spectrometer at a coastal site in southern China during late summer of 2012.A clear diurnal pattern of ClNO2was observed with nighttime 1-min average mixing ratio up to 1997 pptv,which is among the highest values ever reported in the world.The elevated ClNO2mixing ratios were observed in plumes from Hong Kong and the Pearl River Delta region compared to the lower levels in maritime air.Calculations suggest that the production of chlorine atom from photolysis of ClNO2in the early morning exceeds the production of hydroxyl radical via ozone photolysis by several factors.Therefore,ClNO2plays an important role in jump-starting the atmospheric photochemistry in polluted marine boundary layer of southern China. | Yee Jun Tham Chao Yan Likun Xue Qiaozhi Zha Xinfeng Wang Tao Wang | 2014 | Chinese Science Bulletin2014，59，4： | 3 |
| 13 | Pharmacokinetic interactions between 20(S)- ginsenoside Rh2 and the HIV protease inhibitor ritonavir in vitro and in vivo显示文摘 | Jian SHI Bei CAO Wei-bin ZHA Xiao-lan WU Lin-sheng LIU Wen-jing XIAO Rong-rong GU Run-bin SUN Xiao-y YU Tian ZHENG Meng-jie LI Xin-wen WANG Jun ZHOU Yong MAO Chun GE Ting MA Wen-juan XIA Ji-ye AA Guang-ji WANG Chang-xiao LIU | 2013 | Acta Pharmacologica Sinica2013，34，10： | 3 |
| 14 | Two-dimensional multimetallic sulfide nanosheets with multi-active sites to enhance polysulfide redox reactions in liquid Li2S6-based lithium-polysulfide batteries显示文摘The lithium-sulfur battery has attracted enormous attention as being one of the most significant energy storage technologies due to its high energy density and cost-effectiveness.However,the 'shuttle effect' of polysulfide intermediates represents a formidable challenge towards its wide applications.Herein,we have designed and synthesized two-dimensional Cu,Zn and Sn-based multimetallic sulfide nanosheets to construct multi-active sites for the immobilization and entrapment of polysulfides with offering better performance in liquid Li2S6-based lithium-polysulfide batteries.Both experimental measurements and theoretical computations demonstrate that the interfacial multi-active sites of multimetallic sulfides not only accelerate the multi-chained redox reactions of highly diffusible polysulfides,but also strengthen affinities toward polysulfides.By adopting multimetallic sulfide nanosheets as the sulfur host,the liquid Li2 S6-based cell exhibits an impressive rate capability with 1200 mAh/g and retains 580 mAh/g at 0.5 mA/cm^(2) after 1000 cycles.With high sulfur mass loading conditions,the cell with 2.0 mg/cm^(2) sulfur loading delivers a cell capacity of 1068 mAh/g and maintains 480 mAh/g with 0.8 mA/cm^(2) and 500 cycles.This study provides new insights into the multifunctional material design with multi-active sites for elevated lithium-polysulfide batteries. | Chenyang Zha Donghai Wu Yuwei Zhao Jun Deng Jinghua Wu Rong Wu Meng Yang Lin Wang Houyang Chen | 2021 | Journal of Energy Chemistry2021，30，1： | 3 |
| 15 | Synthesis and evaluation of in vitro anticancer activity of novel solasodine derivatives显示文摘Solasodine 11 是有各种各样的生物活动的 steroidal 碱。此处, 8 新奇 solasodine 衍生物被综合,他们前列腺癌症房间增长上的效果在 vitro 被估计。在 antiproliferative 活动的重要改进在一些合成类似物之中被完成。特别地, 19 展出了大多数有势力对 PC-3 房间线的增长的禁止的效果(IC50 = 3.91 渭 m ol/L ) 。 | Xiao Ming Zha Fei Ran Zhang Jia Qi Shan Yi Hua Zhang Jun O. Liu Hong Bin Sun | 2010 | Chinese Chemical Letters2010，21，9： | 2 |
| 16 | Dielectric properties of reduced graphene oxide/polypropylene composites with ultralow percolation threshold显示文摘 | Dongrui Wang Xiaoman Zhang Jun-Wei Zha Jun Zhao Zhi-Min Dang Guo-Hua Hu | 2013 | Polymer2013，，7： | 1 |
| 17 | Antioxidant properties of polysaccharide fractions with different molecular mass extracted with hot - water from rice bran 显示文摘 | Xue - Qiang Zha Jun - Hui Wang Xue - Fei Yang | 2009 | Carbohydrate Polymers2009，，78： | 1 |
| 18 | Krüppel-like factor 4 negatively regulates β-catenin expression andinhibits the proliferation, invasion and metastasis of gastric cancer显示文摘 | Neng Zhang Jun Zhang Leiyuan Shuai Lang Zha Miao He Zhen Huang Ziwei Wang | 2012 | International Journal of Oncology2012，，6： | 1 |
| 19 | Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides显示文摘 | Jingwei Li Liang Feng Li Fan Yuan Zha Liangran Guo Qizhi Zhang Jun Chen Zhiqing Pang Yuchen Wang Xinguo Jiang Victor C. Yang Longping Wen | 2011 | Biomaterials2011，，21： | 1 |
| 20 | Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides显示文摘 | Jingwei Li Liang Feng Li Fan Yuan Zha Liangran Guo Qizhi Zhang Jun Chen Zhiqing Pang Yuchen Wang Xinguo Jiang Victor C. Yang Longping Wen | 2011 | Biomaterials2011，，21： | 1 |
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