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| 1 | Effect of Helicobacter pylori infection on gastric epithelial proliferation in progression from normal mucosa to gastric carcinoma显示文摘EfectofHelicobacterpyloriinfectionongastricepithelialproliferationinprogressionfromnormalmucosatogastriccarcinomaLIUWenZhon... | LIU Wen Zhong, ZHENG Xiong, SHI Yao, DONG Quan Jiang and XIAO Shu Dong | 1998 | World Journal of Gastroenterology1998，4，3： | 30 |
| 2 | Twenty-five years of change in scleractinian coral communities of Daya Bay (northern South China Sea) and its response to the 2008 AD extreme cold climate event显示文摘世界范围的珊瑚礁石逐渐地正在变得并且有害地影响在之上由包括的许多因素,重要气候变化,例如全球温暖和增加的 El Nino 南部的摆动活动。通常,珊瑚礁石的坚持,在特别低纬度,部分地,海运被管理不超过集体死亡能在发生的批评限制(∼30 ° C ) 的表面温度。因此,它被想珊瑚那生活在高纬度(即,当前更凉爽的海表面温度) 将多半比珊瑚生活在对假设未来温度增加更有利作出回应低纬度(即,当前更温暖的海表面温度) 。因而,高纬度的珊瑚社区可以有潜力在面临潜在的未来时为许多珊瑚种类充当 refugia 的区域全球温暖。Daya 海湾(22 ° 3 1 ′22 ° 5 0 ′N ) ,北华南海,包含几个高纬度的 non-reefal 珊瑚社区并且在这个区域以内代表 scleractinian 珊瑚的最在北方的分布之一。显著地, Daya 海湾经历了在整个过去的 50 年的在空和海表面温度中的戏剧的温暖。在这篇论文,我们在 Daya 海湾珊瑚社区分析 25 年变化,把两个基于历史性的调查并且我们的最近 2006 2008 地区性的生态的调查。我们的结果建议与预言相反,在过去的 25 年期间在在 Daya 海湾以内的珊瑚盖子有重要衰落(即,在到在 2008 的 15.3% 仅仅珊瑚盖子的 1983/1984 的 76.6% 珊瑚盖子) 。如此的变化也在最丰富的珊瑚种类反映重要移动,从 Acropora pruinosa 到 Favites abdita。大多数现代珊瑚社区变得以前在 15 和 30 年之间建立了,相应于增加的冬季海表面温度的一个时期。然而,很少的殖民地变得在最后 15 年以内建立了,尽管有温暖的一个更强烈的时期。由考虑另外的因素,我们假设那直接人为的影响,而非气候的事件,限制了发展,并且驾驶了衰落,最后 15 年里的 Daya 海湾珊瑚社区。Daya 海湾也在过去的 50 年期间受到了偶尔的极端冷事件,与最近的发生在 2008 年初(13 年 1 月 13 日 2 月) 。在 2008 冷事件期间,最低空气温度到达仅仅 6.6 ° C,和吝啬的海表面温度 2 月秋天,包括在 12.3 ° C 的六连续的天 < 14 ° C。显著地,海表面温度在通常在 scleractinian 珊瑚社区导致集体死亡的假设批评更低的温度阀值(∼13 ° C ) 下面掉落。令人惊讶地,我们的珊瑚社区调查,以前进行了两个(2007 年 8 月) 并且在以后(2008 年 2 月下旬) 极端 2008 冷事件,证明 Daya 海湾珊瑚生态系统恰好被影响在之上在冷时期期间。那些观察建议 Daya 海湾 scleractinian 珊瑚社区开发了改编到低海表面温度。总的来说,我们的数据支持高纬度的珊瑚社区例如 Daya 海湾,有的假设在潜在的未来的来临为 scleractinian 珊瑚充当 refugia 的区域的潜力全球温暖。 | CHEN TianRan YU KeFu SHI Qi LI Shu Gilbert J. Price WANG Rong ZHAO MeiXia CHEN TeGu ZHAO JianXin | 2009 | Chinese Science Bulletin2009，54，12： | 22 |
| 3 | Isolation,characterization,and phylogenic analysis of three new severe fever with thrombocytopenia syndrome bunyavirus strains derived from Hubei Province,China显示文摘Hubei Province is a major epidemic area of severe fever with thrombocytopenia syndrome bunyavirus(SFTSV) in China. However, to date, a few SFTSV strains have been isolated from Hubei Province, preventing effective studies of epidemic outbreaks. Here, we report three confirmed patients(2015–2016) with typical symptoms of severe fever with thrombocytopenia syndrome disease(SFTS) who were farmers resident in different regions in Hubei Province. Three new SFTSV strains were isolated from the serum samples of each patient. Characterization of viral growth properties showed that there were no significant differences in virus production. All strains were completely sequenced, and phylogenetic analysis showed that unlike the other strains from Hubei province, which belonged to the SFTSV C3 genotype, one of the three strains belonged to the SFTSV C2 genotype. These results suggested that multiple SFTSV genotypes have been circulating in Hubei Province, providing insights into SFTSV evolution and improving our understanding of SFTSV prevalence in Hubei Province. | Yanfang Zhang Shu Shen Junming Shi Zhengyuan Su Mingyue Li Wenjing Zhang Mengmeng Li Zhihong Hu Cheng Peng Xin Zheng Fei Deng | 2017 | Virologica Sinica2017，32，1： | 21 |
| 4 | Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing显示文摘Hepatocellular 癌(HCC ) 是癌症实质词法,基因并且 phenotypic 差异。然而,我们不理解在 intratumor 异质和肿瘤的联系词法 / 组织学的特征之间的关系。用介绍 96 个肿瘤房间(30-36 各个) 和 15 个正常的肝房间(5 各个) 的单个房间的整个染色体的定序,与联系 HBV 的 HCC 从三个男病人收集了,我们证实拷贝数字变化在 hepatocarcinogenesis 早发生,但是此后在整个肿瘤仍然保持相对稳定前进。重要地,我们证明特定的 HCC 能具有 monoclonal 或 polyclonal 起源。有汇合的 multinodular 形态学的肿瘤是典型 polyclonal 肿瘤并且显示最高的 intratumor 异质。除了 mutational 和拷贝数字侧面,我们把了用导出 HBV 的外国 genomic 标记的 HCC 的同种细胞的起源。在 monoclonal HCC,所有肿瘤单身者房间展出一样的 HBV 集成,显示 HBV 集成是一个早司机事件并且在肿瘤前进期间仍然保持极其稳定。另外,我们的结果显示那两个都转移,迟了的传播并且早播种当模特儿,在 HCC 有一个角色前进。尤其是,开始的克隆传播的早 intrahepatic 导致同步 multifocal 肿瘤的形成。同时,我们在 HCC 识别了潜在的司机基因 ZNF717,它展出变化的高频率在单个房间并且人口铺平,,通过调整 IL-6/STAT3 小径行动的肿瘤 suppressor。这些调查结果热点多重不同肿瘤在 HCC 的进化机制,它为特定的处理策略建议需要。 | Meng Duan, Shu Zhang, Zhichao Wang, Jieyi Shi, Longzi Liu, Xiaoying Wang, Aiwu Ke, Jian Zhou, Jia Fan, Qiang Gao Junfeng Hao, Chong Li Sijia Cui Daniel L Worthley Ya Cao Ruibin Xi Xiaoming Zhang Jian Zhou, Jia Fan Qiang Gao | 2018 | Cell Research2018，28，3： | 21 |
| 5 | Assessment of Heavy Metal Pollution in Estuarine Surface Sediments of Tangxi River in Chaohu Lake Basin显示文摘A total of 30 surface sediments samples from the estuary wetland of the Tangxi River, Chaohu Lake Basin were obtained and tested.Enrichment factor(EF) and geoaccumulation index(I geo ) as well as multivariate statistical analysis methods including Factor Analysis(FA) and Hierarchical Cluster Analysis(HCA) were applied for the assessment of heavy metal pollution in surface sediments.The results of EF values show that the pollution of copper(Cu) and cadmium(Cd) occurs in the estuarine sediments, and that zinc(Zn), lead(Pb) and chrome(Cr) may originate from crustal materials or natural weathering process.The mean EF values of the five heavy metals are in the decreasing order:Cu>Cd>Zn>Pb>Cr.Based on the I geo of target heavy metals, the surface sediments collected from the study area can be approximately categorized as unpolluted with Zn, Pb and Cr, and moderately polluted with Cu and Cd.The degree of heavy metal pollution decreases in the order of Cu>Cd>Zn>Pb>Cr.Three groups of pollution factors are presented from FA:Zn-TOC, Cu-Cd and Cr-Pb, which respectively accounte for 27.22%, 25.20% and 21.05% of variance.By means of HCA, a total number of seven groups are distinguished from 30 sampling sites.Results indicate that Cu and Cd are the prior controlled pollutants in the estuarine sediments of the Tangxi River. | LI Ruzhong SHU Kun LUO Yueying SHI Yong | 2010 | Chinese Geographical Science2010，20，1： | 18 |
| 6 | Percutaneous catheter drainage in combination with choledochoscope-guided debridement in treatment of peripancreatic infection显示文摘AIM:To introduce and evaluate the new method used in treatment of pancreatic and peripancreatic infections secondary to severe acute pancreatitis(SAP).METHODS:A total of 42 SAP patients initially underwent ultrasound-guided percutaneous puncture and catheterization.An 8-Fr drainage catheter was used to drain the infected peripancreatic necrotic foci for 3-5 d.The sinus tract of the drainage catheter was expanded gradually with a skin expander,and the 8-Fr drainage catheter was replaced with a 22-Fr drainage tube after 7-10 d.Choledochoscope-guided debridement was performed repeatedly until the infected peripancreatic tissue was effectively removed through the drainage sinus tract.RESULTS:Among the 42 patients,the infected peripancreatic tissue or abscess was completely removed from 38 patients and elective cyst-jejunum anastomosis was performed in 4 patients due to formation of pancreatic pseudocysts.No death and complication occurred during the procedure.CONCLUSION:Percutaneous catheter drainage in combination with choledochoscope-guided debridement is a simple,safe and reliable treatment procedure for peripancreatic infections secondary to SAP. | Tang, Li-Jun Wang, Tao Cui, Jian-Feng Zhang, Bing-Yin Li, Shi Li, Dong-Xuan Zhou, Shu | 2010 | World Journal of Gastroenterology2010，16，4： | 17 |
| 7 | Assessment of coral bleaching using symbiotic zooxanthellae density and satellite remote sensing data in the Nansha Islands,South China Sea显示文摘Coral bleaching,characterized by a significant loss of symbiotic zooxanthellae,is the primary cause of mass coral mortality and reef degradation throughout the world.The characteristics,processes,and resistance of corals to bleaching varies significantly and is dependent on environmental conditions.We documented a mass coral bleaching event in June 2007 at the Meiji and Zhubi Reefs,Nansha Islands (NS),South China Sea using ecological surveys and measurement of coral zooxanthellae density and sea surface temperatures (SST).More than 35 species of corals (between 0-20 m in depth) were bleached.These bleached corals accounted for 15.6% of total corals in the investigated quadrats.The branching corals Pocillopora and Acropora were the most vulnerable species whereas the massive corals Porites and Favia were more tolerant of the high SSTs.Surprisingly,we found no evidence of bleaching in Agariciidae corals suggesting that this family is resistant to thermal stresses.The bleached corals had lost 72%-90% of their symbiotic zooxanthellae.Furthermore,corals that had no visual signs of bleaching had also lost 31%-53% of their zooxanthellae suggesting that most corals were experiencing the early stage of bleaching.The monthly mean SST during June 2007 was 30.8°C,the highest since 1998.Based on measurements of SST and the Hotspots and DHW data (NOAA),we conclude that it the extremely high SSTs triggered this coral bleaching event.Our results suggest that the previously accepted temperature thresholds used to predict coral bleaching based on satellite data are likely to underestimate the extent and intensity of coral bleaching,at least in the NS. | LI Shu,YU KeFu,CHEN TianRan,SHI Qi & ZHANG HuiLing CAS Key Laboratory of Marginal Sea Geology,South China Sea Institute of Oceanology,Chinese Academy of Sciences Guangzhou 510301,China | 2011 | Chinese Science Bulletin2011，56，10： | 15 |
| 8 | Effect of Kuanxiong Aerosol(宽胸气雾剂)on Patients with Angina Pectoris:A Non-inferiority Multi-center Randomized Controlled Trial显示文摘Objective: To evaluate the effect and safety of Kuanxiong Aerosol(宽胸气雾剂, KA) on patients with angina pectoris. Methods: Block randomization was performed to randomly allocate 750 patients into KA(376 cases) and control groups(374 cases). During an angina attack, the KA group received 3 consecutive sublingual sprays of KA(0.6 m L per spray). The control group received 1 sublingual nitroglycerin tablet(NT, 0.5 mg/tablet). Log-rank tests and Kaplan-Meier estimations were used to estimate the angina remission rates at 6 time-points after treatment(1, 2, 3, 4, 5, and >5 min). Logistic regression analysis was performed to observe the factors influencing the rate of effective angina remission, and the remission rates and incidences of adverse reactions were compared for different Canadian Cardiovascular Society(CCS) classes of angina. Results: The 5-min remission rates in the KA and control groups were not significantly different(94.41% vs. 90.64%, P>0.05). The angina CCS class significantly influenced the rate of remission (95% confidence interval = 0.483–0.740, P<0.01). In the CCS subgroup analysis, the 3-and 5-min remission rates for KA and NT were similar in the CCSⅠ and Ⅳ subgroups(P>0.05), while they were significantly better for KA in the CCSⅡ and Ⅲ subgroups(P<0.05 or P<0.01). Furthermore, the incidence of adverse reactions was significantly lower in the KA group than in the control group for the CCSⅡ and Ⅲ subgroups(9.29% vs. 26.22%, 10.13% vs. 20.88%, P<0.05 or P<0.01). Conclusions: KA is not inferior to NT in the remission of angina. Furthermore, in CCSⅡ and Ⅲ patients, KA is superior to NT, with a lower incidence of adverse reactions. | YANG Qiao-ning BAI Rui-na DONG Guo-ju GE Chang-jiang ZHOU Jing-min HUANG Li HE Yan WANG Jun REN Ai-hua HUANG Zhan-quan ZHU Guang-li LU Shu XIONG Shang-quan XIAN Shao-xiang ZHU Zhi-jun SHI Da-zhuo LU Shu-zheng LI Li-zhi CHEN Ke-ji | 2018 | Chinese Journal of Integrative Medicine2018，24，5： | 15 |
| 9 | Genetic pattern of belt-wide petroliferous phenomenon in the eastern Pearl River Mouth Basin and its practical application显示文摘The Pearl River Mouth Basin(PRMB) covers an area of approximately 20×104 km2. However, oil-gas fields detected in this area thus far are highly concentrated and controlled predominantly by second-order structural belts, the seven largest of which aggregate proved oil reserves of 7.7×108 m3, accounting for 86% of the total discovered reserve in the basin. These second-order structures have one common phenomenon: oil is contained in all traps present in them. In other words, they are all belt-wide petroliferous reservoirs. Research has identified eight types of second-order structural belts under two categories in the eastern PRMB. Their petroliferous properties are subject to three typical constraints: petroliferous properties of subsags hosting these structural belts, locations of these belts in the petroleum system, and availability of traps prior to the hydrocarbon expulsion and migration. The formation and distribution of oil reservoirs in these belts are characterized by subsag–belt integration and 'three-in-one'. The former indicates that sags and the second-order structural belts within the supply range of the sags constitute the basic units of hydrocarbon accumulations and are therefore inseparable. The latter indicates that a belt-wide petroliferous second-order structural belt always contains three important elements: hydrocarbon richness, effective pathway and pre-existing traps. | Shi Hesheng Dai Yiding Liu Lihua Shu Yu Mei Lianfu | 2014 | Petroleum Science2014，11，1： | 14 |
| 10 | Preliminary study on the production of transgenic mice harboring hepatitis B virus X gene显示文摘INTRODUCTIONDespiteoverwhelmingepidemiologicalevidencelinkingpersistentHepatitisBVirus(HBV)infectionandthedevelopmentofhepato... | ZHU Huan Zhang 1, CHENG Guo Xiang 2, CHEN Jian Qu 2, KUANG Shu Yuan 3, CHENG Yong 2, ZHANG Xin Li 1, Ll Hou Da 2, XU Shao Fu 2, SHI Jing Quan 1, QIAN Geng Sun 3 and GU Jian Ren 3 | 1998 | World Journal of Gastroenterology1998，4，6： | 14 |
| 11 | NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens显示文摘像点头的受体(NLR ) 是对微生物引起的感染在天生的免疫起关键作用的细胞内部的蛋白质的一个家庭。NLRC5, NLR 家庭的最大的成员,最近吸引了许多注意。然而,在 vitro,研究在主人防卫并且在调整有免疫力的发信号的小径关于 NLRC5 的角色报导了不一致的结果。在里面 NLRC5 的 vivo 功能仍然保持未知。这里,我们报导 NLRC5 是对在 vivo 的细胞内部的病原体的主人防卫的一个批评管理者。NLRC5 明确地为涉及 MHC 一级抗原表示的基因的表示被要求。NLRC5 缺乏的老鼠显示了在 MHC 一级基因和伴随物失败的表示的一个深刻缺点激活 L。monocytogenes 特定的 CD8 + T 房间回答,包括的激活,增长和 cytotoxicity,和变异的老鼠更产生病原体感染。调停 NLRP3 的 inflammasome 激活部分也在 NLRC5 缺乏的老鼠被损害。然而, NLRC5 为 NF-κ 的导致病原体的表示是非必需的; B 依赖的支持 inflammatory 基因以及类型我干扰素基因。因此, NLRC5 极其调整 MHC 一级抗原表示控制细胞内部的病原体感染。 | Yikun Yao Yalong Wang Fuxiang Chen Yin Huang Shu Zhu Qibin Leng Hongyan Wang Yufang Shi Youcun Qian | 2012 | Cell Research2012，22，5： | 13 |
| 12 | Interferon and lamivudine combination therapy versus lamivudine monotherapy for hepatitis B e antigen-negative hepatitis B treatment:a meta-analysis of randomized controlled trials显示文摘BACKGROUND:It has been demonstrated that only a minority of patients with hepatitis B e antigen(HBeAg)-negative chronic hepatitis B(CHB) obtain a sustained response after either interferon(IFN) or nucleos(t)ide analogue monotherapy.Therefore,combination therapy of drugs with synergistic antiviral effects was proposed to have a sustained response in these patients.We compared the effect and safety of lamivudine monotherapy and its combination with IFN including conventional interferon(CON-IFN) and pegylated interferon(PEG-IFN) for HBeAg-negative CHB patients.DATA SOURCES:A group of three independent reviewers identified 9 eligible randomized controlled trials through electronic searches(MEDLINE,OVID,EMBASE,the Cochrane Library Clinical Trials Registry,and the Chinese Medical Database),manual searches,and contact with experts.Sustained virological and biochemical responses were defined as primary efficacy measures.We performed quantitative meta-analyses to assess differences between CON-IFN plus lamivudine combination and lamivudine monotherapy groups.RESULTS:No greater sustained virological and biochemical rates were found in patients receiving CON-IFN/lamivudine combination therapy [29.1% vs.26.7%,odds ratio(OR)=0.98,95% confidence interval(CI) 0.65-1.50,P=0.94,and 41.8% vs.40.3%,OR=1.13,95% CI 0.78-1.65,P=0.51,respectively],though a reduced YMDD mutation rate was achieved in the combination group [8.39% vs.30.0%,OR=0.16,95% CI 0.076-0.33,P<0.001].However,data from one PEG-IFN trial showed greater sustained virological and biochemical rates in patients receiving combination therapy [response rate 19.5% vs.6.6%,OR=3.42,95% CI 1.71-6.84,P<0.001 and 60.0% vs.44.2%,OR=1.88,95% CI 1.23-2.85,P=0.003,respectively].CONCLUSIONS:Addition of CON-IFN to lamivudine did not improve treatment efficacy but suppressed YMDD mutation by lamivudine.Combination of PEG-IFN and lamivudine might increase the sustained response,and further clinical trials are needed for confirmation. | Shi, Yu Wu, Yi-Hua Shu, Zhe-Yue Zhang, Wan-Jun Yang, Jun Chen, Zhi | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，5： | 12 |
| 13 | Interspecies and spatial diversity in the symbiotic zooxanthellae density in corals from northern South China Sea and its relationship to coral reef bleaching显示文摘珊瑚礁石漂白被共生 zooxanthellae, zooxanthellae 色素沉着的损失,或两个的逐出通常描绘。我们收集了分别地,在海南岛的 Sanya 和广东省的 Daya 海湾从 Luhuitou 和 Xiaodonghai 包括礁石大楼珊瑚的 21 个类的 39 种类的 128 件样品并且分析了共生 zooxanthellae 人口密度。结果显示出那:( 1 )共生 zooxanthella 密度从 0.67x10 ( 6 )变化,显示 8.48x10 ( 6 )房间/厘米( 2 )重要内部种可变性,与通常相对有更少的 zooxanthellae 的分支珊瑚(从 0.67x10 ( 6 ) 到 2.47x10 ( 6 )房间/厘米( 2 ))比巨大的种类(从 1.0x10 ( 6 )到 8.48x10 ( 6 )房间/厘米( 2 ));(2 ) 在 4 m 水深度以内住在的珊瑚比那些生活在底部有共生 zooxanthellae 的高水平(类似于 7 m 深度) 礁石区域;(3 ) 在在从相对高的纬度 Daya 海湾的珊瑚之间的 zooxanthellae 密度没有可辨别的差别(类似于 22 度 N ) 并且那些从相对低的纬度 Sanya (类似于 18 度 N ) 在可比较的海表面温度(SST ) ;(4 ) 在里面部分 -- 漂白珊瑚, zooxanthellae 的密度显示出下列顺序:看似健康的部分 > 漂白半的部分 > 漂白部分。基于上述结果,我们建议(1 ) 分叉之间的 zooxanthellae 密度差别和巨大的珊瑚种类是分叉的珊瑚对比巨大的珊瑚漂白更脆弱的主要原因。例如,共生 zooxanthellae 层次在分叉的 Acropora 和 Pocillopora 珊瑚并且这样是低的这些珊瑚更产生漂白和死亡;(2 ) 共生 zooxanthellae 密度能被环境条件也影响,例如沉积负担,潜水相关的混浊,和水产业相关的硝酸盐和磷酸盐输入,并且他们的增加可以在珊瑚减少共生 zooxanthellae 密度。 | LI Shu YU KeFu SHI Qi CHEN TianRan ZHAO MeiXia ZHAO JianXin | 2008 | Chinese Science Bulletin2008，53，2： | 12 |
| 14 | Four new constituents from Taraxacum mongolicum显示文摘二新黄酮 glycosides ,isoetin-7-O-β- d-glucopyranosyl-2 ′- O -- l-arabinopyranoside ( 1 )和isoetin-7-O-β- d-glucopyranosyl-2 ′- O -- d-glucopyranoside ( 2 ),新 lignan , mongolicumin A ( 3 ),和新 guaianolide , mongolicumin B ( 4 )从薄公英属 mongolicum 的天线部分被孤立。他们的结构被主要阐明光谱分析。 | Shu Yun Shi Qi Zhou Hua Peng Chang Xin Zhou Ming Hui Hu Qiao Feng Tao Xiao Jiang Hao Joachim Stoeckigt Yu Zhao | 2007 | Chinese Chemical Letters2007，18，11： | 11 |
| 15 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021，10，2： | 11 |
| 16 | Effect of dry density on ^(125)I diffusion in GMZ bentonite显示文摘Gaomiaozi(GMZ) bentonite is regarded as the favorable candidate backfilling material for a potential repository in China.It is important to understand the diffusion behavior of 125 I in GMZ bentonite and compare the diffusion behavior in GMZ and other types of bentonite like MX-80,Avonlea,etc.Therefore,through-and out-diffusion experiments were conducted to obtain the effective diffusion coefficient(D e) and distribution coefficient(K d).A computer code named Fitting for diffusion coefficient(FDP) was used for the experimental data processing and theoretical modeling.At the dry density of GMZ bentonite from 1600-2000 kg/m 3,the D e values of 125 I were(2.4-20.4) × 10-12 m 2 /s and K d values were constants.At dry density above 1800 kg/m 3,the diffusion behaviors were almost the same,indicating that the anion exclusion was ineffective.Out-diffusion results showed that the species of 125 I may be changed during the diffusion processing.It was probably caused by some organic matters or reducing substances in GMZ bentonite.Since the main composition of bentonite is montmorillonite,similar diffusion parameters were obtained in GMZ and other types of bentonite.The relationship of D e and accessible porosity(acc) could be described by Archie's law with exponent n = 1.2-2.8 for 125 I diffusion in bentonite,whereas n = 2.0 in GMZ bentonite.Furthermore,bentonite with the dry density of 1800 kg/m 3 was proposed as the backfilling materials used in the construction of high level radioactivity waste repository. | WU Tao LI JinYing DAI Wei XIAO GuoPing SHU FuJun YAO Jun SU YuLan SHI Lei | 2012 | Science China Chemistry2012，55，9： | 11 |
| 17 | Hydrographic field investigations in the Northern South China Sea by open cruises during 2004-2013显示文摘 | Lili Zeng Qiang Wang Qiang Xie Ping Shi Lei Yang Yeqiang Shu Ju Chen Dandan Sui Yunkai He Rongyu Chen Dongxiao Wang | 2015 | Science Bulletin2015，60，6： | 10 |
| 18 | Tick-Borne Viruses显示文摘Ticks are important vectors for the transmission of pathogens including viruses.The viruses carried by ticks also known as tick-borne viruses(TBVs),contain a large group of viruses with diverse genetic properties and are concluded in two orders,nine families,and at least 12 genera.Some members of the TBVs are notorious agents causing severe diseases with high mortality rates in humans and livestock,while some others may pose risks to public health that are still unclear to us.Herein,we review the current knowledge of TBVs with emphases on the history of virus isolation and identification,tick vectors,and potential pathogenicity to humans and animals,including assigned species as well as the recently discovered and unassigned species.All these will promote our understanding of the diversity of TBVs,and will facilitate the further investigation of TBVs in association with both ticks and vertebrate hosts. | Junming Shi Zhihong Hu Fei Deng Shu Shen | 2018 | Virologica Sinica2018，33，1： | 10 |
| 19 | Wrist-ankle acupuncture and Fluoxetine in the treatment of post-stroke depression: a randomized controlled clinical trial显示文摘OBJECTIVE: To investigate the effects of WAA combined with fluoxetine in the clinical treatment of post-stroke depression(PSD).METHODS: In this randomized, controlled and single-blind trial, 105 PSD patients who met the inclusion criteria were randomly divided into three equal groups: Thin wrist-ankle acupuncture(WAA)group(Thin WAA needle + Fluoxetine), Thick WAA group(Thick WAA needle + Fluoxetine), and Sham WAA group(sham WAA needle + Fluoxetine). In this trial, the primary outcome was Hamilton Depression Scale(HAMD), while the secondary outcomes included Zung self-rating depression scale(SDS) and World Health Organization Quality of Life BREF(QQL).RESULTS: Ninety nine PSD patients completed all the treatment. The HAMD scores and SDS scores of all the three groups decreased after treatment(P <0.05);thick WAA group and thin WAA group decreased more obviously than the sham WAA group(P < 0.05). There was no significant difference between the QQL scores of the three groups(P >0.05). There was no significant difference in the scores of the three scales between the thick wrist ankle needles and the thin wrist ankle needles(P >0.05).CONCLUSION: The present study showed that WAA combined with fluoxetine can relieve the symptoms of depression after stroke. WAA therapy could improve the antidepressant effect of fluoxetine. | You Yanli Zhang Tianfang Shu Shi Qian Xiaolu Zhou Shuang Yao Fei | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 10 |
| 20 | A Five-year Surveillance of Carbapenemase-producing Klebsiella pneumoniae in a Pediatric Hospital in China Reveals Increased Predominance of NDM-1显示文摘Objective To characterize carbapenem(CPM)-non-susceptible Klebsiel a pneumoniae(K. pneumoniae) and carbape-nemase produced by these strains isolated from Beijing Children's Hospital based on a five-year surveillance. Methods The Minimal Inhibition Concentration values for 15 antibiotics were assessed using the Phonix100 compact system. PCR amplification and DNA sequencing were used to detect genes encoding carbapenemases. WHONET 5.6 was finally used for resistance analysis. Results In total, 179 strains of CPM-non-susceptible K. pneumoniae were isolated from January, 2010 to December, 2014. The rates of non-susceptible to imipenem and meropenem were 95.0% and 95.6%, respectively. In the 179 strains, 95(53.1%) strains carried the blaIMP gene, and IMP-4 and IMP-8 were detected in 92(96.8%) and 3(3.2%) IMP-producing isolates, respectively. 65(36.3%) strains carried the blaNDM-1 gene. 6(3.4%) strains carried the blaKPC gene, and KPC-2 were detected in 6 KPC-producing isolates. In addition, New Delhi-Metallo-1(NDM-1) producing isolates increased from 7.1% to 63.0% in five years and IMP-4 producing isolates decreased from 75.0% to 28.3%. Conclusion High frequencies of multiple resistances to antibiotics were observed in the CPM-non-susceptible K. pneumoniae strains isolated from Beijing Children's Hospital. The production of IMP-4 and NDM-1 metallo-β-lactamases appears to be an important mechanism for CPM-nonsusceptible in K. pneumoniae. | DONG Fang LU Jie WANG Yan SHI Jin ZHEN Jing Hui CHU Ping ZHEN Yang HAN Shu Jing GUO Yong Li SONG Wen Qi | 2017 | Biomedical and Environmental Sciences2017，30，8： | 10 |
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