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| 1 | LMM5.1 and LMM5.4,two eukaryotic translation elongation factor 1Alike gene family members,negatively affect cell death and disease resistance in rice显示文摘Lesion mimic mutant(LMM) genes, stimulating lesion formation in the absence of pathogens, play significant roles in immune response. In this study, we characterized a rice lesion mimic mutant, lmm5,which displayed light-dependent spontaneous lesions. Additionally, lmm5 plants exhibited enhanced resistance to all of the tested races of Magnaporthe oryzae and Xanthomonas oryzae pv. oryzae(Xoo) by increasing the expression of defense-related genes and the accumulation of hydrogen peroxide. Genetic analysis showed that the lesion mimic phenotype of lmm5 was controlled by two genes, lmm5.1 and lmm5.4, which were isolated with a map-based cloning strategy. Remarkably, LMM5.1 and LMM5.4 share a 97.4% amino acid sequence identity, and they each encode a eukaryotic translation elongation factor 1A(e EF1A)-like protein. Besides, LMM5.1 and LMM5.4 were expressed in a tissue-specific and an indicaspecific manner, respectively. In addition, high-throughput m RNA sequencing analysis confirmed that the basal immunity was constitutively activated in the lmm5 mutant. Taken together, these results suggest that the homologous e EF1A-like genes, LMM5.1 and LMM5.4, negatively affect cell death and disease resistance in rice. | Jiying Zhao Pengcheng Liu Chunrong Li Yanyan Wang Lequn Guo Guanghuai Jiang Wenxue Zhai | 2017 | Journal of Genetics and Genomics2017，44，2： | 10 |
| 2 | The normal cell proliferation and wound healing effect of polysaccharides from Ganoderma amboinense显示文摘To study the cell proliferation and wound healing activity of polysaccharides from Ganoderma amboinense(GAMPS),the polysaccharide was extracted by water extraction and alcohol precipitation method,and its monosaccharide composition and molecular weight were analyzed.The effects of different concentrations of GAMPS on the cell proliferation were determined by cell survival rate test,and the wound healing ability of GAMPS to NIH/3T3 cells was detected.The preliminary evaluation of the antioxidant ability of GAMPS was conducted by the oxygen radical absorbance capacity(ORAC).The results showed that the GAMPS was composed of glucose,mannose,and galactose at a molar ratio of 67.62:14.07:7.50,and the weightaverage molecular weights were 5.439×10^(6) and 1.704×10^(5) g/mol by using high-performance gel-permeation chromatography-multiple angle laser scatter(HPGPC-MALS)analysis.GAMPS(0.2μg/μL)showed the strongest proliferation ability to THP-1 cells,with cell survival rate of 178.7%.The wound healing effect of GAMPS(0.1μg/μL)was obvious on NIH/3T3 and 3.75μg/μL of GAMPS showed the strongest total antioxidant ability.All the results indicate that GAMPS promotes cell proliferation,and has cell wound healing effect and strong antioxidant activity.The results provide theoretical foundation for the development and utilization of GAMPS. | Shuangzhi Zhao Ming Lei Hui Xu Hailun He Alexander Suvorov Junhua Wang Jiying Qiu Qingxin Zhou Jinyu Yang Leilei Chen | 2021 | Food Science and Human Wellness2021，10，4： | 4 |
| 3 | Acetytation of ACAP4 regutates CCL18-elicited breast cancer cell migration and invasion显示文摘Tumor metastasis represents the main causes of cancer-related death.Our recent study showed that chemokine CCL18 secreted from tumor-associated macrophages regulates breast tumor metastasis,but the underlying mechanisms remain less clear.Here, we show that ARF6 GTPase-activating protein ACAP4 regulates CCL18-elicited breast cancer cell migration via the acetyltransferase PCAF-mediated acetylation.CCL18 stimulation elicited breast cancer cell migration and invasion via PCAF-dependent acetylation.ACAP4 physically interacts with PCAF and is a cognate substrate of PCAF during CCL18 stimulation.The acetylation site of ACAP4 by PCAF was mapped to Lys311 by mass spectrometric analyses.Importantly,dynamic acetylation of ACAP4 is essential for CCL18-induced breast cancer cell migration and invasion,as overexpression of the persistent acetylation-mimicking or nonacetylatable ACAP4 mutant blocked CCL18-elicited cell migration and invasion.Mechanistically,the acetylation of ACAP4 at Lys311 reduced the lipid-binding activity of ACAP4 to ensure a robust and dynamic cycling of ARF6-ACAP4 complex with plasma membrane in response to CCL18 stimulation.Thus,these results present a previously undefined mechanism by which CCL18-elicited acetylation of the PH domain controls dynamic interaction between ACAP4 and plasma membrane during breast cancer cell migration and invasion. | Xiaoyu Song Wei Liu Xiao Yuan Jiying Jiang Wanjuan Wang McKay Mullen Xuannv Zhao Yin Zhang Fusheng Liu Shihao Du Adeel Rehman Ruijun Tian Jian Li Andra Frost Zhenwei Song Hadiyah-Nicole Green Calmour Henry Xing Liu Xia Ding Dongmei Wang Xuebiao Yao | 2018 | Journal of Molecular Cell Biology2018，10，6： | 3 |
| 4 | Human visual system based adaptive digital image watermarking 显示文摘 | Qi Huiyan Zheng Dong Zhao Jiying | 2008 | Singal Processing2008，88，1： | 1 |
| 5 | RST Invariant image watermarking algorithm with mathematical modeling and analysis of the watermarking processes显示文摘 | ZHENG Dong WANG Sha ZHAO Jiying | 2009 | IEEE Transactions Image processing2009，18，5： | 1 |
| 6 | Human visual system based adaptive digital image watermarking显示文摘 | Qi Huaiyan Zheng Dong Zhao Jiying | 2008 | Signal Processing2008，88，1： | 1 |
| 7 | RST invariant digital image watermarking based on log-polar mapping and phase correlation显示文摘 | Zheng Dong Zhao Jiying | 2003 | IEEE Trans on Circuits and Systems for Video Technology2003，13，8： | 1 |
| 8 | Identification and Evaluation of UV-Tolerant Streptomyces araujoniae Strain Isolated from Tibet Plateau Soil as Biocontrol Agent Against Rice Blast显示文摘Rice blast is the most important and destructive crop disease in rice paddies and poses a continued threat to the production of rice(Rossman et al,1990;Khush,2005;Wang et al,2018;Chen et al,2019).Biological control is given increasing attentions on the control of rice blast for its outstanding advantages,such as safety,low-cost,and sustainability and environmentally friendly attributes.Streptomyces Waksman&Henrici is an important actinomycete genus that is well known for its biological control potential.S.araujoniae is a relatively new species and known for its antagonistic effects against many phytopathogenic fungi(da Silva et al,2013).However,there is no report about the antagonistic efiect of S.araujoniae on Magnaporthe oryzae,much less the disease control effects at the field experiment level. | Liu Lianmeng Zhao Yuan Lu Jiying Liang Mengqi Sun Lei Gao Jian Wang Ling Hou Yuxuan Huang Shiwen | 2020 | Rice science2020，27，5： | 1 |
| 9 | Human visual system based adaptive digital image watermarking显示文摘 | Huiyan Qi Dong Zheng Jiying Zhao | 2008 | Signal Processing2008，，88： | 1 |
| 10 | Human visual system basedadaptive digital image watermarking显示文摘 | Qi Huiyan Zheng Dong Zhao Jiying | | Signal Processing ElsevierNorth-Holland 200S0，1，： | 1 |
| 11 | A new video watermarking algo- rithm based on 1D DFT and radon transform 显示文摘 | Liu Yan Zhao Jiying | 2010 | Signal Processing2010，90，1： | 1 |
| 12 | An image quality evaluation method based on digital watermarking显示文摘 | Wang Sha Zheng Dong Zhao Jiying | 2007 | IEEE transactions on circuits and systems for video technology2007，17，1： | 1 |
| 13 | Human visual system based adaptive digital image watermarking显示文摘 | QI HUIYAN ZHENG DONG ZHAO JIYING | 2008 | Signal Processing2008，88，1： | 1 |
| 14 | Removal of Cesium From Low-level Radioactive Wastew aters Using M agnetic Potassium Titanium Hexacyanoferrate显示文摘 | ZHANG Hengxuan ZHAO Xuan WEI Jiying | 2015 | Chemical Engineering Journal2015，275，26： | 1 |
| 15 | Human Visual SystemBased Adaptive Digital Image Watermarking显示文摘 | Qi Huiyan Zheng Dong Zhao Jiying | 2008 | Signal Processing2008，88，1： | 1 |
| 16 | RST invariant image watermarking algorithm with mathematical modeling and a- nalysis of the watermarking processes 显示文摘 | Zheng Dong Wang Sha Zhao Jiying | 2009 | IEEE Transac- tions on Image Processing2009，18，5： | 1 |
| 17 | Acetylation of ezrin regulates membrane–cytoskeleton interaction underlying CCL18-elicited cell migration显示文摘Ezrin,a membrane–cytoskeleton linker protein,plays an essential role in cell polarity establishment,cell migration,and division.Recent studies show that ezrin phosphorylation regulates breast cancer metastasis by promoting cancer cell survivor and promotes intrahepatic metastasis via cell migration.However,it was less characterized whether there are additional post-translational modifications and/or post-translational crosstalks on ezrin underlying context-dependent breast cancer cell migration and invasion.Here we show that ezrin is acetylated by p300/CBP-associated factor(PCAF)in breast cancer cells in response to CCL18 stimulation.Ezrin physically interacts with PCAF and is a cognate substrate of PCAF.The acetylation site of ezrin was mapped by mass spectrometric analyses,and dynamic acetylation of ezrin is essential for CCL18-induced breast cancer cell migration and invasion.Mechanistically,the acetylation reduced the lipid-binding activity of ezrin to ensure a robust and dynamic cycling between the plasma membrane and cytosol in response to CCL18 stimulation.Biochemical analyses show that ezrin acetylation prevents the phosphorylation of Thr567.Using atomic force microscopic measurements,our study revealed that acetylation of ezrin induced its unfolding into a dominant structure,which prevents ezrin phosphorylation at Thr567.Thus,these results present a previously undefined mechanism by which CCL18-elicited crosstalks between the acetylation and phosphorylation on ezrin control breast cancer cell migration and invasion.This suggests that targeting PCAF signaling could be a potential therapeutic strategy for combating hyperactive ezrin-driven cancer progression. | Xiaoyu Song Wanjuan Wang Haowei Wang Xiao Yuan Fengrui Yang Lingli Zhao McKay Mullen Shihao Du Najdat Zohbi Saravanakumar Muthusamy Yalei Cao Jiying Jiang Peng Xia Ping He Mingrui Ding Nerimah Emmett Mingming Ma Quan Wu Hadiyah-Nicole Green Xia Ding Dongmei Wang Fengsong Wang Xing Liu | 2020 | Journal of Molecular Cell Biology2020，12，6： | 1 |
| 18 | MgNiO-based metal-semiconductor-metal ultraviolet photodetector显示文摘 | Zhao Yanmin Zhang Jiying Jiang Dayong | 2009 | J Phys D:Appl Phys2009，42，09： | 1 |
| 19 | Human visual system based adaptive digital image watermarking 显示文摘 | Huiyan Qi Dong Zheng Jiying Zhao | 2008 | Signal Processing2008，88，1： | 1 |
| 20 | Mitochondrial 12S rRNA variants in 1642 Han Chinese pediatric subjects with aminoglycoside-induced and nonsyndromic hearing loss显示文摘 | Jianxin Lu Zhiyuan Li Yi Zhu Aifen Yang Ronghua Li Jing Zheng Qin Cai Guanghua Peng Wuwei Zheng Xiaowen Tang Bobei Chen Jianfu Chen Zhisu Liao Li Yang Yongyan Li Junyan You Yu Ding Hong Yu Jindan Wang Dongmei Sun Jianyue Zhao Ling Xue Jiying Wang Min-Xin | 2010 | Mitochondrion2010，，4： | 1 |
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