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| 1 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 2 | Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review显示文摘Background:The coronavirus disease(COVID-19)has been identified as the cause of an outbreak of respiratory illness in Wuhan,Hubei Province,China beginning in December 2019.As of 31 January 2020,this epidemic had spread to 19 countries with 11791 confirmed cases,including 213 deaths.The World Health Organization has declared it a Public Health Emergency of International Concern.Methods:A scoping review was conducted following the methodological framework suggested by Arksey and O'Malley.In this scoping review,65 research articles published before 31 January 2020 were analyzed and discussed to better understand the epidemiology,causes,clinical diagnosis,prevention and control of this virus.The research domains,dates of publication,journal language,authors'affiliations,and methodological characteristics were included in the analysis.All the findings and statements in this review regarding the outbreak are based on published information as listed in the references.Results:Most of the publications were written using the English language(89.2%).The largest proportion of published articles were related to causes(38.5%)and a majority(67.7%)were published by Chinese scholars.Research articles initially focused on causes,but over time there was an increase of the articles related to prevention and control.Studies thus far have shown that the virus7 origination is in connection to a seafood market in Wuhan,but specific animal associations have not been confirmed.Reported symptoms include fever,cough,fatigue,pneumonia,headache,diarrhea,hemoptysis,and dyspnea.Preventive measures such as masks,hand hygiene practices,avoidance of public contact,case detection,contact tracing,and quarantines have been discussed as ways to reduce transmission.To date,no specific antiviral treatment has proven effective;hence,infected people primarily rely on symptomatic treatment and supportive care.Conclusions:There has been a rapid surge in research in response to the outbreak of COVID-19.During this early period,published research primarily explored the epidemiology,causes,clinical manifestation and diagnosis,as well as prevention and control of the novel coronavirus.Although these studies are relevant to control the current public emergency,more high-quality research is needed to provide valid and reliable ways to manage this kind of public health emergency in both the short-and long-term. | Sasmita Poudel Adhikari Sha Meng Yu-Ju Wu Yu-Ping Mao Rui-Xue Ye Qing-Zhi Wang Chang Sun Sean Sylvia Scott Rozelle Hein Raat Huan Zhou | 2020 | Infectious Diseases of Poverty2020，9，2： | 28 |
| 3 | Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis显示文摘 | Yao Chen Yuxuan Zheng Yun Gao Zhen Lin Suming Yang Tongtong Wang Qiu Wang Nannan Xie Rong Hua Mingxi Liu Jiahao Sha Michael D. Griswold Jinsong Li Fuchou Tang Ming-Han Tong | 2018 | Cell Research2018，28，9： | 26 |
| 4 | Effects and mechanism of glucagon-like peptide-1 on injury of rats cardiomyocytes induced by hypoxia-reoxygenation显示文摘背景尽管在类型 2 糖尿病 mellitus 的象glucagon一样 peptide-1 ( GLP-1 )的 insulinotropic 角色被证实了,它在大部分, unknown.This 学习试图在心脏的 myocytes 由 hypoxia-reoxygenation ( H/R )和可能的 mechanisms.Methods 导致了的老鼠的损害上决定 GLP-1 的效果的 cardioprotection 遗体的角色有教养的新生的老鼠心脏的 myocytes 随机被划分成七个 groups:the 正常控制组, H/R 组, GLP-1+H/R 组, GLP-1+H/R+UO126 ( | XIE Yun WANG Shao-xin SHA Wei-wei ZHOU Xue WANG Wei-tin HAN Li-pin LI Dai-qing YU De-min | 2008 | Chinese Medical Journal2008，，21： | 24 |
| 5 | Leptin-induced vascular smooth muscle cell proliferation via regulating cell cycle, activating ERK1/2 and NF-κB显示文摘Leptin 是首先涉及食物吸入和精力开销的规定的肽荷尔蒙。最近的研究建议了 leptin 是为包括动脉粥样硬化和高血压的心血管的疾病的风险因素之一。脉管的光滑的肌肉房间(VSMC ) 在动脉的内层的变厚并且脉管的改变起一个重要作用。在这研究,我们在 VSMC 房间周期规定和可能的小径上调查了 leptin 的效果。我们发现 leptin 刺激了 VSMC 增长并且增加了房间前进到 S 和 G2/M 阶段。cyclinD1 的表示, phosphorylated 细胞外的调整信号的 kinase 1/2 (ERK1/2 ) ,和原子因素(NF )-Bp65 被增加。有 leptin 对手三元组异种的房间的处理稀释了导致 leptin 的 ERK1/2 和 NF-B 激活。这些结果建议 leptin 由从 G1 把转变提升到 S 阶段和 ERK1/2 和 NF-B 小径刺激了 VSMC 增长可能贡献这行列。 | Fen Huang Xiaofang Xiong Huabin Wang Sha You Hesong Zeng | 2010 | Acta Biochimica et Biophysica Sinica2010，42，5： | 20 |
| 6 | Therapeutic effect of recombinant tissue plasminogen activator on acute cerebral infarction at different times显示文摘BACKGROUND:The study aimed to compare the therapeutic effect of recombinant tissue plasminogen activator(rt-PA) on the onset of acute cerebral infarction(ACI) at different time points of the first 6 hours.METHODS:A retrospective analysis was conducted in 74 patients who received rt-PA thrombolysis treatment within 4.5 hours after ACI and another 15 patients who received rt-PA thrombolysis treatment between 4.5-6 hours after ACI.RESULTS:National Institute of Health Stroke Scale(NIHSS) scores were statistically decreased in both groups(P>0.05) at 24 hours and 7 days after ACI.There was no significant difference in modified ranking scores and mortality at 90 days after the treatment between the two groups(P>0.05).CONCLUSIONS:The therapeutic effect and mortality of rt-PA treatment in patients with ACI between 4.5-6 hours after the onset of the disease were similar to those in patients who received rtPA within 4.5 hours after the onset of this disease.Therefore,intravenous thrombolytic therapy for ACI within 4.5-6 hours after ACI was effective and safe. | Ming Liu Hai-rong Wang Jia-fu Liu Hao-jun Li Shen-xing Chen Sha Shen Shu-ming Pan | 2013 | World Journal of Emergency Medicine2013，4，3： | 20 |
| 7 | Fluxes of CH4 and N_2O from soil under a tropical seasonal rain forest in Xishuangbanna, Southwest China显示文摘从在在 Xishuangbanna 的热带季节的雨林下面的土壤的 CH4 和 N2O 流动,西南中国用关上的静态的房间技术和气体色层法方法被测量一年。三个处理被放在学习的地里:(A) 没有崽,有垃圾的(B) ,和有垃圾和幼苗的(C) 。结果证明在我们的学习的土壤是大气的 CH4 的一个水池和大气的 N2O 的来源。从处理 A, B,和 C 的观察吝啬的 CH4 流动是 50.0 ± 4.0, 35.9 ± 2.8, 31.6 ± 2.8 μ g C/(m2 · h ) ,分别地并且在 2003 的计算年度流动分别地是 4.1, 3.1,和 2.9 kgC/hm2。从处理 A, B,和 C 的观察吝啬的 N2O 流动是 30.9 ± 3.1, 28.2 ± 3.5, 50.2 ± 3 .7 μ g N/(m2 · h ) ,分别地并且在 2003 的计算年度流动分别地是 4.1, 3.1,和 2.9 kgC/hm2。从处理 A, B,和 C 的观察吝啬的 N2O 流动是 30.9 ± 3.1, 28.2 ± 3.5, 50.2 ± 3 .7 μ g N/(m2 · h ) ,分别地并且在 2003 的计算年度流动是 2.8, 2.6,和 3.7 kgN/hm 2 分别地。在 CH4 和 N2O 流动的季节变化在所有三个处理之中是重要的。垃圾的存在减少了 CH4 举起在湿季节期间(P < 0.05 ) ,然而并非在干旱期期间。调停幼苗的 N2O 排出物有类似的增加在期间湿并且干旱期,显示幼苗在两个季节增加了 N2O 排放。一种强壮的积极关系为处理 B 和处理 C 为所有三个处理,和在 CH4 流动和土壤温度之间的弱关系在 CH4 流动和土壤潮湿之间存在。N2O 流动为所有三个处理与土壤温度相关。 | YAN Yuping SHA Liqing CAO Min ZHENG Zheng TANG Jianwei WANG Yinghong ZHANG Yiping WANG Rui LIU Guangren WANG Yuesi SUN Yang | 2008 | Journal of Environmental Sciences2008，20，2： | 18 |
| 8 | Additive Benefits of Twice Forest Bathing Trips in Elderly Patients with Chronic Heart Failure显示文摘长期的心失败(CHF ) ,源于各种各样的心血管的疾病(CVD ) 的后果的临床的症候群,逐渐地正在成为病态和死亡的一个全球原因。我们更早证明了洗旅行的一个 4 天的森林能在病人上向附属治疗学的影响提供 CHF。为了进一步调查影响和森林洗澡的最佳的频率的持续时间,与 CHF 在病人摔倒,我们招募了经历了在 4 个星期以后再洗旅行的第一个森林并且也就是,随机把他们分成了二个组的那些对象城市的控制组(城市)和洗组(森林)的森林。在洗旅行的第二个 4 天的森林以后,我们象氧化应力一样在大脑 natriuretic 肽层次,心失败的 biomarker,和稀释煽动性的回答观察了稳定的衰落。因此,这探索研究表明了添加剂好处两次,森林洗澡与 CHF 在老病人摔倒,它能进一步为在 CVD 分析如此的干预的效果铺平道路。 | MAO Gen Xiang CAO Yong Bao YANG Yan CHEN Zhuo Mei DONG Jian Hua CHEN Sha Sha WU Qing LYU Xiao Ling JIA Bing Bing YAN Jing WANG Guo Fu | 2018 | Biomedical and Environmental Sciences2018，31，2： | 18 |
| 9 | Antigenic variation of the human influenza A(H3N2) virus during the 2014–2015 winter season显示文摘The human influenza A(H3N2) virus dominated the 2014–2015 winter season in many countries and caused massive morbidity and mortality because of its antigenic variation. So far, very little is known about the antigenic patterns of the recent H3N2 virus. By systematically mapping the antigenic relationships of H3N2 strains isolat ed since 2010, we discov ered that two groups with obvious antigenic divergence, named SW13(A/Switzerland/9715293/2013-like strains) and HK14(A/Hong Kong/5738/2014-like strains), co-circulated during the 2014–2015 winter season. HK14 group co-circulated with SW13 in Europe and the United States during this season, while there were few strains of HK14 in China's Mainland, where SW13 has dominated since 2012. Furthermore, we found that substitutions near the receptor-binding site on hemagglutinin played an important role in the antigenic variation of both the groups. These findings provide a comprehensive understanding of the recent antigenic evolution of H3N2 virus and will aid in the selection of vaccine strains. | HUA Sha LI XiYan LIU Mi CHENG YanHui PENG YouSong HUANG WeiJuan TAN MinJu WEI HeJiang GUO JunFeng WANG DaYan WU AiPing SHU YueLong JIANG TaiJiao | 2015 | Science China(Life Sciences)2015，58，9： | 17 |
| 10 | Effects of chemical fertilizer combined with organic manure on Fuji apple quality,yield and soil fertility in apple orchard on the Loess Plateau of China显示文摘To evaluate the effects of chemical fertilizer combined with organic manure on apple yield,quality and soil fertility,an experiment was conducted in an apple orchard on the Loess Plateau of China.Six treatments,i.e.,1)no nitrogen(N)with chemical phosphorus(P)and potassium(K)(PK),2)no P with chemical N and K(NK),3)no K with chemical N and P(NP),4)N,P and K chemical fertilizers only(NPK),5)swine manure(M)only(M),and 6)half chemical fertilizers combined with half swine manure(NPKM)were included with three replications for each.The NPKM treatment achieved 36.9 t/ha average annual yield,which was 42.5%greater than the yield of PK treatment.The average annual yields followed the sequence of NPKM>NPK>M>NK>NP>PK.In NPKM treatment 71.3%of the collected apples had an apple diameter greater than 80 mm compared with 58.2%,41.5%and 37.2%in NK,PK and NP treatments,respectively.The sugar to acid(S:A)ratio was the greatest in NPKM treatment.The results of Vitamin C,soluble solid and firmness showed that NPKM treatment had the highest values.The concentration of soil organic carbon(SOC)in the 0 to 20 cm depth of soil was significantly affected by addition of M.Compared to the antecedent soil properties,the SOCS in the NPKM and M treatments were increased by 28.8%,29.4%,and TN contents were 56.5,49.8%more for soil at 0-20 cm depths,respectively.The major soil nutrients of N,P and K were also significantly increased by M and NPKM treatments in surface soil for five years.The data support the conclusion that,for a production of 35-40 t/ha in an apple orchard on the Loess Plateau of China,the 25-30 t/ha organic manure,160-200 kg/ha N,100-150 kg/ha P2O5 and 120-160 kg/ha K2O were the most suitable fertilizer application.The finding will be helpful for harmonious development of apple production technology,economic income increase for farmers,and improvement of the apple orchard ecosystem. | Zhao Zuoping Yan Sha Liu Fen Ji Puhui Wang Xiaoying Tong Yan’an | 2014 | International Journal of Agricultural and Biological Engineering2014，7，2： | 17 |
| 11 | Involvement of hepatitis B X-interacting protein (HBXIP) in proliferation regulation of cells显示文摘瞄准:到 investigat 肝炎 B X 交往的效果蛋白质(HBXIP ) oncell proliferation.Methods:对 HBXIP 的兔子抗体是 HBXIP 基因的 generated.The RNA 干扰( RNAi )碎片在编码 HBXIP 基因和 pSilencer-hbxip weretransfected 进人的胸癌 MCF-7 房间, hepatoma H7402 房间,和正常的 pcDNA3-hbxip 的 pSilencer-3.0-H1 向量 termedpSilencer-hbxip.Plasmids 被构造 humanhepatic 房间线 L-O2 ,respectively.3-[ 4,5-dimethylthiazol-2-yl ] -2,5-diphenyltetrazolium 溴化物( MTT )试金和 5-bromo-2-deoxyuridine 加入试金被用于 dete HBXIP 的功能之一是它在房间增长的参与。 | Feng-ze WANG Li SHA Wei-ying ZHANG Lian-ying WU Ling QIAO Nan LI Xiao-dong ZHANG Li-hong YE | 2007 | Acta Pharmacologica Sinica2007，28，3： | 16 |
| 12 | Types,Characteristics and Significances of Migrating Pathways of Gas-bearing Fluids in the Shenhu Area,Northern Continental Slope of the South China Sea显示文摘The first marine gas hydrate expedition in China has been conducted by Guangzhou Marine Geological Survey in the Shenhu Area, northern continental slope of the South China Sea. Previous study has analyzed the P-T conditions, geophysical anomalies and saturation calculations of these gas hydrates, but has not documented in detail the migration of gas-bearing fluids in the study area. Based on the interpretations of 2D/3D seismic data, this work identified two types of migration pathways for gas-bearing fluids in the Shenhu area, i.e., vertical and lateral pathways. The vertical pathways(largescale faults, gas chimneys and mud diapirs) presented as steep seismic reflection anomalies, which could be traced downward to the Eocene source rocks and may penetrate into the Late Miocene strata. The deeper gases/fluids might be allowed migrating into the shallower strata through these vertical conduits. However, the distributions showed distinct differences between these pathways. Large-scale faults developed only in the north and northeast of the Shenhu area, while in the drilling area gas chimneys were the sole vertical migration pathways. Since the Pliocene, normal faults, detachment faults and favorable sediments have constituted the lateral pathways in the Shenhu gas hydrate drilling area. Although these lateral pathways were connected with gas chimneys, they exerted different effects on hydrate formation and accumulation. Gas-bearing fluids migrated upward along gas chimneys might further migrate laterally because of the normal faults, thereby enlarging the range of the chimneys. Linking gas chimneys with the seafloor, the detachment faults might act as conduits for escaping gases/fluids. Re-deposited sediments developed at the early stage of the Quaternary were located within the gas hydrate stability zone, so hydrates would be enriched in these favorable sediments. Compared with the migration pathways(large-scale faults and mud diapirs) in the LW3-1 deep-sea oil/gas field, the migration efficiency of the vertical pathways(composed of gas chimneys) in the gas hydrate drilling area might be relatively low. Description and qualitative discrimination of migration pathways in the Shenhu gas hydrate drilling area are helpful to further understand the relationship between good-quality deep source rocks and shallow, mainly biogenicallyproduced, hydrates. As the main source rocks of the Baiyun sag, lacustrine mudstones in the Wenchang and Enping Formations may provide thermogenic methane. Gas chimneys with relatively low migration efficiency created the vertical pathways. Caused by the Dongsha tectonic movement, the release of overpressured fluids might reduce the vertical migration rates of the thermogenic methane. The thick bathyal/abyssal fine-grained sediments since the Late Miocene provided migration media with low permeability. These preconditions may cause carbon isotopic fractionation ofthermogenic methane during long-distance vertical migrations. Therefore, although geochemical analyses indicate that the methane forming gas hydrate in the Shenhu area was mainly produced biogenically, or was mixed methane primarily of microbial origin, thermogenic methane still contribute significantly. | SU Ming SHA Zhibin ZHANG Cuimei WANG Hongbin WU Nengyou YANG Rui LIANG Jinqiang QIAO Shaohua CONG Xiaorong LIU Jie | 2017 | Acta Geologica Sinica(English Edition)2017，91，1： | 16 |
| 13 | Evidence of human papilloma virus infection and its epidemiology in esophageal squamous cell carcinoma显示文摘瞄准:在食道的有鳞的房间癌(ESCC ) 寻找病毒(HPV ) 感染人的乳突淋瘤的证据并且在河南省移民在食道的癌的致病调查 HPV 感染的潜在的角色和传染病学。方法:乳突淋瘤病毒(PV ) 和 HPV 被 Ultrasensive S-P 免疫组织化学(IHC ) 和原位杂交(ISH ) 在食道的癌纸巾(82 个案例) 和正常粘膜(40 个案例) 决定。结果:当时, IHC 表明 PV 的积极的率分别地是 75.0% , 68.18% 和 72.5% 积极的率是的 HPV (16/18-E6 )45.0%,36.36% , 37.5% ,分别地在从在湖北癌症的河南省移民,本地公民和病人的食道的癌组织标本医院。PV 和 HPV (16/18-E6 ) 在所有正常食道的粘膜标本是否定的。没有关联在食道的有鳞的房间癌纸巾并且在等级 1-3 在 HPV 之间被发现食道的有鳞的房间癌房间。原位杂交证明 HPV (16/18 ) DNA 积极的率是 30.0% , 31.8% , 25.0% ,分别地在 3 组样品。没有积极杂交信号在 40 个正常食道的粘膜标本被发现。在食道的癌标本的 HPV (16/18 ) DNA 的积极的率在正常粘膜标本(P<0.05 ) 比那显著地高。积极的率不在 3 组食道的癌组织标本(P>0.05 ) 之中是不同的。结论:HPV 感染在在湖北癌症 Hospital.HPV 的河南省移民,本地居民和病人的食道的癌高仔细与食道的有鳞的房间癌被联系。HPV 感染可以在食道的有鳞的房间癌起一个重要作用。 | Pin-Fang Yao Guang-Can Li Jin Li He-Shun Xia Xiao-Ling Yang Huan-Yuan Huang You-Gao Fu Rui-Qin Wang Xi-Yin Wang Ju-Wei Sha | 2006 | World Journal of Gastroenterology2006，12，9： | 15 |
| 14 | Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway显示文摘Glioblastoma multiforme(GBM)in the central nervous system is the most lethal advanced glioma and currently there is no effective treatment for it.Studies of sinomenine,an alkaloid from the Chinese medicinal plant,Sinomenium acutum,showed that it had inhibitory effects on several kinds of cancer.Here,we synthesized a sinomenine derivative,sino-wcj-33(SW33),tested it for antitumor activity on GBM and explored the underlying mechanism.SW33 significantly inhibited proliferation and colony formation of GBM and reduced migration and invasion of U87 and U251 cells.It also arrested the cell cycle at G2/M phase and induced mitochondria-dependent apoptosis.Differential gene enrichment analysis and pathway validation showed that SW33 exerted anti-GBM effects by regulating PI3 K/AKT and AMPK signaling pathways and significantly suppressed tumorigenicity with no obvious adverse effects on the body.SW33 also induced autophagy through the PI3 K/AKT/mTOR and AMPK/mTOR pathways.Thus,SW33 appears to be a promising drug for treating GBM effectively and safely. | Xiangjin Zheng Wan Li Huanli Xu Jinyi Liu Liwen Ren Yihui Yang Sha Li Jinhua Wang Tengfei Ji Guanhua Du | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 15 |
| 15 | Jurassic sedimentary features and tectonic settings of southeastern China显示文摘Two types of the Jurassic basins are distinguished in SE China based on their geodynamic features: the Late Triassic-Early Jurassic post-orogenic basins and the Middle Jurassic intra-continental extensional basins. The Lower Jurassic sequence shows a change from coarseto fine-grained accumulation, suggesting a gradually deepening depositional environment from river to shore-lake and to deep-water lake. In contrast, the Middle Jurassic accumulation was changed from claystone to conglomerate along the coastal provinces in SE China, indicative of an initial crustal uplift. The Wuyi Mountains have been a paleogeograghic separating zone since the Middle Jurassic. The Late Jurassic strata are absent in most areas of SE China. A large-scale bimodal intra-continental rift-type volcanism occurred during the Middle Jurassic along a 40-60 km wide and 200 km long area in western Fujian and southern Jiangxi provinces, which is most likely the strongest volcanism in SE China since the Cambrian. The SHRIMP zircon U-Pb analyses on the rhyolite from the Dongkeng basin in the southern Jiangxi area yield a concord U-Pb age of 160±0.5 Ma, providing an upper age limit for the bimodal volcanic eruption. The analyses of the basin features indicate a change of the depositional environment during the interval from Middle Triassic to Late Triassic from a shallow-sea to an intra-continent in SE China in response to the strong collision between the Yangtze and North China Blocks. Sedimentary structures record a southward direction of Early Jurassic paleo-currents, reflecting that their source areas were to the north side. We propose that the Wuyi region was uplifted as early as Middle Jurassic, followed by a wide E-W-trending extended depression and bimodal volcanism in the western foot of the Wuyi Mountains. Presumably the uplift of the Wuyi domain changed the Middle Jurassic paleo geographic outline and formed the transformational tectonic regime from compression to extension as a tectonic response to the Pacific plate subduction. | SHU LiangShu WANG Yan SHA JinGeng JIANG ShaoYong YU JinHai WANG YanBin | 2009 | Science China Earth Sciences2009，52，12： | 15 |
| 16 | Effects of Salvia miltiorrhiza on intestinal microflora in rats with ischemia/reperfusion liver injury显示文摘BACKGROUND: Hepatic ischemia/reperfusion injury may induce intestinal microflora imbalance. Salvia miltiorrhiza is effective in promoting blood circulation and counteracting peroxidation in tissues. The aim of the present study was to determine the effects of Salvia miltiorrhiza on intestinal mi- croflora, endotoxemia, and bacterial translocation in rats with hepatic I/R injury. METHODS: Sprague-Dawley rats in specific pathogen free grade were divided into 3 groups: group I(n =6) for sham operation: groups ( n = 7) for liver ische- mia for 20 minutes and reperfusion for 22 hours. Group was also pretreated with 4 ml/day of Salvia miltiorrhiza solu- tion (250 mg/kg) by daily gavage for 7 days. The levels of serum alanine aminotransferase (ALT), aspartate amino- transferase (AST), malondialdehyde ( MDA) and supero- xide dismutase ( SOD ) in liver tissues, serum endotoxin, intestinal bacterial counts, intestinal mucosal histology and bacterial translocation were studied. RESULTS: The levels of ALT, AST, plasma endotoxin and MDA in liver tissues were decreased more markedly in group (57.57 ± 18.08 U/L, 147.57 ±40.84 U/L, 0.42 ± 0.144 EU/ml and 0. 52 ±0.19 nmol/mg-prot respectively) in group 295.9±216.92 U/L, 0.80± 0.262 EU/ml and 0.72±0.12 nmol/mg-prot; P <0.05-0.01 respectively). Liver SOD activity was increased more sig- nificantly in group (318.47±64.62 U/mg-prot) than in group U/mg-prot, P<0.05). The counts of Bifidobacteria and Bacteroides increased more significantly in group than in group but were similar to those in group I. Bacterial translocation to the kidney in group was 50% (5/10), whereas no bacterial translocation to the kidney occurred in the other two groups (P <0. 01). Ileal mucosal structure was markedly ameliorated in group as compared with group CONCLUSIONS: Salviae miltiorrhiza could partially restore intestinal microflora balance, improve intestinal mucosal integrity, and reduce bacterial translocation and plasma en- dotoxin in rats with hepatic ischemia/reperfusion injury. | Hui-Chun Xing, Lan-Juan Li, Kai-Jin Xu, Tian Shen, Yun-Bo Chen, Yu Chen, Su-Zhen Fu, Ji-Fang Sheng, Chun-Lei Chen, Jian-Guo Wang, Dong Yan, Fang-Wei Dai and Xiao-Ying Sha Hangzhou, China Key Laboratory of Infectious Diseases, Ministry of Public Health of China, and Institute of Infectious Diseases, Department of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China Zhejiang Academy of Medical Sciences, Hangzhou 310012, China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，2： | 14 |
| 17 | Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination显示文摘 | Yiqiang Cui Yuyu Niu Jiankui Zhou Yongchang Chen Yiwei Cheng Shangang Li Zongyong Ai Chu Chu Hong Wang Bo Zheng Xuejin Chen Jiahao Sha Xuejiang Guo Xingxu Huang Weizhi Ji | 2018 | Cell Research2018，28，3： | 13 |
| 18 | Multi-Class Classification Methods of Cost-Conscious LS-SVM for Fault Diagnosis of Blast Furnace显示文摘Aiming at the limitations of rapid fault diagnosis of blast furnace,a novel strategy based on cost-conscious least squares support vector machine(LS-SVM)is proposed to solve this problem.Firstly,modified discrete particle swarm optimization is applied to optimize the feature selection and the LS-SVM parameters.Secondly,cost-conscious formula is presented for fitness function and it contains in detail training time,recognition accuracy and the feature selection.The CLS-SVM algorithm is presented to increase the performance of the LS-SVM classifier.The new method can select the best fault features in much shorter time and have fewer support vectors and better generalization performance in the application of fault diagnosis of the blast furnace.Thirdly,a gradual change binary tree is established for blast furnace faults diagnosis.It is a multi-class classification method based on center-of-gravity formula distance of cluster.A gradual change classification percentage is used to select sample randomly.The proposed new method raises the speed of diagnosis,optimizes the classification accuracy and has good generalization ability for fault diagnosis of the application of blast furnace. | LIU Li-mei WANG An-na SHA Mo ZHAO Feng-yun | 2011 | Journal of Iron and Steel Research(International)2011，18，10： | 13 |
| 19 | Soil respiration in tropical seasonal rain forest in Xishuangbanna, SW China显示文摘With the static opaque chamber and gas chromatography technique, from January 2003 to January 2004 soil respiration was investigated in a tropical seasonal rain forest in Xishuangbanna, SW China. In this study three treatments were applied, each with three replicates: A (bare soil), B (soil+litter), and C (soil+litter+seedling). The results showed that soil respiration varied seasonally, low from December 2003 to February 2004, and high from June to July 2004. The annual average values of CO2 efflux from soil respiration differed among the treatments at 1% level, with the rank of C (14642 mgCO2· m-2. h-1)>B (12807 mgCO2· m-2. h-1)>A (9532 mgCO2· m-2. h-1). Diurnal variation in soil respiration was not apparent due to little diurnal temperate change in Xishuangbanna. There was a parabola relationship between soil respiration and soil moisture at 1% level. Soil respiration rates were higher when soil moisture ranged from 35% to 45%. There was an exponential relationship between soil respiration and soil temperature (at a depth of 5cm in mineral soil) at 1% level. The calculated Q1o values in this study,ranging from 2.03 to 2.36, were very near to those of tropical soil reported. The CO2 efflux in 2003was 5.34 kgCO2· m-2. a-1 from soil plus litter plus seedling, of them 3.48 kgCO2· m-2. a-1 from soil (accounting for 62.5%), 1.19 kgCO2· m-2. a-1 from litter (22.3%) and 0.67 kgCO2·m-2. a-1 from seedling (12.5%). | SHA Liqing, ZHENG Zheng, TANG Jianwei, WANG Yinghong, ZHANG Yiping, CAO Min, WANG Rui, LIU Guangren, WANG Yuesi & SUN Yang Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming 650223, China Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China Graduate School of Chinese Academy of Sciences, Beijing 100039, China | 2005 | Science China Earth Sciences2005，48，z1： | 12 |
| 20 | A commentary review on the use of normalized diff erence vegetation index(NDVI)in the era of popular remote sensing显示文摘The Normalized Diff erence Vegetation Index(NDVI),one of the earliest remote sensing analytical products used to simplify the complexities of multi-spectral imagery,is now the most popular index used for vegetation assessment.This popularity and widespread use relate to how an NDVI can be calculated with any multispectral sensor with a visible and a near-IR band.Increasingly low costs and weights of multispectral sensors mean they can be mounted on satellite,aerial,and increasingly—Unmanned Aerial Systems(UAS).While studies have found that the NDVI is effective for expressing vegetation status andquantified vegetation attributes,its widespread use and popularity,especially in UAS applications,carry inherent risks of misuse with end users who received little to no remote sensing education.This article summarizes the progress of NDVI acquisition,highlights the areas of NDVI application,and addresses the critical problems and considerations in using NDVI.Detailed discussion mainly covers three aspects:atmospheric eff ect,saturation phenomenon,and sensor factors.The use of NDVI can be highly eff ective as long as its limitations and capabilities are understood.This consideration is particularly important to the UAS user community. | Sha Huang Lina Tang Joseph P.Hupy Yang Wang Guofan Shao | 2021 | Journal of Forestry Research2021，32，1： | 12 |
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