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| 1 | Tea aroma formation显示文摘Besides water,tea is one of the most popular beverages around the world.The chemical ingredients and biological activities of tea have been summarized recently.The current review summarizes tea aroma compounds and their formation in green,black,and oolong tea.The flavor of tea can be divided into two categories:taste(non-volatile compounds)and aroma(volatile compounds).All of these aroma molecules are generated from carotenoids,lipids,glycosides,etc.precursors,and also from Maillard reaction.In the current review,we focus on the formation mechanism of main aromas during the tea manufacturing process.©2015 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Chi-Tang Ho Xin Zheng Shiming Li | 2015 | Food Science and Human Wellness2015，4，1： | 62 |
| 2 | Blunted nitric oxide regulation in Tibetans under high-altitude hypoxia显示文摘Nitric oxide(NO) is an important molecule for vasomotor tone, and elevated NO signaling was previously hypothesized as a unique and adaptive physiological change in highland Tibetans. However, there has been lack of NO data from Tibetans living at low altitude and lowlander immigrants living at high altitude, which is crucial to test this hypothesis. Here, through cross-altitude(1990–5018 m) and cross-population(Tibetans and Han Chinese) analyses of serum NO metabolites(NOx) of 2086 individuals, we demonstrate that although Tibetans have a higher serum NOx level compared to lowlanders, Han Chinese immigrants living at high altitude show an even higher level than Tibetans. Consequently, our data contradict the previous proposal of increased NO signaling as the unique adaptive strategy in Tibetans.Instead, Tibetans have a relatively lower circulating NOx level at high altitude. This observation is further supported by data from the hypoxic experiments using human umbilical vein endothelial cells and gene knockout mice. No difference is detected between Tibetans and Han Chinese for endothelial nitric oxide synthase(e NOS), the key enzyme for circulating NO synthesis, suggesting that e NOS itself is unlikely to be the cause. We show that other NO synthesis-related genes(e.g. GCH1) carry Tibetan-enriched mutations significantly associated with the level of circulating NOx in Tibetans. Furthermore, gene network analysis revealed that the downregulation and upregulation of NOx is possibly achieved through distinct pathways.Collectively, our findings provide novel insights into the physiological and genetic mechanisms of the evolutionary adaptation of Tibetans to high-altitude hypoxia. | Yaoxi He Xuebin Qi Ouzhuluobu Shiming Liu Jun Li Hui Zhang Baimakangzhuo Caijuan Bai Wangshan Zheng Yongbo Guo Duojizhuoma Baimayangji Dejiquzong Bianba Gonggalanzi Yongyue Pan Qula Kangmin Cirenyangji Wei Guo Yangla Yi Peng Xiaoming Zhang Kun Xiang Zhaohui Yang Liangbang Wang Gengdeng Yanfeng Zhang Tianyi Wu Bing Su Chaoying Cui | 2018 | National Science Review2018，5，4： | 7 |
| 3 | De novo assembly of a Tibetan genome and identification of novel structural variants associated with high-altitude adaptation显示文摘Structural variants(SVs) may play important roles in human adaptation to extreme environments such as high altitude but have been under-investigated. Here, combining long-read sequencing with multiple scaffolding techniques, we assembled a high-quality Tibetan genome(ZF1), with a contig N50 length of 24.57 mega-base pairs(Mb) and a scaffold N50 length of 58.80 Mb. The ZF1 assembly filled 80 remaining N-gaps(0.25 Mb in total length) in the reference human genome(GRCh38). Markedly, we detected17 900 SVs, among which the ZF1-specific SVs are enriched in GTPase activity that is required for activation of the hypoxic pathway. Further population analysis uncovered a 163-bp intronic deletion in the MKL1 gene showing large divergence between highland Tibetans and lowland Han Chinese. This deletion is significantly associated with lower systolic pulmonary arterial pressure, one of the key adaptive physiological traits in Tibetans. Moreover, with the use of the high-quality de novo assembly, we observed a much higher rate of genome-wide archaic hominid(Altai Neanderthal and Denisovan) shared non-reference sequences in ZF1(1.32%–1.53%) compared to other East Asian genomes(0.70%–0.98%),reflecting a unique genomic composition of Tibetans. One such archaic hominid shared sequence-a662-bp intronic insertion in the SCUBE2 gene-is enriched and associated with better lung function(the FEV1/FVC ratio) in Tibetans. Collectively, we generated the first high-resolution Tibetan reference genome, and the identified SVs may serve as valuable resources for future evolutionary and medical studies. | Ouzhuluobu Yaoxi He Haiyi Lou Chaoying Cui Lian Deng Yang Gao Wangshan Zheng Yongbo Guo Xiaoji Wang Zhilin Ning Jun Li Bin Li Caijuan Bai Baimakangzhuo Gonggalanzi Dejiquzong Bianba Duojizhuoma Shiming Liu Tianyi Wu Shuhua Xu Xuebin Qi Bing Su | 2020 | National Science Review2020，7，2： | 4 |
| 4 | Updating preconditioner for iterative method in time domain simulation of power systems显示文摘The numerical solution of the differential-algebraic equations(DAEs) involved in time domain simulation(TDS) of power systems requires the solution of a sequence of large scale and sparse linear systems.The use of iterative methods such as the Krylov subspace method is imperative for the solution of these large and sparse linear systems.The motivation of the present work is to develop a new algorithm to efficiently precondition the whole sequence of linear systems involved in TDS.As an improvement of dishonest preconditioner(DP) strategy,updating preconditioner strategy(UP) is introduced to the field of TDS for the first time.The idea of updating preconditioner strategy is based on the fact that the matrices in sequence of the linearized systems are continuous and there is only a slight difference between two consecutive matrices.In order to make the linear system sequence in TDS suitable for UP strategy,a matrix transformation is applied to form a new linear sequence with a good shape for preconditioner updating.The algorithm proposed in this paper has been tested with 4 cases from real-life power systems in China.Results show that the proposed UP algorithm efficiently preconditions the sequence of linear systems and reduces 9%-61% the iteration count of the GMRES when compared with the DP method in all test cases.Numerical experiments also show the effectiveness of UP when combined with simple preconditioner reconstruction strategies. | WANG Ke XUE Wei LIN HaiXiang XU ShiMing ZHENG WeiMin | 2011 | Science China(Technological Sciences)2011，54，4： | 3 |
| 5 | Anomaly detection in smart grid based on encoder-decoder framework with recurrent neural network显示文摘Anomaly detection in smart grid is critical to enhance the reliability of power systems.Excessive manpower has to be involved in analyzing the measurement data collected from intelligent motoring devices while performance of anomaly detection is still not satisfactory.This is mainly because the inherent spatio-temporality and multi-dimensionality of the measurement data cannot be easily captured.In this paper,we propose an anomaly detection model based on encoder-decoder framework with recurrent neural network(RNN).In the model,an input time series is reconstructed and an anomaly can be detected by an unexpected high reconstruction error.Both Manhattan distance and the edit distance are used to evaluate the difference between an input time series and its reconstructed one.Finally,we validate the proposed model by using power demand data from University of California,Riverside(UCR) time series classification archive and IEEE 39 bus system simulation data.Results from the analysis demonstrate that the proposed encoder-decoder framework is able to successfully capture anomalies with a precision higher than 95%. | Zheng Fengming Li Shufang Guo Zhimin Wu Bo Tian Shiming Pan Mingming | 2017 | The Journal of China Universities of Posts and Telecommunications2017，24，6： | 2 |
| 6 | The quasi-newton method in parallel cir calar iterantion显示文摘 | Wang Xinghua Zheng Shiming | 1984 | J Comp Math1984，，2： | 1 |
| 7 | Approximate degree reduction of rectangular Bézier surfaces 显示文摘 | Hu Shiming Zheng Guoqin Sun Jiaguang | 1997 | Chinese Journal of Advanced Software Research1997，4，4： | 1 |
| 8 | Some simultaneous iterations for finding all zeros of a polynomial with high order convergence显示文摘 | ZHENG Shiming SUN Fangyu | 1999 | Applied Mathematics and Computation1999，99，： | 1 |
| 9 | Bio-oil production through pyrolysis of blue-green algae blooms (BGAB): Product distribution and bio-oil characterization显示文摘 | Zhiquan Hu Yang Zheng Feng Yan Bo Xiao Shiming Liu | 2013 | Energy2013，，： | 1 |
| 10 | Parallel Halley iteration method with circular arithmetic for fining all zeros of a polynimial 显示文摘 | Wang Xinghua Zheng Shiming | 1985 | A Journal of Chinese University Numer Math1985，4，： | 1 |
| 11 | The characteristics of space cooling load and indoor humidity control for residences in the subtropics显示文摘 | LI Zheng CHEN Wu DENG Shiming | 2006 | Building and Environment2006，41，9： | 1 |
| 12 | Parallel Halley iteration method with circular arithmetic for finding all zeros of a polynomial显示文摘 | Wang Xinghua Zheng Shiming | 1985 | A Journal of Chinese University Numer Math1985，4，： | 1 |
| 13 | Anticancer Activities of Citrus Peel Polymethoxyflavones Related to Angiogenesis and Others显示文摘 | Liwen Wang Jinhan Wang Lianying Fang Zuliang Zheng Dexian Zhi Suying Wang Shiming Li Chi-Tang Ho Hui Zhao Zongjin Li | 2014 | BioMed Research International2014，，： | 1 |
| 14 | Microstructure and mechanical properties of Mg-Nd-Zn-Zr billet prepared by direct chill casting显示文摘High-quality Mg-Nd-Zn-Zr magnesium alloy billets with diameter of 200 mm were successfully prepared by direct chill(DC)casting.The results show that microstructures of the as-cast billet prepared by DC casting are mainly composed of equiaxed a-Mg and Mg 12 Nd eutectic compound distributing along the grain boundaries.The average grain size decreases along the radius of the billet.And the alloying elements of Nd and Zn distribute homogeneously across the large billet.The optimum process parameters for DC casting of the Mg-Nd-Zn-Zr magnesium alloy billet with diameter of 200 mm have been experimentally determined as follows:casting temperature 710℃ and casting speed 80 mm/min. | Xingwei Zheng Jie Dong Shiming Wang | 2018 | Journal of Magnesium and Alloys2018，6，1： | 1 |
| 15 | A Note on the Convergence of Halley’s Method for Solving Operator Equations显示文摘 | Zheng Shiming Robbie D | 1955 | Journal of the Australian Mathematical Society1955，37，1： | 1 |
| 16 | HIGH TEMPERATURE DEFORMATION BEHAVIOR OF TiAl INTERMETALLIC COMPOUND显示文摘The behavior of TiAl interrnetallic compound of Ll0 type under compressive deformation athigh temperatures and its recrystallization microstructure have been studied.The compressiveproof stress of the polycrystalline TiAl was found to be positive temperature dependence assame as the single crystai one.The correlation of the flow stress together with strain rate anddeformation temperature is in good agreement with the expression:ε=Aσpnexp(-Q/RT)Adjusting the deformation temperature and strain rate to a decrease in flow stress of alloydown to below its brittle fracture stress may improve successfully not only the hot working ofthe TiAl-base alloy but also the fineness of the recrystallized grains. | HAO Shiming ZHENG Zhanqing Northeast University of Technology,Shenyang,China | 1990 | Acta Metallurgica Sinica(English Letters)1990，3，12： | 0 |
| 17 | ON THE INVARIANT FOR A FAMILY OF DEFORMED HALLEY METHODS显示文摘In this paper,an invariant determined by a function used to guarantee the convergence of all members with ι≤κ in the family of deformed Halley iterative methods for solving nonlinear equation in complex field is given.Results include some known ones as this special cases.We get not only the error estimates of the iterative sequences {zn,ι} but also those of f(zn,ι) for all ι≤κ. | HUANG Zhengda ZHENG Shiming (Department of Mathematics, Xixi Campus, Zhejiang University, Hangzhou 310028, China) | 2003 | Journal of Systems Science & Complexity2003，16，1： | 0 |
| 18 | A calculation method of the sensible heat flux by sodar显示文摘- During the second course of USA - PRC joint air sea interaction experiment in 1986, the temperature structure parameters CT2 were measured by sodar over the Western Pacific Ocean. Based on similarity theory, a method is discussed to calculate the sensible heat flux over the ocean in unstable stratification. Becausehumidity is great over the ocean, so we have to consider the influence of water vapor structure parameter Ce2and the correlation coefficient betweene and T on the calculation of sensible heat flux using CT2 profiles measured by sodar. A new formula is suggested in terms of parameterization. The sensible heat flux calculated by sodar measurements is compared with that by bulk transfer method, and the results agree well. | Lu Naiping, Li Shiming, Chen Jingnan, Zheng Yueming Zhou Mingyu National Recsearch Center for Marine Environmcntul Forecasts, Beijing, China | 1989 | Acta Oceanologica Sinica1989，8，2： | 0 |
| 19 | Identification of Styryl Sulfonyl Fluoride as a Near-Perfect Michael Acceptor for Diversified Protein Bioconjugations显示文摘Cysteine(Cys)-specific bioconjugation has widespread applications in the synthesis of protein conjugates,particularly for the functionalization of antibodies.Here,we report the discovery of transstyryl sulfonyl fluoride(SSF)as a near-perfect Michael acceptor for Cys-specific protein bioconjugation.Compared to maleimides,which are predominantly used,SSF exhibited better chemoselectivity,selfstability,and conjugate stability while maintaining comparable reactivity.Using SSF-derived probes,proteins can be readily modified on the Cys residue(s)to install functionalities,for example,fluorescent dyes,toxins,and oligonucleotides,without influencing the activity.Further applications of SSF-derived serum-stable antibody-drug conjugates and PD-L1 nanobody-oligo conjugates demonstrate the great translational value of SSF-based bioconjugation in drug development and single-cell sequencing. | Qingsong Wu Qi Xue Ji Li Qinheng Zheng Xinlu Zhao Wannan Li Shiming Sun Wanxing Sha Yang Yang Yi Yang Jie P.Li | 2023 | CCS Chemistry2023，5，10： | 0 |
| 20 | REVIVING THE CITY'S RIVERS显示文摘0n September 27,with the opening of the Qujiadian hydro-junction,the 865-kilometre(km)channel of the Yongding River was replenished with water and connected once again to the Bohai Sea.In recent times,Beijing has been carrying out ecological water replenishment for the channels of various rivers throughout the city.In addition to the Yongding River,the entire channels of the Chaobai,Beiyunhe,Juhe and Juma rivers have already been reflled with water and connected to the Bohai Sea.These five major rivers in the city do not flow into Bohai Sea at the same location.Using multiple sources,basins and approaches,these rivers,with their replenished water,are now connected to the sea for the first time. | Wang Wei(Translated) Brad Green Feng Yongguo(Photos) Hu Shengli(Photos) Qi Shiming(Photos) Wei Zheng(Photos) Xiao Zhuang(Photos) | 2021 | Beijing2021，，43： | 0 |
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