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| 1 | The Sunway TaihuLight supercomputer: system and applications显示文摘The Sunway Taihu Light supercomputer is the world's first system with a peak performance greater than 100 PFlops. In this paper, we provide a detailed introduction to the Taihu Light system. In contrast with other existing heterogeneous supercomputers, which include both CPU processors and PCIe-connected many-core accelerators(NVIDIA GPU or Intel Xeon Phi), the computing power of Taihu Light is provided by a homegrown many-core SW26010 CPU that includes both the management processing elements(MPEs)and computing processing elements(CPEs) in one chip. With 260 processing elements in one CPU, a single SW26010 provides a peak performance of over three TFlops. To alleviate the memory bandwidth bottleneck in most applications, each CPE comes with a scratch pad memory, which serves as a user-controlled cache. To support the parallelization of programs on the new many-core architecture, in addition to the basic C/C++and Fortran compilers, the system provides a customized Sunway Open ACC tool that supports the Open ACC2.0 syntax. This paper also reports our preliminary efforts on developing and optimizing applications on the Taihu Light system, focusing on key application domains, such as earth system modeling, ocean surface wave modeling, atomistic simulation, and phase-field simulation. | Haohuan FU Junfeng LIAO Jinzhe YANG Lanning WANG Zhenya SONG Xiaomeng HUANG Chao YANG Wei XUE Fangfang LIU Fangli QIAO Wei ZHAO Xunqiang YIN Chaofeng HOU Chenglong ZHANG Wei GE Jian ZHANG Yangang WANG Chunbo ZHOU Guangwen YANG | 2016 | Science China(Information Sciences)2016，59，7： | 45 |
| 2 | Lake geochemistry reveals marked environmental change in Southwest China during the Mid Miocene Climatic Optimum显示文摘中间中新世的气候的最佳(MMCO;~ 15-17 ? 妈) 是标点的短期的气候的温暖的事件之一新生代长期的冷却趋势。因为有这个事件的很少的陆上的记录,大多数我们的理解来自海洋的核心。在这份报告,我们首先介绍修订标明日期的新 palaeomagnetic 数据我们的 400 ? 在 Wenshan (云南) 的 m 厚的湖的节,以前想了晚中新世。这些新数据建议老年, ca。15.2-16.5 ? 妈,与 MMCO 与一致。我们测量了 13 体积有机物上的 C (13 C 器官的碳(TOC ) ,全部的氮(TN ) 和在高度的 C/N 比率取样的 org ), 总数分辨率:(1 ) 重建在湖集水区域的 palaeoenvironmental 变化,并且(2 ) 推断为这些变化负责的机制。我们的结果证明所有四个 geochemical 参数证明一个强壮的环境变化发生在节的中间附近,立即在在 15.97 点的 C5Cn/C5Br 地磁气的颠倒和早 / 中间中新世的边界以后 ? 妈。我们建议环境移动可能由于在气候的一个变化的联合,它变得更凉爽,和在有机物在湖以内骑车的一个变化。这研究提供新卓见进 MMCO 并且证明尽管 MMCO 通常是一个温暖的事件,它也是气候的不稳定性和突然的环境变化的一倍。 | Julie Lebreton-Anberree Shihu Li Shu-Feng Li Robert A. Spicer Shi-Tao Zhang Tao Su Chenglong Deng Zhe-Kun Zhou | 2016 | Science Bulletin2016，61，11： | 8 |
| 3 | Zircon U–Pb Geochronology and Petrogenesis of Early–Midlle Permian Arc–Related Volcanic Rocks in Central Jilin: Implications for the Tectonic Evolution of the Eastern Segment of Central Asian Orogenic Belt显示文摘This paper presents age and geochemical data of a recently identified Late Paleozoic volcanic sequence in central Jilin Province, with aims to discuss the petrogenesis and to constrain the tectonic evolution of the Central Asian Orogenic Belt in this area. Firstly, the volcanic rocks have zircon U-Pb ages of 290–270 Ma. Secondly, they are characterized by(a) ranging in composition from the low-K tholeiite series to high-K calc-alkaline series;(b) enrichment in light rare earth elements and depletion of heavy rare earth elements, with negative Eu anomalies;and(c) negative Nb, Ta, and Ti anomalies. Finally, the volcanic rocks yield εHf(t) values of +7.1 to +17. These data suggest that the central Jilin volcanic rocks were possibly derived from predominant partial melting of a depleted lithospheric mantle that might have been modified by subducted slab–derived fluids. Combined with previous studies, the Late Paleozoic–Early Mesozoic magmatism in Central Jilin can be divided into two stages:(a) a volcanic arc stage(290–270 Ma) represented by low-K to high–K, tholeiite to calc–alkaline plutons and(b) a syn–collisional stage(260–240 Ma) represented by high-K calc–alkaline I-type granites. Furthermore, the timing and the tectonic setting of the above magmatic rocks show that the arc was probably produced by the northward subduction of the Paleo-Asian Ocean and that the final closure of the Paleo-Asian Ocean occurred prior to the Early Triassic. | SHI Chenglong DING Xiaozhong LIU Yanxue ZHOU Xiaodong NIE Lijun | 2020 | Acta Geologica Sinica(English Edition)2020，94，4： | 4 |
| 4 | Fossil leaves of Berhamniphyllum(Rhamnaceae) from Markam,Tibet and their biogeographic implications显示文摘A new occurrence of buckthorn fossil leaves is reported from the upper Eocene strata of Markam Basin,southeastern Tibet,China.The leaf margin is either entire or slightly sinuous.Secondary veins are regularly spaced,forming eucamptodromous venation.These secondaries exist as straight lines from midvein to near margin and then arch abruptly upward and enter into a margin vein.The tertiary veins are densely spaced and parallel,and are percurrent to secondary veins.This leaf architecture conforms with Berhamniphyllum Jones and Dilcher,an extinct fossil genus reported from America.Our fossils are characterized by their dense secondaries,with secondary veins on the upper half portion of the blade accounting for over 40%of all secondaries.A new species,Berhamniphyllum junrongiae Z.K.Zhou,T.X.Wang et J.Huang sp.nov.,is proposed.Further analysis shows that confident assignment among Rhamnidium,Berchemia,and Karwinskia cannot be made based on leaf characters alone.Berhamniphyllum might represent an extinct common ancestor of these genera.In this study,several fossil Berchemia from Yunnan and Shandong are emended and reassigned to Berhamniphyllum.A new complex,namely the Berchemia Complex,is proposed based on morphology,molecular evidence,and the fossil record.This complex contains the fossil leaves of Rhamnidium,Karwinskia,Berchemia,and Berhamniphyllum.The historical biogeography of the Berchemia Complex is also discussed in this paper.This complex might have originated in the late Cretaceous in Colombia,South America,and dispersed to North America via Central America during the Eocene.Subsequently,the complex moved from North America to East Asia via the Bering Land Bridge no later than the late Eocene.Besides,the complex migrated from North America to Europe via the North Atlantic Land Bridge and then migrated further to Africa.In East Asia,it first appeared in Markam on the Qinghai-Tibetan Plateau,and then dispersed to other regions of Asia. | Zhekun ZHOU Tengxiang WANG Jian HUANG Jia LIU Weiyudong DENG Shihu LI Chenglong DENG Tao SU | 2020 | Science China Earth Sciences2020，63，2： | 4 |
| 5 | An insight into failure mechanism of NASICON-structured Na3V2(PO4)3 in hybrid aqueous rechargeable battery显示文摘NASICON (Na-super-ionic-conductors)-structured materials have attracted extensive research interest due to their great application potential in secondary batteries. However, the mechanism of capacity fading for NASICON-structured electrode materials has been rarely studied. In this paper, we synthesized the NASICON-structured Na3V2(PO4)3/C composite by simple sol-gel and high-temperature solid-phase method and investigated its electrochemical performance in Na-Zn hybrid aqueous rechargeable batteries. After characterizing the structure, morphology and composition variations as well as the interfacial resistance changes of Na3V2(PO4)3/C cathode during cycling, we propose a mechanical and interfacial degradation mechanism for capacity fading of NASICON-structured Na3V2(PO4)3/C in Na-Zn hybrid aqueous rechargeable batteries. This work will shed light on enhancing the mechanical and in terfacial stability of NASICON-structured Na3V2(PO4)3/C in Na-Zn hybrid aqueous rechargeable batteries. | Xinxin Zhang Jun Ma Pu Hu Bingbing Chen Chenglong Lu Xinhong Zhou Pengxian Han Lihua Chen Guanglei Cui | 2019 | Journal of Energy Chemistry2019，28，5： | 3 |
| 6 | Ultrastructural analysis of neuronal synapses using state-of-the-art nano-imaging techniques显示文摘Neuronal synapses are functional nodes in neural circuits.Their organization and activity define an individual's level of intelligence,emotional state and mental health.Changes in the structure and efficacy of synapses are the biological basis of learning and memory.However,investigation of the molecular architecture of synapses has been impeded by the lack of efficient techniques with sufficient resolution.Recent developments in state-of-the-art nano-imaging techniques have opened up a new window for dissecting the molecular organization of neuronal synapses with unprecedented resolution.Here,we review recent technological advances in nano-imaging techniques as well as their applications to the study of synapses,emphasizing super-resolution light microscopy and 3-dimensional electron tomography. | Changlu Tao Chenglong Xia Xiaobing Chen Z. Hong Zhou Guoqiang Bi | 2012 | Neuroscience Bulletin2012，28，4： | 3 |
| 7 | Fossil seeds of Euryale(Nymphaeaceae) indicate a lake or swamp environment in the late Miocene Zhaotong Basin of southwestern China显示文摘Euryale(Nymphaeaceae) is a monotypic genus distributed in eastern Asia, but fossils in its native distribution are sparse as compared to Europe where the genus has disappeared. Here, we describe a new fossil species, Euryale yunnanensis sp. nov., from the late Miocene Zhaotong Basin in southwestern China on the basis of seed remains. Characteristics including an ellipsoidal to almost spherical shape,a smooth surface, a germination cap that covers the micropyle, the separation of the hilum and germination cap(micropyle), elliptic testa surface cells with undulate margins and thickened cell walls collectively indicate a close affinity with the genus Euryale in Nymphaeaceae. Comparisons ofseed morphology and anatomy demonstrate that the newly described fossil species differs from modern and other fossil species of Euryale and thus verify the assignment to a new fossil species. As the modern Euryale is an aquatic plant,preferably living in swamps and lakes with shallow and stable water, we hypothesize that a lake and/or swamp environment with shallow water was present near Shuitangba in the Zhaotong Basin, where the Shuitangba hominoid lived during the late Miocene. This inference is generally consistent with paleoenvironmental data extracted from avian, fish, frog, turtle and crocodile fossils, as well as from aquatic pollen. The fossil history suggests a comparatively recent(Miocene) emergence of Euryale, which is roughly in agreement with the divergence time inferred from the molecular information. | Yongjiang Huang Xueping Ji Tao Su Li Wang Chenglong Deng Wenqi Li Hongfen Luo Zhekun Zhou | 2015 | Science Bulletin2015，60，20： | 3 |
| 8 | Novel methods by using non-vacuum insulated tubing to extend the lifetime of the tubing显示文摘失败力学的分析,也就是,真空的氢浸透绝缘管料(VIT ) ,显示 VIT 的失败能被减少,但是不能被避免。解决这个问题,由使用非真空材料的一些措施在这被求婚并且分析纸。结果显示那用泡沫眼镜祷告填满管料或高压力氩可以导致好表演。 | Chenglong ZHOU Guojin ZHU Yongxiang XU Jifei YU Xiaoliang ZHANG Hongzhi SHENG | 2015 | Frontiers in Energy2015，9，2： | 2 |
| 9 | Regulation of mATG9 trafficking by Src- and ULK1mediated phosphorylation in basal and starvation-induced autophagy显示文摘Autophagy 要求多样的膜来源并且包含 mATG9 的膜 trafficking,在 ATG 家庭的唯一的膜蛋白质。然而,为 autophagy 开始的 mATG9 trafficking 的分子的规定仍然保持不清楚。这里,我们识别了在 mATG9 的 cytosolic N 终点以内排序信号的二保存经典适配器蛋白质,它调停从经由和 AP1/2 建筑群的相互作用的血浆膜和 trans-Golgi 网络(TGN ) 的 mATG9 的 trafficking。在 Tyr8 到的 Src phosphorylates mATG9 处于不着重的条件维持它的 endocytic 和组成的 trafficking。响应饥饿,在由 Src 的 Tyr8 并且在由 ULK1 的 Ser14 的 mATG9 的 phosphorylation 机能上地合作支持在 mATG9 和 AP1/2 建筑群之间的相互作用,为 autophagy 从血浆膜和 juxta 原子的区域导致 mATG9 的再分配到外部水池开始。我们的调查结果揭开 mATG9 trafficking 的新奇机制并且建议基础、导致压力的 autophagy 的协作。 | Changqian Zhou Kaili Ma Ruize Gao Chenglong Mu Linbo Chen Qiangqiang Liu Qian Luo Du Feng Yushan Zhu Quan Chen | 2017 | Cell Research2017，27，2： | 2 |
| 10 | Boosting Zn-ion storage capability of self-standing Zn-doped Co_(3)O_(4)nanowire array as advanced cathodes for high-performance wearable aqueous rechargeable Co//Zn batteries显示文摘Neutral aqueous rechargeable Co_(3)O_(4)//Zn batteries with high-output voltage and outstanding cycling stability have yielded new insights into wearable energy-storage devices.To meet the increasing demand for a means of powering wearable and portable devices,the development of a high-performance fiber-shaped Co//Zn battery would be highly desirable.However,the intrinsically poor conductivity of C 03O4 significantly restricts the application of these high-capacity and high-rate aqueous rechargeable battery.Encouragingly,density functional theory(DFT)calculations demonstrate that the substitution of Zn for Co^(3+)leads to an insulatormetal transition in the Zn-doped Co_(3)O_(4)(Zn-Co_(3)O_(4)).In this study,we used metallic Zn-Co_(3)O_(4)nanowire arrays(NWAs)as a novel binder-free cathode to successfully fabricate an all-solid-state fiber-shaped aqueous rechargeable(AFAR)Co//Zn battery.The resulting fiber-shaped Co//Zn battery takes advantage of the enhanced conductivity,increased capacity,and improved rate capability of Zn-Co_(3)O_(4)NWAs to yield a remarkable capacity of 1.25 mAh·cm^(-2)at a current density of 0.5 mA·cm^(-2),extraordinary rate capability(60.8%capacity retention at a high current density of 20 mA·cm^(-2))and an admirable energy density of 772.6 mWh·cm^(-3).Thus,the successful construction of Zn-Co_(3)O_(4)NWAs provides valuable insights into the design of high-capacity and high-rate cathode materials for aqueous rechargeable high-voltage batteries. | Qiulong Li Qichong Zhang Zhengyu Zhou Wenbin Gong Chenglong Liu Yongbao Feng Guo Hong Yagang Yao | 2021 | Nano Research2021，14，1： | 2 |
| 11 | Energy-efficient computing-in-memory architecture for AI processor: device, circuit, architecture perspective显示文摘An artificial intelligence(AI) processor is a promising solution for energy-efficient data processing, including health monitoring and image/voice recognition. However, data movements between compute part and memory induce memory wall and power wall challenges to the conventional computing architecture.Recently, the memory-centric architecture has been revised to solve the data movement issue, where the memory is equipped with the compute-capable memory technique, namely, computing-in-memory(CIM). In this paper, we analyze the requirement of AI algorithms on the data movement and low power requirement of AI processors. In addition, we introduce the story of CIM and implementation methodologies of CIM architecture. Furthermore, we present several novel solutions beyond traditional analog-digital mixed static random-access memory(SRAM)-based CIM architecture. Finally, recent CIM tape-out studies are listed and discussed. | Liang CHANG Chenglong LI Zhaomin ZHANG Jianbiao XIAO Qingsong LIU Zhen ZHU Weihang LI Zixuan ZHU Siqi YANG Jun ZHOU | 2021 | Science China(Information Sciences)2021，64，6： | 1 |
| 12 | Comparative proteomic analysis of plasma from bipolar depression and depressive disorder: identification of proteins associated with immune regulatory显示文摘 | Jin Chen (1) (2) (3) ChengLong Huang (2) (3) (5) YiRen Song (1) (2) (3) HaiYang Shi (1) (2) (3) Dong Wu (2) (3) (5) YongTao Yang (2) (3) (4) ChengLong Rao (2) (3) (7) Li Liao (2) (3) (5) You Wu (2) (3) (6) JianYong Tang (2) (3) (5) Ke Cheng (1) (2) (3) Jian Zhou (2) (3) Peng Xie (1) (2) (3) | 2015 | Protein & Cell2015，6，12： | 1 |
| 13 | Pattern recognition of typical defects in high-voltage storage capacitors based on DC partial discharge显示文摘High-voltage storage capacitors(hereinafter call capacitors for short)have been widely used in pulsed power technology.In accordance with the actual work conditions of capacitors,direct current partial discharge(DCPD)detection was put forward.The whole test system was based on the impedance balance circuit characterized by good configuration and anti-interference ability.Through DCPD detection on capacitors which contained four typical defects respectively,test results revealed that DCPD signals could well reflect the state of capacitor insulation.DCPD distribution spectra of capacitors containing four typical defects were obviously different.Defects in capacitors could be exactly judged by computer–aided pattern recognition based on support vector machine(SVM). | WU GuangNing BIAN ShanShan ZHOU LiRen ZHANG XueQin RAN HanZheng YU ChengLong | 2009 | Science China(Technological Sciences)2009，52，12： | 1 |
| 14 | A polymer electrolyte with a thermally induced interfacial ion-blocking function enables safety-enhanced lithium metal batteries显示文摘Lithium metal batteries(LMBs)have recently been revitalized as one of the most promising electrochemical energy storage systems,owing to the ultrahigh specific capacity(3860 mAh g^(-1))and ultralow potential(-3.04 V vs.standard hydrogen electrode)of lithium metal anodes.However,safety hazards originating from lithium dendrite growth and pulverization during cycling and thermal stimulation present significant challenges to the practical application of LMBs.To address this issue,we have developed an in situ polymer electrolyte with thermally induced interfacial ion-blocking ability.We demonstrate that the repolymerization and deposition of residual vinylene carbonate in the as-prepared electrolyte under thermal abuse predominantly results in thermally induced ion blocking at the solid electrolyte interface,thus achieving superior LMB safety.The developed polymer electrolyte also yields superior cyclability in LMBs.This design philosophy provides a good paradigm for improving the safety of LMBs. | Huanrui Zhang Lang Huang Hantao Xu Xiaohu Zhang Zhou Chen Chenhui Gao Chenglong Lu Zhi Liu Meifang Jiang Guanglei Cui | 2022 | eScience2022，2，2： | 1 |
| 15 | Visualizing the spatial distribution and alteration of metabolites in continuously cropped Salvia miltiorrhiza Bge using MALDI-MSI显示文摘Salvia miltiorrhiza Bge(SMB)has long been used in traditional Chinese medicine to treat cardiovascular and cerebrovascular diseases.Growing clinical usage has led to a huge demand for artificial planting of SMB.Thus,continuous cropping of SMB is an important challenge that needs to be addressed.Continuous cropping can alter the metabolic profile of plants,resulting in poor growth and low yield.In this study,we tried to image the spatial location and variation of endogenous metabolites in continuously cropped SMB using matrix-assisted laser desorption/ionization mass spectrometry imaging(MALDIMSI).Spatially resolved expressions of tanshinones,salvianolic acids,polyamines,phenolic acids,amino acids,and oligosaccharides in normal and continuously cropped SMB roots were compared.The expressions of dihydrotanshinone Ⅰ,tanshinone Ⅱ A,dehydromiltirone,miltirone,dehydrotanshinone ⅡA,spermine,salvianolic acid B/E,tetrasaccharide,and pentasaccharide in continuously cropped SMB roots were much lower than those in normal roots.There was little difference in the expressions of caffeic acid and salvianolic acid A in normal and continuously cropped SMB roots.Ferulic acid was more widely distributed in xylem of normal SMB but strongly expressed in xylem,phloem,and cambium of continuously cropped SMB.The spatially resolved metabolite information enhances our understanding of the metabolic signature of continuously cropped SMB and also provides insights into the metabolic effects of continuous cropping in other plants. | Chenglong Sun Li Cui Bingqian Zhou Xiao Wang Lanping Guo Wei Liu | 2022 | Journal of Pharmaceutical Analysis2022，12，5： | 1 |
| 16 | Shear viscosity to entropy density ratio in BUU transport model显示文摘Shear viscosity (η) is a basic transport coefficient of the medium.In this work,we calculate shear viscosity to entropy density ratio (η/S) of an equilibrated system in intermediate energy heavy ion collisions within the framework of the Boltzmann-Uehling-Uhlenbeck model (BUU) model.After the equilibration of Au + Au system at central collision in a fixed volume is reached,temperature,pressure and energy density are extracted by the phase space information and then η/S is calculated using the Green-Kubo formulas.The results show that η/S drops with the incident energy and its value is not so drastically different from the RHIC results. | LI Shaoxin FANG Deqing MA Yugang ZHOU Chenglong | 2011 | Nuclear Science and Techniques2011，22，4： | 1 |
| 17 | Boosting reversible anionic redox reaction with Li/Cu dual honeycomb centers显示文摘The anionic redox reaction(ARR)is a promising charge contributor to improve the reversible capacity of layeredoxide cathodes for Na-ion batteries;however,some practical bottlenecks still need to be eliminated,including a low capacity retention,large voltage hysteresis,and low rate capability.Herein,we proposed a high-Na content honeycomb-ordered cathode,P2–Na_(5/6)[Li_(1/6)Cu_(1/6)Mn_(2/3)]O_(2)(P2-NLCMO),with combined cationic/anionic redox.Neutron powder diffraction and X-ray diffraction of P2-NLCMO suggested P2-type stacking with rarely found P6322 symmetry.In addition,advanced spectroscopy techniques and density functional theory calculations confirmed the synergistic stabilizing relationship between the Li/Cu dual honeycomb centers,achieving fully active Cu^(3+)/Cu^(2+) redox and stabilized ARR with interactively suppressed local distortion.With a meticulously regulated charge/discharge protocol,both the cycling and rate capability of P2-NLCMO were significantly. | Xiaohui Rong Dongdong Xiao Qinghao Li Yaoshen Niu Feixiang Ding Xueyan Hou Qiyu Wang Juping Xu Chenglong Zhao Dong Zhou Ruijuan Xiao Xiqian Yu Wen Yin Lin Gu Hong Li Xuejie Huang Liquan Chen Yong-Sheng Hu | 2023 | eScience2023，3，5： | 0 |
| 18 | An in-situ generated composite solid-state electrolyte towards high-voltage lithium metal batteries显示文摘The solid-state electrolyte(SSE) has promising applications in next-generation lithium(Li) metal batteries(LMBs) because of its significantly enhanced safety and more compatible interface characteristics than flammable traditional liquid electrolytes.However,only a few attempts have achieved high-performance high-voltage LMBs,which is attributed to the fact that both high ionic conductivity and good compatibility with electrodes can hardly be achieved simultaneously.Herein,a composite solid-state electrolyte(CSE) based on star-shaped siloxane-based polymer electrolyte coupled with Li_(6.75)La_(3)Zr_(1.75)Ta_(0.25)O_(12)(LLZTO)ceramic fillers is designed and prepared through a facile in-situ polymerization method.The obtained CSE exhibits high ionic conductivity(i.e.,1.68 × 10^(-4) S cm^(-1) at a temperature of 60 ℃),superior anodic stability,and high Li-ion transference number(i.e.,0.53) because of the multifunctional synergistic effect of the polymer electrolyte with LLZTO ceramic fillers.Moreover,the as-developed CSE shows excellent compatibility with Li anodes.As a result,the as-developed CSE enables the development of long-life 4.4-V-class solid-state LMBs with a Li CoO_(2) cathode,with 79.7% capacity retention and 99.74% average Coulombic efficiency after 500 cycles at a 0.5 C rate.Postmortem analysis of cycled batteries confirms that such superior battery performance can be mainly ascribed to the formation of a compatible electrode/electrolyte interface.Furthermore,excellent safety features can be observed in LiCoO_(2)/Li pouch batteries.This work provides an important guide for the rational design of SSEs for high-voltage LMBs. | Qinglei Wang Tiantian Dong Qian Zhou Zili Cui Xuehui Shangguan Chenglong Lu Zhaolin Lv Kai Chen Lang Huang Huanrui Zhang Guanglei Cui | 2022 | Science China Chemistry2022，65，5： | 0 |
| 19 | Therapeutic potential of exosome-based personalized delivery platform in chronic inflammatory diseases显示文摘In the inflammatory microenvironment,there are numerous exosomes secreted by immune cells(Macrophages,neutrophils,dendritic cells),mesenchymal stem cells(MSCs)and platelets as intercellular communicators,which participate in the regulation of inflammation by modulating gene expression and releasing anti-inflammatory factors.Due to their good biocompatibility,accurate targeting,low toxicity and immunogenicity,these exosomes are able to selectively deliver therapeutic drugs to the site of inflammation through interactions between their surface-antibody or modified ligand with cell surface receptors.Therefore,the role of exosome-based biomimetic delivery strategies in inflammatory diseases has attracted increasing attention.Here we review current knowledge and techniques for exosome identification,isolation,modification and drug loading.More importantly,we highlight progress in using exosomes to treat chronic inflammatory diseases such as rheumatoid arthritis(RA),osteoarthritis(OA),atherosclerosis(AS),and inflammatory bowel disease(IBD).Finally,we also discuss their potential and challenges as anti-inflammatory drug carriers. | Chenglong Wang Maochang Xu Qingze Fan Chunhong Li Xiangyu Zhou | 2023 | Asian Journal of Pharmaceutical Sciences2023，18，1： | 0 |
| 20 | Jujube witches’ broom phytoplasmas inhibit ZjBRC1-mediated abscisic acid metabolism to induce shoot proliferation显示文摘Jujube witches’broom(JWB)phytoplasmas parasitize the sieve tubes of diseased phloem and cause an excessive proliferation of axillary shoots from dormant lateral buds to favour their transmission.In previous research,two JWB effectors,SJP1 and SJP2,were identified to induce lateral bud outgrowth by disrupting ZjBRC1-mediated auxin flux.However,the pathogenesis of JWB disease remains largely unknown.Here,tissue-specific transcriptional reprogramming was examined to gain insight into the genetic mechanisms acting inside jujube lateral buds under JWB phytoplasma infection.JWB phytoplasmas modulated a series of plant signalling networks involved in lateral bud development and defence,including auxin,abscisic acid(ABA),ethylene,jasmonic acid,and salicylic acid.JWB-induced bud outgrowth was accompanied by downregulation of ABA synthesis within lateral buds.ABA application rescued the bushy appearances of transgenic Arabidopsis overexpressing SJP1 and SJP2 in Col-0 and ZjBRC1 in the brc1-2 mutant.Furthermore,the expression of ZjBRC1 and ABA-related genes ZjHB40 and ZjNCED3 was negatively correlated with lateral main bud outgrowth in decapitated healthy jujube.Molecular evidence showed that ZjBRC1 interacted with ZjBRC2 via its N-terminus to activate ZjHB40 and ZjNCED3 expression and ABA accumulation in transgenic jujube calli.In addition,ZjBRC1 widely regulated differentially expressed genes related to ABA homeostasis and ABA signalling,especially by binding to and suppressing ABA receptors.Therefore,these results suggest that JWB phytoplasmas hijack the ZjBRC1-mediated ABA pathways to stimulate lateral bud outgrowth and expansion,providing a strategy to engineer plants resistant to JWB phytoplasma disease and regulate woody plant architecture to promote crop yield and quality. | Fuli Ma Shanqi Zhang Yu Yao Mengting Chen Ning Zhang Mingsheng Deng Wei Chen Chi Ma Xinyue Zhang Chenglong Guo Xiang Huang Zhenyuan Zhang Yamei Li Tingyi Li Junyong Zhou Qibao Sun Jun Sun | 2023 | Horticulture Research2023，10，9： | 0 |
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