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| 1 | VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex显示文摘肺癌症是与高发生和死亡世界范围的大多数破坏疾病之一。河马(Hpo ) 小径是在果蝇和哺乳动物的机关尺寸的一个保存管理者。新兴的证据在癌症开发建议了 Hpo 小径的意义。在这研究,我们通过否定地调整 YAP-TEAD 建筑群的形成在肺 carcinogenesis 作为新奇肿瘤 suppressor 识别 VGLL4, Hpo 的核心部件小径。我们 VGLL4 经常被观察低层的数据表演在老鼠和人的肺癌症标本表示了。VGLL4 的宫外的表示显著地在 vitro 压制肺癌症房间的生长。更重要地, VGLL4 显著地在 de novo 老鼠模型禁止肺癌症前进。我们进一步发现 VGLL4 禁止 YAP-TEAD transcriptional 建筑群的活动。我们 VGLL4 直接在绑定与笨蛋竞争到 TEAD 并且执行的数据表演它通过二 TDU 域的生长禁止的函数。一起,我们的学习证明 VGLL4 是为通过否定地调整 YAP-TEAD 复杂形成并且这样的肺癌症的新奇肿瘤 suppressor Hpo 小径。 | Wenjing Zhang Yijun Gao Peixue Li Zhubing Shi Tong Guo Fei Li Xiangkun Han Yan Feng Chao Zheng Zuoyun Wang Fuming Li Haiquan Chen Zhaocai Zhou Lei Zhang Hongbin Ji | 2014 | Cell Research2014，24，3： | 25 |
| 2 | A two degree of freedom stable quasi-zero stiffness prototype and its applications in aseismic engineering显示文摘In this paper, an archetypal aseismic system is proposed with 2-degree of freedom based on a smooth and discontinuous(SD)oscillator to avoid the failure of electric power system under the complex excitation of seismic waves. This model comprises two vibration isolation units for the orthogonal horizontal directions, and each of them admits the stable quasi-zero stiffness(SQZS)with a pair of inclined linear elastic springs. The equation of motion is formulated by using Lagrange equation, and the SQZS condition is obtained by optimizing the parameters of the system. The analysis shows that the system behaves a remarkable vibration isolation performance with low resonant frequency and a large stroke of SQZS interval. The experimental investigations are carried out to show a high sonsistency with the theoretical results, which demonstrates the improvement of aseismic behavior of the proposed model under the seismic wave. | ZHU GuangNan LIU JiYe CAO QingJie CHENG YongFeng LU ZhiCheng ZHU ZhuBing | 2020 | Science China(Technological Sciences)2020，63，3： | 10 |
| 3 | MiR156 regulates anthocyanin biosynthesis through SPL targets and other microRNAs in poplar显示文摘Anthocyanins biosynthesized from the flavonoid pathway are types of pigments that are involved in the protection of poplar from biotic and abiotic stresses.Previous researchers studying anthocyanin-related transcription factors and structural genes in poplar have made significant discoveries.However,little is known about the regulatory role of microRNAs in anthocyanin biosynthesis in poplar.Here,we overexpressed miR156 in poplar to study the comprehensive effects of the miR156-SPL module on the biosynthesis of anthocyanins.Small RNA sequencing analysis revealed 228 microRNAs differentially expressed in transgenic poplar plants with dramatically increased miR156 levels.Furthermore,integrated microRNAomic and transcriptomic analysis suggested that two microRNAs,miR160h,and miR858,have the potential to affect anthocyanin accumulation in poplar by regulating auxin response factors and MYB transcription factors,respectively.Additionally,the accumulation of miR160h and miR858 displayed a positive correlation with miR156 levels,suggesting a possible interaction between the miR156-SPL module and these microRNAs in poplar.Last,metabolomics analysis revealed that the levels of anthocyanins,flavones,and flavonols were substantially elevated in transgenic poplar plants overexpressing miR156 compared with the wild type,whereas the total lignin content was reduced in the transgenic plants.Taken together,our results indicate that miR156 can fine tune the anthocyanin biosynthetic pathway via multiple factors,including microRNAs,transcription factors,and the levels of structural genes,in poplar.This provides additional clues for understanding the complex regulatory network of anthocyanin biosynthesis in woody plants. | Yamei Wang Wenwen Liu Xinwei Wang Ruijuan Yang Zhenying Wu HanWang LeiWang Zhubing Hu Siyi Guo Hailing Zhang Jinxing Lin Chunxiang Fu | 2020 | Horticulture Research2020，7，1： | 9 |
| 4 | Heteroexpression of the wheat phytochelatin synthase gene (TaPCS1) in rice enhances cadmium sensitivity显示文摘Phytochelatin synthase (PCS )(EC 2.3.2.15 ) 催化 phytochelatins (PC ) 的最后的步生合成。PC 是在植物在重金属的隐遁和 detoxification 起一个重要作用的充满半胱氨酸的 thiol 反应、重的金属绑定肽的一个家庭。以前的研究显示了那种显示的那 overexpressed PCS 对比显型,从提高的镉(Cd )忍耐到在 Arabidopsis thaliana 的 Cd 超敏性。在这研究,小麦 phytochelatin synthase 基因, TaPCS1,是在野类型的米饭的 heteroexpressed (Oryza sativa L. , cv。Zhonghua 11 ) 在米饭评估在 PC 和 Cd 忍耐的合成之间的关系。数据证明在米饭的 TaPCS1 的 heteroexpression 提高了 Cd 敏感并且显著地在射击,然而并非在根增加了 Cd 累积。另外, PCS 线在射击展出了 PC 和非蛋白质 thiols (NPT ) 的一个高得多的内容。在导致的 NPT 作文的突出的变化在射击在房间细胞器减少了谷胱甘肽水池弄空和更高的 Cd 内容,由更高氧化的应力列在后面,它可能导致 Cd 敏感。因此,在米饭的 TaPCS1 的 heteroexpression 能够在米饭射击增加 Cd 累积并且提高 Cd 敏感。 | Feijuan Wang Zhubing Wang Cheng Zhu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，10： | 8 |
| 5 | F-box protein AFB4 plays a crucial role in plant growth, development and innate immunity显示文摘 | Zhubing Hu Mehmet Ali Kegeli Maria Piisila Jing Li Mantas Survila Pekka Heino Gtinter Brade E Tapio Palva | 2012 | Cell Research2012，22，4： | 7 |
| 6 | Structural insights into SUN-KASH complexes across the nuclear envelope显示文摘nucleoskeleton 和细胞骨架(LINC ) 的连接器建筑群由阳光和 KASH 包含域的蛋白质组成并且衔接原子信封的内部、外部的膜。LINC 建筑群在原子放,房间极化和细胞的僵硬起关键作用。以前,我们报导了人的 SUN2 的 homotrimeric 结构。我们现在决定了人的 SUN2-KASH 建筑群的水晶结构。在复杂结构, SUN 领域 homotrimer 绑在三独立 “ hook”相似 KASH 肽。在建筑群的 SUN 领域的全面符合构造非常处于它的 apo 状态类似于 SUN 领域。一个主要 conformational 变化包含 KASH 固定的阳光领域的 AA'-loop,它重排形成微型 β与 KASH 肽交往的表。KASH 领域的磅主题在 SUN 领域的 homotrimeric 接口上紧适合进一个恐水病的衣袋,我们它称为双性人衣袋。而且, SUN 领域 homotrimer 三明治的二邻近的 protomers 由结合的恐水病的相互作用和氢的 KASH 领域。这些有约束力的地点的变化在 vitro 破坏或减少在 SUN 和 KASH 域之间的协会。另外, transfection 野类型,然而并非变异, SUN2 在 Ovcar-3 房间支持房间移植。这些结果提供 LINC 建筑群的一个结构的模型,它为另外的学习是必要的物理、功能在细胞质和核质之间联合。 | Wenjia Wang Zhubing Shi Shi Jiao Cuicui Chen Huizhen Wang Guoguang Liu Qiang Wang Yun Zhao Mark I Greene Zhaocai Zhou | 2012 | Cell Research2012，22，10： | 3 |
| 7 | Genetic control of compound leaf development in the mungbean(Vigna radiata L.)显示文摘Many studies suggest that there are distinct regulatory processes controlling compound leaf development in different clades of legumes.Loss of function of the LEAFY(LFY)orthologs results in a reduction of leaf complexity to different degrees in inverted repeat-lacking clade(IRLC)and non-IRLC species.To further understand the role of LFY orthologs and the molecular mechanism in compound leaf development in non-IRLC plants,we studied leaf development in unifoliate leaf(un)mutant,a classical mutant of mungbean(Vigna radiata L.),which showed a complete conversion of compound leaves into simple leaves.Our analysis revealed that UN encoded the mungbean LFY ortholog(VrLFY)and played a significant role in leaf development.In situ RNA hybridization results showed that STM-like KNOXI genes were expressed in compound leaf primordia in mungbean.Furthermore,increased leaflet number in heptafoliate leaflets1(hel1)mutants was demonstrated to depend on the function of VrLFY and KNOXI genes in mungbean.Our results suggested that HEL1 is a key factor coordinating distinct processes in the control of compound leaf development in mungbean and its related non-IRLC legumes. | Keyuan Jiao Xin Li Shihao Su Wuxiu Guo Yafang Guo Yining Guan Zhubing Hu Zhenguo Shen Da Luo | 2019 | Horticulture Research2019，6，1： | 2 |
| 8 | Structural and biochemical studies of RIG-I antiviral signaling显示文摘Retinoic acid-inducible gene I(RIG-I)is an important pattern recognition receptor that detects viral RNA and triggers the production of type-I interferons through the downstream adaptor MAVS(also called IPS-1,CARDIF,or VISA).A series of structural studies have elaborated some of the mechanisms of dsRNA recognition and activation of RIG-I.Recent studies have proposed that K63-linked ubiquitination of,or unanchored K63-linked polyubiquitin binding to RIG-I positively regulates MAVS-mediated antiviral signaling.Conversely phos-phorylation of RIG-I appears to play an inhibitory role in controlling RIG-I antiviral signal transduction.Here we performed a combined structural and biochemical study to further define the regulatory features of RIG-I signaling.ATP and dsRNA binding triggered dimeriza-tion of RIG-I with conformational rearrangements of the tandem CARD domains.Full length RIG-I appeared to form a complex with dsRNA in a 2:2 molar ratio.Com-pared with the previously reported crystal structures of RIG-I in inactive state,our electron microscopic struc-ture of full length RIG-I in complex with blunt-ended dsRNA,for the first time,revealed an exposed active conformation of the CARD domains.Moreover,we found that purified recombinant RIG-I proteins could bind to the CARD domain of MAVS independently of dsRNA,while S8E and T170E phosphorylation-mimick-ing mutants of RIG-I were defective in binding E3 ligase TRIM25,unanchored K63-linked polyubiquitin,and MAVS regardless of dsRNA.These findings suggested that phosphorylation of RIG inhibited downstream signaling by impairing RIG-I binding with polyubiquitin and its interaction with MAVS. | Miao Feng Zhanyu Ding Liang Xu Liangliang Kong Wenjia Wang Shi Jiao Zhubing Shi Mark IGreene Yao Cong Zhaocai Zhou | 2013 | Protein & Cell2013，4，2： | 2 |
| 9 | Post-translational modifications of hepatitis C viral proteins and their biological significance显示文摘Replication of hepatitis C virus(HCV)depends on the interaction of viral proteins with various host cellular proteins and signalling pathways.Similar to cellular proteins,post-translational modifications(PTMs)of HCV proteins are essential for proper protein function and regulation,thus,directly affecting viral life cycle and the generation of infectious virus particles.Cleavage of the HCV polyprotein by cellular and viral proteases into more than 10 proteins represents an early protein modification step after translation of the HCV positivestranded RNA genome.The key modifications include the regulated intramembranous proteolytic cleavage of core protein,disulfide bond formation of core,glycosylation of HCV envelope proteins E1 and E2,methylation of nonstructural protein 3(NS3),biotinylation of NS4A,ubiquitination of NS5B and phosphorylation of core and NS5B.Other modifications like ubiquitination of core and palmitoylation of core and NS4B proteins have been reported as well.For some modifications such as phosphorylation of NS3 and NS5A and acetylation of NS3,we have limited understanding of their effects on HCV replication and pathogenesis while the impact of other modifications is far from clear.In this review,we summarize the available information on PTMs of HCV proteins and discuss their relevance to HCV replication and pathogenesis. | Jana Hundt Zhubing Li Qiang Liu | 2013 | World Journal of Gastroenterology2013，19，47： | 2 |
| 10 | Ternary polymer nanocomposites with concurrently enhanced dielectric constant and breakdown strength for high-temperature electrostatic capacitors显示文摘The exploration of high-energy-density electrostatic capacitors capable of operating both efficiently and reliably at elevated temperatures is of great significance in order to meet advanced power electronic applications.The energy density of a capacitor is strongly dependent on dielectric constant and breakdown strength of a dielectric material.Here,we demonstrate a class of solution-processable polymer nanocomposites exhibiting a concurrent improvement in dielectric constant and breakdown strength,which typically show a negative correlation in conventional dielectric materials,along with a reduction in dielectric loss.The excellent performance is enabled by the elegant combination of nanostructured barium titanate and boron nitride fillers with complementary functionalities.The ternary polymer nanocomposite with the optimized filler compositions delivers a discharged energy density of 2.92 J cm^−3 and a Weibull breakdown strength of 547 MV m^−1 at 150℃,which are 83%and 25%,respectively,greater than those of the pristine polymer.The conduction behaviors including interfacial barrier and carrier transport process have been investigated to rationalize the energy storage performance of ternary polymer nanocomposite.This contribution provides a new design paradigm for scalable high-temperature polymer film capacitors. | He Li Lulu Ren Ding Ai Zhubing Han Yang Liu Bin Yao Qing Wang | 2020 | InfoMat2020，2，2： | 2 |
| 11 | The genetic equidistance result:misreading by the molecular clock and neutral theory and reinterpretation nearly half of a century later显示文摘In 1963,Margoliash discovered the unexpected genetic equidistance result after comparing cytochrome c sequences from different species.This finding,together with the hemoglobin analyses of Zuckerkandl and Pauling in 1962,directly inspired the ad hoc molecular clock hypothesis.Unfortunately,however,many biologists have since mistakenly viewed the molecular clock as a genuine reality,which in turn inspired Kimura,King,and Jukes to propose the neutral theory of molecular evolution.Many years of studies have found numerous contradictions to the theory,and few today believe in a universal constant clock.What is being neglected,however,is that the failure of the molecular clock hypothesis has left the original equidistance result an unsolved mystery.In recent years,we fortuitously rediscovered the equidistance result,which remains unknown to nearly all researchers.Incorporating the proven virtues of existing evolutionary theories and introducing the novel concept of maximum genetic diversity,we proposed a more complete hypothesis of evolutionary genetics and reinterpreted the equidistance result and other major evolutionary phenomena.The hypothesis may rewrite molecular phylogeny and population genetics and solve major biomedical problems that challenge the existing framework of evolutionary biology. | HU TaoBo LONG MengPing YUAN DeJian ZHU ZhuBing HUANG YiMin HUANG Shi | 2013 | Science China(Life Sciences)2013，56，3： | 2 |
| 12 | Engineering of dendritic dopant-free hole transport molecules:enabling ultrahigh fill factor in perovskite solar cells with optimized dendron construction显示文摘Developing dopant-free hole-transporting materials(HTMs)for high-performance perovskite solar cells(PVSCs)has been a very active research topic in recent years since HTMs play a critical role in optimizing interfacial charge carrier kinetics and in turn determining device performance.Here,a novel dendritic engineering strategy is first utilized to design HTMs with a D-A type molecular framework,and diphenylamine and/or carbazole is selected as the building block for constructing dendrons.All HTMs show good thermal stability and excellent film morphology,and the key optoelectronic properties could be fine-tuned by varying the dendron structure.Among them,MPA-Cz-BTI and MCz-Cz-BTI exhibit an improved interfacial contact with the perovskite active layer,and non-radiative recombination loss and charge transport loss can be effectively suppressed.Consequently,high power conversion efficiencies(PCEs)of 20.8%and 21.35%are achieved for MPA-Cz-BTI and MCz-Cz-BTI based devices,respectively,accompanied by excellent long-term storage stability.More encouragingly,ultrahigh fill factors of 85.2%and 83.5%are recorded for both devices,which are among the highest values reported to date.This work demonstrates the great potential of dendritic materials as a new type of dopant-free HTMs for high-performance PVSCs with excellent FF. | Wei Chen Yang Wang Bin Liu Yajun Gao Ziang Wu Yongqiang Shi Yumin Tang Kun Yang Yujie Zhang Weipeng Sun Xiyuan Feng Frédéric Laquai Han Young Woo Aleksandra B.Djurisic Xugang Guo Zhubing He | 2021 | Science China Chemistry2021，64，1： | 2 |
| 13 | The interaction of GSSG modified magnetic nanoparticles with SPC-A1 cells in vitro显示文摘Magnetic nanoparticles(MNPs) are promising materials for various biomedical applications,including magnetic resonance imaging,stem cell tracking,gene/drug delivery,and cancer treatment.To increase the effectiveness of MNPs,high capture efficiency and controlled uptake of the particles by cells is required.In this paper we report the cytotoxicity and cellular uptake into SPC-A1 cells of oxidized glutathione(GSSG)-modified MNPs(GSSG@Fe3O4).Experimental findings indicated that GSSG@Fe3O4 were biocompatible,and could be efficiently taken up by SPC-A1 cells(up to 160 pg iron per cell).The internalized GSSG@Fe3O4 was retained in the cell cytoplasm for 6 generations.The uptake of GSSG@Fe3O4 into SPC-A1 cells was energy-,concentration-and time-dependent.Pinocytosis may be involved in the internalization process of GSSG@Fe3O4 into SPC-A1 cells,but this mechanism remains to be elucidated.The controlled and efficient localization of GSSG@Fe3O4 into the cytosol and long intracellular retention provides theoretical and experimental insight into the biomedical applications for these molecules. | MA YongJie YAN ZhuBing XU Hong GU HongChen | 2012 | Chinese Science Bulletin2012，57，26： | 2 |
| 14 | Single zinc-doped Indium Oxide Nanowire as Driving Transistor for Organic Light-emitting Diode显示文摘 | ZHANG Wenfeng JIE Jiansheng HE Zhubing | 2008 | Applied Physics Letters2008，92，： | 1 |
| 15 | Heavy metal absorption status of five plant species in monoculture and in- tercropping 显示文摘 | Lingyao An Yanhui Panl Zhubing Wang | 2011 | Plant and Soil2011，345，12： | 1 |
| 16 | Two Arabidopsis Receptor-like Cytoplasmic Kinases SZE1 and SZE2 Associate with the ZAR1-ZED1 Complex and Are Required for Effector-Triggered Immunity显示文摘Plants utilize intracellular nucleotide-binding leucine-rich repeat domain-containing receptors (NLRs) to recognize pathogen effectors and induce a robust defense response named effector-triggered immunity (ETI). The Arabidopsis NLR protein HOPZ-ACTIVATED RESISTANCE 1 (ZAR1) forms a precomplex with HOPZ-ETI-DEFICIENT 1 (ZED1),a receptor-like cytoplasmic kinase (RLCK) XII-2 subfamily member, to recognize the Pseudomonas syringae effector HopZ1 a. We previously described a dominant mutant of Arabi-dopsis ZED1, zed1-D, which displays temperature-sensitive autoimmunity in a ZAR1-dependent manner. Here, we report that the RLCKs SUPPRESSOR OF ZED1-D1 (SZE1) and SZE2 associate with the ZAR1-ZED1 complex and are required for the ZED7-D-activated autoimmune response and HopZ1a-triggered immunity. We show that SZE1 but not SZE2 has autophosphorylation activity, and that the N-terminal myristoylation of both SZE1 and SZE2 is critical for their plasma membrane localization and ZED1-D-activated autoimmunity. Furthermore, we demonstrate that SZE1 and SZE2 both interact with ZAR1 to form ja functional complex and are required for resistance against P. syringae pv. tomato DC3000 ex-pressing HopZIa. We also provide evidence that SZE1 and SZE2 interact with HopZ1a and function together with ZED1 to change the intramolecular interactions of ZAR1, leading to its activation. Taken together, our re-sults reveal SZE1 and SZE2 as critical signaling components of HopZ1a-triggered immunity. | Cheng Liu Dayong Cui Jingbo Zhao Na Liu Bo Wang Jing Liu Enjun Xu Zhubing Hu Dongtao Ren Dingzhong Tang Yuxin Hu | 2019 | Molecular Plant2019，12，7： | 1 |
| 17 | Failure Behavior of Thermal Barrier Coatings on Cylindrical Superalloy Tube Under Thermomechanical Fatigue显示文摘Failure behavior of thermal barrier coatings on cylindrical superalloy tube was investigated under thermomechanical fatigue(TMF).Two types of TMF tests,i.e.in phase(IP) and out of phase(OP),were performed in the temperature range of 450-850℃.All tests were carried out under mechanical strain control at a given period of 300 s.The bond coat NiCrA1Y was produced by high velocity oxygen fuel(HVOF),and the top coat 7%Y2O3-ZrO2 was deposited by air plasma spraying(APS).The testing results showed that the OP TMF life was longer than the IP TMF one under the same mechanical strain amplitude.Observations of the fractured specimens revealed that the interface damage and cracking behavior in the two phasing conditions were different.In OP loading,the top coat was cracked and detached from the bond coat while no spallation was found in the IP loading. | Zhubing CHEN Zhongguang WANG Shijie ZHU | 2013 | Acta Metallurgica Sinica(English Letters)2013，26，4： | 1 |
| 18 | Improved PCR method for amplification of GC-rich DNA sequences显示文摘 | ZHube F Reverdiau P Iochmann S | 2005 | Mol Biotechnol2005，31，1： | 1 |
| 19 | A Kinase-Phosphatase-Transcription Factor Module Regulates Adventitious Root Emergence in Arabidopsis Root-Hypocotyl Junctions显示文摘Adventitious roots form from non-root tissues as part of normal development or in response to stress or wounding.The root primordia form in the source tissue,and during emergence the adventitious roots penetrate the inner cell layers and the epidermis;however,the mechanisms underlying this emergence remain largely unexplored.Here,we report that a regulatory module composed of the AP2/ERF transcription factor ABSCISIC ACID INSENSITIVE 4(ABI4),the MAP kinases MPK3 and MPK6,and the phosphatase PP2C12 plays an important role in the emergence of junction adventitious roots(J-ARs)from the root-hypocotyl junctions in Arabidopsis thaliana.ABI4 negatively regulates J-AR emergence,preventing the accumulation of reactive oxygen species and death of epidermal cells,which would otherwise facilitate J-AR emergence.Phosphorylation by MPK3/MPK6 activates ABI4 and dephosphorylation by PP2C12 inactivates ABI4.MPK3/MPK6 also directly phosphorylate and inactivate PP2C12 during J-AR emergence.We propose that this'double-check'mechanism increases the robustness of MAP kinase signaling and finely regulates the local programmed cell death required for J-AR emergence. | Zechen Bai Jing Zhang Xin Ning Hailong Guo Xiumei Xu Xiahe Huang Yingchun Wang Zhubing Hu Congming Lu Lixin Zhang Wei Chi | 2020 | Molecular Plant2020，13，8： | 1 |
| 20 | Robust nonlinear control of a hypersonic aircraft based on sliding mode con- trol 显示文摘 | Hu Zhubing Mo bo Zhou Dezhi | 2012 | Procedia Engineering2012，29，3： | 1 |
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