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| 1 | Effect of preoperative regional artery chemotherapy on proliferation and apoptosis of gastric carcinoma cells显示文摘AIM: To study the effects of preoperative regional arterychemotherapy (PRACT) in inducing growth inhibition andapoptosis of gastric carcinorna (GC) calls.METHODS: TUNEL ( terminal-deoxynucleotidyl-transferaseTdT-mediated dUTP-fluorescein and labeling) method andimmunohistochemical techniques were used to detect thestate of apoptosis and proliferation of GC cells inhistopathologic sections. A total of 110 cases of GC and 68cases of metastatic lymph node with or without PRACT wereadopted. Correlations between apoptosis index (Al),proliferation index (PI) and PRACT and prognosis wereanalysed.RESULTS: The apoptosis index (Al) was significantly higherin the PRACT group (12.5 ‰ + 4.33‰) than in the untreatedgroup (7. 1‰ + 3. 43 ‰, P < 0. 001 ), whereas theproliferation index (PI) in the PRACT group (33.8 % ± 8.8% ) was eignificantly lower than that in untreated group (43.6 % + 12.8 %, P<0.01). Both Al and PI were correlated tothe differentiation degree of GC in PRACT group, the Al inthe differentiated group was higher than that inundifferentiated group (P<0.001), but the PI was lower inthe differentiated group than that of the undifferentiatedgroup ( P < 0.01 ). The Al of GC cells in metastatic lymphnode was also significantly higher in the PRACT group (7.9‰+ 3.41‰) than in the untreated group (3.6 ‰ + 2.93 ‰,P < 0.01 ), though the PI of GC cells in metastatic lymphnodes in the PRACT group (17. 2 % + 6. 8 % ) wassignificantly lower than that in the untreated group (26.7 %+ 9. 3 %, P < 0. 01 ). The severity of histopathologicchanges was significantly higher in the PRACT group than inthe untreated group ( P < 0.05). In addition, postoperativesurveys demonstrated that the 5-year survival rate of GCpatients in the PRACT group was significantly higher than thatof patients in the untreated group (P<0.01).CONCLUSION: Preoperative regional artery chemotherapy(PRACT) showed inhibitory action on the growth of GC cellsmainly through inhibiting proliferation and inducing theapoptosis of tumor cells. PRACT can improve the prognosisof GC patients also. | Tao, HQ Zou, SC | 2002 | World Journal of Gastroenterology2002，8，3： | 49 |
| 2 | Detection of serum tumor markers in the diagnosis and treatment of patients with pancreatic cancer显示文摘BACKGROUND: Although a variety of tumor markers areavailable for diagnosis of pancreatic cancer, their sensitivityand specificity have not yet been ideal. The aims of thisstudy was to detect a panel of serum tumor markers and toevaluate their significance in the diagnosis and prognosis ofpancreatic cancer patients.METHODS: Eight serum tumor markers including AFP,CEA, CA-50, CA72-4, CA-125, CA153, CA19-9 and CA242were detected in 129 patients with pancreatic cancer by usingchemiluminescence immunoassay, immunofluorescence as-say and immunoradiometric assay, respectively. The levelsof these markers were compared in 99 patients with non-pancreatic malignant tumor, 63 patients with other benigndiseases, and 27 patients with pancreatic cancer after pan-createctomy.RESULTS: Among the 8 tumor markers, CA19-9, CA242,CA-50, and CA72-4 were more sensitive in the diagnosis ofpancreatic cancer. Parallel combined testing could increasethe diagnostic sensitivity to 89.2%, and serial combined exa-mination could increase the diagnostic specificity to 92.3%.The serum tumor markers levels were decreased significant-ly after radical tumor resection.CONCLUSIONS: Serum CA19-9, CA242, CA-50, andCA72-4 are the preferred tumor markers to be used in thediagnosis and follow-up of operated cases of pancreaticcancer. Testing of a panel of multiple serum tumor mark-ers may increase the sensitivity and specificity in the diag-nosis of pancreatic cancer. | Xiao-Ting Jiang, Hou-Quan Tao and Shou-Chun Zou Clinical Medical Laboratory and Depart-ment of Surgery , Zhejiang Provincial People’ sHospital, Hangzhou 310014 , China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，3： | 35 |
| 3 | Progress in China's Unconventional Oil & Gas Exploration and Development and Theoretical Technologies显示文摘The new century has witnessed a strategic breakthrough in unconventional oil & gas.Hydrocarbon accumulated in micro-/nano-scale pore throat shale systems has become an important domain that could replace current oil & gas resources.Unconventional oil & gas plays an increasingly important role in our energy demand.Tight gas,CBM,heavy oil and asphaltic sand have served as a key domain of exploration & development,with tight oil becoming a 'bright spot' domain and shale gas becoming a 'hotspot' domain.China has made great breakthroughs in unconventional oil & gas resources,such as tight gas,shale gas,tight oil and CBM,and great progress in oil shale,gas hydrate,heavy oil and oil sand.China has an estimated(223-263)×10~8t of unconventional oil resources and(890-1260)×l0^(12)m^3 of gas resources.China has made a breakthrough for progress in unconventional oil & gas study.New progress achieved in fine-grained sedimentary studies related to continental open lacustrine basin large-scale shallow-water delta sand bodies,lacustrine basin central sandy clastic flow sediments and marine-continental fine-grained sediments provide a theoretical basis for the formation and distribution of basin central reservoir bodies.Great breakthroughs have been made in unconventional reservoir geology in respect of research methodology & technology,multi-scale data merging and physical simulation of formation conditions.Overall characterization of unconventional reservoirs via multi-method and multi-scale becomes increasingly popular and facilitates the rapid development of unconventional oil & gas geological theory,method and technology.The formation of innovative,continuous hydrocarbon accumulation theory,the establishment of the framework of the unconventional oil & gas geological theory system,and the determination of the implications,geological feature,formation mechanism,distribution rule and core technology of unconventional oil& gas geological study lays a theoretical foundation for extensive unconventional oil & gas exploration and development.Theories and technologies of unconventional oil & gas exploration and development developed rapidly,including some key evaluation techniques such as 'sweet spot zone' integrated evaluation and a six-property evaluation technique that uses hydrocarbon source,lithology,physical property,brittleness,hydrocarbon potential and stress anisotropy,and some key development &engineering technologies including micro-seismic monitoring,horizontal drilling & completion and 'factory-like' operation pattern, 'man-made reservoir' development,which have facilitated the innovative development of unconventional oil & gas.These breakthroughs define a new understanding in four aspects:①theoretical innovation;② key technologies;③ complete market mechanism and national policy support;and ④ well-developed ground infrastructure,which are significant for prolonging the life cycle of petroleum industry,accelerating the upgrade and development of theories and technologies and altering the global traditional energy structure. | ZOU Caineng YANG Zhi ZHU Rukai ZHANG Guosheng HOU Lianhua WU Songtao TAO Shizhen YUAN Xuanjun DONG Dazhong WANG Yuman WANG Lan HUANG Jinliang WANG Shufang | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 27 |
| 4 | Magma mixing of granites at Lianghe:In-situ zircon analysis for trace elements, U-Pb ages and Hf isotopes显示文摘In this paper, we report an integrated study of trace element, U-Pb age and Hf isotopic composition of zircons from alkali feldspar granites, granodiorites and diorite enclaves in a recently discovered ring complex at Lianghe in western Yunnan, Chi na. The granitoids showed identical U-Pb ages of 127, 115 and 122 Ma, from felsic to mafic, but had different zircon trace el ements and Hf isotopic compositions. Trace element content decreased with a gradual increase in εHf(t) values of ?9.1 to ?5.4, ?4.5 to 0, and 3.6 to 6.2, respectively. Results indicate that changes in zircon trace elements generally correlate with changes in Hf isotope signatures within single samples and among various granitoids. These relationships reflect the mixing of felsic and mafic magmas. Evidence indicates that depleted mantle-derived mafic magma underplating caused ancient crustal melting, and then formed large-scale granites in Lianghe during the Early Cretaceous. These granodiorites were formed mainly by the mix ing of mafic magma and granitic magma. | CONG Feng LIN ShiLiang ZOU GuangFu LI ZaiHui XIE Tao PENG ZhiMin LIANG Ting | 2011 | Science China Earth Sciences2011，54，9： | 26 |
| 5 | Geologic characteristics, controlling factors and hydrocarbon accumulation mechanisms of China’s Large Gas Provinces of low porosity and permeability显示文摘Based on the analysis of the geological characteristics and controlling factors, we analyzed the formation mechanism of different types of gas reservoirs. The main characteristics of gas provinces with low porosity and permeability are mainly as follows: large area, low abundance, small gas pools and large gas provinces; widely distributed excellent hydrocarbon source rocks with closely contacted source-reservoir-cap association; development mainly in large continental depressions or in paralic shallow-river delta systems; many kinds of traps coexisting in large areas, dominantly para-layered lithologic, digenetic and capillary pressure traps; double fluid flow mechanisms of Darcy flow and non-Darcy flow; complicated gas and water relations; and having the resource distribution of highly productive 'sweet spots', banding concentration, and macroscopically large areas integrated. The main controlling factors of large sandstone gas provinces with low porosity and permeability are stable dynamic backgrounds and gentle structural frameworks which control the extensive distribution of alternate (interbedded) sandstones and mudstones; weak hydropower of large gentle lake basins controlling the formation of discontinuous, low porosity and permeability reservoirs in shallow-water deltas; regionally differential diagenesis and no homogeneous digenetic facies controlling the development of favorable reservoirs and digenetic traps; and weak and dispersive reservoir-forming dynamic forces leading to the widely distributed small traps with low abundance. Low porosity and permeability gas provinces with different trap types have different formation mechanisms which include fluid diversion pressure difference interactive mechanism of lithologic-trap gas accumulations, separated differential collection mechanism of digenetic-trap gas accumulations, and the Non-Darcy flow mechanism of capillary-pressure gas accumulations. | ZOU CaiNeng TAO ShiZhen ZHANG XiangXiang HE DongBo ZHOU ChuanMin GAO XiaoHui | 2009 | Science China Earth Sciences2009，52，8： | 22 |
| 6 | A method to estimate concentrations of surface-level particulate matter using satellite-based aerosol optical thickness显示文摘We propose a new method to estimate surface-level particulate matter(PM)concentrations by using satellite-retrieved Aerosol Optical Thickness(AOT).This method considers the distribution and variation of Planetary Boundary Layer(PBL)height and relative humidity(RH)at the regional scale.The method estimates surface-level particulate matter concentrations using the data simulated by an atmospheric boundary layer model RAMS and satellite-retrieved AOT.By incorporation MODIS AOT,PBL height and RH simulated by RAMS,this method is applied to estimate the surface-level PM 2.5 concentrations in North China region.The result is evaluated by using 16 ground-based observations deployed in the research region,and the result shows a good agreement between estimated PM 2.5 concentrations and observations,and the coefficient of determination R2 is 0.61 between the estimated PM 2.5 concentrations and the observations.In addition,surface-level PM 2.5 concentrations are also estimated by using MODIS AOT,ground-based LIDAR observations and RH measurements.A comparison between the two estimated PM 2.5 concentrations shows that the new method proposed in this paper is better than the traditional method.The coefficient of determination R2 is improved from 0.32 to 0.62. | TAO JinHua ZHANG MeiGen CHEN LiangFu WANG ZiFeng SU Lin GE Cui HAN Xiao ZOU MingMin | 2013 | Science China Earth Sciences2013，56，8： | 20 |
| 7 | A clinical and long-term follow-up study of perioperative sequential triple therapy for gastric cancer显示文摘INTRODUCTIONAlthough the long-term postoperative survival rateof gastric cancer(GC) patients has been improvedsignificantly since the local dissection of lymph nodewas widely used in China,yet the low curativeresection rate and the high recurrence rate fromperitoneal and hepatic metastases hinder it fromfurther improvement.To alter the currentunsatisfactory status of GC treatment,a | Zou SC Qiu HS Zhang CW Tao HQ | 2000 | World Journal of Gastroenterology2000，6，2： | 18 |
| 8 | Discrimination of abiogenic and biogenic alkane gases显示文摘We have combined the analytical data of the carbon isotope distribution pattern, R/Ra and CH4/3He values of abiogenic and biogenic (referring to the thermogenic and bacterial or microbial) alkane gases in China with those of alkane gases from USA, Russia, Germany, Australia and other countries. Four discrimination criteria are derived from this comparative study: 1) Carbon isotopic composition is generally greater than -30‰ for abiogenic methane and less than -30‰ for biogenic methane; 2) Abiogenic alkane gases have a carbon isotopic reversal trend (δ 13C1> δ 13C2> δ 13C3> δ 13C4) with δ 13C1>-30‰ in general; 3) Gases with R/Ra >0.5 and δ 13C11 δ 13C2>0 are of abiogenic origin; 4) Gases (meth- ane) with CH4/3He≤106 are of abiogenic origin, whereas gases with CH4/3He≥1011 are of biogenic origin. | DAI JinXing ZOU CaiNeng ZHANG ShuiChang LI Jian NI YunYan HU GuoYi LUO Xia TAO ShiZhen ZHU GuangYou MI JingKui LI ZhiSheng HU AnPing YANG Chun ZHOU QingHua SHUAI YanHua ZHANG Ying MA ChengHua | 2008 | Science China Earth Sciences2008，51，12： | 17 |
| 9 | PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130显示文摘Golgi 仪器(GA ) 的维护结构和功能取决于 Golgi 矩阵蛋白质。象 golgin 和掌握家庭的成员的 phosphorylation 那样的 Golgi 蛋白质的 posttranslational 修正为决定 Golgi 建筑学是重要的。包括 golgin-84 的一些 Golgi 蛋白质也被知道是 methylated,但是 golgin methylation 的功能仍然保持不清楚。这里,我们证明蛋白质精氨酸 methyltransferase (PRMT5 ) 5 本地化到 GA 和形式建筑群,几个部件在拴住的 GA 带子形成和泡包含了。PRMT5 在 Golgi 带子形成与 PRMT5 原因缺点的 golgin GM130,和弄空交往。而且,在 GM130 的 PRMT5 甲醇化物 N 终端精氨酸,和如此的精氨酸 methylation 为 GA 显得批评带子形成。我们的调查结果揭示 GM130 的 PRMT5 依赖的精氨酸 methylation 由控制 GA 建筑学的维护的分子的机制。 | Zhongwei Zhou Xiaotian Sun Zhenhua Zou Litao Sun Tao Zhang Shaoshi Guo Ya Wen Lin Liu Yi Wang Jun Qin Lei Li Weimin Gong Shilai Bao | 2010 | Cell Research2010，20，9： | 16 |
| 10 | Geochronology and Petrogenesis for the Protolith of Biotite Plagioclase Gneiss at Lianghe,Western Yunnan显示文摘在这份报纸,我们在西方的云南在 Lianghe 从黑云母斜长石片麻岩报导 U-Pb 年龄的综合研究和锆石的 Hf 同位素作文。锆石保存了继承核心和边界质地。火的锆石谷物和边界产出 120.4 的加权的吝啬的 206Pb/238U 年龄 ????晈 吗?? | CONG Feng LIN Shiliang ZOU Guangfu XIE Tao LI Zaihui TANG Fawei PENG Zhimin | 2011 | Acta Geologica Sinica(English Edition)2011，85，4： | 16 |
| 11 | A Dual-mode Nonlinear Model Predictive Control with the Enlarged Terminal Constraint Sets显示文摘Aiming at a class of nonlinear systems with multiple equilibrium points, we present a dual-mode model predictive control algorithm with extended terminal constraint set combined with control invariant set and gain schedule. Local LQR control laws and the corresponding maximum control invariant sets can be designed for finite equilibrium points. It is guaranteed that control invariant sets are overlapped each other. The union of the control invariant sets is treated as the terminal constraint set of predictive control. The feasibility and stability of the novel dual-mode model predictive control are investigated with both variable and fixed horizon. Because of the introduction of extended terminal constrained set, the feasibility of optimization can be guaranteed with short prediction horizon. In this way, the size of the optimization problem is reduced so it is computationally efficient. Finally, a simulation example illustrating the algorithm is presented. | ZOU Tao LI Shao-Yuao DING Bao-Cang | 2006 | 自动化学报2006，32，1： | 16 |
| 12 | Analysis of Reservoir Forming Conditions and Prediction of Continuous Tight Gas Reservoirs for the Deep Jurassic in the Eastern Kuqa Depression,Tarim Basin显示文摘The exploration targets in the Kuqa Depression at present are mainly structure traps in Cretaceous-Tertiary.Due to the complexity of mountain distribution and reservoir forming conditions, the exploration of Jurassic in the eastern Kuqa Depression has been in a state of semi-stagnation since the discovery of the Yinan-2 gas reservoir.According to the concept and theory of 'continuous petroleum reservoirs' and the re-analysis of the forming conditions of the Yinan-2 gas reservoir and regional natural gas ... | ZOU Caineng JIA Jinhua TAO Shizhen TAO Xiaowan | 2011 | Acta Geologica Sinica(English Edition)2011，85，5： | 15 |
| 13 | Generation of RAG 1- and 2-deficient rabbits by embryo microinjection of TALENs显示文摘 | Jun Song Juan Zhong Xiaogang Guo Yongqiang Chen Qingjian zou Jiao Huang Xiaoping Li Quanjun Zhang Zhiwu Jiang Chengcheng Tang Huaqiang Yang Tao Liu Peng Li Duanqing Pei Liangxue Lai | 2013 | Cell Research2013，23，8： | 15 |
| 14 | The causes and impacts for heat stress in spring maize during grain filling in the North China Plain--A review显示文摘High-temperature stress(HTS) at the grain-filling stage in spring maize(Zea mays L.) is the main obstacle to increasing productivity in the North China Plain(NCP). To solve this problem, the physiological mechanisms of HTS, and its causes and impacts, must be understood. The HTS threshold of the duration and rate in grain filling, photosynthetic characteristics(e.g., the thermal stability of thylakoid membrane, chlorophyll and electron transfer, photosynthetic carbon assimilation), water status(e.g., leaf water potential, turgor and leaf relative water content) and signal transduction in maize are reviewed. The HTS threshold for spring maize is highly desirable to be appraised to prevent damages by unfavorable temperatures during grain filling in this region. HTS has negative impacts on maize photosynthesis by damaging the stability of the thylakoid membrane structure and degrading chlorophyll, which reduces light energy absorption, transfer and photosynthetic carbon assimilation. In addition, photosynthesis can be deleteriously affected due to inhibited root growth under HTS in which plants decrease their water-absorbing capacity, leaf water potential, turgor, leaf relative water content, and stomatal conductance. Inhibited photosynthesis decrease the supply of photosynthates to the grain, leading to falling of kernel weight and even grain yield. However, maize does not respond passively to HTS. The plant transduces the abscisic acid(ABA) signal to express heat shock proteins(HSPs), which are molecular chaperones that participate in protein refolding and degradation caused by HTS. HSPs stabilize target protein configurations and indirectly improve thylakoid membrane structure stability, light energy absorption and passing, electron transport, and fixed carbon assimilation, leading to improved photosynthesis. ABA also induces stomatal closure to maintain a good water status for photosynthesis. Based on understanding of such mechanisms, strategies for alleviating HTS at the grain-filling stage in spring maize are summarized. Eight strategies have the potential to improve the ability of spring maize to avoid or tolerate HTS in this study, e.g., adjusting sowing date to avoidHTS, breeding heat-tolerance varieties, and tillage methods, optimizing irrigation, heat acclimation, regulating chemicals, nutritional management, and planting geometric design to tolerate HTS. Based on the single technology breakthrough, a comprehensive integrated technical system is needed to improve heat tolerance and increase the spring maize yield in the NCP. | TAO Zhi-qiang CHEN Yuan-quan LI Chao ZOU Juan-xiu YAN Peng YUAN Shu-fen WU Xia SUI Peng | 2016 | Journal of Integrative Agriculture2016，15，12： | 15 |
| 15 | Effect and mechanism of Irbesartan on occurrence of ventricular arrhythmias in rats with myocardial ischemia through connexin43(cx43)显示文摘Objective: To explore the effect and mechanism of angiotensin Ⅱ receptor blockers-Irbesartan on occurrence of ventricular arrhythmias in rats with myocardial ischemia. Methods: Rats with embryonic cardiomyocytes-H9c2 were randomly divided into control group, ischemia group, Irbesartan group and Irbesartan+ischemia group. The cell viability of rats in each group was tested using MTT. Real-time PCR was employed to detect the expression of connexin43(Cx43) mR NA and western blot to detect the expression of Cx43 and phosphorylated Cx43. SD rats were randomly divided into the sham-operation group(SO), myocardial infarction group(MI), Irbesartan group and MI+ Irbesartan group, with 10 rats in each group. HE staining was employed to observe the change in the pathomorphology of left ventricular tissue and TUNEL method to analyze the cell apoptosis in the tissue. The immunofluorescence was adopted to observe the expression and distribution of Cx43 in the left ventricular myocardium and study the change in the expression of Cx43 in the cardiac muscular tissue at mR NA and protein level. Results: The intervention of Irbesartan in the condition of ischemia indicated the significant decrease in the number of necrotic cells. The expression of Cx43 was significantly decreased under the culture of ischemia(P<0.05), but in the presence of Irbesartan, the expression of Cx43 was increased compared with the ischemia group(P<0.01). The results of WB assay showed the similar trend of change at mRNA level. There was the significant difference in the score of ventricular arerythmia between MI group and SO group(P<0.01). The incidence of ventricular tachycardia or ventricular fibrillation was significantly increased compared with the one in SO group(P<0.05). There was the significant difference in the overall score between MI+Irbesartan group and MI group(P<0.05). The expression of Cx43 in the cardiac muscular tissue in MI group was significantly decreased(P<0.01 vs SO group). But the expression of Cx43 was increased after the treatment with Irbesartan. Conclusions: Irbesartan can inhibit the injury of H9c2 cardiomyocytes and the decreased expression of Cx43 that are induced by the ischemic myocardial infarction. Irbesartan can also improve the reconstruction of Cx43 in rats with ischemic myocardium to inhibit the myocardial infarction-induced arrhythmias. | Tao Wu Dan Wu Qinghua Wu Bing Zou Xiao Huang Xiaoshu Cheng Yanqing Wu Kui Hong Ping Li | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，10： | 15 |
| 16 | Mogroside V inhibits LPS-induced COX-2 expression/ROS production and overexpression of HO-1 by blocking phosphorylation of AKT1 in RAW264.7 cells显示文摘Momordica grosvenori is a valuable edible plant with medicinal purposes, and it is widely used in medicated diets and traditional Chinese medicine in Asia. Mogroside V (MV), the main bioactive component from M. grosvenori, is comm only used as a natural sweetener. M. grosvenori extracts have been reported to exert potent anti-inflammatory property, however the underlying molecular mechanism still remains unknown. In the present study, the biological effect of MV in inflammation was investigated in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. The ELISA and western blot analysis results showed that MV significantly inhibited LPS-induced prostaglandin E2 (PGE2) production and cyclooxygenase-2 (COX-2) expression. MV markedly decreased the phosphorylation of IxB-a, increased IkB-oc, and reduced nuclear p-65 and C/EBP6. Furthermore, MV attenuated LPS-induced phosphorylation of MAPKs and AKT1, and only the phosphorylation status of AKT1 was found to be consistent with the expression trend of COX-2. Moreover, MV reduced ROS level and restored overexpressed HO-1 and AP-1 to basal level, which can be markedly reversed by AKT1 inhibitor LY294002. These results revealed that AKT1 plays a key role in LPS-induced COX-2 expression, and acts as a mediator to keep the redox balance in LPS-stimulated RAW264.7 cells. MV exerts anti-inflammatory property by blocking AKT1-mediated NF-kB and C/EBP6 activation, ROS generation and AP-1/ HO-1 expression. Therefore, the present study indicated that MV has a significant chemopreventive effect on the inflammatory lesions and suggested that AKT1 is a potential specific target of MV for relieving inflammation. | Yong Li Luyan Zou Tao Li Dengni Lai Yanyang Wu Si Qin | 2019 | Acta Biochimica et Biophysica Sinica2019，51，4： | 14 |
| 17 | Simultaneous virus identification and characterization of severe unexplained pneumonia cases using a metagenomics sequencing technique显示文摘Many viruses can cause respiratory diseases in humans.Although great advances have been achieved in methods of diagnosis,it remains challenging to identify pathogens in unexplained pneumonia(UP) cases.In this study,we applied next-generation sequencing(NGS) technology and a metagenomic approach to detect and characterize respiratory viruses in UP cases from Guizhou Province,China.A total of 33 oropharyngeal swabs were obtained from hospitalized UP patients and subjected to NGS.An unbiased metagenomic analysis pipeline identified 13 virus species in 16 samples.Human rhinovirus C was the virus most frequently detected and was identified in seven samples.Human measles virus,adenovirus B 55 and coxsackievirus A10 were also identified.Metagenomic sequencing also provided virus genomic sequences,which enabled genotype characterization and phylogenetic analysis.For cases of multiple infection,metagenomic sequencing afforded information regarding the quantity of each virus in the sample,which could be used to evaluate each viruses' role in the disease.Our study highlights the potential of metagenomic sequencing for pathogen identification in UP cases. | Xiaohui Zou Guangpeng Tang Xiang Zhao Yan Huang Tao Chen Mingyu Lei Wenbing Chen Lei Yang Wenfei Zhu Li Zhuang Jing Yang Zhaomin Feng Dayan Wang Dingming Wang Yuelong Shu | 2017 | Science China(Life Sciences)2017，60，3： | 14 |
| 18 | Characteristics and Origin of Tight Oil Accumulations in the Upper Triassic Yanchang Formation of the Ordos Basin,North-Central China显示文摘The Upper Triassic oil accumulations in the Ordos Basin is the most successful tight oil play in China,with average porosity values of less than 10% and permeability values below 1.0 mD.This study investigated the geological characteristics and origin of the tight oil accumulations in the Chang 6 member of the Upper Triassic Yanchang Formation in the Shanbei area based on over 50,000 petrological,source-rock analysis,well logging and production data.The tight oil accumulation of the Chang 6 member is distributed continuously in the basin slope and the centre of the basin.The oilwater relationships are complex.Laumontite dissolution pores are the most important storage spaces,constituting 30%-60% of total porosity and showing a strong positive relationship with oil production.The pore-throat diameter is less than 1 μm,and the calculated critical height of the oil column is much larger than the tight sand thickness,suggesting that the buoyancy was probably of limited importance for oil migration.The pressure difference between the source rocks and sandstone reservoirs is inferred to have provided driving force for hydrocarbon migration.Two factors of source-reservoir configuration and laumontite dissolution contributed to the formation of the Chang 6 tight oil accumulations.Intense hydrocarbon generation and continuous sand bodies close to the hydrocarbon kitchen are the foundation for the large-scale oil distribution.Dissolution of feldspar-laumontite during the process of organic matter evolution generated abundant secondary pores and improved the reservoir quality. | WU Songtao ZOU Caineng ZHU Rukai YAO Jingli TAO Shizhen YANG Zhi ZHAI Xiufen CUI Jingwei LIN Senhu | 2016 | Acta Geologica Sinica(English Edition)2016，90，5： | 13 |
| 19 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 20 | Geological characteristics and accumulation mechanisms of the 'continuous' tight gas reservoirs of the Xu2 Member in the middle-south transition region,Sichuan Basin,China显示文摘'Continuous' tight gas reservoirs are those reservoirs which develop in widespread tight sandstones with a continuous distribution of natural gas.In this paper,we summarize the geological features of the source rocks and 'continuous' tight gas reservoirs in the Xujiahe Formation of the middle-south transition region,Sichuan Basin.The source rocks of the Xu1 Member and reservoir rocks of the Xu2 Member are thick(Xu1 Member:40 m,Xu2 Member:120 m) and are distributed continuously in this study area.The results of drilled wells show that the widespread sandstone reservoirs of the Xu2 Member are charged with natural gas.Therefore,the natural gas reservoirs of the Xu2 Member in the middle-south transition region are 'continuous' tight gas reservoirs.The accumulation of 'continuous' tight gas reservoirs is controlled by an adequate driving force of the pressure differences between source rocks and reservoirs,which is demonstrated by a 'one-dimensional' physical simulation experiment.In this simulation,the natural gas of 'continuous' tight gas reservoirs moves forward with no preferential petroleum migration pathways(PPMP),and the natural gas saturation of 'continuous' tight gas reservoirs is higher than that of conventional reservoirs. | Zou Caineng Gong Yanjie Tao Shizhen Liu Shaobo | 2013 | Petroleum Science2013，10，2： | 11 |
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