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| 1 | Efficacy and safety of Xinglouchengqi decoction for acute ischemic stroke with constipation:study protocol for a randomized con-trolled trial显示文摘OBJECTIVE: To investigate the efficacy and safety of Xinglouchengqi(XLCQ) decoction in treatment of acute ischemic stroke with constipation.METHODS: In this prospective, multicenter, assessor-blinded, randomized controlled trial, 360 eligible participants will be randomized to the XLCQ group or the control group. Participants in the XLCQ group will receive XLCQ decoction, while those in the control group will undergo clysis therapy using glycerin enemas or oral administration of lactulose solution. Both groups will undergo a treatment period of(5 ± 2) d and a 1-month follow-up.The primary outcome measure will be the Constipation Scale score. The secondary outcome measures will include scores on the National Institutes of Health Stroke Scale, the Traditional Chinese Medicine(TCM) Stroke Scale, the Diagnostic Scale for TCM Syndromes of Ischemic Stroke and TCM Scale for Syndrome of Phlegm-heat and Fu-organ Excess.Therapeutic mechanism outcomes and safety outcomes will also be assessed. Assessments will be conducted at baseline, at the end of the treatment period, and at the follow-up. Moreover, daily visits will be scheduled to grade the status of constipation during the treatment period.DISCUSSION: The results of this study will provide scientific and objective data with which to assess the efficacy and safety of XLCQ decoction for patients with acute ischemic stroke and constipation. | Chen Pei Zhang Yong Ling Lili Chen Xing Ren Yi Jiang Lan Wu Shuang Wang Wenting Wang Yuguang Zou Yihuai | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 7 |
| 2 | Effect of Panaxtriol Saponins on synaptophysin and postsynaptic density-95 expression at different periods of cerebral infarction显示文摘BACKGROUND:The change in expression of synaptophysin (Syp) and postsynaptic density-95 (PSD-95) alters after cerebral infarction,and the plasticity of synapses contributes greatly to nerve function recovery. Chinese medicinal substances may play an important role in the expression of Syp and PSD-95. OBJECTIVE: To observe the effect of Panaxtriol Saponins (PTS),an active component in Sanqi tongshu capsules,on the expression of Syp and PSD-95 after cerebral infarction at different time points in rats,so as to examine the cerebral function remodeling mechanism. DESIGN,TIME AND SETTING: A randomized and controlled observation which was performed in Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine from January to March,2007. MATERIALS: Twenty-six healthy male Sprague Dawley rats were used to establish middle cerebral artery occlusion based on the Longa method. Sanqi tongshu capsules (containing 100 mg PTS per tablet) were provided by the Chengdu Huashen Group and nimodipine tablets (30 mg) by Tianjin Zhongyang Pharmaceutical Co.,Ltd. METHODS: Twenty-six rats were randomly divided into an operation group (n=21) and a control group (n=5). The operation group underwent the EZ Longa procedure to make the middle cerebral artery occlusion model. After surgery rats were randomly divided into a model group,a PTS group and a nimodipine group,with seven rats in each group. Rats were intragastrically administrated with saline (2 mL/d) in the model group,with Sanqi tongshu capsule (5.4 mg/100 g/d) in the PTS group,and with nimodipine (1.73 mg/100 g/d) in the nimodipine group. Rats in the control group did not undergo model establishment and drug administration. MAIN OUTCOME MEASURES: The expressions of Syp and PSD-95 were measured by immunohistochemical and image analysis at days 3,7 and 28 after the operation. RESULTS: The expression of Syp and PSD-95 in the operation group was significantly lower than in the control group at days 3,7,28 postoperatively (P<0.05). The expression of Syp and PSD-95 in the PTS group and nimodipine group was significantly higher than in the model group at day 28 postoperatively (P< 0.05-0.01). Additionally,after PTS and nimodipine treatment at different intervals,the expression of Syp and PSD-95 at day 28 postoperatively was significantly higher than those at days 3 and 7 postoperatively,respectively (P<0.01). CONCLUSION: PTS can promote the expression of Syp and PSD-95,i.e. the remodeling process of synapses,after cerebral infarction at different time points in rats,which contributes to cerebral function remodeling. | Fangyuan Cui Jiangying Zhai Weimeng Zou Xiling Wang Yihuai Zou Linggqun Zhu | 2008 | Neural Regeneration Research2008，3，11： | 1 |
| 3 | Efficacy of chuanxiongdingtong herbal formula granule in the treatment and prophylactic of migraine patients:a randomized,double-blind,multicenter,placebo-controlled trial显示文摘 | Fu Caihong Yu Lihua Zou Yihuai | 2012 | Evidence-Based Complementary and Alternative Medicine2012，，96： | 1 |
| 4 | Efficacy of chuanxiong Ding Tong herbal formula granule in the treatment and prophylactic of migraine patients:a randomized,Double-Blind,multicenter,Placebo-Controlled trial显示文摘 | FU Caihong YU Lihua ZOU Yihuai | 2012 | Evidence-Based Complementary and Alternative Medicine2012，，96： | 1 |
| 5 | Efficacy of chuanxiong ding tong herbal formula granule in the treatment and prophylactic of migraine patients:A randomized,double-blind,multicenter,placebo-controlled trial显示文摘 | Fu Caihong Yu Lihua Zou Yihuai | | 0，，： | 1 |
| 6 | Clinical relevance of Chinese syndrome factors and thromboelastography levels in patients with phlegm-heat and fu-organ excess syndrome显示文摘Objective:Syndrome differentiation is a unique part of traditional Chinese medicine(TCM).Syndrome factors play an important role in the diagnosis and treatment of TCM syndromes.Thromboelastography(TEG)intuitively reflects the blood status of patients with acute ischemic stroke(AIS)and is important in the treatment and prognosis of AIS.To identify the relationship between TCM syndrome factors and TEG in AIS patients and standardize TCM syndrome differentiation and treatment objectives,we designed a prospective cohort study of 103 AIS patients.Methods:We used the diagnostic criteria for AIS in the Chinese Guideline for Diagnosis and Management of Acute Ischemic Stroke 2010.Diagnosis of phlegm-heat and fu-organ excess syndrome was based on the TCM Scale for the Syndrome of Phlegm-heat and fu-organ Excess.The ischemic Stroke TCM Syndrome Factor Diagnostic Scale was used to identify and diagnose syndrome factors.General information,scores of syndrome factors and values of TEG parameters of all enrolled patients were recorded.Results:There were significant differences in internal fire and phlegm-dampness scores between patients with and without phlegm-heat and fu-organ excess syndrome(P<.05).In patients with phlegm-heat and fu-organ excess syndrome,internal fire was negatively correlated with TEG parameters R and K(P<.05)and positively correlated with alpha Angle and coagulation index(P<.01).There were no significant correlations between the two syndrome factors and MA(P Z.058)and LY30(P>.05)or between both syndrome factors and TEG parameters in patients without phlegm-heat and fu-organ excess syndrome.Conclusion:The syndrome factor internal fire is a potential predictor of increased platelet function and fibrinogen activity in AIS patients with phlegm-heat and fu-organ excess,and a potentially important predictor of blood hypercoagulability in TCM. | Shuang Wu Pei Chen Yihuai Zou Lan Jiang Hualei Geng Ruyu Yan Shan Wang Lingqun Zhu | 2019 | Journal of Traditional Chinese Medical Sciences2019，6，3： | 1 |
| 7 | Current trends in tai chi for stroke rehabilitation显示文摘Background:There are an increasing number of studies focusing on the effect of tai chi for different diseases.As a special form of physical activity,tai chi may be beneficial for the rehabilitation of stroke,a leading cause of disability worldwide.Objective:This review summarizes the existing literature on the potential benefits of tai chi for stroke rehabilitation and offers recommendations for future research.Methods:Studies on the biomechanics and physiology of tai chi for stroke rehabilitation are reviewed.Research on tai chi for stroke rehabilitation and related diseases are summarized.Finally,the shortcomings of existing studies and recommendations for future studies are discussed.Conclusions:Tai chi appears to be beneficial for stroke rehabilitation.But reporting quality of existing studies are sub-optimal.Future trials should define tai chi style,apply rigorous methodology to sample size calculation,randomization,recruiting criteria,and outcome measures.To avoid inadequacies during the research and reporting processes,investigators may wish to follow CONSORT guidelines and refer to well-conducted clinical studies on tai chi. | Yong Zhang Yanzhe Ning Hongwei Liu Li Zhou Yihuai Zou Zongheng Li | 2015 | Journal of Traditional Chinese Medical Sciences2015，2，3： | 1 |
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