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| 1 | Ultra Dense Network:Challenges,Enabling Technologies and New Trends显示文摘5G sets an ambitious goal of increasing the capacity per area of current 4G network by 1000 fold. Due to the high splitting gain of dense small cells, ultra dense network(UDN) is widely considered as a key component in achieving this goal. In this paper, we outline the main challenges that come with dense cell deployment, including interference, mobility, power consumption and backhaul. Technologies designed to tackle these challenges in long term evolution system(LTE) and their deficiencies in UDN context are also analyzed. To combat these challenges more efficiently, a series of technologies are introduced along with some of our initial research results. Moreover, the trends of user-centric and peer-to-peer design in UDN are also elaborated. | HAO Peng YAN Xiao Yu-Ngok Ruyue YUAN Yifei | 2016 | China Communications2016，13，2： | 21 |
| 2 | Vision,application scenarios,and key technology trends for 6G mobile communications显示文摘With the global commercialization of the fifth-generation(5G)network,many countries,including China,USA,European countries,Japan,and Korea,have started exploring 6G mobile communication network,following the tradition of“planning the next while commercializing one generation”.Currently,studies on 6G networks are at the infancy stage.Research on the vision and requirements for 6G is still ongoing,and the industry is yet to clarify the key enabling technologies for 6G.However,6G will certainly build on the success of 5G.Therefore,developing high-quality 5G networks and seamlessly integrating 5G with verticals are the priorities before 2030,when 6G is projected to be commercialized.Also,global 5G standards will keep evolving to better support vertical applications.As a milestone,the Third-Generation Partnership Project(3GPP)published Release 16 in July 2020,which continuously enhanced the capabilities of mobile broadband service based on Release 15 and realized the support for low-delay and high-reliability applications,such as Internet of Vehicles and industrial Internet.Currently,3GPP is working on Releases 17 and 18,focusing on meeting the demands of medium-and high-data-rate machine communication with low-cost and high-precision positioning,which will be published in June 2022.Thus,6G networks will further expand the application fields and scope of the Internet of Things to accommodate those services and applications that are beyond the capabilities of 5G networks.Herein,we present our vision,application scenarios,and key technological trends for 6G networks.Furthermore,we propose several future research opportunities in 6G networks with regard to industrialization and standardization. | Zhiqin WANG Ying DU Kejun WEI Kaifeng HAN Xiaoyan XU Guiming WEI Wen TONG Peiying ZHU Jianglei MA Jun WANG Guangjian WANG Xueqiang YAN Jiying XIANG He HUANG Ruyue LI Xinhui WANG Yingmin WANG Shaohui SUN Shiqiang SUO Qiubin GAO Xin SU | 2022 | Science China(Information Sciences)2022，65，5： | 17 |
| 3 | Western medication plus Traditional Chinese Medicine preparations in patients with chronic heart failure:a prospective,single-blind,randomized,controlled,and multicenter clinical trial显示文摘OBJECTIVE: To assess the efficacy and safety in patients with chronic heart failure(CHF) of Western medication plus Traditional Chinese Medicine(TCM) preparations.METHODS: This prospective, single-blind, randomized, controlled, and multicenter clinical trial began on September 17, 2008, and was completed on June 25, 2011. A total of 340 inpatients, aged 40-79 years, with exacerbating CHF from 10 hospitals were enrolled and randomly allocated within 24 h of admission. The trial included three intervention periods. During hospitalization, the control group received western medication for CHF and the treatment group received Danhong injection with Shenfu injection or Shenmai injection. After discharge,all patients were treated with Qiliqiangxin capsules and Buyiqiangxin tablets or a placebo for 6 months. After the 6-month intervention, both groups received only continuous western medication. The primary endpoint was all-cause mortality.The efficacy assessments were as follows: B-type natriuretic peptide(BNP), Lee's HF score, the 6-minute walking test(6 MWT), left ventricular ejection fraction(LVEF), and the Minnesota Living with Heart Failure Questionnaire(MLHFQ). The safety assessments were as follows: blood and urine routine examination, hepatic and renal function, electrolytes in blood and adverse events.RESULTS: Compared with the control group, the treatment group showed a 30.99% reduction in all-cause mortality and an improved survival rate.The treatment group showed greater improvement in 6 MWT(P = 0.02) than the control group on discharge, after 12-month follow-up, there was a time-group interaction for MLHFQ(P = 0.03). Incidence rate of adverse events and other relevant safety indexes were not statistically significant between the two groups.CONCLUSION: Western medication plus TCM treatment can increase 6-minute walking distance(improve exercise tolerance) and quality of life with heart failure patients. | Wang Xianliang Hou Yazhu Mao Jingyuan Zhao Yingqiang Niu Tianfu Yuan Ruyu Wang Yonggang Cui Jin-rong Shi Le Jia Xiuli Fan Ruihong Lin Qian Zhang Yan Li Zhijun Shang Hongcai Wang Baohe Wang Hongwu Wang Henghe Cui Xiaolei Soh Shanbin Ruan Jishou Zhang Boli | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 15 |
| 4 | Synergistic anti-tumor therapy by a homotypic cell membranecloaked biomimetic nanocarrier with exceptionally potent activity against hepatic carcinoma显示文摘Hepatic carcinoma(HC)is the sixth most frequently occurring malignancies and the third leading cause of cancer death worldwide.Sepantronium bromide(YM155)is a small molecule inhibitor of survivin,which has broad-spectrum anticancer therapeutic effects in various xenograft models.However,several-day continuous infusion is required to achieve greater antitumor efficacy because of rapid elimination from the blood circulation.Herein,a SMMC-7721 cancerous cyto-membrane-cloaked drug delivery system(DDS)(named as iM7721@GQD-YM),was developed for co-encapsulation of YM155 and graphene quantum dots(GQDs).Cytomembrane coating endowed iM7721@GQD-YM with effective targeting for homologous HC cells,excellent biocompatibility and favorable immunocompatibility for in vivo application.Surface decoration of iRGD peptide further enhanced its tumor targeting activity by iRGD-integrin recognition.In addition,under the irradiation of near-infrared ray(NIR),GQDs can directly kill tumors through photothermal effect and cause cell membrane rupture,accurately releasing YM155 at tumor sites.The physicochemical properties,in vivo and ex vivo anti-tumor efficacy,and mechanisms of iM7721@GQD-YM nanoparticles(NPs)were systematically investigated in this work.The experimental results clearly indicate that the versatile biomimetic DDS holds great potential for the treatment of HC,which merits further investigation in both pre-clinical and clinical studies. | Shini Feng Pinyue Ni Yan Gong Bijiang Geng Hui Li Chenlin Miao Ruyu Fan Levon Galstyan Dengyu Pan Fuxue Chen Huafei Li | 2022 | Nano Research2022，15，9： | 1 |
| 5 | Jumonji domain-containing 6 (JMJD6) identified as a potential therapeutic target in ovarian cancer显示文摘Jumonji domain-containing 6(JMJD6)is a candidate gene associated with tumorigenesis,and JMJD6 overexpression predicts poor differentiation and unfavorable survival in some cancers.However,there are no studies reporting the expression of JMJD6 in ovarian cancer,and no JMJD6 inhibitors have been developed and applied to targeted cancer therapy research.In the present study,we found that the high expression of JMJD6 in ovarian cancer was correlated with poor prognosis in ovarian cancer.A potential inhibitor(SKLB325)was designed based on the crystal structure of the jmjC domain of JMJD6.This molecule significantly suppressed proliferation and induced apoptosis in a dose-dependent manner in SKOV3 cell lines as detected by CCK-8 cell proliferation assays and flow cytometry.A Matrigel endothelial tube formation assay showed that SKLB325 inhibited capillary tube organization and migration in HUVECs in vitro.We also observed that JMJD6 colocalized with p53 protein in the nucleus,with mRNA and protein expression of p53 as well as its downstream effectors significantly increasing both in vitro and in intraperitoneal tumor tissues treated with SKLB325.In addition,SKLB325 significantly reduced the intraperitoneal tumor weight and markedly prolonged the survival of tumor-bearing mice.Taken together,our findings suggest that JMJD6 may be a marker of poor prognosis in ovarian cancer and that SKLB325 may be a potential candidate drug for the treatment of ovarian cancer. | Heng Zheng Yan Tie Zhen Fang Xiaoai Wu Tao Yi Shuang Huang Xiao Liang Yanping Qian Xi Wang Ruyu Pi Siyuan Chen Yong Peng Shengyong Yang Xia Zhao Xiawei Wei | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 1 |
| 6 | Clinical relevance of Chinese syndrome factors and thromboelastography levels in patients with phlegm-heat and fu-organ excess syndrome显示文摘Objective:Syndrome differentiation is a unique part of traditional Chinese medicine(TCM).Syndrome factors play an important role in the diagnosis and treatment of TCM syndromes.Thromboelastography(TEG)intuitively reflects the blood status of patients with acute ischemic stroke(AIS)and is important in the treatment and prognosis of AIS.To identify the relationship between TCM syndrome factors and TEG in AIS patients and standardize TCM syndrome differentiation and treatment objectives,we designed a prospective cohort study of 103 AIS patients.Methods:We used the diagnostic criteria for AIS in the Chinese Guideline for Diagnosis and Management of Acute Ischemic Stroke 2010.Diagnosis of phlegm-heat and fu-organ excess syndrome was based on the TCM Scale for the Syndrome of Phlegm-heat and fu-organ Excess.The ischemic Stroke TCM Syndrome Factor Diagnostic Scale was used to identify and diagnose syndrome factors.General information,scores of syndrome factors and values of TEG parameters of all enrolled patients were recorded.Results:There were significant differences in internal fire and phlegm-dampness scores between patients with and without phlegm-heat and fu-organ excess syndrome(P<.05).In patients with phlegm-heat and fu-organ excess syndrome,internal fire was negatively correlated with TEG parameters R and K(P<.05)and positively correlated with alpha Angle and coagulation index(P<.01).There were no significant correlations between the two syndrome factors and MA(P Z.058)and LY30(P>.05)or between both syndrome factors and TEG parameters in patients without phlegm-heat and fu-organ excess syndrome.Conclusion:The syndrome factor internal fire is a potential predictor of increased platelet function and fibrinogen activity in AIS patients with phlegm-heat and fu-organ excess,and a potentially important predictor of blood hypercoagulability in TCM. | Shuang Wu Pei Chen Yihuai Zou Lan Jiang Hualei Geng Ruyu Yan Shan Wang Lingqun Zhu | 2019 | Journal of Traditional Chinese Medical Sciences2019，6，3： | 1 |
| 7 | Enhanced antibiotic degradation performance of Cd_(0.5)Zn_(0.5)S/Bi_(2)MoO_(6) S-scheme photocatalyst by carbon dot modification显示文摘S-scheme heterojunction engineering is an effective strategy to attain distinctive photocatalysts.Herein,a carbon dots modulated S-scheme hetero-structured photocatalyst of Cd_(0.5)Zn_(0.5)S nanoparticles/Bi_(2)MoO_(6) microspheres/carbon dots (CZCBM),aiming to conquer the photo-corrosion and strengthen the photocatalytic property of Cd_(0.5)Zn_(0.5)S,was developed via a facile solvothermal route.Under visible light,the optimal CZCBM-2 affords a 1.8-,1.5-,or 0.6-time reinforcement in the oxytetracycline degradation rate constant compared to Bi_(2)MoO_(6),Cd_(0.5)Zn_(0.5)S or Cd_(0.5)Zn_(0.5)S/Bi_(2)MoO_(6),which is credited to the strengthened visible-light response,increased reactive sites,and efficient dissolution of photo-carriers with optimal redox capacity because of the co-effect of carbon dots and S-scheme heterostructure.Significantly,the photo-corrosion of Cd_(0.5)Zn_(0.5)S is significantly suppressed and CZCBM-2 affords superior stability and reusability during cycling tests.Besides,CZCBM-2 can be well adapted to various environments.The toxicology appraisement unravels the decreased eco-toxicity of most intermediates compared to oxytetracycline.Lastly,an S-scheme charge transfer mechanism with carbon dots as electron reservoir in CZCBM is deduced,which uncloses that •O_(2)− and h+ dominantly account for oxytetracycline eradication and detoxification.This study demonstrates the design of unique carbon dots favored S-scheme heterostructures as an effective “Two Birds with One Stone” strategy to achieve high anti-photo-corrosion performance and reinforced photocatalytic performance of sulfides. | Shijie Li Ruyu Yan Mingjie Cai Wei Jiang Mingyi Zhang Xin Li | 2023 | Journal of Materials Science & Technology2023，，33： | 0 |
| 8 | A review of tidal triggering of global earthquakes显示文摘Earthquake prediction remains a challenging and difficult task for scientists all over the world.The tidal triggering of earthquakes is being proven by an increasing number of investigations,most of which have shown that earthquakes are positively correlated with tides,and thus,tides provide a potential tool for earthquake prediction,especially for imminent earthquakes.In this study,publications concerning the tidal triggering of earthquakes were compiled and analyzed with regard to global earthquakes,which were classified into three main types:tectonic,volcanic,and slow earthquakes.The results reveal a high correlation between tectonic earthquakes and tides(mainly for semidiurnal and diurnal tides;14-day tides) before and after the occurrence of significant earthquakes.For volcanic earthquakes,observations of volcanoes on the seafloor and land indicate that volcanic earthquakes in near-shore volcanic areas and mid-ocean ridges have a strong correlation with tidal forces,mostly those with semidiurnal and diurnal periods.For slow earthquakes,the periodicity of the tremor duration is highly correlated with semidiurnal and diurnal tides.In conclusion,the tidal triggering of these three types of earthquakes makes a positive contribution to earthquake preparation and understanding the triggering mechanism,and thus,the prediction of these types of earthquakes should be investigated.However,there are still several inadequacies on this topic that need to be resolved to gain a definitiveanswer regarding the tidal triggering of all earthquakes.The main inadequacies are discussed in this paper from our point of view. | Ruyu Yan Xiaodong Chen Heping Sun Jianqiao Xu Jiangcun Zhou | 2023 | Geodesy and Geodynamics2023，14，1： | 0 |
| 9 | Identifying Factors of Integrated Industry Based on the Complex Systems Theory显示文摘 | Qiuyan Zhang GuohongWang Ruyu Yan Jing Zhang | 2009 | Journal of Systems Science and Information2009，7，2： | 0 |
| 10 | Effects of Mechanical Harvesting of Main Crop on Soil Rolling and Yield of Ratooned Rice显示文摘[Objectives]To study the effect of mechanical harvesting of main crop on soil rolling and yield of ratooned rice.[Methods]In this study,the harvesting method was optimized and improved through field research and theoretical research.[Results]Compared with farmers'habits,the mechanical harvesting method could significantly increase the working area per unit time and reduce the rolling area in the field,but it would increase the rolling rate of the land or transfer area.At the same time,the optimization method could reduce the soil bulk density in the primary rolling area,but it had no significant impact on soil compactness.[Conclusions]Compared with the farmer's customary method,the optimization method could reduce the crushing and damage of rice piles in the field,increase the seedling rate and panicle extraction rate,thus increasing the yield of rice in the ratooning season. | Ruyu YAN Ximei ZHAO Jifu LI | 2022 | Asian Agricultural Research2022，14，10： | 0 |
| 11 | CRISPR accelerates the cancer drug discovery显示文摘Emerging cohorts and basic studies have associated certain genetic modifications in cancer patients,such as gene mutation,amplification,or deletion,with the overall survival prognosis,underscoring patients’genetic background may directly regulate drug sensitivity/resistance during chemotherapies.Understanding the molecular mechanism underpinning drug sensitivity/resistance and further uncovering the effective drugs have been the major ambition in the cancer drug discovery.The emergence and popularity of CRISPR/Cas9 technology have reformed the entire life science research,providing a precise and simplified genome editing tool with unlimited editing possibilities.Furthermore,it presents a powerful tool in cancer drug discovery,which hopefully facilitates us with a rapid and reliable manner in developing novel therapies and understanding the molecular mechanisms of drug sensitivity/resistance.Herein,we summarized the application of CRISPR/Cas9 in drug screening,with the focus on CRISPR/Cas9 mediated gene knockout,gene knock-in,as well as transcriptional modification.Additionally,this review provides the concerns,cautions,and ethnic considerations that need to be taken when applying CRISPR in the drug discovery. | RUYU YAN JUNJIE WANG MINXIA LIU KECHENG ZHOU | 2022 | BIOCELL2022，46，10： | 0 |
| 12 | Preparation and Properties of Vegetable-Oil-Based Thioether Polyol and Ethyl Cellulose Supramolecular Composite Films显示文摘Ethyl cellulose(EC),an important biomass-based material,has excellent film-forming properties.Nevertheless,the high interchain hydrogen bond interaction leads to a high glass transition temperature of EC,which makes it too brittle to be used widely.The hydroxyl group on EC can form a supramolecular system in the form of a non-covalent bond with an effective plasticizer.In this study,an important vegetable-oil-based derivative named dimer fatty acid was used to prepare a novel special plasticizer for EC.Dimer-fatty-acid-based thioether polyol(DATP)was synthesized and used to modify ethyl cellulose films.The supramolecular composite films of DATP and ethyl cellulose were designed using the newly-formed van der Waals force.The thermal stability,morphology,hydrophilicity,and mechanical properties of the composite films were all tested.Pure EC is fragile,and the addition of DATP makes the ethyl cellulose films more flexible.The elongation at the break of EC supramolecular films increased and the tensile strength decreased with the increasing DATP content.The elongation at the break of EC/DATP(60/40)and EC/DATP(50/50)was up to 40.3%and 43.4%,respectively.Noticeably,the thermal initial degradation temperature of the film with 10%DATP is higher than that of pure EC,which may be attributed to the formation of a better supramolecular system in this composite film.The application of bio-based material(EC)is environmentally friendly,and the novel DATP can be used as a special and effective plasticizer to prepare flexible EC films,making it more widely used in energy,chemical industry,materials,agriculture,medicine,and other fields. | Ruyu Yan Jian Fang Xiaohua Yang Na Yao Mei Li Yuan Nie Tianxiang Deng Haiyang Ding Lina Xu Shouhai Li | 2023 | Journal of Renewable Materials2023，11，4： | 0 |
| 13 | Targeted mutations of BnPAP2 lead to a yellow seed coat in Brassica napus L.显示文摘The yellow seed trait is preferred by breeders for its potential to improve the seed quality and commercial value of Brassica napus.In the present study,we produced yellow seed mutants using a CRISPR/Cas9 system when the two BnPAP2 homologs were knocked out.Histochemical staining of the seed coat demonstrated that proanthocyanidin accumulation was significantly reduced in the pap2 double mutants and decreased specifically in the endothelial and palisade layer cells of the seed coat.Transcriptomic and metabolite profiling analysis suggested that disruption of the BnPAP2 genes could reduce the expression of structural and regulated genes in the phenylpropanoid and flavonoid biosynthetic pathways.The broad suppression of these genes might hinder proanthocyanidin accumulation during seed development,and thereby causing the yellow seed trait in B.napus.These results indicate that BnPAP2 might play a vital role in the regulatory network controlling proanthocyanidin accumulation. | Wei Huang Ruyu Jiao Hongtao Cheng Shengli Cai Jia Liu Qiong Hu Lili Liu Bao Li Tonghua Wang Mei Li Dawei Zhang Mingli Yan | 2024 | Journal of Integrative Agriculture2024，23，2： | 0 |
| 14 | The effect of baduanjin exercise in rehabilitation for functional ankle instability:A study protocol for a randomized controlled pilot trial显示文摘Introduction:Patients with functional ankle instability(FAI)have problems with joint control,balance,gait,and postural symmetry.Baduanjin is a type of traditional Chinese exercise that has been shown to be effective in treating many diseases and symptoms.However,to date,the effect of Baduanjin in patients with FAI has not been proved.This pilot trial is an assessor-blinded randomized controlled trial,and its objective is to study the efficacy and safety of Baduanjin on the rehabilitation of patients with FAI.Methods:Seventy-two participants,who are eligible according to specified inclusion and exclusion criteria,will be randomized(in a 1:1 ratio),using a random number table,into two groups:a Baduanjin group and a conventional treatment group.The Baduanjin group will be subjected to the Baduanjin exercise in addition to the conventional treatment therapy.Participants’exercise programs will be implemented for 4 weeks(5 days a week).All participants will be assessed at baseline,and after two and 4 weeks of treatment.The surface electromyography results of the bilateral erector spinae,tibialis anterior,and peroneus longus will be the primary outcomes,while the balance function under different conditions and the level of FAI in daily life measured using the Cumberland Ankle Instability Tool will be the secondary outcomes.Ethics and Dissemination:The trial has been approved by the Research Ethical Committee of Dongzhimen Hospital,the First Affiliated Hospital of Beijing University of Chinese Medicine(no.DZMEC-KY-2019-18),and it will follow the principles of the Consolidated Standards of Reporting Trials statements as well as the Declaration of Helsinki.The findings of this study will be submitted for publication in peer-reviewed journals.The results will also be disseminated to the participants via phone calls or e-mail. | Li ZHOU Juanjuan AI Qingwen GENG Kuangshi LI Yiting SUN Ruyu YAN Diyang LYU Zongheng LI | 2021 | Journal of Integrative Nursing2021，3，2： | 0 |
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