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| 1 | Mechanisms of activation and inhibition of Zika virus NS2B-NS3 protease显示文摘 | Xia Chen Kailin Yang Chen Wu Cheng Chen Can Hu Olga Buzovetsky Zefang Wang Xiaoyun Ji Yong Xiong Haitao Yang | 2016 | Cell Research2016，26，11： | 10 |
| 2 | Structural basis of Zika virus helicase in recognizing its substrates显示文摘Zika 的最近的爆炸爆发病毒(ZIKV ) 感染在南方和中美洲和加勒比海被报导了。与 ZIKV 感染联系的新生的头小畸型已经引起了国际担心的一种公共健康紧急情况。没有特定的疫苗或药当前是可得到的治疗 ZIKV 感染。ZIKV helicase,在病毒的 RNA 复制起一个枢轴的作用,是为治疗的一个吸引人的目标。我们决定了 ZIKV helicase-ATP-Mn 2+ 和 ZIKV helicase-RNA 的水晶结构。这是到 ATP 的任何 flavivirus helicase 界限的第一结构。有相关 flavivirus helicases 的比较证明了尽管在活跃地点的批评 P 环在不同种类之中有可变符合构造,认出 ATP/Mn 2+ 采用一个相同模式。ZIKV helicase-RNA 的结构表明了在 RNA 绑定之上,马达领域的旋转能引起重要 conformational 变化。惊人地,尽管 ZIKV 和登革热病毒(DENV ) apo-helicases 份额为 RNA 绑定保存了残余,他们在为 RNA 识别的不同单个模式的马达域旋转结果的不同礼貌。它建议 flavivirus helicases 能发展了一台保存引擎为 RNA 放松,而是不同马达领域旋转从 nucleoside triphosphate 把化学能变换成机械精力在可变 RNA 识别的结果适应单个病毒的复制的模式。 | Hongliang Tian Xiaoyun Ji Xiaoyun Yang Zhongxin Zhang zuoku Lu Kailin Yang Cheng Chen Qi Zhao Heng Chi Zhongyu Mu Wei Xie Zefang Wang Huiqiang Lou Haitao Yang Zihe Rao | 2016 | Protein & Cell2016，7，8： | 3 |
| 3 | Issues and rational design of aqueous electrolyte for Zn-ion batteries显示文摘Aqueous Zn-ion batteries(AZIBs)are regarded as a promising alternative to the widely used lithium-ion batteries in large-scale energy storage systems.The researches on the development of novel aqueous electrolyte to improve battery performance have also attracted great interest since the electrolyte is a key com-ponent for Zn2+migration between cathode and anode.Herein,we briefly sum-marized and illuminated the recent development tendency of aqueous electrolyte for AZIBs,then deeply analyzed its existing issues(water decomposition,cathode dissolution,corrosion and passivation,and dendrite growth)and discussed the corresponding optimization strategies(pH regulation,concentrated salt solution,electrolyte composition design,and functional additives).The internal mecha-nisms of these strategies were further revealed and the relationships between issues and solutions were clarified,which could guide the future development of aqueous electrolytes for AZIBs. | Qi Zhang Zefang Yang Huimin Ji Xiaohui Zeng Yougen Tang Dan Sun Haiyan Wang | 2021 | SusMat2021，1，3： | 3 |
| 4 | Cost-efficient and flexible fabrication of rectangular-shaped microlens arrays with controllable aspect ratio and spherical morphology显示文摘 | Yang Hu Qing Yang Feng Chen Hao Bian Zefang Deng Guangqing Du Jinhai Si Feng Yun Xun Hou | 2013 | Applied Surface Science2013，，： | 1 |
| 5 | Intrinsically zincophobic protective layer for dendrite-free zinc metal anode显示文摘Aqueous zinc anodes have attracted the attention of many researchers owing to their high safety,low cost,and high theoretical specific capacity.However,its practical application is severely limited by the dendrite growth on zinc anode.Herein,we develop an intrinsically zincophobic barium-titanate protective layer with a porous structure to suppress the zinc dendrite formation by homogenizing the ion distribution on the anode surface,increasing the nucleation sites,and limiting the irregular zinc growth.Based on these synergistic effects,the coated zinc anode can exhibit long cycle life(840 h at 0.5 mA/cm^(2) for 0.5 mAh/cm^(2))and low voltage hysteresis(36 mV).This work can provide a feasible direction for the design of intrinsically zincophobic coating materials to uniformize the zinc stripping and plating. | Chunlin Xie Qi Zhang Zefang Yang Huimin Ji Yihu Li Huanhuan Li Liang Fu Dan Huang Yougen Tang Haiyan Wang | 2022 | Chinese Chemical Letters2022，33，5： | 1 |
| 6 | Structural insight into the Zika virus capsid encapsulating the viral genome显示文摘 | Ting Li Qi Zhao Xiaoyun Yang Cheng Chen Kailin Yang Chen Wu Tianqing Zhang Yinkai Duan Xiaoyu Xue Kaixia Mi Xiaoyun Ji Zefang Wang Haitao Yang | 2018 | Cell Research2018，28，4： | 0 |
| 7 | Functionalizing the interfacial double layer to enable uniform zinc deposition显示文摘Due to the unsatisfactory electrode/electrolyte interface,the metallic Zn dendrites and corrosion are easily induced,severely hindering the applications of zinc-ion batteries(ZIBs).Herein,a strategy that engineers the interfacial double layer by an extremely low concentration of sulfolane is proposed to tune the Zn stripping/plating behavior.It is revealed that the highly-polar sulfolane can predominately occupy the inner Helmholtz layer over water,and then regulate the upcoming Zn2+to directly deposit downward.Simultaneously,the widened Helmholtz layer can weaken the electric field intensity,which will generate more nucleation sites and reduce the nuclei radius,thereby promoting uniform zinc deposition as well.Moreover,corrosion byproducts can be inhibited since fewer water molecules can contact the Zn electrodes.Consequently,the battery performance can be naturally optimized.With an optimum amount of sulfolane,the Zn||Zn battery can operate for more than 1,100 h under1 m A cm^(-2)and 1 m Ah cm^(-2).And the as-constructed Zn||NaV_(3)O_(8)·1.5H_(2)O battery demonstrates considerably higher cycling stability than that without sulfolane.Overall,this work has provided a deep insight into constructing a functional interfacial double layer to regulate zinc deposition,which can also act as a reference for other metal-based batteries. | Yihu Li Hao Wang Tingqing Wu Chunlin Xie Zefang Yang Qi Zhang Dan Sun Yougen Tang Liang Fu Haiyan Wang | 2023 | Science China Chemistry2023，66，6： | 0 |
| 8 | Studies of the linearity of the readout module assembling using the eXTP-GPD chips显示文摘Background The Gas Pixel Detector(GPD)is a key part of the Polarimetry Focusing Array(PFA)sub-system onboard the enhance X-ray Timing and Polarimetry mission(eXTP).The GPD can accurately provide the polarized angle and degree for incoming soft X-rays(requirements of minimum detectable polarization<1%(10^(6) s,1 mCrab))from celestial objects under extreme conditions of density,gravity and magnetism.Purpose Paste the GPD chips on a matched ceramic package is one of the most important procedures for the GPD assembly,and the parallelism between the top surface of an ASIC chip and the bottom surface of a Gas Electron Multiplier(GEM)foil can have impact on the distribution of electric field within transfer region and reconstruction of photoelectric trajectories,resulting in deterioration of the GPD sensitivity.This study quantifies the influence and gives a reasonable expectation of the parallelism.Methods A simulation framework of the GPD is constructed to quantify the influence on the GPD performance and values of the parallelism are measured by a gauge with a position resolution of o.1μm.Results:The difference of degree of modulation is less than 1% comparing the parallelism with a value of 20μm to a value of 0μm in response to both polarized and unpolarized X-rays.Meanwhile,the value of parallelism can reach 6.9±3.4μm(0.0176°±0.0087°)by testing and verifying.Conclusions The impact on the GPD performance can be less than 1%as the parallelism with an order of 20μm,and we also give a reasonable measuring method and verify the controllability and feasibility of the parallelism with an order of 20μm for pasting the ASIC chip on the surface of a ceramic package. | Jiechen Jiang Liang Sun Yang Jiao Weichun Jiang Yupeng Xu Huilin He Xiaohua Liu Yuanyuan Du Sheng Yang Zefang Dong Xiaojing Liu Boyu Dai | 2023 | Radiation Detection Technology and Methods2023，7，2： | 0 |
| 9 | Mechanism and effects of extramedullary hematopoiesis on anti-tumor immunity显示文摘Cancer immunotherapy is a preferred strategy for boosting anti-tumor immunity to eliminate malignant cells and is considered a major breakthrough in the field of cancer treatment however,immunosuppressive cells in the tumor microenvironment(TME)pose a major obstacle to the efficacy of immunotherapy.Myeloid cells,such as tumor-a ssociated macrophages(TAMs)and myeloid-derived suppressor cells(MDSCs). | Zefang Chen Xinyu Cheng Li Yang Xiaoming Cheng Bo Zhu Haixia Long | 2023 | Cancer Biology & Medicine2023，20，7： | 0 |
| 10 | Designing Zinc Deposition Substrate with Fully Preferred Orientation to Elude the Interfacial Inhomogeneous Dendrite Growth显示文摘The development of zinc-ion batteries with high energy density remains a great challenge due to the uncontrollable dendrite growth on their zinc metal anodes.Film anodes plated on the substrate have attracted increasing attention to alleviate these dendrite issues.Herein,we first point out that both the random crystal orientation and the low metal affinity of the substrate are important factors of zinc dendrite formation.Accordingly,the(1 O 1)fully preferred tin interface layer with high zinc affinity was fabricated by chemical tin plating on(1 O o)oriented copper.This tin decorated copper substrate can realize high reversible zinc plating/stripping behavior,and full cell using this zinc plated substrate can be operated for more than 1000 cycles with high capacity retention(85.3%)and low electrochemical impedance.The proposed strategy can be also applied to lithium metal batteries,which demonstrates that the substrate orientation regulation and metal affinity design are the promising approaches to achieve dendrite-free metal anode and overcome the challenges of highly reactive metal anodes. | Chunlin Xie Zefang Yang Qi Zhang Huimin Ji Yihu Li Tingqing Wu Wenbin Li Pengfei Wu Haiyan Wang | 2023 | Research2023，，1： | 0 |
| 11 | Traffic accidents of autonomous vehicles based on knowledge mapping:A review显示文摘As a characteristic representative of the new generation of vehicles,autonomous driving is expected to improve people's driving experience.The study on traffic accident of autonomous vehicles(AVs)helps provide suggestions for autonomous driving safety from multiple disciplines and perspectives,and provide support for formulating traffic accident treatment schemes.Knowledge mapping,as a cutting-edge research method in bibliometrics,scientifically and objectively displays the relevant research status using visual means.This paper uses CiteSpace 6.1.r3 to analyze 5068 related literature on the Web of Science database from 1991 to 2022 and finds out major thematic clusters,important documents and representative journals according to citation frequency.The results show that research on traffic accidents involving AVs focuses on accident preventing technologies,including how to avoid collisions,track lane-position,and enhance vehicle-toeverything(V2X)communication.This paper extracts the mean research topics and key points involved in the field and illustrates journals related to AVs and traffic accidents,which provides guidance for subsequent researchers to carry out in-depth research and contribute their papers.Popular journals are in disciplines of mathematics,systems,computer,economics,and social science.This paper also suggests scholars to consider the aspects of scene reconstruction,cause analysis,and injury of vulnerable road users,so as to investigate traffic accidents and put forward effective treatment schemes to reduce AV accidents,and ultimately improve road safety. | Wei Ji Quan Yuan Gang Cheng Shengnan Yu Min Wang Zefang Shen Tiantong Yang | 2023 | Journal of Traffic and Transportation Engineering(English Edition)2023，10，6： | 0 |
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