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| 1 | Photovoltaic and Solar Power Forecasting for Smart Grid Energy Management显示文摘Due to the challenge of climate and energy crisis,renewable energy generation including solar generation has experienced significant growth.Increasingly high penetration level of photovoltaic(PV)generation arises in smart grid.Solar power is intermittent and variable,as the solar source at the ground level is highly dependent on cloud cover variability,atmospheric aerosol levels,and other atmosphere parameters.The inherent variability of large-scale solar generation introduces significant challenges to smart grid energy management.Accurate forecasting of solar power/irradiance is critical to secure economic operation of the smart grid.This paper provides a comprehensive review of the theoretical forecasting methodologies for both solar resource and PV power.Applications of solar forecasting in energy management of smart grid are also investigated in detail. | Can Wan Jian Zhao Yonghua Song Zhao Xu Jin Lin Zechun Hu | 2015 | CSEE Journal of Power and Energy Systems2015，1，4： | 29 |
| 2 | Matrine attenuates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via maintaining AMPKα/UCP2 pathway显示文摘Oxidative stress and cardiomyocyte apoptosis are involved in the pathogenesis of doxorubicin(DOX)-induced cardiotoxicity. Matrine is well-known for its powerful anti-oxidant and anti-apoptotic capacities. Our present study aimed to investigate the effect of matrine on DOX-induced cardiotoxicity and try to unearth the underlying mechanisms. Mice were exposed with DOX to generate DOX-induced cardiotoxicity or normal saline as control. H9 C2 cells were used to verify the effect of matrine in vitro.DOX injection triggered increased generation of reactive oxygen species(ROS) and excessive cardiomyocyte apoptosis, which were significantly mitigated by matrine. Mechanistically, we found that matrine ameliorated DOX-induced uncoupling protein 2(UCP2) downregulation, and UCP2 inhibition bygenipin could blunt the protective effect of matrine on DOX-induced oxidative stress and cardiomyocyte apoptosis. Besides, 50-AMP-activated protein kinase α2(Ampkα2) deficiency inhibited matrine-mediated UCP2 preservation and abolished the beneficial effect of matrine in mice. Besides, we observed that matrine incubation alleviated DOX-induced H9 C2 cells apoptosis and oxidative stress level via activating AMPKα/UCP2, which were blunted by either AMPKα or UCP2 inhibition with genetic or pharmacological methods. Matrine attenuated oxidative stress and cardiomyocyte apoptosis in DOX-induced cardiotoxicity via maintaining AMPKα/UCP2 pathway, and it might be a promising therapeutic agent for the treatment of DOX-induced cardiotoxicity. | Can Hu Xin Zhang Wenying Wei Ning Zhang Haiming Wu Zhenguo Ma Lingli Li Wei Deng Qizhu Tang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 25 |
| 3 | Values of the Wells and Revised Geneva Scores Combined with D-dimer in Diagnosing Elderly Pulmonary Embolism Patients显示文摘 | Dan-Jie Guo Can Zhao Ya-Dan Zou Xu-Hang Huang Jing-Min Hu Lin Guo | 2015 | Chinese Medical Journal2015，，8： | 14 |
| 4 | Polysaccharide extracts of Astragalus membranaceus and Atractylodes macrocephala promote intestinal epithelial cell migration by activating the polyamine-mediated K^+ channel显示文摘Astragalus membranaceus(Radix Astragali, RA) and Atractylodes macrocephala(Rhizoma Atractylodis Macrocephalae, RAM) are often used to treat gastrointestinal diseases. In the present study, we determined the effects of polysaccharides extracts from these two herbs on IEC-6 cell migration and explored the potential underlying mechanisms. A migration model with IEC-6 cells was induced using a single-edged razor blade along the diameter of cell layers in six-well polystyrene plates. The cells were grown in control--media or media containing spermidine(5 μmol·L^(-1), SPD), alpha-difluoromethylornithine(2.5 mmol·L^(-1), DFMO), 4-Aminopyridine-(40 μ-mol·L^(-1), 4-AP), the polysaccharide extracts of RA or RAM(50, 100, or 200 mg·L^(-1)), DFMO plus SPD, or DFMO plus polysaccharide extracts of RA or RAM for 12 or 24 h. Next, cytosolic free Ca^(2+)([Ca^(2+)]cyt) was measured using laser confocal microscopy, and cellular polyamine content was quantified with HPLC. Kv1.1 mRNA expression was assessed using RT-qPCR and Kv1.1 and RhoA protein expressions were measured with Western blotting analysis. A cell migration assay was carried out using Image-Pro Plus software. In addition, GC-MS was introduced to analyze the monosaccharide composition of both polysaccharide extracts. The resutls showed that treatment with polysaccharide extracts of RA or RAM significantly increased cellular polyamine content, elevated [Ca^(2+)]cyt and accelerated migration of IEC-6 cells, compared with the controls(P < 0.01). Polysaccharide extracts not only reversed the inhibitory effects of DFMO on cellular polyamine content and [Ca^(2+)]cyt, but also restored IEC-6 cell migration to control level(P < 0.01 or < 0.05). Kv1.1 mRNA and protein expressions were increased(P < 0.05) after polysaccharide extract treatment in polyamine-deficient IEC-6 cells and RhoA protein expression was increased. Molar ratios of D-ribose, D-arabinose, L-rhamnose, D-mannose, D-glucose, and D-galactose was 1.0:14.1:0.3:19.9:181.3:6.3 in RA and 1.0:4.3:0.1:5.7:2.8:2.2 in RAM. In conclusion, treatment with RA and RAM polysaccharide extracts stimulated migration of intestinal epithelial cells via a polyamine-Kv1.1 channel activated signaling pathway, which facilitated intestinal injury healing. | ZENG Dan HU Can LI Ru-Liu LIN Chuan-Quan CAI Jia-Zhong WU Ting-Ting SUI Jing-Jing LU Wen-Biao CHEN Wei-Wen | 2018 | Chinese Journal of Natural Medicines2018，16，9： | 14 |
| 5 | Biodegradation of Gaseous Chlorobenzene by White-rot Fungus Phanerochaete chrysosporium显示文摘Objective To evaluate the effect of white rot fungus Phanerochaete chrysosporium on removal of gaseous chlorobenzene. Methods Fungal mycelium mixed with a liquid medium was placed into airtight bottles. A certain amount of chlorobenzene was injected into the headspace of the bottles under different conditions. At a certain interval, the concentrations in the headspace were analyzed to evaluate the degradation of chlorobenzene by P. chrysosporium. Results The degradation effects of P. chrysosporium on chlorobenzene under different conditions were investigated. The difference in the optimum temperature for the growth of the fungi and chlorobenzene degradation was observed. The data indicated that a lower temperature (28℃) would promote the degradation of chlorobenzene than the optimum temperature for the growth of the fungi (37℃). A low nitrogen source concentration (30 mg N/L) had a better effect on degrading chlorobenzene than a high nitrogen source concentration (higher than 100 mg N/L). A high initial concentration (over 1100 mg/m3) of chlorobenzene showed an inhibiting effect on degradation by P. chrysosporium. A maximum removal efficiency of 95% was achieved at the initial concentration of 550 mg/m3. Conclusion P. chrysosporium has a rather good ability to remove gaseous chlorobenzene. A low nitrogen source concentration and a low temperature promote the removal of chlorobenzene by P. chrysosporium. However, a high initial chlorobenzene concentration can inhibit chlorobenzene degradation. | CAN WANC JIN-YING XI HONG-YING HU XIANG-HUA WEN | 2008 | Biomedical and Environmental Sciences2008，21，6： | 11 |
| 6 | Chromosomal localization of the major ribosomal RNA genes in scallop Chlamys farreri显示文摘The chromosomes of Chlamys farreri were analyzed by means of silver staining and fluorescence in situ hybridization (FISH) with 18S—28S rDNA probe. Probe was made by PCR amplification of a DNA fragment containing internal transcribed spacers ITS1 between 18S and 5.8S ribosomal RNA gene, ITS2 between 5.8S and 28S ribosomal RNA gene and 5.8S rRNA gene, and labeled by PCR incorporation of bio-16-dUTP. FISH signals were located on the short arm of subtelocentric chromosome 10. After silver-staining, nucleolus organizer regions (NORs) could be observed on the telomere of the short arm of chromosome 10. However, one metaphase spread displayed an additional silver spot on the short arm of subtelocentric chromosome 12. | HUANG Xiaoting BAO Zhenmin BI Ke HU Jingjie ZHANG Can ZHANG Quanqi HU Xiaoli | 2006 | Acta Oceanologica Sinica2006，25，3： | 10 |
| 7 | Mechanisms of activation and inhibition of Zika virus NS2B-NS3 protease显示文摘 | Xia Chen Kailin Yang Chen Wu Cheng Chen Can Hu Olga Buzovetsky Zefang Wang Xiaoyun Ji Yong Xiong Haitao Yang | 2016 | Cell Research2016，26，11： | 10 |
| 8 | Adsorption of Phosphate onto Ferrihydrite and Ferrihydrite-Humic Acid Complexes显示文摘The adsorption of phosphate onto ferrihydrite(FH) and two FH-humic acid(HA) complexes, obtained by co-precipitating FH with low(FH-HA1) and relatively high amounts of humic acid(FH-HA2), was studied through kinetics and isotherm experiments to determine the differences in phosphate adsorption between FH-HA complexes and FH and to reveal the mechanisms of phosphate adsorption onto two soil compositions. The isoelectric point(IEP) and the specific surface area(SSA) of the mineral decreased as the particle porosity of the mineral increased, which corresponded to an increase in the amount of organic carbon. The adsorption capacity of phosphate was higher on FH than on FH-HA1 and FH-HA2 at the scale of micromoles per kilogram. The initial adsorption rate and adsorption affinity of phosphate decreased with an increase in the amount of HA in the mineral. The sensitivity of phosphate adsorption to the change in the pH was greater for FH than for FH-HA complexes. Ionic strength did not affect the adsorption of phosphate onto FH and FH-HA1 at a lower p H, and the increase in the ionic strength promoted phosphate adsorption at a higher p H.However, for the FH-HA2 complex, the increase in the ionic strength inhibited the adsorption of phosphate onto FH-HA2 at a lower p H and increased the adsorption at a higher pH. | WANG Hui ZHU Jun FU Qing-Ling XIONG Jun-Wei HONG Can HU Hong-Qing Antonio VIOLANTE | 2015 | Pedosphere2015，25，3： | 10 |
| 9 | Assessing environmental factors associated with regional schistosomiasis prevalence in Anhui Province,Peoples’Republic of China using a geographical detector method显示文摘Background:Schistosomiasis is a water-borne disease caused by trematode worms belonging to genus Schistosoma,which is prevalent most of the developing world.Transmission of the disease is usually associated with multiple biological characteristics and social factors but also factors can play a role.Few studies have assessed the exact and interactive influence of each factor promoting schistosomiasis transmission.Methods:We used a series of different detectors(i.e.,specific detector,risk detector,ecological detector and interaction detector)to evaluate separate and interactive effects of the environmental factors on schistosomiasis prevalence.Specifically,(i)specific detector quantifies the impact of a risk factor on an observed spatial disease pattern,which were ranked statistically by a value of Power of Determinate(PD)calculation;(ii)risk detector detects high risk areas of a disease on the condition that the study area is stratified by a potential risk factor;(iii)ecological detector explores whether a risk factor is more significant than another in controlling the spatial pattern of a disease;(iv)interaction detector probes whether two risk factors when taken together weaken or enhance one another,or whether they are independent in developing a disease.Infection data of schistosomiasis based on conventional surveys were obtained at the county level from the health authorities in Anhui Province,China and used in combination with information from Chinese weather stations and internationally available environmental data.Results:The specific detector identified various factors of potential importance as follows:Proximity to Yangtze River(0.322)>Land cover(0.285)>sunshine hours(0.256)>population density(0.109)>altitude(0.090)>the normalized different vegetation index(NDVI)(0.077)>land surface temperature at daytime(LST_(day))(0.007).The risk detector indicated that areas of schistosomiasis high risk were located within a buffer distance of 50 km from Yangtze River.The ecological detector disclosed that the factors investigated have significantly different effects.The interaction detector revealed that interaction between the factors enhanced their main effects in most cases.Conclusion:Proximity to Yangtze River had the strongest effect on schistosomiasis prevalence followed by land cover and sunshine hours,while the remaining factors had only weak influence.Interaction between factors played an even more important role in influencing schistosomiasis prevalence than each factor on its own.High risk regions influenced by strong interactions need to be targeted for disease control intervention. | Yi Hu Congcong Xia Shizhu Li Michael PWard Can Luo Fenghua Gao Qizhi Wang Shiqing Zhang Zhijie Zhang | 2017 | Infectious Diseases of Poverty2017，6，1： | 9 |
| 10 | Matrine attenuates pathological cardiac fibrosis via RPS5/p38 in mice显示文摘Pathological cardiac fibrosis is a common feature in multiple cardiovascular diseases that contributes to the occurrence of heart failure and life-threatening arrhythmias.Our previous study demonstrated that matrine could attenuate doxorubicin-induced oxidative stress and cardiomyocyte apoptosis.In this study,we investigated the effect of matrine on cardiac fibrosis.Mice received aortic banding(AB)operation or continuous injection of isoprenaline(ISO)to generate pathological cardiac fibrosis and then were exposed to matrine lavage(200 mg·kg^(−1)·d^(−1))or an equal volume of vehicle as the control.We found that matrine lavage significantly attenuated AB or ISO-induced fibrotic remodeling and cardiac dysfunction.We also showed that matrine(200μmol/L)significantly inhibited the proliferation,migration,collagen production,and phenotypic transdifferentiation of cardiac fibroblasts.Mechanistically,matrine suppressed p38 activation in vivo and in vitro,and overexpression of constitutively active p38 completely abolished the protective effects of matrine.We also demonstrated that ribosomal protein S5(RPS5)upregulation was responsible for matrine-mediated inhibition on p38 and fibrogenesis.More importantly,matrine was capable of ameliorating preexisting cardiac fibrosis in mice.In conclusion,matrine treatment attenuates cardiac fibrosis by regulating RPS5/p38 signaling in mice,and it might be a promising therapeutic agent for treating pathological cardiac fibrosis. | Xin Zhang Can Hu Ning Zhang Wen-ying Wei Ling-li Li Hai-ming Wu Zhen-guo Ma Qi-zhu Tang | 2021 | Acta Pharmacologica Sinica2021，42，4： | 8 |
| 11 | A novel integrated UV-biofilter system to treat high concentration of gaseous chlorobenzene显示文摘A novel integrated UV-biofilter system using UV reactor as the pretreatment process was setup to trea high concentration of gaseous volatile organic compounds (VOCs). Another control biofilter withou the UV pretreatment was also established to compare the performance of the two systems. Chloro benzene was selected as a model compound. The two systems were operated in parallel under differen inlet chlorobenzene concentrations (500, 1000, 1600, mg·m?3). The experimental results indicate tha the integrated system could eliminate chlorobenzene completely (100% removal efficiency) at the inle concentration of 500 mg·m?3, whereas only 60% removal efficiency was achieved for the control biofi ter. Also the elimination capacity for the organic carbon of the integrated system was much higher tha that of the control biofilter. On the basis of intermediates analysis by Ion Chromatography and Ga Chromatography-Mass Spectrometry, the UV pretreatment has been proven to be able to enhance th performance of the following biofilter by transferring the recalcitrant target to some more biodegrad able and soluble organic products (such as formic acid and chlorophenol). Furthermore, the produce ozone, a harmful by-product from UV photo-degradation, could be easily eliminated by the followin biofiltration process. | WANG Can XI JinYing HU HongYing | 2008 | Chinese Science Bulletin2008，53，17： | 7 |
| 12 | The spatial pattern of farming and factors influencing it during the Peiligang culture period in the middle Yellow River valley, China显示文摘The Peiligang culture(ca.7000–5000 cal BC)is the earliest Neolithic culture in the middle Yellow River valley and represents the emergence of cereal farming in the region[1].It has long been considered representative of millet farming[2],which requires a dry field,a certain amount of rainfall,and minimal crop management,but new records reveal that mixed farming of millet and rice(Oryza sp.)took place during this period[3].Therefore,it is possible | Can Wang Houyuan Lu Wanfa Gu Naiqin Wu Jianping Zhang Xinxin Zuo Fengjiang Li Daojing Wang Yajie Dong Songzhi Wang Yanfeng Liu Yingjian Bao Yayi Hu | 2017 | Science Bulletin2017，62，23： | 6 |
| 13 | Accurate mirror-based camera pose estimation with explicit geometric meanings显示文摘An accurate closed form solution is proposed to estimate camera pose by several mirrored reference object images acquired via a planar mirror under different unknown poses. Compared with state-of-the-art methods, our method is more accurate when there are more than three images and has explicit geometric meanings. This method also properly handles cases in which some of the mirror poses are parallel. The central idea is to minimize an error metric based on all reflections of rotation, which enables the camera rotation to be estimated directly by SVD of sum of mirrored camera rotations. After that, the camera translation is computed by solving a large system of linear equations to minimize object space collinearity error. Both synthesized data and real data experiments show the advantages of our approach. | LI Xin LONG Gu Can GUO Peng Yu LIU Jin Bo ZHANG Xiao Hu YU Qi Feng | 2014 | Science China(Technological Sciences)2014，57，12： | 6 |
| 14 | Nondestructive 3D Image Analysis Pipeline to Extract Rice Grain Traits Using X-Ray Computed Tomography显示文摘The traits of rice panicles play important roles in yield assessment,variety classification,rice breeding,and cultivation management.Most traditional grain phenotyping methods require threshing and thus are time-consuming and labor-intensive;moreover,these methods cannot obtain 3D grain traits.In this work,based on X-ray computed tomography,we proposed an image analysis method to extract twenty-two 3D grain traits.After 104 samples were tested,the R^(2) values between the extracted and manual measurements of the grain number and grain length were 0.980 and 0.960,respectively.We also found a high correlation between the total grain volume and weight.In addition,the extracted 3D grain traits were used to classify the rice varieties,and the support vector machine classifier had a higher recognition accuracy than the stepwise discriminant analysis and random forest classifiers.In conclusion,we developed a 3D image analysis pipeline to extract rice grain traits using X-ray computed tomography that can provide more 3D grain information and could benefit future research on rice functional genomics and rice breeding. | Weijuan Hu Can Zhang Yuqiang Jiang Chenglong Huang Qian Liu Lizhong Xiong Wanneng Yang Fan Chen | 2020 | Plant Phenomics2020，2，1： | 6 |
| 15 | Mechanically exfoliated MoS_(2) nanosheets decorated with SnS_(2) nanoparticles for high-stability gas sensors at room temperature显示文摘Due to its unique physical,chemical and surface electronic properties,molybdenum disulfide(MoS_(2))nanosheets open up a new avenue for nitrogen dioxide(NO2)detection at room temperature.Nevertheless,the gas sensing properties of pure MoS_(2) nanosheets are inevitably degenerated by the adsorption of atmospheric oxygen,which results in weak stability for MoS_(2)-based gas sensors.Reducing surface defects and constructing heterojunctions may be effective strategies to improve the gas sensing properties of MoS_(2) nanosheets.In this work,we design a novel nanocomposite based on MoS_(2) nanosheets decorated with tin disulfide(SnS_(2))nanoparticles(MoS_(2)/SnS_(2))via combining the mechanical exfoliation method with the facile hydrothermal method.The experimental results indicate that,after surfaces decoration with SnS_(2) nanoparticles,the as-prepared gas sensor based on MoS_(2)/SnS_(2) nanocomposites exhibits reliable long-term stability with the maximum response value drift of less than 3%at room temperature.Moreover,the MoS_(2)/SnS_(2) sensor also possesses desirable gas sensing properties upon NO_(2) at room temperature,such as high sensitivity,rapid response/recovery speed(28 s/3 s,5×10^(-6) NO_(2)),satisfactory selectivity,favorable repeatability and reversibility.The improved gas sensing properties of MoS_(2)/SnS_(2) nanocomposites can be attributed to the unique electronic properties of MoS 2 nanosheets with the fewer layers structure and the competitive adsorption effect of SnS_(2) nanoparticles.This work elucidates that SnS_(2) nanoparticles serving as an effective antioxidative decoration can promote the stability of MoS_(2) nanosheets,providing a promising approach to achieve high-stability NO2 gas sensors at room temperature. | Jia-Bei Liu Jin-Yong Hu Can Liu Yu-Ming Tan Xiang Peng Yong Zhang | 2021 | Rare Metals2021，40，6： | 5 |
| 16 | Impact of agricultural residual plastic film on the growth and yield of drip-irrigated cotton in arid region of Xinjiang, China显示文摘Long-term and widespread use of plastic mulching has led to the accumulation of residual plastic film(RPF)in farmland soils of Xinjiang,China.However,there is no specific quantitative basis for RPF pollution or a clear understanding of the influence of residual film on crop growth.The aim of this study was to investigate the effect of RPF on the growth of cotton,an important cash crop of Xinjiang.Based on the field conditions and previous reports,various amount of residual film was applied in 0-30 cm soil layer.The growth index including emergence rate,dry matter,and yield of cotton was examined at different growth stages under different soil residual film levels.Results demonstrated a significant effect of RPF on soil moisture distribution and movement.Plastic residues had a significant effect on cotton growth at levels above 200 kg/hm2,and the yield decreased as the RPF amount increased.Based on these findings,200 kg/hm2 was suggested as a threshold level to determine the effects of RPF on cotton.This study provided a basis to rate RPF pollution in farmland soils and help understand the impact of pollution on crop productivity. | Can Hu Xufeng Wang Shiguo Wang Bing Lu Wensong Guo Chaoji Liu Xiuying Tang | 2020 | International Journal of Agricultural and Biological Engineering2020，13，1： | 5 |
| 17 | Specific targeting of angiogenesis in lung cancer with RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a 4.7T magnetic resonance scanner显示文摘 | LIU Can LIU Dong-bo LONG Guo-xian WANG Jun-feng MEI Qi HU Guang-yuan QIU Hong HU Guo-qing | 2013 | Chinese Medical Journal2013，，12： | 5 |
| 18 | Effect of side deep placement of nitrogen on yield and nitrogen use efficiency of single season late japonica rice显示文摘Side deep placement of nitrogen plays an important role in improving rice yield and nitrogen use efficiency.Few studies have examined the effects of reducing the times of nitrogen(RTN)application and reducing the nitrogen rate(RNR)of application on rice yield and nitrogen use efficiency under side deep placement of nitrogen in paddy fields.Therefore,a field experiment of RNT and RNR treatments was conducted with nine fertilization modes during the 2018–2019 rice growing seasons in a rice–wheat cropping system of the lower reaches of the Yangtze River,China.Rice yield and nitrogen use efficiency were investigated under side deep placement of nitrogen.We found that under the same nitrogen application rate,the yield of RTN3 increased by 9.64 and 10.18%in rice varieties NJ9108 and NJ5718,respectively,compared with the farmers’fertilizer practices(FFP).The nitrogen accumulation of RTN3 was the highest at heading stage,at 11.30 t ha^(–1)across 2018 and 2019.Under the same nitrogen application rate,the N agronomic use efficiency(NAE),N physiological efficiency(NPE)and N recovery efficiency(NRE)of RTN3 were 8.1–21.28%,8.51–41.76%and 0.28–14.52%higher than those of the other fertilization modes,respectively.RNR led to decreases in SPAD value,leaf area index(LAI),dry matter accumulation,nitrogen accumulation,and nitrogen use efficiency.These results suggest that RTN3 increased rice yield and nitrogen use efficiency under the side deep placement of nitrogen,and RNR1 could achieve the goals of saving cost and increasing resource use efficiency.Two fertilization modes RTN3 and RNR1 both could achieve the dual goals of increasing grain yield and resource use efficiency and thus are worth further application and investigation. | ZHAO Can HUANG Heng QIAN Zi-hui JIANG Heng-xin LIU Guang-ming XU Ke HU Ya-jie DAI Qigen HUO Zhong-yang | 2021 | Journal of Integrative Agriculture2021，20，6： | 5 |
| 19 | Cost-effectiveness analysis of the integrated control strategy for schistosomiasis japonica in a lake region of China: a case study显示文摘Background:Schistosomiasis japonica remains an important public health concern due to its potential to cause severe outcomes and Iong-term sequelae.An integrated control strategy implemented in the Peoples' Republic of China has been shown to be effective to control or interrupt the transmission of schistosomiasis.The objective of this study is to estimate the disease burden of schistosomiasis and assess the cost-effectiveness of the integrated control strategy focused on different major interventions at three stages for schistosomiasis control in a lake setting,to provide reference for policy making or planning. | Ling-Ling Wu He-Hua Hu Xia Zhang Xiao-Nong Zhou Tie-Wu Jia Can Wang Zhong Hon Jing Xu | 2021 | Infectious Diseases of Poverty2021，10，3： | 5 |
| 20 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
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