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| 1 | Outcome of aggressive B-cell lymphoma with TP53 alterations administered with CAR T-cell cocktail alone or in combination with ASCT显示文摘TP53 gene alteration confers inferior prognosis in refractory/relapse aggressive B-cell non-Hodgkin lymphoma(r/r B-NHL).From September 2016 to September 2020,257 r/r B-NHL patients were assessed for eligibility for two trials in our center,assessing anti-CD19 and anti-CD22 chimeric antigen receptor(CAR19/22)T-cell cocktail treatment alone or in combination with autologous stem cell transplantation(ASCT).TP53 alterations were screened in 123 enrolled patients and confirmed in 60.CAR19/22 T-cell administration resulted in best objective(ORR)and complete(CRR)response rate of 87.1%and 45.2%in patients with TP53 alterations. | Jia Wei Min Xiao Zekai Mao Na Wang Yang Cao Yi Xiao Fankai Meng Weimin Sun Ying Wang Xingcheng Yang Liting Chen Yicheng Zhang Haichuan Zhu Shangkun Zhang Tongcun Zhang Jianfeng Zhou Liang Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 2 |
| 2 | Deep learning for non-parameterized MEMS structural design显示文摘The geometric designs of MEMS devices can profoundly impact their physical properties and eventual performances.However,it is challenging for researchers to rationally consider a large number of possible designs,as it would be very time-and resource-consuming to study all these cases using numerical simulation.In this paper,we report the use of deep learning techniques to accelerate the MEMS design cycle by quickly and accurately predicting the physical properties of numerous design candidates with vastly different geometric features.Design candidates are represented in a nonparameterized,topologically unconstrained form using pixelated black-and-white images.After sufficient training,a deep neural network can quickly calculate the physical properties of interest with good accuracy without using conventional numerical tools such as finite element analysis.As an example,we apply our deep learning approach in the prediction of the modal frequency and quality factor of disk-shaped microscale resonators.With reasonable training,our deep learning neural network becomes a high-speed,high-accuracy calculator:it can identify the flexural mode frequency and the quality factor 4.6×10^(3)times and 2.6×10^(4)times faster,respectively,than conventional numerical simulation packages,with good accuracies of 98.8±1.6%and 96.8±3.1%,respectively.When simultaneously predicting the frequency and the quality factor,up to~96.0%of the total computation time can be saved during the design process.The proposed technique can rapidly screen over thousands of design candidates and promotes experience-free and data-driven MEMS structural designs. | Ruiqi Guo Fanping Sui Wei Yue Zekai Wang Sedat Pala Kunying Li Renxiao Xu Liwei Lin | 2022 | Microsystems & Nanoengineering2022，8，4： | 2 |
| 3 | Retraction notice to:M1 macrophage-derived exosomes moderate the differentiation of bone marrow mesenchymal stem cells显示文摘The published article titled“M1 macrophage-derived exosomes moderate the differentiation of bone marrow mesenchymal stem cells”,has been retracted from journal BIOCELL,Vol.46,No.2,2022,pp.495-503. | TAILIN WU XIANG ZHOU CANHUA YE WENCAN LU HAITAO LIN YANZHE WEI ZEKAI KE ZHENGJI HUANG JIANZHOU LUO HUIREN TAO CHUNGUANG DUAN | 2022 | BIOCELL2022，46，4： | 1 |
| 4 | Application of Cloud Precipitation Analysis System in Weather Modification in Fuxin显示文摘Based on Cloud Precipitation Analysis System(CPAS),the potential for weather modification during the four types of typical precipitation processes in Fuxin area in 2019 was analyzed,and the model forecast products before weather modification operation and the surface rainfall were compared. | Ke SUN Xu ZHANG Xilong NING Jianing BAI Ning LI Baoli SUN Zekai WEI | 2021 | Meteorological and Environmental Research2021，12，4： | 0 |
| 5 | Cholesterol-25-Hydroxylase Suppresses Seneca Valley Virus Infection via Producing 25-Hydroxycholesterol to Block Adsorption Procedure显示文摘Cholesterol-25-hydroxylase(CH25 H)is a membrane protein associated with endoplasmic reticulum,and it is an interferon-stimulated factor regulated by interferon.CH25 H catalyzes cholesterol to produce 25-hydroxycholesterol(25 HC)by adding a second hydroxyl to the 25 th carbon atom of cholesterol.Recent studies have shown that both CH25 H and 25 HC could inhibit the replication of many viruses.In this study,we found that ectopic expression of CH25 H in HEK-293 T and BHK-21 cell lines could inhibit the replication of Seneca Valley virus(SVV)and that there was no species difference.On the other hand,the knockdown of CH25 H could enhance the replication of SVV in HEK-293 T and BHK-21 cells,indicating the importance of CH25 H.To some extent,the CH25 H mutant without hydroxylase activity also lost its ability to inhibit SVV amplification.Further studies demonstrated that 25 HC was involved in the entire life cycle of SVV,especially in repressing its adsorption process.This study reveals that CH25 H exerts the advantage of innate immunity mainly by producing 25 HC to block virion adsorption. | Hui Li Zekai Zhao Xiangmin Li Liuxing Qin Wei Wen Huanchun Chen Ping Qian | 2021 | Virologica Sinica2021，36，5： | 0 |
| 6 | Climate Change and Its Impact on Ecological Environment in Western Liaoning in Recent 50 years显示文摘Based on the observation data of meteorological stations in western Liaoning from 1971 to 2020,the trend,Morlet wavelet,MK mutation and other methods were used to analyze the data.The results show that the annual average temperature of western Liaoning was 9.29℃;the annual average precipitation was 542.2 mm,and the trend change was not obvious;the temperature had obvious quasi-13-year,quasi-19-year and quasi-45-year cycles,and the precipitation had quasi-3-year,quasi-6-year,quasi-14-year and quasi-29-year cycles;there was a sudden change in temperature in 1990,and the warming was significant after the sudden change;the typical abrupt changes of precipitation occurred in 1979 and 2000,but the abrupt changes were not significant. | Xiaotong YANG Haiyan SHU Qian TAO Xiangyi CHANG Zekai WEI Jinglun LI | 2022 | Meteorological and Environmental Research2022，13，2： | 0 |
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