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| 1 | Activation of mitogen-activated protein kinases in satellite glial cells of the trigeminal ganglion contributes to substance P-mediated inflammatory pain显示文摘Inflammatory orofacial pain,in which substance P (SP) plays an important role,is closely related to the cross-talk between trigeminal ganglion (TG) neurons and satellite glial cells (SGCs).SGC activation is emerging as the key mechanism underlying inflammatory pain through different signalling mechanisms,including glial fibrillary acidic protein (GFAP) activation,phosphorylation of mitogen-activated protein kinase (MAPK) signalling pathways,and cytokine upregulation.However,in the TG,the mechanism underlying SP-mediated orofacial pain generated by SGCs is largely unknown.In this study,we investigated whether SP is involved in inflammatory orofacial pain by upregulating interleukin (IL)-1β and tumour necrosis factor (TNF)-α from SGCs,and we explored whether MAPK signalling pathways mediate the pain process.In the present study,complete Freund’s adjuvant (CFA) was injected into the whisker pad of rats to induce an inflammatory model in vivo.SP was administered to SGC cultures in vitro to confirm the effect of SP.Facial expression analysis showed that pre-injection of L703,606 (an NK-1 receptor antagonist),U0126 (an inhibitor of MAPK/extracellular signal-regulated kinase [ERK] kinase [MEK] 1/2),and SB203580 (an inhibitor of P38) into the TG to induce targeted prevention of the activation of the NK-1 receptor and the phosphorylation of MAPKs significantly suppressed CFA-induced inflammatory allodynia.In addition,SP promoted SGC activation,which was proven by increased GFAP,p-MAPKs,IL-1β and TNF-α in SGCs under inflammatory conditions.Moreover,the increase in IL-1β and TNF-α was suppressed by L703,606,U0126 and SB203580 in vivo and in vitro.These present findings suggested that SP,released from TG neurons,activated SGCs through the ERK1/2 and P38 pathways and promoted the production of IL-1β and TNF-α from SGCs,contributing to inflammatory orofacial pain associated with peripheral sensitization. | Yanyan Zhang Ning Song Fei Liu Jiu Lin Mengke Liu Chaolan Huang Daqing Liao Cheng Zhou Hang Wang Jiefei Shen | 2019 | International Journal of Oral Science2019，11，3： | 6 |
| 2 | Remediation Technology for Combined Pollution of Lead and Cadmium in Farmland Soil显示文摘At present,the problem of heavy metal pollution in farmland in southern China is serious. Especially,the cadmium and lead are two heavy metal elements with serious pollution and great harm to human body. This paper reviewed some common methods and materials used in the control of cadmium and lead pollution in farmland soil. Then,it discussed the problems in the repair of cadmium and lead pollution in farmland soil. It came up with the future research direction,to provide references for remediation of lead and cadmium pollution in farmland soil. | Jun TAN Yongxian LIU Xiangfeng WEI Yanfei HUANG Liumei XIONG Liping PAN Jinping CHEN Bin LIU Chaolan ZHANG | 2018 | Asian Agricultural Research2018，10，9： | 3 |
| 3 | Assessment of metals pollution on agricultural soil surrounding a lead-zinc mining area in the Karst region of Guangxi, China显示文摘 | ZHANG Chaolan LI Zhongyi YANG Weiwei | 2013 | Bulletin of Environmental Contamination and Toxicology2013，90，6： | 1 |
| 4 | Confirmation of three inflammatory bowel disease susceptibility loci in a Chinese cohort显示文摘 | Chaolan Lv Xiaoming Yang Yiyang Zhang Xinmei Zhao Zhengyan Chen Jinghua Long Yingchun Zhang Changqing Zhong Jia Zhi Guopeng Yao Bo Jiang Fachao Zhi | 2012 | International Journal of Colorectal Disease2012，，11： | 1 |
| 5 | Assessment of metal pollution on agricultural soil surrounding a lead-zinc mining area in the Karst Region of Guangxi, China 显示文摘 | Zhang Chaolan Li Zhongyi Yang Weiwei | 2013 | Bulle- tin of Environmental Contamination and Toxicology2013，90，6： | 1 |
| 6 | Mercury contaminated and its potential health effects in a lead-zinc mining area in the karst region of Guangxi, China 显示文摘 | DENG Ghaohing ZHANG Chaolan LI Lihe | 2011 | Appl Geochem2011，26，2： | 1 |
| 7 | An overview on transparent ceramics with pyrochlore and fluorite structures显示文摘Transparent ceramics have potential applications in various areas,including aerospace,relativistic optics industries,medical cares and defense.Specifically,they can be used as laser gain media,armor windows,IR domes,solid-state phosphors,scintillators and electro-optical components.From crystal structure point of view,transparent ceramic materials should have high crystallographic symmetries(cubic,tetragonal and hexagonal),which have minimal birefringent effect.Currently,transparent ceramics are dominantly based on oxide materials,although there are also nonoxides,such as fluorides and nitrides(oxynitrides).Transparent ceramics with pyrochlore and fluorite structures have attracted much attention in recent years,whereas fluorides are not well described in the open literature.Therefore,this paper is aimed to deliver an overview on the progress of the two categories of transparent ceramics,from material processing and characterization point of view. | Yu He Kaige Liu Bingxi Xiang Chaolan Zhou Ling Zhang Gang Liu Xiaoyang Guo Jianpang Zhai Tao Li Ling Bing Kong | 2020 | Journal of Advanced Dielectrics2020，10，3： | 0 |
| 8 | The KL system in wheat permits homoeologous crossing over between closely related chromosomes显示文摘The Chinese wheat landrace Kaixianluohanmai(KL)expresses the ph-like phenotype.A major QTL,QPh.sicau-3A(syn.phKL),responsible for this effect has been mapped to chromosome arm 3AL.This study presents some characteristics of homoeologous pairing and recombination induced by phKL.In KL haploids,the level of homoeologous pairing was elevated relative to Ph1 Chinese Spring(CS)haploids.There was a clear preference for A–D pairing and less frequent for A–B and B–D,reflecting the higher levels of affinity between genomes A and D in wheat.The characteristics of pairing were affected by temperature and magnesium ion supplementation.The suitability of phKL for chromosome engineering was tested on three pairs of homoeologues:2Sv-2B,2Sv-2D,and 2RL-2BL.The recombination rates were 1.68%,0.17%,and 0%,respectively.The phKL locus in KL induced a moderate level of homoeologous chromosome pairing and recombination when the Ph1 locus of wheat was present,both in wheat haploids and hexaploids.The Ph1-imposed criteria for chromosome pairing and crossing over were relaxed to some degree,permitting homoeologous crossing over but only between closely related chromosomes;there was no crossing over between more differentiated chromosomes.Therefore,the phKL system(QPh.sicau-3A)can be a useful tool in chromosome engineering of wheat to transfer genes from closely related species with the benefit of reduced genomic chaos generated by the ph1b mutation. | Chaolan Fan Jiangtao Luo Jiaojiao Sun Hong Chen Liqiong Li Lanyue Zhang Xue Chen Yazhou Li Shunzong Ning Zhongwei Yuan Bo Jiang Lianquan Zhang Xuejiao Chen Adam J.Lukaszewski Dengcai Liu Ming Hao | 2023 | The Crop Journal2023，11，3： | 0 |
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