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| 1 | Innate recognition of microbial-derived signals in immunity and inflammation显示文摘Microbes generate a vast array of different types of conserved structural components called pathogen-associated molecular patterns(PAMPs),which canbe recognized by cells of the innate immune system.This recognition of 'nonself' signatures occurs through host pattern recognition receptors(PRRs),suggesting that microbial-derived signals are good targets for innate immunity to discriminate between self- and nonself.Such PAMP-PRR interactions trigger multiple but distinct downstream signaling cascades,subsequently leading to production of proinflammatory cytokines and interferons that tailor immune responses to particular microbes.Aberrant PRR signals have been associated with various inflammatory diseases and fine regulation of PRR signaling is essential for avoiding excessive inflammatory immune responses and maintaining immune homeostasis.In this review we summarize the ligands and signal transduction pathways of PRRs and highlight recent progress of the mechanisms involved in microbe-specific innate immune recognition during immune responses and inflammation,which may provide new targets for therapeutic intervention to the inflammatory disorders. | Yue Zhang Chunli Liang | 2016 | Science China(Life Sciences)2016，59，12： | 14 |
| 2 | Occurrence and Diversity of Marine Yeasts in Antarctica Environments显示文摘A total of 28 yeast strains were obtained from the sea sediment of Antarctica.According to the results of routine identi-fication and molecular characterization,the strains belonged to species of Yarrowia lipolytica,Debaryomyces hansenii,Rhodotorula slooffiae,Rhodotorula mucilaginosa,Sporidiobolus salmonicolor,Aureobasidium pullulans,Mrakia frigida and Guehomyces pullu-lans,respectively.The Antarctica yeasts have wide potential applications in biotechnology,for some of them can produce b-galactosidase and killer toxins. | ZHANG Xue HUA Mingxia SONG Chunli CHI Zhenming | 2012 | Journal of Ocean University of China2012，11，1： | 11 |
| 3 | Local and long-range transport influences on PM_(2.5) at a cities-cluster in northern China,during summer 2008显示文摘Hourly PM2.5 concentrations were observed simultaneously at a cities-cluster comprising 10 cities/towns in Hebei province in China from July 1 to 31,2008. Among the 10 cities/towns, Baoding showed the highest average concentration level(161.57(jig/m3) and Yanjiao exhibited the lowest(99.35(jig/m3). These observed data were also studied using the joint potential source contribution function with 24-h and72-h backward trajectories, to identify more clearly the local and countrywide-scale long-range transport sources. For the local sources, three important influential areas were found, whereas five important influential areas were defined for long-range transport sources. Spatial characteristics of PM2.5 were determined by multivariate statistical analyses. Soil dust, coal combustion, and vehicle emissions might be the potential contributors in these areas. The results of a hierarchical cluster analysis for back trajectory endpoints and PM2.5 concentrations datasets show that the spatial characteristics of PM2.5 in the cities-cluster were influenced not only by local sources, but also by long-range transport sources. Different cities in the cities-cluster obtained different weighted contributions from local or long-range transport sources. Cangzhou, Shijiazhuang, and Baoding are near the source areas in the south of Hebei province,whereas Zhuozhou, Yangfang, Yanjiao, Xianghe, and Langfang are close to the sources areas near Beijing and Tianjin. | Lijie Gao Yingze Tian Caiyan Zhang Guoliang Shi Huize Hao Fang Zeng Chunli Shi Meigen Zhang Yinchang Feng Xiang Li | 2014 | Particuology2014，12，2： | 9 |
| 4 | Research on the Mechanism of Penetration Increase by Flux in A-TIG Welding显示文摘The mechanism of penetration depth increased by activating flux in activating tungsten inert gas (A-TIG) weldingwas studied by measuring the distribution of trace element Bi in the weld and monitoring the change of arc voltageduring A-TIG welding of stainless steel 0Crl8Ni9 with fluxes SiO2 and TiO2. The results show that the mechanismof penetration depth in A-TIG welding depends on the sort of flux used. The weld pool convection after coating theflux SiO2 and flux TiO2 is changed inversely compared with convectional TIG welding without flux. The arc voltageis increased by flux SiO2 whilst flux TiO2 does not have effect on the arc voltage. The reason of penetration depthincrease for SiO2 is due to the constriction of arc plasma and the change of surface tension gradient. The increaseof weld penetration depth with TiO2 only ascribes to the change of surface tension gradient. | Chunli YANG Sanbao LIN Fengyao LIU Lin WU Qingtao ZHANG | 2003 | Journal of Materials Science & Technology2003，19，z1： | 8 |
| 5 | Synthesis of water-soluble Cu nanoparticles and evaluation of their tribological properties and thermal conductivity as a water-based additive显示文摘Efficient and sustainable use of water-based lubricants is essential for energy efficiency.Therefore,the use of water-lubricated mechanical systems instead of conventional oil lubricants is extremely attractive from the viewpoint of resource conservation.In this study,water-soluble Cu nanoparticles of size approximately 3 nm were prepared at room temperature(around 25 °C) via in-situ surface modification.The tribological behavior of the as-synthesized Cu nanoparticles as an additive in distilled water was evaluated using a universal micro-tribotester.The results show that the as-synthesized Cu nanoparticles,as a water-based lubricant additive,can significantly improve the tribological properties of distilled water.In particular,the lowest friction coefficient of 0.06 was obtained via lubrication with a concentration of 0.6 wt% of Cu nanoparticles in distilled water,which is a reduction of 80.6% compared with that obtained via lubrication with distilled water alone.It is considered that some Cu nanoparticles entered the contact area of the friction pairs to form a complex lubricating film and prevent direct contact of the friction pairs.Furthermore,some Cu nanoparticles in the solution accelerate the heat transfer process,which also results in good tribological properties. | Junhua ZHAO Guangbin YANG Chunli ZHANG Yujuan ZHANG Shengmao ZHANG Pingyu ZHANG | 2019 | Friction2019，7，3： | 6 |
| 6 | Neoproterozoic magmatism in eastern Himalayan terrane显示文摘Geochronological investigation on gneisses of granitic to leucogranitic compositions in Cuona,south Tibet,reveal that their protoliths formed at 808.8 ± 7.9-816.4 ± 3.4 Ma and 855.8 ± 7.0 Ma,respectively.Zircon rims from the granitic gneiss record a metamorphic age of 739.4 ± 4.3 Ma.Lu-Hf isotopic analyses on zircon grains with Neoproterozoic ages yield negative ε_(Hf)(t) values from-9.0 to-4.2,and the corresponding two-stage Hf model ages are 1965-2228 Ma.Whole-rock geochemical data indicate that all granitic gneisses are K-riched calc-alkali series.These new data together with literature data show that(1) the Himalayan terrane experienced an episode of Neoproterozoic magmatism at 850-800 Ma;(2) the Neoproterozoic magma of granitic compositions were derived from partial melting of ancient crusts,possibly due to the thermal perturbation related with the breakup of the Rodinia supercontinent. | Yuhua Wang Lingsen Zeng Li-E Gao Chunli Guo Kejun Hou Lifei Zhang Wei Wang Huiyi Sun | 2017 | Science Bulletin2017，62，6： | 5 |
| 7 | Rapid Assessment on Potential Risks of Schistosomiasis Transmission—7 PLADs,China,2019 and 2021显示文摘Summary What is already known about this topic?Oncomelania hupensis(O.hupensis)and livestock are main infection sources of schistosomiasis.The schistosome infected O.hupensis and livestock’s feces are important risk factors in the transmission of schistosomiasis.What is added by this report?The potential risks of schistosomiasis transmission remain prevalent,giving an early warning to local government with information on existing transmission risks.It is expected that the effectiveness and efficiency of schistosomiasis surveillance could be improved by conducting rapid risk assessment at the beginning of transmission season. | Junyi He Hongqing Zhu Ziping Bao Lijuan Zhang Yinlong Li Ting Feng Suying Guo Wangping Deng Can Wang Hui Dang Tiewu Jia Chao Lyu Zhiqiang Qin Chunli Cao Jing Xu Shizhu Li Xiaonong Zhou | 2021 | China CDC weekly2021，3，51： | 5 |
| 8 | Electromechanical Fields Near a Circular PN Junction Between Two Piezoelectric Semiconductors显示文摘We study electromechanical fields near the interface between a circular piezoelectric semiconductor cylinder and another piezoelectric semiconductor in which it is embedded.The cylinder is p-doped. The surrounding material is n-doped. The phenomenological theory of piezoelectric semiconductors consisting of the equations of piezoelectricity and the conservation of charge for holes and electrons is used. The theory is linearized for small carrier concentration perturbations. An analytical solution is obtained, showing the formation of a PN junction near the interface. Various electromechanical fields associated with the junction are calculated. The effects of a few physical parameters are examined. | Yixun Luo Ruoran Cheng Chunli Zhang Weiqiu Chen Jiashi Yang | 2018 | Acta Mechanica Solida Sinica2018，31，2： | 5 |
| 9 | Nuclear Aurora kinase A switches m^(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4显示文摘Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression,yet how this process is regulated by oncogenic signal remains largely unknown.Here,we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 directed by m^(6)A reader YTHDC1 in lung cancer.Nuclear translocation of AURKA is a prerequisite for RNA aberrant splicing,specifically triggering RBM4 splicing from the full isoform(RBM4-FL)to the short isoform(RBM4-S)in a kinase-independent manner. | SiSi Li YangFan Qi JiaChuan Yu YuChao Hao Bin He MengJuan Zhang ZhenWei Dai TongHui Jiang SuYi Li Fang Huang Ning Chen Jing Wang MengYing Yang DaPeng Liang Fan An JinYao Zhao WenJun Fan YuJia Pan ZiQian Deng YuanYuan Luo Tao Guo Fei Peng ZhiJie Hou ChunLi Wang FeiMeng Zheng LingZhi Xu Jie Xu QingPing Wen BiLian Jin Yang Wang Quentin Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 4 |
| 10 | Arabidopsis ROOT HAIR DEFECTIVE3 is involved in nitrogen starvation-induced anthocyanin accumulation显示文摘Anthocyanin accumulation is a common phenomenon seen in plants under environmental stress. In this study,we identified a new allele of ROOT HAIR DEFECTIVE3(RHD3)showing an anthocyanin overaccumulation phenotype under nitrogen starvation conditions. It is known that ethylene negatively regulates light- and sucrose-induced anthocyanin biosynthesis. We hypothesized that RHD3 achieves its negative effect on anthocyanin biosynthesis via an ethylene-regulating pathway. In support of this, similar to rhd3 mutants, the Arabidopsis ethylene signaling mutants etr1, ein2, and ein3/eil1 showed an anthocyanin overaccumulation phenotype under nitrogen starvation conditions. The ethylene precursor ACC strongly suppressed anthocyanin accumulation, dependent on ETR1, EIN2, EIN3/EIL1, and, partially, RHD3. In addition,inactivating RHD3 partially reversed the suppressive effect of ETO1 inactivation-evoked endogenous ethylene production on anthocyanin accumulation. The expression of nitrogen starvation-induced anthocyanin biosynthesis genes was negatively regulated by RHD3, but ethylene response genes were Researchpositively regulated by RHD3. Wild-type seedlings overexpressing RHD3 showed similar phenotypes to rhd3 mutants,indicating the existence of a fine-tuned relationship between gene expression and function. RHD3 was initially identified as a gene involved in root hair development. This study uncovered a new physiological function of RHD3 in nitrogen starvationinduced anthocyanin accumulation and ethylene homeostasis. | Jing Wang Yan Wang Ju Yang Chunli Ma Ying Zhang Ting Ge Zhi Qi Yan Kang | 2015 | Journal of Integrative Plant Biology2015，57，8： | 3 |
| 11 | A Case of New Variant COVID-19 First Emerging in South Africa Detected in a Security Guard at the Isolation Point—Shenzhen,China,January 23,2021显示文摘On January 22,2021,a 34-year-old male,who served as a security guard at the isolation point in Shenzhen,tested positive for coronavirus disease 2019(COVID-19)during the every-three-day routine test.After the nasopharyngeal swab was further confirmed as positive for COVID-19 by Shenzhen CDC,the patient was transferred to the Third People’s Hospital of Shenzhen and was diagnosed as a COVID-19 asymptomatic infection.On January 25,2021,Shenzhen CDC identified the 20H/501.Y.V2(B.1.351)variant,which was a variant of COVID-19 virus first emerging in the South Africa. | Jun Meng Shujiang Mei Long Chen Chunli Wu Shisong Fang Bo Peng Dongfeng Kong Xiaomin Zhang Linghong Xiong Yalan Huang Qiongcheng Chen Renli Zhang Yaqing He | 2021 | China CDC weekly2021，3，10： | 3 |
| 12 | Voltage-dependent anion channel involved in the α-synuclein-induced dopaminergic neuron toxicity in rats显示文摘包含神经蛋白质 -synuclein 的包括身体(-syn) 在几 neurodegenerative 疾病被观察,包括 Parkinson 的疾病(PD ) 。而且,在老鼠大脑的 -syn 的在表示上部分由在 substantia nigra (SN ) 触发 dopaminergic 神经原的退化模仿 neuropathological 和 PD 的行为的特征。Mitochondrial 机能障碍对 PD 致病也中央,并且 -syn 在线粒体被发现。然而, -syn-induced neurotoxicity 的精确机制留下逃犯。检验 -syn-induced neurodegeneration 的潜在的机制,我们在用 recombinant 的老鼠的 SN 的过去表示的 -syn 联系 adeno 的病毒的向量(rAAV-syn ) 。把结果标记的 Immunohistochemical 和 immunogold 显示 -syn 在向量注射以后在 SN 和 striatum 是成功地过去表示的。酷氨酸的数字 hydroxylase 积极(dopaminergic ) 神经原显著地在当时,与 rAAV-syn 注射的老鼠被减少与控制老鼠相比。与控制老鼠相比, -syn-conjugated 金牌粒子的密度在轴突是更大的,细胞质,原子核,并且尤其是另外在在 rAAV-syn-injected 老鼠的 SN 神经原的线粒体。另外,有 rAAV-syn 的 SN 神经原 transfected 与不连续的外部膜和内部像液泡的结构展出了肿的线粒体,强烈建议 -syn-induced mitochondrial 机能障碍。在 rAAV-syn-injected 老鼠的线粒体也在 autophagosomes 被观察。有电压依赖者阴离子隧道 1 的 -Syn co-immunoprecipitated (VDAC1 ) ,导致 mitochondrial 解开的 mitochondrial 渗透转变毛孔(mPTP ) 的一个部件和 apoptosis。-syn 的在表示上可以通过和 mitochondrial VDAC1 的一个相互作用引起 dopaminergic 神经原的退化,它导致 mPTP 激活,解开的 mitochondrial,和房间死亡。 | Lingling Lu Chunyan Zhang Qing Cai Qiang Lu Chunli Duan Yuangang Zhu Hui Yang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，3： | 3 |
| 13 | Effects of low doses of aerosolized iloprost combined with tadalafil in treatment of adult congenital heart disease with severe pulmonary arterial hypertension显示文摘Pulmonary arterial hypertension (PAH) is a common and serious complication of congenital heart disease (CHD).Many studies have confirmed that the prostacyclin analogues,5-phosphodiesterase (PDE-5) inhibitors,and endothelin receptor antagonists,were safe and effective in the treatment for PAH due to CHD.1,2 But whether the combination of targeted PAH therapy drugs provides similar synergistic effects is still controversial.1,2 Therefore,we investigated whether adult patients with severe PAH secondary to CHD would benefit from iloprost combined with low-dose tadalafil. | Zhang Caojin Huang Yigao Huang Tao Xia Chunli Huang Xinsheng Zhang Guolin Chen Jimei Chen Jiyan Zhuang Jian | 2014 | Chinese Medical Journal2014，，5： | 3 |
| 14 | Electrical Response of a Multiferroic Composite Semiconductor Fiber Under a Local Magnetic Field显示文摘We study the electrical response of a multiferroic composite semiconductor fiber consisting of a piezoelectric semiconductor layer and two piezomagnetic layers under a transverse magnetic field applied locally to a finite part of the fiber.The phenomenological theory of piezomagnetic-piezoelectric semiconductors is employed.A one-dimensional model is derived for magnetically induced extension of the fiber.For open-circuit boundary conditions at the two ends of the fiber,an analytical solution is obtained from the model linearized for small carrier perturbations.The solution shows a local electric polarization and a pair of local electric potential barrier-well.When the two ends of the fiber are under a voltage,a nonlinear numerical solution shows that the potential barrier and well forbid the passage of currents when the voltage is low.The results have potential applications in piezotronic devices when magnetic fields are involved for manipulating the devices or sensing and transduction. | Chao Liang Chunli Zhang Weiqiu Chen Jiashi Yang | 2020 | Acta Mechanica Solida Sinica2020，33，5： | 3 |
| 15 | Construction of TiO_(2)-covalent organic framework Z-Scheme hybrid through coordination bond for photocatalytic CO_(2) conversion显示文摘In this work,a covalent organic framework(COF),which is constructed by the building blocks of[5,10,15,20-tetrakis(4-aminophenyl)porphinato]copper(Ⅱ)(CuTAPP)and p-benzaldehyde,is employed to integrate with TiO_(2) for the purpose of establishing a Z-scheme hybrid.Within the system,isonicotinic acid performs the role of a bridge that connects the two components through a coordination bond.Further photocatalytic application reveals the hybrid framework is able to catalyze CO_(2) conversion under simulated solar light,resulting in CO production rate of 50.5 μmol g^(-1)·h^(-1),about 9.9 and 24.5 times that of COF and pristine TiO_(2),respectively.The ameliorated catalytic performance owes much to the por-phyrin block acting as photosensitizer that augments the light absorbance,and the establishment of Z-scheme system between the inorganic and orga nic comp on ents that enhances the separati on of the carriers.In addition,the chemical bridge also ensures a steady usage and stable charge delivery in the catalysis.Our study sheds light on the development of versatile approaches to covalently in corporate COFs with inorga nic semic on ductors. | Lei Wang Guofang Huang Liang Zhang Rui Lian Jingwei Huang Houde She Chunli Liu Qizhao Wang | 2022 | Journal of Energy Chemistry2022，31，1： | 3 |
| 16 | Design of a high-repetition rate photon source in a quantum key distribution system显示文摘Photon source with high-repetition quantum message transmission is needed in the quantum key distribution (QKD) system for long distance and high-repetition rate. We design high-repetition-rate weak coherent light by applying a practical QKD system with decoy states and polarization coding including an FPGA-based true random number generator, narrow pulse shaping under the modulation of high-speed true random number as well as its laser driver. The test indicates that the repetition rate of such light can attain a high performance of 650 MHz, pulse width less than 300 ps, stability of pulse amplitude better than 5%, and extinction rate better than 1000:1. | WANG Jian CUI Ke LUO ChunLi ZHANG HongFei ZHOU Lei CHEN TengYun LIANG Hao JIN Ge | 2013 | Science China(Information Sciences)2013，56，9： | 3 |
| 17 | The multi-soliton solutions of the CH-γ equation显示文摘This paper solves the integrable CH-γequation for analytical multiple soliton solutions with the Darboux transformation method.Some properties of the soliton solutions are different from the CH equation. | CHEN ChunLi~(1+) LI YiShen~2 ZHANG JinE~3 1 Department of Mathematics,Shanghai Jiaotong University,Shanghai 200240,China 2 Department of Mathematics,University of Science and Technology of China,Hefei 230026,China 3 SB and SEF,University of Hong Kong,Pokfulam Road,Hong Kong,China | 2008 | Science China Mathematics2008，51，2： | 3 |
| 18 | Synthesis,Characterization and Electromagnetic Studies on Nanocrystalline Nickel Zinc Ferrite by Polyacrylamide Gel显示文摘Nanocrystalline 镍锌铁酸盐粉末(Ni_xZni_(1-x ) Fe2O4,为 x=0 的 A,为 x=0.2 的 B,为 x=0.5 的 C,为 x-0.8 的 D 和为 x=1 的 E ) 被聚丙烯酰氨综合胶化方法。X 光检查衍射(XRD ) ,传播电子显微镜学(TEM ) 和波导被用来描绘作文。弄干的胶化粉末是非结晶的 XRD 结果表演,和特征尖晶石Ni_( 0.5 )Zn_( 0.5 ) Fe2O4 达到顶点在胶化为锻烧的温度是的 1 h.When 在 400 °C 被锻烧以后,出现 600 和 800 °C ,平均谷物尺寸被是 10 和 30 nm 的 TEM 识别, respectively.The Ni_xZn_( 1-x ) Fe2O4 粉末在Ni^(2+)离子的增加满足的 8.2-11.0GHz .With 的频率范围有绝缘的损失和磁性的损失,当时,绝缘的参数(epsilon')和Ni_xZn_( 1-x ) Fe2O4 粉末的渗透(mu')减少绝缘的损失( epsilon “),磁性的损失(亩”)并且思考损失增加。 | Ruiting MA Yi WANG Yanwen TIAN Chunli ZHANG Xikun LI | 2008 | Journal of Materials Science & Technology2008，24，3： | 2 |
| 19 | Distribution Patterns of the Snail Intermediate Host of Schistosoma japonicum-China,2015−2019显示文摘What is already known about this topic?The endemic status of schistosomiasis appeared to continuously decrease in China from 2015 to 2019.The snail species Oncomelania hupensis is the only intermediate host involved in the transmission of Schistosoma japonicum,and this snail’s geographic distribution is strictly consistent with that of schistosomiasis.What is added by this report?The snail’s habitats did not decrease significantly in China from 2015 to 2019,and some habitats have been newly detected or recurrent in some regions.Snail habitats among nine counties in Hunan and Jiangxi covered nearly half of the areas with snails.What are the implications for public health practice?Considering the situation of snail distribution,strategies and measures on snail control should focus on key areas.In addition,study of the origin and causes of the newly-detected snail habitats and recurrent areas with snails needs to be strengthened,and comprehensive measures should be taken to prevent the spread of snails. | Lijuan Zhang Shan Lv Chunli Cao Jing Xu Shizhu Li | 2021 | China CDC weekly2021，3，5： | 2 |
| 20 | Comparison of carbonaceous particulate matter emission factors among different solid fuels burned in residential stoves显示文摘 | Guofeng Shen Miao Xue Yuanchen Chen Chunli Yang Wei Li Huizhong Shen Ye Huang Yanyan Zhang Han Chen Ying Zhu Haisuo Wu Aijun Ding Shu Tao | 2014 | Atmospheric Environment2014，，： | 2 |
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