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| 1 | 14-3-3 mediates apeHn-13-induced enhancement of adhesion of monocytes to human umbilical vein endothelial cells显示文摘调查 apelin-13 是否导致了 THP-1 单核白血球(MC ) 对经由表明 transduction 小径和潜在的小说的 14-3-3 的 ECV304 人的脐的静脉 endothelial 房间(HUVEC ) 的粘附生理的功能和 apelin-APJ 的发信号的 transduction 小径, HUVEC ECV304 在 DMEM 和 MC THP-1 是有教养的在 RPMI 1640 是有教养的中等。单核白血球粘附和脉管的房间粘附 molecule-1 (VCAM-1 ) 和 14-3-3 的表示与单核白血球粘附试金和西方的污点分析被测量。数据证明 apelin-13 在一个集中依赖者和时间依赖者举止增加了 MC 的粘附到 HUVEC,它分别地在 1 M 和 12 h 到达了他们的山峰。同样, apelin-13 导致了 HUVEC 粘附分子的表示,在一个集中依赖者和时间依赖者举止, VCAM-1 分别地在 1 M 和 12 h 到达了他们的山峰。Apelin-13 在一个集中依赖者和时间依赖者举止导致了 14-3-3 的表示,它分别地在 1 M 和 5 min 到达了他们的山峰。而且,有势力 14-3-3 禁止者 difopein 显著地减少了 14-3-3 的表示,在 apelin-13 的 VCAM-1 刺激了 HUVEC,并且 difopein 显著地在对 HUVEC 的 MC 粘附的正式就职上禁止了 apelin-13 的效果。这些数据建议 14-3-3 调停了到由 Apelin-13 的 HUVEC 的 MC 的粘附的正式就职。 | Xin Li Xianhui Zhang Fang Li Linxi Chen Lanfang Li Xuping Qin Jing Gao Tao Su Yixin Zeng Duanfang Liao | 2010 | Acta Biochimica et Biophysica Sinica2010，42，6： | 21 |
| 2 | Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation显示文摘apelin/apelin 受体(APJ, apelinangiotensin 像受体 1 ) 系统是一最新 deorphanized G 联合蛋白质的受体系统。是重要规章的因素的 apelin 和 APJ 在心血管的系统被表示。我们的以前的研究显著地表明了那 apelin-13 刺激脉管的光滑的肌肉房间(VSMC ) 增长。在这份报纸,我们的数据建议表明 transduction 小径的 Jagged-1/Notch3 被支持 Cyclin D1 的表示涉及 apelin-13-induced VSMC 增长。结果显示 apelin-13 在集中依赖者和时间依赖者礼貌刺激 VSMC 和 Jagged-1 和 Notch3 的表示的增长。apelin-13 导致的 Jagged-1 和 Notch3 的增加的表示能被细胞外的调整信号的蛋白质 kinase (英皇家空军之阶级最低之兵) 废除封锁。PD98059 (英皇家空军之阶级最低之兵禁止者) 能禁止 apelin-13 导致的 Jagged-1/Notch3 的激活。用小介入 RNA 的 Notch3 的下面规定禁止 Cyclin D1 的表示并且阻止 apelin-13-induced VSMC 增长。在结论, Jagged-1/Notch3 发信号 transduction 小径涉及 apelin-13 导致的 VSMC 增长。 | Lifang Li Lanfang Li Feng Xie Zidong Zhang Yu Guo Guotao Tang Deguan Lv Qixuan Lu Linxi Chen Jian Li | 2013 | Acta Biochimica et Biophysica Sinica2013，45，10： | 18 |
| 3 | A mussel-inspired supramolecular hydrogel with robust tissue anchor for rapid hemostasis of arterial and visceral bleedings显示文摘In recent years,the developed hemostatic technologies are still difficult to be applied to the hemostasis of massive arterial and visceral hemorrhage,owing to their weak hemostatic function,inferior wet tissue adhesion,and low mechanical properties.Herein,a mussel-inspired supramolecular interaction-cross-linked hydrogel with robust mechanical property(308.47±29.20 kPa)and excellent hemostatic efficiency(96.5%±2.1%)was constructed as a hemostatic sealant.Typically,we combined chitosan(CS)with silk fibroin(SF)by cross-linking them through tannic acid(TA)to maintain the structural stability of the hydrogel,especially for wet tissue adhesion ability(shear adhesive strength=29.66±0.36 kPa).Compared with other materials reported previously,the obtained CS/TA/SF hydrogel yielded a lower amount of blood loss and shorter time to hemostasis in various arterial and visceral bleeding models,which could be ascribed to the synergistic effect of wound closure under wet state as well as intrinsic hemostatic activity of CS.As a superior hemostatic sealant,the unique hydrogel proposed in this work can be exploited to offer significant advantages in the acute wound and massive hemorrhage with the restrictive access of therapeutic moieties. | Ziwen Qiao Xueli Lv Shaohua He Shumeng Bai Xiaochen Liu Linxi Hou Jingjing He Dongmei Tong Renjie Ruan Jin Zhang Jianxun Ding Huanghao Yang | 2021 | Bioactive Materials2021，6，9： | 14 |
| 4 | Effect of baicalin and berberine on transport of nimodipine on primarycultured,rat brain microvascular endothelial cells显示文摘目的:调查 baicalin 和 berberine 是否越过血大脑障碍( BBB )影响运输 ofnimodipine ( NMD ) .Methods :主要有教养,老鼠大脑 microvascularendothelial 房间( rBMEC )是被使用一在里面 BBB.When 房间的 vitro 模型变得汇合,由 rBMEC 与或没有 baicalin 和 berberine 的 NMD 的thesteady状态举起是 measured.The effectsof baicalin ,从 rBMEC 的 NMD 的流出上的 berberine 也是 studied.Results : Baicalin ( 2-5 mug/mL )增加了 NMD ,和 baical | Dong-mei ZHANG Hai-yan LIU LinXIE Xiao-dong LIU | 2007 | Acta Pharmacologica Sinica2007，28，4： | 11 |
| 5 | High-precision RCS measurement of aircraft's weak scattering source显示文摘The radar cross section(RCS) of weak scattering source on the surface of an aircraft is usually less than 40 d Bsm.How to accurately measure the RCS characteristics of weak scattering source is a technical challenge for the aircraft's RCS measurement.This paper proposes separating and extracting the two-dimensional(2D) reflectivity distribution of the weak scattering source with the microwave imaging algorithm and spectral transform so as to enhance its measurement precision.Firstly,we performed the 2D microwave imaging of the target and then used the 2D gating function to separate and extract the reflectivity distribution of the weak scattering source.Secondly,we carried out the spectral transform of the reflectivity distribution and eventually obtained the RCS of the weak scattering source through calibration.The prototype experimental results and their analysis show that the measurement method is effective.The experiments on an aircraft's low-scattering conformal antenna verify that the measurement method can eliminate the clutter on the surface of aircraft.The precision of measuring a 40 d Bsm target is 3–5 d B better than the existing RCS measurement methods.The measurement method can more accurately obtain the weak scattering source's RCS characteristics. | Hu Chufeng Li Nanjing Chen Weijun Zhang Linxi | 2016 | Chinese Journal of Aeronautics2016，29，3： | 7 |
| 6 | Elabela-APJ axis contributes to embryonic development and prevents pre-eclampsia in pregnancy显示文摘 | Qionglin Zhou Kai Zhang Yu Guo Linxi Chen Lanfang Li | 2018 | Acta Biochimica et Biophysica Sinica2018，50，3： | 5 |
| 7 | Additive manufacturing technologies of porous metal implants显示文摘Biomedical metal materials with good corrosion resistance and mechanical properties are widely used in orthopedic surgery and dental implant materials,but they can easily cause stress shielding due to the significant difference in elastic modulus between the implant and human bones.The elastic modulus of porous metals is lower than that of dense metals.Therefore,it is possible to adjust the pore parameters to make the elastic modulus of porous metals match or be comparable with that of the bone tissue.At the same time,the open porous metals with pores connected to each other could provide the structural condition for bone ingrowth,which is helpful in strengthening the biological combination of bone tissue with the implants.Therefore,the preparation technologies of porous metal implants and related research have been drawing more and more attention due to the excellent features of porous metals.Selective laser melting(SLM)and electron beam melting technology(EBM)are important research fields of additive manufacturing.They have the advantages of directly forming arbitrarily complex shaped metal parts which are suitable for the preparation of porous metal implants with complex shape and fine structure.As new manufacturing technologies,the applications of SLM and EBM for porous metal implants have just begun.This paper aims to understand the technology status of SLM and EBM,the research progress of porous metal implants preparation by using SLM and EBM,and the biological compatibility of the materials,individual design and manufacturing requirements.The existing problems and future research directions for porous metal implants prepared by SLM and EBM methods are discussed in the last paragraph. | Zhou Linxi Yang Quanzhan Zhang Guirong Zhao Fangxin Shen Gang Yu Bo | 2014 | China Foundry2014，11，4： | 5 |
| 8 | Evaluation of the toxicity of fluorine in Antarctic krill on soft tissues of Wistar rats显示文摘Antarctic krill are a potential food source for humans and animals, but krill are known to contain high levels of fluorine (F). In this study, we investigated the toxicity of F in Antarctic krill using Wistar rats. There were three experimental groups: The control group were fed a basal diet, the krill treatment group were fed the same basal diet mixed with krill powder (150 mg·kg-1 F), and the sodium fluoride (NaF) treatment group were fed the basal diet with added NaF (150 mg·kg-1 F). General toxicity indicators including body weight and food intake were measured during the experiment. After three months the rats were dissected and tissue samples were collected from the liver, kidney, spleen, brain, and testis. Morphological changes in the cells of these tissues were assessed using HE staining. There were no significant differences in the body weight, the food intake, or the viscera coefficients among the three groups. In both treatment groups some pathological changes were observed in all soft tissue samples except the testis, although there were fewer and less severe pathological changes in the krill treatment group than in the NaF treatment group. The results showed that the toxicity of F in Antarctic krill was lower than for an equivalent amount of F in NaF, but it was still toxic to rats consuming large quantities of krill. The findings of this study highlight the need for further investigation into potential F toxicity if krill is to be used for human consumption. | ZHANG Ling LU Xiaoqi WANG Zhangmin QIN Liqiang YUAN Linxi YIN Xuebin | 2013 | Advances in Polar Science2013，24，2： | 2 |
| 9 | Mitochondria-associated endoplasmic reticulum membranes (MAMs) involve in the regulation of mitochondrial dysfunction and heart failure显示文摘 | Kai Zhang Qionglin Zhou Yu Guo Linxi Chen Lanfang Li | 2018 | Acta Biochimica et Biophysica Sinica2018，50，6： | 2 |
| 10 | Folding rate prediction using n-order contact distance for proteins with two-and three-state folding kinetics显示文摘 | Zhang Linxi Sun Tingting | 2005 | Biophys Chem2005，113，： | 1 |
| 11 | Dynamic and static properties of polyoxymethylene chains显示文摘 | Zhang Linxi Xia Agena Zhao Delu | 1999 | European polymer journal1999，35，： | 1 |
| 12 | Folding rate prediction based on neural network model显示文摘 | Zhang Linxi Li Jing Jiang Zhouting | 2003 | Polymer2003，44，： | 1 |
| 13 | Evaluation of the biological toxicity of fluorine in Antarctic krill显示文摘Antarctic krill is a potentially nutritious food source for humans, but fluorine(F) toxicity is a matter of concern. To evaluate the toxicity of F in Antarctic krill, 30 Wistar rats were divided into three groups with different dietary regimens: a control group, a krill treatment group(150 mg·kg-1 F), and a sodium fluoride(NaF) treatment group(150 mg·kg-1 F). After three months, F concentrations in feces, plasma, and bone were determined, and the degree of dental and skeletal fluorosis was assessed. The F concentrations in plasma and bone from the krill treatment group were 0.167 0±0.020 4 mg.L-1 and 2 709.8±301.9 mg·kg-1, respectively, compared with 0.043 8±0.005 5 mg·L-1 and 442.4±60.7 mg·kg-1, respectively, in samples from the control group. Concentrations of F in plasma and bone in the krill treatment group were higher than in the control group, but lower than in the NaF treatment group. The degree of dental fluorosis in the krill treatment group was moderate, compared with severe in the NaF treatment group and normal in the control group. The degree of skeletal fluorosis did not change significantly in any group. These results showed that the toxicity of F in Antarctic krill was lower than for an equivalent concentration of F in NaF, but it was toxic for rats consuming krill in large quantities. To conclude, we discuss possible reasons for the reduced toxicity of F in Antarctic krill. The present study provides a direct toxicological reference for the consideration of Antarctic krill for human consumption. | ZHANG Ling LU Xiaoqi WANG Zhangmin QIN Liqiang LIN Zhiqin YUAN Linxi ZHANG Wen YIN Xuebin | 2014 | Advances in Polar Science2014，25，1： | 1 |
| 14 | S-scheme ZnO/WO3 heterojunction photocatalyst for efficient H2O2 production显示文摘Designing highly efficient photocatalyst for hydrogen peroxide(HO)production is an ideal strategy to avoid the shortcomings of traditional HOproduction and to realize the conversion of solar energy to chemical energy.In this work,a step-scheme(S-scheme)heterojunction photocatalyst composed of Zn O and WOis carefully prepared by hydrothermal and calcination method for efficient photocatalytic HOproduction.The ZW30 composite photocatalysts exhibit enhanced activity with the highest HO-production rate of 6788μmol Lh.The results show that the photocatalytic HOproduction process is dominated by a direct two-electron Oreduction pathway.The enhanced photocatalytic HO-production activity is attributed to the formation of interfacial internal electric field(IEF)in the S-scheme heterojunction,which boosts the spatial separation of charge carriers and enables electrons with the strongest reduction power to participate in HOproduction.This work provides an in-depth insight of the great advantages of S-scheme heterojunction in photocatalytic HOproduction. | Zicong Jiang Bei Cheng Yong Zhang S.Wageh Ahmed A.Al-Ghamdi Jiaguo Yu Linxi Wang | 2022 | Journal of Materials Science & Technology2022，，29： | 1 |
| 15 | Repurposing diacerein to suppress colorectal cancer growth by inhibiting the DCLK1/STAT3 signaling pathway显示文摘Double cortin-like kinase 1(DCLK1)exhibits high expression levels across various cancers,notably in human colorectal cancer(CRC).Diacerein,a clinically approved interleukin(IL)-1βinhibitor for osteoarthritis treatment,was evaluated for its impact on CRC proliferation and migration,alongside its underlying mechanisms,through both in vitro and in vivo analyses.The study employed MTT assay,colony formation,wound healing,transwell assays,flow cytometry,and Hoechst 33342 staining to assess cell proliferation,migration,and apoptosis.Additionally,proteome microarray assay and western blotting analyses were conducted to elucidate diacerein’s specific mechanism of action.Our findings indicate that diacerein significantly inhibits DCLK1-dependent CRC growth in vitro and in vivo.Through high-throughput proteomics microarray and molecular docking studies,we identified that diacerein directly interacts with DCLK1.Mechanistically,the suppression of p-STAT3 expression following DCLK1 inhibition by diacerein or specific DCLK1 siRNA was observed.Furthermore,diacerein effectively disrupted the DCLK1/STAT3 signaling pathway and its downstream targets,including MCL-1,VEGF,and survivin,thereby inhibiting CRC progression in a mouse model,thereby inhibiting CRC progression in a mouse model. | YE Qiaobei ZHU Yu SHI Meng LV Linxi GONG Yuyan ZHANG Luyao YANG Lehe ZHAO Haiyang ZHAO Chengguang XU Huanhai | 2024 | Chinese Journal of Natural Medicines2024，22，4： | 0 |
| 16 | The combination of four cell-cycle regulators: a new direction for inducing adult cardiomyocyte proliferation显示文摘Cardiomyocytes, also known as myocardial fibers, are the muscle cells which form the heart tissue. Previous studies have indicated that fetal mammalian cardiomyocytes maintain the regeneration capacity, which promotes the fetal heart growth. Regardless of environment insults including nutrient deprivation, changes of blood flow, along with mechanical and volume loading [1], embryonic mammalian cardiac muscle cells are also related to robust proliferation response. Similarly, the hearts of 1-day-old neonatal mice could also be fully regenerated after surgical resection of the left ventricular apex or myocardial infarction (MI)[2]. Intriguingly, studies have also shown that certain fish, such as adult zebrafish, or urodele amphibians retain an observable capacity for regeneration [3]. | Yiyuan Yang Kai Zhang Linxi Chen Lanfang Li | 2019 | Acta Biochimica et Biophysica Sinica2019，51，4： | 0 |
| 17 | Observations on potential novel transcripts from RNA-Seq data显示文摘With the rapid development of next generation deep sequencing technologies,sequencing cDNA reverse-transcribed from RNA molecules(RNA-Seq)has become a key approach in studying gene expression and transcriptomes.Because RNA-Seq does not rely on annotation of known genes,it provides the opportunity of discovering transcripts that have not been annotated in current databases.Studying the distribution of RNASeq signals and a systematic view on the potential new transcripts revealed from the signals is an important step toward the understanding of transcriptomes. | Chao YE Linxi LIU Xi WANG Xuegong ZHANG | 2011 | Frontiers of Electrical and Electronic Engineering in China2011，6，2： | 0 |
| 18 | Electron transfer dynamics in Schottky junction photocatalyst during electron donor-assisted hydrogen production显示文摘Electron donors(EDs)are widely used to improve the H 2 production performance of Schottky junction photocatalysts,but the functions of EDs are still unknown from the perspective of electron transfer dy-namics.Herein,Pt nanocluster-decorated CdS nanorod is successfully prepared to construct a typical CdS/Pt Schottky junction.Pt nanoclusters with a diameter of∼2 nm are deposited on the surface of CdS nanorods by in situ photoreduction at sub-zero temperature.The CdS/Pt photocatalyst using lactic acid shows a higher H_(2)production rate of 4762μmol g^(-1)h^(-1)compared to that using methanol,tri-ethanolamine,and glycerol.To understand the cause,the dynamics of photogenerated carriers in CdS/Pt photocatalysts during ED-assisted H_(2)production are revealed by femtosecond transient absorption spec-troscopy.Among the four organic EDs,lactic acid enables the fastest electron transfer rate of 1.8×10^(9)s^(-1)and the highest electron transfer efficiency of 76%at the CdS/Pt interface due to the most efficient hole consumption.This work sheds light on the importance of efficient interfacial electron transfer for im-proving the photocatalytic performance of Schottky junction photocatalysts. | Jianjun Zhang Jingjing Liu Zheng Meng Sanjib Jana Linxi Wang Bicheng Zhu | 2023 | Journal of Materials Science & Technology2023，，28： | 0 |
| 19 | Molecular-level Engineering of S-scheme Heterojunction:the Site-specific Role for Directional Charge Transfer显示文摘The promising S-scheme heterojunction photocatalysts are considered as a novel frontier due to their superiority in various solar-driven energy-related applications.Recently,a novel atom-specific tailoring strategy has been introduced on the construction of S-scheme het-erojunction for promoting the electronic transferability.The S-scheme heterojunction is regulated by integrating high-crystalline carbon nitride with Co-doped CeO_(2).Specifically,this atom-specific regulation of S-scheme heterojunction boosts directional electron-driving effect towards functionalized Co sites,benefit-ing for effective photogenerated charge carrier transferability.Moreover,a series of tracking characterizations show that Co-embedded modification promotes CO_(2)photoreduction into hydrogenation steps,resulting in high performance towards CO_(2)-to-CH_(4)photoreduction,which provides new opportunities for the development of multifunctional cooperation in heterogeneous photocatalysis. | Jianjun Zhang Linxi Wang Mitra Mousavi Jahan B.Ghasemi Jiaguo Yu | 2022 | Chinese Journal of Structural Chemistry2022，41，6： | 0 |
| 20 | Ordered quasi-two-dimensional structure of nanoparticles in semiflexible ring polymer brushes under compression显示文摘在压缩下面的戒指聚合物刷子的一个纹理粗糙的祷告春天模型的分子的动力学模拟被介绍。灵活聚合物刷子在压缩期间总是是混乱的,而 semiflexible 聚合物刷子趋于在足够地强壮的压缩下面被订。进一步, semiflexible 聚合物刷子的聚合物单体密度在刷子表面附近很高,导致表面附近的免费精力的山峰价值。因此,当 nanoparticles 在 semiflexible 戒指聚合物刷子被压缩时,他们趋于展出在刷子表面之间的仔细包装的单个层的结构,刺不进的墙,和伪二维的订的结构接近刷子表面在强壮的压缩下面被形成。这些调查结果提供一条新途径给设计应答的应用。 | Yunfeng Hua Zhenyu Deng Yangwei Jiang Linxi Zhang | 2017 | Frontiers of physics2017，12，3： | 0 |
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