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| 1 | Circular RNAs and human glioma显示文摘As a newly discovered type of RNA, circular RNAs(circRNAs) are widespread throughout the eukaryotic genome. The expression of circRNAs is regulated by both cis-elements and trans-factors, and the expression pattern of circRNAs is cell type-and diseasespecific. Similar to other types of non-coding RNAs, functions of circRNAs are also versatile. CircRNAs have been reported previously to function as microRNA(miRNA) sponges, protein sponges, coding RNAs or scaffolds for protein complexes.Recently, several circRNAs have been reported to play important roles in human malignancies, including glioma. Here, we reviewed several reports related to circRNAs and glioma, as well as the potential diagnostic and therapeutic applications of circRNAs in brain cancer. In general, some circRNAs, such as circSMARCA5 and circCFH, are found to be expressed in a gliomaspecific pattern, these circRNAs may be used as tumor biomarkers. In addition, some circRNAs have been found to play oncogenic roles in glioma(e.g., circNFIX and circNT5E), whereas others have been reported to function as tumor suppressors(e.g.,circFBXW7 and circSHPRH). Furthermore, circRNA is a good tool for protein expression because of its higher stability compared to linear RNAs. Thus, circRNAs may also be an ideal choice for gene/protein delivery in future brain cancer therapies. There are some challenges in circRNA research in glioma and other diseases. Research related to circRNAs in glioma is comparatively new and many mysteries remain to be solved. | Jinglei Liu Kun Zhao Nunu Huang Nu Zhang | 2019 | Cancer Biology & Medicine2019，16，1： | 16 |
| 2 | Simulation study on cavity growth in ductile metal materials under dynamic loading显示文摘 | Ai-Guo Nu Guang-Cai Zhang Yang-Jun Ying Xi-Jun Yu | 2013 | Frontiers of physics2013，8，4： | 5 |
| 3 | Trephination mini-craniectomy for traumatic posterior fossa epidural hematomas in selected pediatric patients显示文摘以后的窝硬膜上的 hematomas (PFEDH ) 在孩子是不平常的,但是通常由于威胁生活的 brainstem 压缩的风险要求及时外科的干预。我们试图由与回顾地考察的 trephination mini-craniectomy.MethodsWe 对待选择小儿科的病人使外科的过程更少侵略从2010年1月为创伤的 PFEDH 在我们的部门被对待到2015年1月 .ResultsDuring 的小儿科的病人的临床的功课,放射学的调查结果,外科的过程,和预测这个时期, 17 个病人的一个总数通过手术为 PFEDH 被对待, 7 为 hemato 与 trephination 微型部分颅骨切除术被管理结果在与格拉斯哥结果 20 评估了的所有 7 个病人好。在这个系列没有死亡。平均 30 月的临床的后续证明没有 complications.ConclusionOur 结果,病人们经历了令人满意的恢复建议 trephination 微型部分颅骨切除术是为有中等 hematoma 的选择 PFEDH 病人的一种安全外科的技术体积和稳定的神经病学的功能。然而,标准部分颅骨切除术是当在神经病学的功能或 hematomas 是的病人有快速的恶化时,推荐大、施加的严重集体效果。 | Han-Song Sheng Chao-Guo You Liang Yang Nu Zhang Jian Lin Fen-Chun Lin Mao-De Wang | 2017 | Chinese Journal of Traumatology2017，20，4： | 5 |
| 4 | Conceptual design of the HIRFL-CSR external-target experiment显示文摘One of the main purposes of heavy-ion collisions over a wide range of beam energy is to study the bulk properties of strong interaction matter and understand the Quantum Chromo Dynamics(QCD)phase diagram,which carries wealth of information of the phase transition and the possibly existing critical point of the strongly interacting system[1].Such system exists as hadron gases at lower temperature and low baryon density.By increasing the temperature or density,the boundary of the hadrons disappears and the confined quarks | LiMing Lu Hart Yi ZhiGang Xiao Ming Shao Song Zhang GuoQing Xiao Nu Xu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，1： | 3 |
| 5 | Successful treatment of pyogenic ventriculitis caused by extensively drug-resistant Acinetobacter baumannii with multi-route tigecycline: A case report显示文摘BACKGROUND Pyogenic ventriculitis caused by extensively drug-resistant Acinetobacter baumannii(A.baumannii)is one of the most severe complications associated with craniotomy.However,limited therapeutic options exist for the treatment of A.baumannii ventriculitis due to the poor penetration rate of most antibiotics through the blood-brain barrier.CASE SUMMARY A 68-year-old male patient with severe traumatic brain injury developed pyogenic ventriculitis on postoperative day 24 caused by extensively drug-resistant A.baumannii susceptible to tigecycline only.Successful treatment was accomplished through multi-route administration of tigecycline,including intravenous combined with continuous ventricular irrigation plus intraventricular administration.The pus was cleared on the 3rd day post-irrigation,and cerebrospinal fluid cultures were negative after 12 d.CONCLUSION Our findings suggest that multi-route administration of tigecycline can be a therapeutic option against pyogenic ventriculitis caused by extensively drugresistant A.baumannii. | Wei Li Dan-Dong Li Bo Yin Dong-Dong Lin Han-Song Sheng Nu Zhang | 2021 | World Journal of Clinical Cases2021，9，3： | 2 |
| 6 | FOXM1 Promotes Lung Adenocarcinoma Invasion and Metastasis by Upregulating SNAIL显示文摘 | WEI Ping ZHANG Nu WANG Yi-qin | 2015 | International Journal of Biologocal Sciences2015，11，2： | 1 |
| 7 | Activation of Src by c-Met overexpression mediates metastatic properties of colorectal carcinoma cells显示文摘 | Herynk MH Zhang J Parikh NU | 2007 | J Exp Ther Oncol2007，6，3： | 1 |
| 8 | A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers显示文摘Mutations of the RAS oncogene are found in around 30%of all human cancers yet direct targeting of RAS is still considered clinically impractical except for the KRAS^(G12C)mutant.Here we report that RAS-ON(RASON),a novel protein encoded by the long intergenic non-protein coding RNA 00673(LINC00673),is a positive regulator of oncogenic RAS signaling.RASON is aberrantly overexpressed in pancreatic ductal adenocarcinoma(PDAC)patients,and it promotes proliferation of human PDAC cell lines in vitro and tumor growth in vivo.CRISPR/Cas9-mediated knockout of Rason in mouse embryonic fibroblasts inhibits KRAS-mediated tumor transformation.Genetic deletion of Rason abolishes oncogenic KRAS-driven pancreatic and lung cancer tumorigenesis in LSL Kras^(G12D);Trp53R172H/+mice.Mechanistically,RASON directly binds to KRAS^(G12D)/V and inhibits both intrinsic and GTPase activating protein(GAP)-mediated GTP hydrolysis,thus sustaining KRAS^(G12D/V)in the GTP-bound hyperactive state.Therapeutically,deprivation of RASON sensitizes KRAS mutant pancreatic cancer cells and patient-derived organoids to EGFR inhibitors.Our findings identify RASON as a critical regulator of oncogenic KRAS signaling and a promising therapeutic target for KRAS mutant cancers. | Rongjie Cheng Fanying Li Maolei Zhang Xin Xia Jianzhuang Wu Xinya Gao Huangkai Zhou Zhi Zhang Nunu Huang Xuesong Yang Yaliang Zhang Shunli Shen Tiebang Kang Zexian Liu Feizhe Xiao Hongwei Yao Jianbo Xu Chao Yan Nu Zhang | 2023 | Cell Research2023，33，1： | 1 |
| 9 | Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival显示文摘 | LI Jun ZHANG Nu SONG Li-bing | 2008 | Clin Cancer Res2008，14，11： | 1 |
| 10 | The effect of rigid-body motions on the whipping response of a ship hull subjected to an underwater bubble显示文摘 | ZHANG Nu Zong Z | 2011 | Journal of Fluids and Structures2011，27，8： | 1 |
| 11 | Integrated location and attribute information matrix group of members of the observation matching algorithm 显示文摘 | Zhang Changfang nu weidong | 2009 | Journal of electronics &information technology2009，，08： | 1 |
| 12 | In vitro neural differentiation of bone marrow stromal cells induced by cocultured olfactory ensheathing cells显示文摘 | Wen-Fei Ni Li-Hui Yin Jike Lu Hua-Zi Xu Yong-Long Chi Jian-Bo Wu Nu Zhang | 2010 | Neuroscience Letters2010，，2： | 1 |
| 13 | Astrocyte elevated gene-1is a novel prognostic marker for breast cancer progression and overall patient survival显示文摘 | LI Jun ZHANG Nu SONG Li-bing | 2008 | Clin Cancer Res2008，14，11： | 1 |
| 14 | Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats显示文摘 | Zhang HT Huang Y Suvarna NU | 2005 | Psychopharmacology (Berl)2005，179，3： | 1 |
| 15 | The Role of Apoptosis in the Development and Function of T Lympho 显示文摘 | NU Zhang | 2008 | Communications of Biotechnologies2008，19，2： | 1 |
| 16 | FoxM1 Promotes β-Catenin Nuclear Localization and Controls Wnt Target-Gene Expression and Glioma Tumorigenesis显示文摘 | Nu Zhang Ping Wei Aihua Gong Wen-Tai Chiu Hsueh-Te Lee Howard Colman He Huang Jianfei Xue Mingguang Liu Yong Wang Raymond Sawaya Keping Xie W.K. Alfred Yung René H. Medema Xi He Suyun Huang | 2011 | Cancer Cell2011，，4： | 1 |
| 17 | Real-time implementation of a new low-m SPIHT image coding algorithm using DSP chip显示文摘 | Sun Y Zhang H Nu G | 2002 | IEEE Transactis Signal Processing2002，11，9： | 1 |
| 18 | Activation of Src by c- Met overexpression mediates metastatic properties of colorectal car- cinoma cells 显示文摘 | Herynk MH Zhang J Parikh NU | 2007 | J Exp Ther Oncol2007，6，3： | 1 |
| 19 | Electron-ion collider in China显示文摘Lepton scattering is an established ideal tool for studying inner structure of small particles such as nucleons as well as nuclei.As a future high energy nuclear physics project,an Electron-ion collider in China(EicC)has been proposed.It will be constructed based on an upgraded heavy-ion accelerator,High Intensity heavy-ion Accelerator Facility(HIAF)which is currently under construction,together with a new electron ring.The proposed collider will provide highly polarized electrons(with a po-larization of 80%)and protons(with a polarization of 70%)with variable center of mass energies from 15 to 20 GeV and the luminosity of(2–3)×1033 cm^(−2)·s^(−1).Polarized deuterons and Helium-3,as well as unpolarized ion beams from Carbon to Uranium,will be also available at the EicC.The main foci of the EicC will be precision measurements of the structure of the nucleon in the sea quark region,including 3D tomography of nucleon;the partonic structure of nuclei and the parton interaction with the nuclear environment;the exotic states,especially those with heavy flavor quark contents.In addition,issues fundamental to understanding the origin of mass could be addressed by measurements of heavy quarkonia near-threshold production at the EicC.In order to achieve the above-mentioned physics goals,a hermetical detector system will be constructed with cutting-edge technologies.This document is the result of collective contributions and valuable inputs from experts across the globe.The EicC physics program complements the ongoing scientific programs at the Jefferson Laboratory and the future EIC project in the United States.The success of this project will also advance both nuclear and particle physics as well as accelerator and detector technology in China. | Daniele PAnderle Valerio Bertone Xu Cao Lei Chang Ningbo Chang Gu Chen Xurong Chen Zhuojun Chen Zhufang Cui Lingyun Dai Weitian Deng Minghui Ding Xu Feng Chang Gong Longcheng Gui Feng-Kun Guo Chengdong Han Jun He Tie-Jiun Hou Hongxia Huang Yin Huang KrešImir KumeričKi LPKaptari Demin Li Hengne Li Minxiang Li Xueqian Li Yutie Liang Zuotang Liang Chen Liu Chuan Liu Guoming Liu Jie Liu Liuming Liu Xiang Liu Tianbo Liu Xiaofeng Luo Zhun Lyu Boqiang Ma Fu Ma Jianping Ma Yugang Ma Lijun Mao Cédric Mezrag HervéMoutarde Jialun Ping Sixue Qin Hang Ren Craig DRoberts Juan Rojo Guodong Shen Chao Shi Qintao Song Hao Sun PawełSznajder Enke Wang Fan Wang Qian Wang Rong Wang Ruiru Wang Taofeng Wang Wei Wang Xiaoyu Wang Xiaoyun Wang Jiajun Wu Xinggang Wu Lei Xia Bowen Xiao Guoqing Xiao Ju-Jun Xie Yaping Xie Hongxi Xing Hushan Xu Nu Xu Shusheng Xu Mengshi Yan Wenbiao Yan Wencheng Yan Xinhu Yan Jiancheng Yang Yi-Bo Yang Zhi Yang Deliang Yao Zhihong Ye Peilin Yin C-PYuan Wenlong Zhan Jianhui Zhang Jinlong Zhang Pengming Zhang Yifei Zhang Chao-Hsi Chang Zhenyu Zhang Hongwei Zhao Kuang-Ta Chao Qiang Zhao Yuxiang Zhao Zhengguo Zhao Liang Zheng Jian Zhou Xiang Zhou Xiaorong Zhou Bingsong Zou Liping Zou | 2021 | Frontiers of physics2021，16，6： | 1 |
| 20 | ORGANOMETALLIC FERROELECTRIC LIQUID CRYSTALS Ⅰ. LIQUID CRYSTAL PROPERTIES OF ORTHO—PALLADATED BINUCLEAR COMPLEXES OF AZINE, IMINE AND AZO DERIVATIVES显示文摘The mesomorphie properties of title complexes are investigated by means of DSC and polarizing microscopy. The mesophase temperature ranges of complexes are wider than that of corresponding organic ligands. The bridging groups of the complexes have profoand effects on the mesomorphic behavior, When the bridging groups are opticallhy active. the compleve show chiral | Liang Fu ZHANG~*, De Jian HUANG, Nu Yun XIONG and Guang Nian LI Chengdu Institute of Organic Chemistry, Academia Sinica, Chengdu 610015 | 1992 | Chinese Chemical Letters1992，3，10： | 1 |
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