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| 1 | ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer显示文摘 | Shunrong Ji Yi Qin Si Shi Xiangyuan Liu Hongli HU Hu Zhou Jing Gao Bo Zhang Wenyan Xu Jiang Liu Dingkong Liang Liang Liu Chen Liu Jiang Long Haijun Zhou Paul J Chiao Jin Xu Quanxing Ni Daming Gao Xianjun Yu | 2015 | Cell Research2015，25，5： | 19 |
| 2 | A Chromosome-Scale Genome Assembly of Paper Mulberry(Bmussonetia papyrifera)Provides New Insights into Its Forage and Papermaking Usage显示文摘Paper mulberry(Broussonetia papyrifera)is a well-known woody tree historically used for Cai Lun papermaking,one of the four great inventions of ancient China.More recently,Paper mulberry has also been used as forage to address the shortage of feedstuff because of its digestible crude fiber and high protein contents.In this study,we obtained a chromosome-scale genome assembly for Paper mulberry using integrated approaches,including Illumina and PacBio sequencing platform as well as Hi-C,optical,and genetic maps.The assembled Paper mulberry genome consists of 386.83 Mb,which is close to the estimated size,and 99.25%(383.93 Mb)of the assembly was assigned to 13 pseudochromosomes.Comparative genomic analysis revealed the expansion and contraction in the flavonoid and lignin biosynthetic gene families,respectively,accounting for the enhanced flavonoid and decreased lignin biosynthesis in Paper mulberry.Moreover,the increased ratio of syringyl-lignin to guaiacyl-lignin in Paper mulberry underscores its suitability for use in medicine,forage,papermaking,and barkcloth making.We also identified the rootassociated microbiota of Paper mulberry and found that Pseudomonas and Rhizobia were enriched in its roots and may provide the source of nitrogen for its stems and leaves via symbiotic nitrogen fixation.Collectively,these results suggest that Paper mulberry might have undergone adaptive evolution and recruited nitrogen-fixing microbes to promote growth by enhancing flavonoid production and altering lignin monomer composition.Our study provides significant insights into genetic basis of the usefulness of Paper mulberry in papermaking and barkcloth making,and as forage.These insights will facilitate further domestication and selection as well as industrial utilization of Paper mulberry worldwide. | Xianjun Peng Hui Liu Peilin Chen Feng Tang Yanmin Hu Fenfen Wang Zhi Pi Meiling Zhao Naizhi Chen Hui Chen Xiaokang Zhang Xueqing Yan Min Liu Xiaojun Fu Guofeng Zhao Pu Yao Lili Wang He Dai Xuming Li Wei Xiong Wencai Xu Hongkun Zheng Haiyan Yu Shihua Shen | 2019 | Molecular Plant2019，12，5： | 18 |
| 3 | Patterns of DNA cytosine methylation between haploids and corresponding diploids in rice显示文摘Eighteen pairs of diploid-haploid twin-seedlings were identified and screened out fromspecial rice SARII-628 population. Five pairs of themwere selected and randomly designated as A, B, C, Dand E. Simple sequence repeats (SSR) analysisshowed that there was no difference among 310 siteswhich indicated that there was no base mutation onDNA primary structure. DNA methylation plays animportant role in gene expression regulation duringgrowth and development stages in eukaryotes. Amodified AFLP technique (methylation-sensitiveAFLP, MSAP) was employed to detect the DNA me-thylation patterns in the 5′-CCGG sites of the fivepairs of twin-seedlings. Although no methylationmutation was detected among the five diploids,forty-three methylation mutation sites were foundfrom the corresponding haploids. The MSAP ratios,which were the ratios of MSAP sites to the total am-plified sites, in five haploids were 18.79%, 19.35%,18.49%, 18.45% and 18.75%, respectively. And cor-responding full methylation levels (5′-CmCGG indouble strands) of those haploids were 10.58%,11.3%, 10.11%, 10.09% and 10.34%, respectively.Both MSAP and full methylation levels in the fivehaploids were higher than that of their correspondingdiploids, which suggested that hypermethylation oc-curred in some 5′-CCGG sites. Five types of MASPpatterns among the five pairs of twin-seedlings weredetected as follows: (1) no changes, methylation lev-els were the same in both haploids and diploids; (2) demethylation, diploid was methylated but no me-thylation in the same site in haploid; (3) hypermethy-lation, the methylation level in haploid was higher than those in diploid; (4) hypomethylation, methyla-tion in haploid was lower than those in diploid; (5) undecided pattern, change trend of methylation lev-els in haploids was not decided. The bands of 18 sites were reclaimed, then sequenced and searched on website to determine the sites of those sequences on rice chromosomes. The result showed that the methylation mutation involved the whole rice genome and 12 pairs of chromosomes. The mutation was site-related and there were different mutation sites for different haploids. Compared to diploids, the higher methylation level in haploids might be a readjusting reaction to the decrease in ploidy for the sake of sur-vival. | ZHANG Hongyu PENG Hai LI Yun XU Peizhou WANG Xudong WU Xianjun | 2006 | Chinese Science Bulletin2006，51，14： | 15 |
| 4 | Relationship between the Flow Blockage of Tip Leakage Vortex and its Evolutionary Procedures inside the Rotor Passage of a Subsonic Axial Compressor显示文摘The near casing flow fields inside the rotor passage of a 1.5 stage axial compressor with different blade-loading levels and tip gap sizes were measured by using stereoscopic particle image velocimetry(SPIV). Based on a carefully defined blockage extracting method, the variations of blockage parameter inside the blade passage were analyzed. It was found that the variation of blockage parameter appeared as a non-monotonic behavior inside the blade passage in most cases. This non-monotonic behavior became much more remarkable as the blade loading increases or mass flow rate decreases.The variations of the blockage parameter inside the blade passage had close relation to the evolutionary procedures of the tip leakage vortex(TLV). The destabilization of the TLV caused a rapid increasing of the blockage parameter. After the TLV lost the features of a concentrated streamwise vortex,the blockage parameter usually got a peak value. And then, because of the intense turbulent mixing between the TLV low momentum flow and its surrounding flows, the flow deficit inside the TLV recovered. | DU Hui YU Xianjun ZHANG Zhibo LIU Baojie | 2013 | Journal of Thermal Science2013，22，6： | 7 |
| 5 | 为细菌的房间的一个非凡的紧、敏感的光可切换的基因表达式系统显示文摘 | Chen, Xianjun Liu, Renmei Ma, Zhengcai Xu, Xiaopei Zhang, Haoqian Xu, Jianhe Ouyang, Qi Yang, Yi | 2016 | Cell Research2016，26，7： | 7 |
| 6 | Neuroprotective effect of pretreatment with ganoderma lucidum in cerebral ischemia/reperfusion injury in rat hippocampus显示文摘Ganoderma lucidum is a traditional Chinese medicine,which has been shown to have both anti-oxidative and anti-inflammatory effects,and noticeably decreases both the infarct area and neuronal apoptosis of the ischemic cortex.This study aimed to investigate the protective effects and mechanisms of pretreatment with ganoderma lucidum(by intragastric administration)in cerebral ischemia/reperfusion injury in rats.Our results showed that pretreatment with ganoder-ma lucidum for 3 and 7 days reduced neuronal loss in the hippocampus,diminished the content of malondialdehyde in the hippocampus and serum,decreased the levels of tumor necrosis fac-tor-αand interleukin-8 in the hippocampus,and increased the activity of superoxide dismutase in the hippocampus and serum.These results suggest that pretreatment with ganoderma lucidum was protective against cerebral ischemia/reperfusion injury through its anti-oxidative and an-ti-inflammatory actions. | Wangxin Zhang Qiuling Zhang Wen Deng Yalu Li Guoqing Xing Xianjun Shi Yifeng Du | 2014 | Neural Regeneration Research2014，9，15： | 6 |
| 7 | Study of real-time LWD data visual interpretation and geo-steering technology显示文摘LWD(logging while drilling) data has been used to explore complex subtle reservoirs by realtime visual interpretation and geo-steering.The method comprises of computer communication,well log data processing,formation recognition,reservoir modeling and model updating in real time.We studied the key technologies related to real-time LWD data visual interpretation and geo-steering and developed computer software with Chinese intellectual property rights covering the following important aspects: 1) real-time computer communication of well site LWD data;2) visualization of geological model and borehole information;3) real-time interpretation of LWD data;4) real-time geological model updating and geo-steering technology.We use field application examples to demonstrate the feasibility and validity of the proposed technologies. | Shao Cairui Zhang Fuming Chen Guoxing Ji Jiaqi Hou Qinggong Tang Jianhong Cao Xianjun | 2013 | Petroleum Science2013，10，4： | 6 |
| 8 | Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-κB and MAPK in macrophages显示文摘发炎是到损害和感染的身体纸巾的回答。能禁止发炎的混合物被显示了有潜在的治疗学的临床的申请。Gambogenic 酸(GEA ) 有有势力 antitumor 和反煽动性的活动。此处, GEA 反煽动性的效果的分子的机制在刺激的 lipopolysaccharide (LPS ) 被调查巨噬细胞房间。结果证明有 GEA 的那个预告的处理能显著地禁止 interleukin (IL )-1, IL-1,肿瘤坏死因素 -- ,以在导致 LPS 的模型的一种剂量依赖者方式的 IFN- , IL-12b,和 IL-23a 生产。而且,这药显著地减少了氮的氧化物的版本(没有) ,并且损害了蛋白质水平可诱导没有 synthase 和 cyclooxygenase 2。发现也证明 GEA 的效果可能与原子 factor-B (NF-B ) 和表明小径的激活 mitogen 的蛋白质 kinase (MAPK ) 的抑制有关。这些结果显示 GEA 能由 attenuating 部分压制模仿 LPS 的煽动性的反应没有合成和 NF-B 和 MAPK 激活,建议它可以成为一个有势力为煽动性的疾病的处理的治疗学的代理人。 | Xianjun Yu Qun Zhao Haiwei Zhang Cunxian Fan Xixi Zhang Qun Xie Chengxian Xu Yongbo Liu Xiaoxia Wu Quanbin Han Haibing Zhang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 5 |
| 9 | Glycosylation of dentin matrix protein 1 is a novel key element for astrocyte maturation and BBB integrity显示文摘血大脑障碍(BBB ) 是在 endothelial 房间和星形细胞之间形成的一条紧密的边界,它在循环把大脑与大多数病原体以及神经毒素分开并且保护。然而,详细说明了涉及 BBB 的形成的分子的播放器完全不被知道。牙质矩阵蛋白质 1 (DMP1 )-proteoglycan (PG ) 被知道涉及骨头和牙质的矿化作用,也与未知功能包括大脑在软纸巾被表示。在现在的学习,我们报导 DMP1-PG 在大脑星形细胞被表示并且在 BBB 充实单位。DMP1 的唯一的 glycosylation 地点在在鼠标的蛋白质的 N 终端域是 serine89 (S89 ) 。有 DMP1 的变异的老鼠削尖把 S89 改变到 glycine (S89G ) 的变化,它蛋白质的完全根除的 glycosylation,表明的严重 BBB 混乱。DMP1 变异的鼠标的另一个品种,缺乏 DMP1 的 C 终端域,表明了正常 BBB 功能。S89G-DMP1 星形细胞的极性被破坏,房间房间粘附被松开。通过一组分析,我们发现 DMP1 glycosylation 极其在 vitro 并且在 vivo 为星形细胞成熟被要求。S89G-DMP1 变异的星形细胞没能表示 aquaporin 4 并且减少了 laminin 和 ZO1 表示,它导致了 BBB 的混乱。有趣地,在 nestin 倡导者驾驶的老鼠大脑的野类型的 DMP1-PG 的 overexpression 在野类型层次以外提高了 laminin 和 ZO1 表示并且能有效地抵抗的静脉内的导致甘露糖醇的 BBB 可逆的洞。一起拿,我们的学习不仅揭示了一个新奇元素,即, DMP1-PG,调整了 BBB 形成,而且把新功能分到 DMP1-PG。 | Bo Jing Chunxue Zhang Xianjun Liu Liqiang Zhou Jiping Liu Yinan Yao Juehua Yu Yuteng Weng Min Pan Jie Liu Zuolin Wang Yao Sun Yi Eve Sun | 2018 | Protein & Cell2018，9，3： | 5 |
| 10 | Signaling pathways in cancer-associated fibroblasts:recent advances and future perspectives显示文摘As a critical component of the tumor microenvironment(TME),cancerassociated fibroblasts(CAFs)play important roles in cancer initiation and progression.Well-known signaling pathways,including the transforming growth factor-β(TGF-β),Hedgehog(Hh),Notch,Wnt,Hippo,nuclear factor kappa-B(NF-κB),Janus kinase(JAK)/signal transducer and activator of transcription(STAT),mitogen-activated protein kinase(MAPK),and phosphoinositide 3-kinase(PI3K)/AKT pathways,as well as transcription factors,including hypoxia-inducible factor(HIF),heat shock transcription factor 1(HSF1),P53,Snail,and Twist,constitute complex regulatory networks in theTMEtomodulate the formation,activation,heterogeneity,metabolic characteristics and malignant phenotype of CAFs.Activated CAFs remodel the TME and influence the malignant biological processes of cancer cells by altering the transcriptional and secretory characteristics,and this modulation partially depends on the regulation of signaling cascades.The results of preclinical and clinical trials indicated that therapies targeting signaling pathways in CAFs demonstrated promising efficacy but were also accompanied by some failures(e.g.,NCT01130142 and NCT01064622).Hence,a comprehensive understanding of the signaling cascades in CAFs might help us better understand the roles of CAFs and the TME in cancer progression and may facilitate the development of more efficient and safer stroma-targeted cancer therapies.Here,we review recent advances in studies of signaling pathways in CAFs and briefly discuss some future perspectives on CAF research. | Zengli Fang Qingcai Meng Jin Xu Wei Wang Bo Zhang Jiang Liu Chen Liang Jie Hua Yingjun Zhao Xianjun Yu Si Shi | 2023 | Cancer Communications2023，43，1： | 5 |
| 11 | Function of the auxin-responsive gene TaSAUR75 under salt and drought stress显示文摘Small auxin-upregulated RNAs(SAURs) are genes regulated by auxin and environmental factors. In this study, we identified a SAUR gene in wheat, Ta SAUR75. Under salt stress,Ta SAUR75 is downregulated in wheat roots. Subcellular localization revealed that Ta SAUR75 was localized in both the cytoplasm and nucleus. Overexpression of Ta SAUR75 increased drought and salt tolerance in Arabidopsis. Transgenic lines showed higher root length and survival rate and higher expression of some stress-responsive genes than control plants under salt and drought stress. Less H_2O_2 accumulated in transgenic lines than in control plants under drought stress. Our findings reveal a positive regulatory role of the auxin-responsive gene Ta SAUR75 in plant responses to drought and salt stress and provide a candidate gene for improvement of abiotic stress tolerance in crop breeding. | Yuan Guo Qiyan Jiang Zheng Hu Xianjun Sun Shoujin Fan Hui Zhang | 2018 | The Crop Journal2018，6，2： | 4 |
| 12 | Preparation of layered oxide Li(Co_(1/3)Ni_(1/3)Mn_(1/3))O_2 via the sol-gel process显示文摘获得同质的分层的氧化物李(Co1/3Ni1/3Mn1/3 ) 是的 O2 锂插入积极电极材料,把柠檬性的酸用作一个 chelating 代理人的大音阶的第五音胶化过程被使用。材料李(Co1/3Ni1/3Mn1/3 ) O2 在不同锻烧温度被综合。XRD 实验显示分层的李(Co1/3Ni1/3Mn1/3 ) O2 材料能在 800 的更低的温度被综合 ? 琠? 楢整漠吗? | ZHANG Wen LIU Hanxing HU Chen ZHU Xianjun LI Yanxi | 2008 | Rare Metals2008，27，2： | 4 |
| 13 | Preliminary results of a new global ocean reanalysis显示文摘Using a new global ocean reanalysis of the second generation Global Ocean Data Assimilation System of the Beijing Climate Center(BCC_GODAS2.0) spanning the period 1990-2009,we firstly quantify the accuracy of BCC_GODAS2.0 in representing the temperature and salinity by comparing with OISST and SODA data.The results show that the assimilation system may effectively improve the estimations of temperature and salinity by assimilating all kinds of observations,especially in the equatorial eastern Pacific.Moreover,the root mean square errors of monthly temperature and salinity are respectively reduced by 0.53℃ and 0.28 psu,compared with the model control simulation results.Then,the applicability of this ocean reanalysis for sea surface temperature(SST) anomaly variability in the tropical Pacific is evaluated with the observational HadISST data.The NINO3 index of the new reanalysis shows a good agreement with that of HadISST,with a correlation of 93.6%.Variations in SST from BCC_GODAS2.0 are similar to those obtained from HadISST data along the equator,showing the major large zonal-scale features such as the strong magnitude of seasonal cycle.The amplitude of SST anomaly standard deviation in the equatorial eastern Pacific is also closer to observations(HadISST) than NCEP GODAS does.Besides,the first two leading empirical orthogonal function(EOF) modes of the monthly SST anomalies over the tropical Pacific region are explored.The EOF1 pattern of BCC_GODAS2.0 captures a traditional El Ni o pattern,which improves magnitudes of the positive SST anomaly in the cold tongue of the eastern Pacific.The EOF2 pattern exhibits a El Ni o Modoki pattern.Comparatively,the EOF2 pattern of BCC_GODAS2.0 extends more strongly toward the subtropics.It also overcomes the problem that negative loadings are confined in the narrow equatorial eastern Pacific.Consequently,the magnitude and spatial distribution of the leading EOF patterns of BCC_GODAS2.0 are well consistent with those of HadISST. | WANG DongXiao QIN YingHao XIAO XianJun ZHANG ZuQiang WU FengMin | 2012 | Chinese Science Bulletin2012，57，26： | 4 |
| 14 | RNA-seq analysis of unintended effects in transgenic wheat overexpressing the transcription factor GmDREB1显示文摘The engineering of plants with enhanced tolerance to abiotic stresses typically involves complex multigene networks and may therefore have a greater potential to introduce unintended effects than the genetic modification for simple monogenic traits. For this reason, it is essential to study the unintended effects in transgenic plants engineered for stress tolerance. We selected drought-and salt-tolerant transgenic wheat overexpressing the transcription factor, GmDREB1, to investigate unintended pleiotropic effects using RNA-seq analysis. We compared the transcriptome alteration of transgenic plants with that of wild-type plants subjected to salt stress as a control. We found that GmDREB1 overexpression had a minimal impact on gene expression under normal conditions.GmDREB1 overexpression resulted in transcriptional reprogramming of the salt response,but many of the genes with differential expression are known to mitigate salt stress and contribute incrementally to the enhanced stress tolerance of transgenic wheat. GmDREB1 overexpression did not activate unintended gene networks with respect to gene expression in the roots of transgenic wheat. This work is important for establishing a method of detecting unintended effects of genetic engineering and the safety of such traits with the development of marketable transgenic crops in the near future. | Qiyan Jiang Fengjuan Niu Xianjun Sun Zheng Hu Xinhai Li Youzhi Ma Hui Zhang | 2017 | The Crop Journal2017，5，3： | 3 |
| 15 | Impacts of a wind stress and a buoyancy flux on the seasonal variation of mixing layer depth in the South China Sea显示文摘The seasonal variation of mixing layer depth(MLD) in the ocean is determined by a wind stress and a buoyance flux.A South China Sea(SCS) ocean data assimilation system is used to analyze the seasonal cycle of its MLD.It is found that the variability of MLD in the SCS is shallow in summer and deep in winter,as is the case in general.Owing to local atmosphere forcing and ocean dynamics,the seasonal variability shows a regional characteristic in the SCS.In the northern SCS,the MLD is shallow in summer and deep in winter,affected coherently by the wind stress and the buoyance flux.The variation of MLD in the west is close to that in the central SCS,influenced by the advection of strong western boundary currents.The eastern SCS presents an annual cycle,which is deep in summer and shallow in winter,primarily impacted by a heat flux on the air-sea interface.So regional characteristic needs to be cared in the analysis about the MLD of SCS. | XIAO Xianjun WANG Dongxiao ZHOU Wen ZHANG Zuqiang QIN Yinghao HE Na ZENG Lili | 2013 | Acta Oceanologica Sinica2013，32，9： | 3 |
| 16 | Energy sources identify metabolic phenotypes n pancreatic cancer显示文摘 | Chen Liang Yi Qin Bo Zhang Shunrong Ji Si Shi Wenyan Xu Jiang Liu Jinfeng Xiang Dingkong Liang Qiangsheng Hu Liang Liu Chen Liu Guopei Luo Quanxing Ni Jin xu Xianjun Yu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 3 |
| 17 | ^99Tc^m-HYNIC-TOC SPECT/CT显像在胰腺神经内分泌肿瘤患者诊断和随访中的临床应用显示文摘目的确定^99Tc^m-联肼尼克酰胺(HYNIC)-酪氨酸3-奥曲肽(TOC)SPECT/CT显像在疑似神经内分泌肿瘤的胰腺肿块评价及胰腺神经内分泌肿瘤患者随访中的价值。方法回顾性分析了184例行^99Tc^m-HYNIC-TOCSPECT/CT显像的患者。所有患者分为2组,组1评价该显像对胰腺可疑肿块的诊断效能(n=140),组2术后随访是否有复发及转移(n=44)。比较注射显像剂后2h的显像结果与最终病理诊断结果及临床随访结果,随后分析肿瘤与本底的比值(TBR)和肿瘤分级的关系。结果组1中,67.9%(95/140)的患者诊断为神经内分泌肿瘤,包括85例神经内分泌瘤和10例神经内分泌癌。^99Tc^m-HYNIC-TOCSPECT/CT显像诊断神经内分泌肿瘤的灵敏度、特异性和准确性分别为81.1%、84.4%和82.1%。 | 唐军(译) Junyan Xu Yi Li Xiaoping Xu Jiangang Zhang Yingjian Zhang Xianjun Yu Dan Huang | 2018 | 中华核医学与分子影像杂志2018，38，12： | 3 |
| 18 | Down-regulation of GPR137 expression inhibits proliferation of colon cancer cells显示文摘G 联合蛋白质的受体(GPR ) 是高度与 oncogenesis 和癌症转移有关。G 联合蛋白质的受体(GPR137 ) 137 大约 10 年以前开始作为新奇孤儿 GPR 被报导。一些孤儿 GPR 在人的癌症被含有。这研究的目的是在人的结肠癌调查 GPR137 的角色。GRP137 的表示层次被量的聚合酶链反应和西方的污点分析在不同结肠癌房间线分析。调停 Lentivirus 的短发卡 RNA 明确地被设计在结肠癌房间将 GPR137 表示击倒。房间生存能力被 methylthiazoletetrazolium 和殖民地形成试金测量。另外,房间周期特征被流动 cytometry 调查。GRP137 表示在不同层次在所有七根结肠癌房间线被观察。GPR137 的 mRNA 和蛋白质层次在在 lentivirus 感染以后的 HCT116 和 RKO 房间是下面调整的。GPR137 的调停 Lentivirus 的 silencing 减少了增长率和殖民地数字。在导致的两根房间线的 GPR137 击倒在 G 0/G1 阶段的房间周期拘捕。这些结果显示 GPR137 在结肠癌房间增长起一个重要作用。GPR137 在结肠癌房间的信号 transduction 小径上的效果的更好的理解可以提供卓见进结肠癌的新奇基因治疗。 | Kai Zhang Zhen Shen Xianjun Liang Tongjun Liu Tiejun Wang Yang Jiang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 3 |
| 19 | Myelin Deficits Caused by Olig2 Deficiency Lead to Cognitive Dysfunction and Increase Vulnerability to Social Withdrawal in Adult Mice显示文摘Oligodendrocyte (OL) and myelin development are crucial for network integration and are associated with higher brain functions. Accumulating evidence has demonstrated structural and functional impairment of OLs and myelin in serious mental illnesses. However, whether these deficits contribute to the brain dysfunction or pathogenesis of such diseases still lacks direct evidence. In this study, we conditionally deleted Olig2 in oligodendroglial lineage cells (Olig2 cKO) and screened the behavioral changes in adult mice. We found that Olig2 ablation impaired myelin development, which further resulted in severe hypomyelination in the anterior cingulate cortex. Strikingly, Olig2 cKO mice exhibited an anxious phenotype, aberrant responses to stress, and cognitive deficits. Moreover, Olig2 cKO mice showed increased vulnerability to social avoidance under the mild stress of social isolation. Together,these results indicate that developmental deficits in OL and myelin lead to cognitive impairment and increase the risk of phenotypes reminiscent of mental illnesses. | Xianjun Chen Fei Wang Jingli Gan Zhonghua Zhang Xuejun Liang Tao Li Nanxin Huang Xiaofeng Zhao Feng Mei Lan Xiao | 2020 | Neuroscience Bulletin2020，36，4： | 3 |
| 20 | Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival显示文摘Genome-wide association studies have suggested a link between primary open-angle glaucoma and the function of ABCA1.ABCA1 is a key regulator of cholesterol efflux and the biogenesis of high-density lipoprotein(HDL) particles. Here, we showed that the POAG risk allele near ABCA1 attenuated ABCA1 expression in cultured cells. Consistently, POAG patients exhibited lower ABCA1 expression, reduced HDL, and higher cholesterol in white blood cells. Ablation of Abca1 in mice failed to form HDL, leading to elevated cholesterol levels in the retina. Counting retinal ganglion cells(RGCs) by using an artificial intelligence(AI) program revealed that Abca1-deficient mice progressively lost RGCs with age. Single-cell RNA sequencing(scRNA-seq) revealed aberrant oxidative phosphorylation in the Abca1-/-retina, as well as activation of the mTORC1 signaling pathway and suppression of autophagy. Treatment of Abca1-/-mice using atorvastatin reduced the cholesterol level in the retina,thereby improving metabolism and protecting RGCs from death. Collectively, we show that lower ABCA1 expression and lower HDL are risk factors for POAG. Accumulated cholesterol in the Abca1-/-retina causes profound aberrant metabolism, leading to a POAG-like phenotype that can be prevented by atorvastatin. Our findings establish statin use as a preventive treatment for POAG associated with lower ABCA1 expression. | Jialiang Yang Yuhong Chen Tongdan Zou Bai Xue Fang Yang Xiangzhou Wang Yibo Huo Boyun Yan Yuxia Xu Shiyu He Yi Yin Jing Wang Xiong Zhu Lin Zhang Yu Zhou Zhengfu Tai Ping Shuai Man Yu Qian Luo Yilian Cheng Bo Gong Xianjun Zhu Jing Zhang Xinghuai Sun Ying Lin Houbin Zhang Zhenglin Yang | 2023 | Science China(Life Sciences)2023，66，2： | 2 |
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