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| 1 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 2 | Vertical distribution of Artemisia halodendron root system in relation to soil properties in Horqin Sandy Land, NE China显示文摘organic carbon;;nitrogen;;allocation;;Horqin Sandy Land;;soil | YongQing Luo XueYong Zhao JiePing Ding Tao Wang | 2016 | Research in Cold and Arid Regions2016，8，5： | 4 |
| 3 | Extra-copy nifA enhances the nodulation efficiency of Sinorhizobium fredii显示文摘Previous investigations have shown that nifA gene is involved in nodulation and symbiotic nitrogen fixation regulation of Rhizobium. We study the role of nifA on nodulation of leguminous plants. We found that Sinorhizo-bium fredii harboring multi-copy plasmid carrying the con-stitutively expressed Klebsiella pneumoniae nifA exhibited an increase of nodulation activity and nodulation competitiveness on soybean plants. The Nod-factor secreted by the rhizobia cells containing the multi-copied nifA was assayed, and preliminary results showed that S. fredii containing the multi-copy plasmid carrying nifA produced higher strength of Nod-factor than the rhizobia containing the same plasmid carrying the vector did. | Zhao Jieping Dai Xiaomi Xu Ling Zhu Jiabi Shen Shanjiong Yu Guanqiao | 2002 | Chinese Science Bulletin2002，47，7： | 2 |
| 4 | Music snippet extraction via melody-based repeated pattern discovery显示文摘In this paper,we present a complete set of procedures to automatically extract a music snippet,defined as the most representative or the highlighted excerpt of a music clip. We first generate a modified and compact similarity matrix based on selected features and distance metrics,and then several improved techniques for music repeated pattern discovery are utilized because a music snippet is usually a part of the repeated melody,main theme or chorus. During the process,redundant and wrongly detected patterns are discarded,boundaries are corrected using beat information,and final clusters are also further sorted according to the occurrence frequency and energy information. Subsequently,following our methods,we designed a music snippet extraction system which allows users to detect snippets. Experiments performed on the system show the superiority of our proposed approach. | XU JiePing ZHAO Yang CHEN Zhe LIU ZiLi | 2009 | Science in China(Series F)2009，52，5： | 2 |
| 5 | Tailoring surface features and pore structure by carbon spiral fibers to construct the high-strength carbon foams for the fast and cyclic photo-thermal oil absorption显示文摘Two key limitations affecting the commercial application of carbon foams for fast clean-up of varied oils are the complex synthesis process and poor mechanical stability.In this work,an effective method is reported to fabricate the efficient oil-absorbing materials(CSF@MCF)of carbon spiral fibers(CSFs)anchored on melamine carbon foam(MCF)with superior mechanical properties and excellent photothermal con-version.The interwoven CSFs can not only provide extra rigidity but also reduce the stress concentration of the carbon skeleton,which greatly improves the mechanical properties with 6.3 times maximum compression stress and 4.5 times ultimate tensile strength than MCF.In addition,the pure carbon component can reduce the interface resistance and excite the free electrons more easily,thus realizing high-efficiency photothermal conversion in a wide range of wavelengths.Under light irradiation,the CSF@MCF can be quickly heated up to 70℃and achieve ultra-high absorption of crude oil,up to 62 g g_(-1),due to its low density and large absorption volume.Meanwhile,the CSF@MCF exhibits impressive absorption stability with persistent superhydrophobicity and a high recovery efficiency of over 85%.Superadding its simple preparation process,low production cost,and excellent acid-alkali resistance,the CSF@MCF shows great commercial potential for effectively absorbing varied oils. | Shaohua Shi Yulin Tang Guizhen Wang Jinchuan Zhao Gengping Wan Lihong Wu Jieping Wang Chul B.Park Guilong Wang | 2023 | Journal of Materials Science & Technology2023，，19： | 0 |
| 6 | Design and Performance Study of an Ultrasonic Bone Scalpel with Composite Horn Structure显示文摘The ultrasonic bone scalpel was often used in all kinds of clinical orthopedic surgery as a new type of medical instrument.Based on the working theory of the ultrasonic bone scalpel and combined with the design method of a quarter wavelength transducer and horn,this study proposed an optimization design method for the ultrasonic bone scalpel with a composite horn structure.The structure of the ultrasonic bone scalpel was simplified,and its length was shortened.Finite element analysis,modal analysis,and harmonic response analysis were used to optimize the design of the ultrasonic bone scalpel.The performance of the ultrasonic bone scalpel was explored through impedance analysis,amplitude measurement,temperature measurement,and cutting tests,and the feasibility of the design was verified through torque analysis.The results showed that when the torque force was 4.0 N,the resonance frequency of the ultrasonic bone scalpel was 30,540 Hz,and the maximum amplitude of the ultrasonic bone scalpel could reach 62μm.After spray cooling,the maximum surface temperature of the rear end cover was reduced from 51.8 to 36.3℃,the maximum surface temperature of the composite horn was reduced from 71 to 45.3℃,and the maximum surface temperature of the cutter head was reduced from 101 to 46.1℃,demonstrating a good cooling effect.Under 89 Voltage,the optimal cutting force for cutting chicken leg bones was 0.1 N,the optimal cutting force for cutting pork ribs was 0.3 N,and the cutting process showed tissue selectivity. | Jieping Wu Yong Yang Zhao Yang Cong Chen Shuai Huang | 2023 | Nanomanufacturing and Metrology2023，6，1： | 0 |
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