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| 1 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 2 | A Small Sphere and Large Margin Approach for Novelty Detection Using Training Data with Outliers显示文摘 | Wu Mingrui Ye Jieping | | 0，，11： | 1 |
| 3 | A small sphere and large margin approach for novelty detection using training data with outliers显示文摘 | Mingrui Wu Jieping Ye | 2009 | IEEE Trans on Pattern Analysis and Machine Intelligence2009，31，11： | 1 |
| 4 | A small sphere and large margin approach for novelty detection using training data with outliers显示文摘 | Wu Mingrui Ye Jieping | 2009 | IEEE Trans on Pattern Analysis and Machine Intelligence2009，31，11： | 1 |
| 5 | A Small Sphere and Large Margin Approach for Novelty Detection Using Training Data with Outliers显示文摘 | Wu Mingrui Ye Jieping | 2009 | IEEE Transactions on Pattern Analysis and Machine Intelligence2009，31，11： | 1 |
| 6 | A small sphere and large margin approach for novelty detection using training data with outliers显示文摘 | Wu Mingrui Ye Jieping | 2009 | IEEE Transactions on Pattern Analysis and Machine Intelligence2009，31，11： | 1 |
| 7 | A Small Sphere and Large Margin Approach for Novelty Detection Using Training Data with Outliers显示文摘 | Wu Mingrui Ye Jieping | | 0，，11： | 1 |
| 8 | A Small Sphere and Large Margin Approach for Novelty Detection Using Training Data with Outliers显示文摘 | Wu Mingrui Ye Jieping | 2009 | Pattern Analysis and Machine Intelligence2009，31，11： | 1 |
| 9 | A small sphere and large margin approach for novelty detection using training data with outliers显示文摘 | Wu Mingrui and Ye Jieping | 2009 | IEEE Transactions on Pattern Analysis and Machine Intelligence2009，31，11： | 1 |
| 10 | An extreme case of the generalized optimal discriminant transformation and its application to face recognition显示文摘 | LU Jieping YANG Jingyu | 2007 | Neurocomputing2007，70，4： | 1 |
| 11 | The relationshipbetween the age of nephroeeto-my with the compensatorygrowth of the remainingkidney after the uilateralephroectomy显示文摘 | Wu Jieping | 1985 | Chinese MediealJournal1985，，65： | 1 |
| 12 | Tailoring surface features and pore structure by carbon spiral fibers to construct the high-strength carbon foams for the fast and cyclic photo-thermal oil absorption显示文摘Two key limitations affecting the commercial application of carbon foams for fast clean-up of varied oils are the complex synthesis process and poor mechanical stability.In this work,an effective method is reported to fabricate the efficient oil-absorbing materials(CSF@MCF)of carbon spiral fibers(CSFs)anchored on melamine carbon foam(MCF)with superior mechanical properties and excellent photothermal con-version.The interwoven CSFs can not only provide extra rigidity but also reduce the stress concentration of the carbon skeleton,which greatly improves the mechanical properties with 6.3 times maximum compression stress and 4.5 times ultimate tensile strength than MCF.In addition,the pure carbon component can reduce the interface resistance and excite the free electrons more easily,thus realizing high-efficiency photothermal conversion in a wide range of wavelengths.Under light irradiation,the CSF@MCF can be quickly heated up to 70℃and achieve ultra-high absorption of crude oil,up to 62 g g_(-1),due to its low density and large absorption volume.Meanwhile,the CSF@MCF exhibits impressive absorption stability with persistent superhydrophobicity and a high recovery efficiency of over 85%.Superadding its simple preparation process,low production cost,and excellent acid-alkali resistance,the CSF@MCF shows great commercial potential for effectively absorbing varied oils. | Shaohua Shi Yulin Tang Guizhen Wang Jinchuan Zhao Gengping Wan Lihong Wu Jieping Wang Chul B.Park Guilong Wang | 2023 | Journal of Materials Science & Technology2023，，19： | 0 |
| 13 | Small molecules in the treatment of COVID-19显示文摘The outbreak of COVID-19 has become a global crisis,and brought severe disruptions to societies and economies.Until now,effective therapeutics against COVID-19 are in high demand.Along with our improved understanding of the structure,function,and pathogenic process of SARS-CoV-2,many small molecules with potential anti-COVID-19 effects have been developed.So far,several antiviral strategies were explored.Besides directly inhibition of viral proteins such as RdRp and M^(pro),interference of host enzymes including ACE2 and proteases,and blocking relevant immunoregulatory pathways represented by JAK/STAT,BTK,NF-κB,and NLRP3 pathways,are regarded feasible in drug development.The development of small molecules to treat COVID-19 has been achieved by several strategies,including computer-aided lead compound design and screening,natural product discovery,drug repurposing,and combination therapy.Several small molecules representative by remdesivir and paxlovid have been proved or authorized emergency use in many countries.And many candidates have entered clinical-trial stage.Nevertheless,due to the epidemiological features and variability issues of SARS-CoV-2,it is necessary to continue exploring novel strategies against COVID-19.This review discusses the current findings in the development of small molecules for COVID-19 treatment.Moreover,their detailed mechanism of action,chemical structures,and preclinical and clinical efficacies are discussed. | Sibei Lei Xiaohua Chen Jieping Wu Xingmei Duan Ke Men | 2023 | Signal Transduction and Targeted Therapy2023，8，1： | 0 |
| 14 | Design and Performance Study of an Ultrasonic Bone Scalpel with Composite Horn Structure显示文摘The ultrasonic bone scalpel was often used in all kinds of clinical orthopedic surgery as a new type of medical instrument.Based on the working theory of the ultrasonic bone scalpel and combined with the design method of a quarter wavelength transducer and horn,this study proposed an optimization design method for the ultrasonic bone scalpel with a composite horn structure.The structure of the ultrasonic bone scalpel was simplified,and its length was shortened.Finite element analysis,modal analysis,and harmonic response analysis were used to optimize the design of the ultrasonic bone scalpel.The performance of the ultrasonic bone scalpel was explored through impedance analysis,amplitude measurement,temperature measurement,and cutting tests,and the feasibility of the design was verified through torque analysis.The results showed that when the torque force was 4.0 N,the resonance frequency of the ultrasonic bone scalpel was 30,540 Hz,and the maximum amplitude of the ultrasonic bone scalpel could reach 62μm.After spray cooling,the maximum surface temperature of the rear end cover was reduced from 51.8 to 36.3℃,the maximum surface temperature of the composite horn was reduced from 71 to 45.3℃,and the maximum surface temperature of the cutter head was reduced from 101 to 46.1℃,demonstrating a good cooling effect.Under 89 Voltage,the optimal cutting force for cutting chicken leg bones was 0.1 N,the optimal cutting force for cutting pork ribs was 0.3 N,and the cutting process showed tissue selectivity. | Jieping Wu Yong Yang Zhao Yang Cong Chen Shuai Huang | 2023 | Nanomanufacturing and Metrology2023，6，1： | 0 |
| 15 | Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin显示文摘Therapeutic targeting FOxO3A(a forkhead transcription factor)represents a prom-ising strategy to suppress acute myeloid leukemia(AML).However,the effective inhibitors that target FOXO3A are lacking and the adaptive response signaling weakens the cytotoxic effect of FOxO3A depletion on AML cells.Here,we show that FOxO3A deficiency induces a compensa-tory response involved in the reactive activation of mTOR that leads to signaling rebound and adaptive resistance.Mitochondrial metabolism acts downstream of mTOR to provoke activa-tion of JNK/c-JUN via reactive oxygen species(ROS).At the molecular level,FOXO3A directly binds to the promoter of G protein gamma subunit 7(GNG7)and preserves its expression,while GNG7 interacts with mTOR and restricts phosphorylated activation of mTOR.Consequently,combinatorial inhibition of FOXO3A and mTOR show a synergistic cytotoxic effect on AML cells and prolongs survival in a mouse model of AML.Through a structure-based virtual screening,we report one potent small-molecule FOxO3A inhibitor(Gardenoside)that exhibits a strong effect of anti-FOXO3A DNA binding.Gardenoside synergizes with rapamycin to substantially reduce tumor burden and extend survival in AML patient-derived xenograft model.These results demonstrate that mTOR can mediate adaptive resistance to FOxO3A inhibition and validate a combinatorial approach for treating AML. | Zhe Chen Qian Guo Shichen Huang Lei Li Feng Wu Zhilong Liu Zhigang Li Tao Chen Guanbin Song Shuangnian Xu Jieping Chen Yu Hou | 2024 | Genes & Diseases2024，11，1： | 0 |
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