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| 1 | The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types显示文摘The Genome Sequence Archive(GSA)is a data repository for archiving raw sequence data,which provides data storage and sharing services for worldwide scientific communities.Considering explosive data growth with diverse data types,here we present the GSA family by expanding into a set of resources for raw data archive with different purposes,namely,GSA(http://gffzz77e3413bc06540edskwk55q6w9vfq6qqc.ffgz.tsg.suse.edu.cn/gsa/),GSA for Human(GSA-Human,http://gffzz77e3413bc06540edskwk55q6w9vfq6qqc.ffgz.tsg.suse.edu.cn/gsa-human/),and Open Archive for Miscellaneous Data(OMIX,http://gffzz77e3413bc06540edskwk55q6w9vfq6qqc.ffgz.tsg.suse.edu.cn/omix/).Compared with the 2017 version,GSA has been significantly updated in data model,online functionalities,and web interfaces.GSA-Human,as a new partner of GSA,is a data repository specialized in human genetics-related data with controlled access and security.OMIX,as a critical complement to the two resources mentioned above,is an open archive for miscellaneous data.Together,all these resources form a family of resources dedicated to archiving explosive data with diverse types,accepting data submissions from all over the world,and providing free open access to all publicly available data in support of worldwide research activities. | Tingting Chen Xu Chen Sisi Zhang Junwei Zhu Bixia Tang Anke Wang Lili Dong Zhewen Zhang Caixia Yu Yanling Sun Lianjiang Chi Huanxin Chen Shuang Zhai Yubin Sun Li Lan Xin Zhang Jingfa Xiao Yiming Bao Yanqing Wang Zhang Zhang Wenming Zhao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 38 |
| 2 | miR-181b functions as an oncomiR in colorectal cancer by targeting PDCDZ显示文摘 | Yanqing Liu Uzair-ur-Rehman Yu Guo Hongwei Liang Rongjie Cheng Fei Yang Yeting Hong Chihao Zhao Minghui Liu Mengchao Yu Xinyan Zhou Kai Yin Jiangning Chen Junfeng Zhang Chen-Yu Zhang Feng Zhi Xi Chen | 2016 | Protein & Cell2016，7，10： | 14 |
| 3 | GSA:Genome Sequence Archive显示文摘With the rapid development of sequencing technologies towards higher throughput and lower cost, sequence data are generated at an unprecedentedly explosive rate. To provide an efficient and easy-to-use platform for managing huge sequence data, here we present Genome Sequence Archive(GSA; http://gffzzdbc7b6aaae734bddhkwk55q6w9vfq6qqc.ffgz.tsg.suse.edu.cn/gsa or http://gffzz4eaf941a184140e3hkwk55q6w9vfq6qqc.ffgz.tsg.suse.edu.cn), a data repository for archiving raw sequence data. In compliance with data standards and structures of the International Nucleotide Sequence Database Collaboration(INSDC), GSA adopts four data objects(Bio Project, Bio Sample,Experiment, and Run) for data organization, accepts raw sequence reads produced by a variety of sequencing platforms, stores both sequence reads and metadata submitted from all over the world,and makes all these data publicly available to worldwide scientific communities. In the era of big data, GSA is not only an important complement to existing INSDC members by alleviating the increasing burdens of handling sequence data deluge, but also takes the significant responsibility for global big data archive and provides free unrestricted access to all publicly available data in support of research activities throughout the world. | Yanqing Wang Fuhai Song Junwei Zhu Sisi Zhang Yadong Yang Tingting Chen Bixia Tang Lili Dong Nan Ding Qian Zhang Zhouxian Bai Xunong Dong Huanxin Chen Mingyuan Sun Shuang Zhai Yubin Sun Lei Yu Li Lan Jingfa Xiao Xiangdong Fang Hongxing Lei Zhang Zhang Wenming Zhao | 2017 | Genomics, Proteomics & Bioinformatics2017，15，1： | 13 |
| 4 | Integrating a weighted-average method into the random walk framework to generate individual friend recommendations显示文摘Friend recommendation is a fundamental service in both social networks and practical applications,and is influenced by user behaviors such as interactions, interests, and activities. In this study, we first conduct in-depth investigations on factors that affect recommendation results. Next, we design Friend++, a hybrid multi-individual recommendation model that integrates a weighted average method(WAM) into the random walk(RW) framework by seamlessly employing social ties, behavior context, and personal information. In Friend++, the first plus signifies recommending a new friend through network features, while the second plus stands for using node features. To verify our method, we conduct experiments on three social datasets crawled from the Sina microblog system(Weibo). Experimental results show that the proposed method significantly outperforms six baseline methods in terms of recall, precision, F1-measure, and MAP. As a final step, we describe a case study that demonstrates the scalability and universality of our method. Through discussion, we reach a meaningful conclusion: although common interests are more important than user activities in making recommendations, user interactions may be the most important factor in finding the most appropriate potential friends. | Jibing GONG Xiaoxia GAO Hong CHENG Jihui LIU Yanqing SONG Mantang ZHANG Yi ZHAO | 2017 | Science China(Information Sciences)2017，60，11： | 7 |
| 5 | Robust Multiclass Classification for Learning from Imbalanced Biomedical Data显示文摘Imbalanced data is a common and serious problem in many biomedical classification tasks. It causes a bias on the training of classifiers and results in lower accuracy of minority classes prediction. This problem has attracted a lot of research interests in the past decade. Unfortunately, most research efforts only concentrate on 2-class problems. In this paper, we study a new method of formulating a multiclass Support Vector Machine (SVM) problem for imbalanced biomedical data to improve the classification performance. The proposed method applies cost-sensitive approach and ramp loss function to the Crammer and Singer multiclass SVM formulation. Experimental results on multiple biomedical datasets show that the proposed solution can effectively cure the problem when the datasets are noisy and highly imbalanced. | Piyaphol Phoungphol Yanqing Zhang Yichuan Zhao | 2012 | Tsinghua Science and Technology2012，17，6： | 6 |
| 6 | Myt1L Promotes Differentiation of Oligodendrocyte Precursor Cells and is Necessary for Remyelination After Lysolecithin-Induced Demyelination显示文摘The differentiation and maturation of oligodendrocyte precursor cells(OPCs) is essential for myelination and remyelination in the CNS. The failure of OPCs to achieve terminal differentiation in demyelinating lesions often results in unsuccessful remyelination in a variety of human demyelinating diseases. However, the molecular mechanisms controlling OPC differentiation under pathological conditions remain largely unknown. Myt1 L(myelin transcription factor 1-like), mainly expressed in neurons,has been associated with intellectual disability, schizophrenia, and depression. In the present study, we found that Myt1 L was expressed in oligodendrocyte lineage cells during myelination and remyelination. The expression level of Myt1 L in neuron/glia antigen 2-positive(NG^(2+))OPCs was significantly higher than that in mature CC1^+ oligodendrocytes. In primary cultured OPCs,overexpression of Myt1 L promoted, while knockdown inhibited OPC differentiation. Moreover, Myt1 L was potently involved in promoting remyelination after lysolecithin-induced demyelination in vivo. Ch IP assays showed that Myt1 L bound to the promoter of Olig1 and transcriptionally regulated Olig1 expression. Taken together, our findings demonstrate that Myt1 L is an essential regulator of OPC differentiation, thereby supporting Myt1 L as a potential therapeutic target for demyelinating diseases. | Yanqing Shi Qi Shao Zhenghao Li Ginez A. Gonzalez Fengfeng Lu Dan Wang Yingyan Pu Aijun Huang Chao Zhao Cheng He Li Cao | 2018 | Neuroscience Bulletin2018，34，2： | 6 |
| 7 | Efficacy and safety of the Qiguiyin formula in severe pneumonia: study protocol for a randomized, double-blind, placebo-controlled clinical trial显示文摘OBJECTIVE: To evaluate the clinical efficacy and safety of Qiguiyin(QGY) formula in patients with severe pneumonia in China compared with a placebo.METHODS: This is a multicenter double-blind, placebo-controlled, randomized clinical trial with two parallel arms. There will be 530 patients enrolled and randomized into either the experimental group(QGY formula) or the control group(placebo). Therapies for patients in the two groups above will be based on the conventional therapy. The primary outcome is 28-day mortality. Secondary outcomes include:(a) duration of hospital stay;(b) duration of time in the intensive care unit(ICU) stays;(c) duration of mechanical ventilation;(d) antibiotic DDD value(which means the doses of antibotics during the treatment period);(e) serum procalcitonin(PCT) level;(f) serum C-reactive protein(CRP)level;(g) Pneumonia severity index(PSI) score;(h)Sequential Organ Failure Assessment(SOFA) score;(i) sputum culture results;(j) blood routine examination results;(k) routine urine test results;(l) stool routine examination results;(m) electrocardiogram results;(n) alanine aminotransferase levels;(o) aspartate amino transferase levels;(p) total bilirubin;(q) creatinine levels;(r) urea nitrogen levels;and(s)adverse events.ETHICS AND DISSEMINATION: The protocol has been approved by the Research Ethics Committee of Beijing Hospital of Traditional Chinese Medicine,Affiliated with Capital Medical University(2018 BL-053-02). This trial aims to provide evidence for QGY formula combined with conventional therapy in treating patients with severe bacterial pneumonia,and to verify the clinical effectiveness and safety of QGY formula in China compared with placebo. Additionally, this trial will reveal the effect of QGY formula on delaying/reversing the characteristics of drug-resistant bacteria.Trial registration number: Chi CTR1800019785. | Huang Po Guo Yuhong Zhao Jingxia Li Bo Wu Yanqing Liu Qingquan | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 6 |
| 8 | Recent advance in electromagnetic shielding of MXenes显示文摘As a new type of two-dimensional material,MXene’s unique layered structure,outstanding electrical conductivity,low density,tunable surface chemistry,and solution processability make it receive extensive attention in various fields,especially for the lightweight shielding mate rials since the report on electromagnetic interference(EMI) shielding of 2D Ti3 C2 Tx in 2016.In this review,the progress on the MXe nes material including their synthetic strategies,prope rties and EMI application is highlighted.First,the recent advance on the different synthesis methods and properties of MXene is summarized.According to their intrinsic characteristics,the application of MXene in EMI fields is then discussed.Finally,the challenges and perspective on the future development of MXene in low-cost preparation and practical application are proposed. | Yanqing Yao Jia Zhao Xuanhe Yang Chunpeng Chai | 2021 | Chinese Chemical Letters2021，32，2： | 5 |
| 9 | Single W18O49 nanowires: A multifunctional nanoplatform for computed tomography imaging and photothermal/ photodynamic/radiation synergistic cancer therapy显示文摘联合治疗是通常基于复杂 nanostructures 的利用,多重部件为 photothermal 作为相片热的精力变换器, photo-sensitizers,或剂量 intensifiers 工作的有希望的癌症治疗策略治疗(PTT ) ,光力学的治疗(太平洋夏季时间) ,或放射治疗(RT ) 。在这研究, ultrathin 钨氧化物 nanowires (W 18 O 49) 用一条 solvothermal 途径被综合并且作为多功能的 theranostic nanoplatform 检验了。在 vitro 并且在 vivo,分析证明这些 nanowires 能导致广泛的热 -- 并且汗衫在 980 nm 在附近下面的癌症房间的调停氧的损坏红外线(NIR ) 激光刺激。他们也被显示作为加强在放射治疗期间局部地并且有选择地提高放热精力免职的代理人的放射剂量工作。独自比作导致 NIR 的 PTT/PDT 和 RT, W 18 O 49-based synergistic tri 形式的治疗根除了异种皮移植肿瘤和没有复发被观察在以内一 9 月列在后面起来。而且,钨元素的强壮的 X 光检查变细能力(Z = 74, 4.438 厘米 2???? ?? ?? 佦 ? 畳 ?? 猯扵￣?? | Jianjian Qiu Qingfeng Xiao Xiangpeng Zheng Libo Zhang Huaiyong Xing Dalong Ni Yanyan Liu Shengjian Zhang Qingguo Ren Yanqing Hua Kuaile Zhao Wenbo Bu | 2015 | Nano Research2015，8，11： | 5 |
| 10 | Label-free fiber nanograting sensor for real-time in situ early monitoring of cellular apoptosis显示文摘The achievement of functional nanomodules for subcellular label-free measurement has long been pursued in order to fully understand cellular functions.Here,a compact label-free nanosensor based on a fiber taper and zinc oxide nanogratings is designed and applied for the early monitoring of apoptosis in individual living cells.Because of its nanoscale dimensions,mechanical flexibility,and minimal cytotoxicity to cells,the sensing module can be loaded in cells for long term in situ tracking with high sensitivity.A gradual increase in the nuclear refractive index during the apoptosis process is observed,revealing the increase in molecular density and the decrease in cell volume.The strategy used in our study not only contributes to the understanding of internal environmental variations during cellular apoptosis but also provides a new platform for nonfluorescent fiber devices for investigation of cellular events and understanding fundamental cell biochemical engineering. | Danran Li Nina Wang Tianyang Zhang Guangxing Wu Yifeng Xiong Qianqian Du Yunfei Tian Weiwei Zhao Jiandong Ye Shulin Gu Yanqing Lu Dechen Jiang Fei Xu | 2022 | Advanced Photonics2022，4，1： | 5 |
| 11 | The mechanosensitive lncRNA Neat1 promotes osteoblast function through paraspeckle-dependent Smurf1 mRNA retention显示文摘Mechanical stimulation plays an important role in bone remodeling. Exercise-induced mechanical loading enhances bone strength,whereas mechanical unloading leads to bone loss. Increasing evidence has demonstrated that long noncoding RNAs(lnc RNAs) play key roles in diverse biological, physiological and pathological contexts. However, the roles of lnc RNAs in mechanotransduction and their relationships with bone formation remain unknown. In this study, we screened mechanosensing lnc RNAs in osteoblasts and identified Neat1, the most clearly decreased lnc RNA under simulated microgravity. Of note, not only Neat1 expression but also the specific paraspeckle structure formed by Neat1 was sensitive to different mechanical stimulations, which were closely associated with osteoblast function. Paraspeckles exhibited small punctate aggregates under simulated microgravity and elongated prolate or larger irregular structures under mechanical loading. Neat1 knockout mice displayed disrupted bone formation, impaired bone structure and strength, and reduced bone mass. Neat1 deficiency in osteoblasts reduced the response of osteoblasts to mechanical stimulation. In vivo, Neat1 knockout in mice weakened the bone phenotypes in response to mechanical loading and hindlimb unloading stimulation. Mechanistically, paraspeckles promoted nuclear retention of E3 ubiquitin ligase Smurf1 m RNA and downregulation of their translation, thus inhibiting ubiquitination-mediated degradation of the osteoblast master transcription factor Runx2, a Smurf1 target. Our study revealed that Neat1 plays an essential role in osteoblast function under mechanical stimulation, which provides a paradigm for the function of the lnc RNA-assembled structure in response to mechanical stimulation and offers a therapeutic strategy for long-term spaceflight-or bedrest-induced bone loss and age-related osteoporosis. | Caizhi Liu Xingcheng Gao Yuheng Li Weijia Sun Youjia Xu Yingjun Tan Ruikai Du Guohui Zhong Dingsheng Zhao Zizhong Liu Xiaoyan Jin Yinlong Zhao Yinbo Wang Xinxin Yuan Junjie Pan Guodong Yuan Youyou Li Wenjuan Xing Guanghan Kan Yanqing Wang Qi Li Xuan Han Jianwei Li Shukuan Ling Yingxian Li | 2022 | Bone Research2022，10，2： | 3 |
| 12 | Phase structure and hydrogen storage properties of REMg8.35Ni2.18Al0.21 (RE=La, Ce, Pr, and Nd) hydrogen storage alloys显示文摘REMg8.35Ni2.18Al0.21 (RE=La, Ce, Pr,和 Nd ) 合金被感应的融化并且列在后面退火准备。X 光检查衍射(XRD ) 和扫描电子显微镜学(SEM ) 结果证明合金由 Mg2Ni 组成,(La, Pr, Nd ) Mg2Ni,(La, Ce ) 2Mg17,(Ce, Pr, Nd ) Mg12 和 Ce2Ni7 阶段。上述阶段是进 Mg2NiH4, MgH2 和 REHx 的 disproportioned (x=2.51 或 3 ) 在 hydriding 的阶段。而 LaH3, PrH3 和 NdH3 阶段仍然保持未改变, CeH2.51 阶段在 dehydriding 转变了成 CeH2.29 阶段。当 CeMg8.35Ni2.18Al0.21 合金介绍了最好的 hydriding/dehydriding 可逆性时, PrMg8.41Ni2.14Al0.20 合金有最快的 hydriding 动力学和最高的 dehydriding 高原压力。CeMg8.35Ni2.18Al0.21 氢化物的发作氢解吸附作用温度由于在 CeH2.51 和 CeH2.29 之间的阶段转变显著地减少了。 | LIU Yanqing HAN Shumin HU Lin LIU Baozhong ZHAO Xin JIA Yanhong | 2013 | Journal of Rare Earths2013，31，8： | 3 |
| 13 | Parallel algorithm for real-time contouring from grid DEM on modern GPUs显示文摘A real-time algorithm for constructing contour maps from grid DEM data is pre-sented.It runs completely within the programmable 3D visualization pipeline.The interpolation is paralleled by rasterizer units in the graphics card,and contour line extraction is paralleled by pixel shader.During each frame of the rendering,we first make an elevation gradient map out of original terrain vertex data,then figure out the final contour lines with image-space processing,and directly blend the results on the original scene to obtain a final scene with contour map using alpha-blending.We implement this method in our global 3D-digitalearth system with Direct3D?9.0c API and tested on some consumer level PC platforms.For arbitrary scene with certain LOD level,the process takes less than 10 ms,giving topologically correct,anti-aliased contour lines. | CHEN Zhuo,SHEN Lei,ZHAO YanQing & YANG ChongJun State Key Laboratory of Remote Sensing Science,Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University,Beijing 100101,China | 2010 | Science China(Technological Sciences)2010，53，S1： | 3 |
| 14 | Study on traveling magnetic field casting of sheet components显示文摘The distribution of a magnetic field over an inductor used for sheet castings has been investigated experimentally.With an increase in height from the surface, the magnetic field density decreases according to the exponential law.In the transverse direction, the magnetic field density is approximately uniform except near the edges.The magnetic field density is direct proportional to the number of turns multiplied by the current in amperes.Ferro-magnetic material in the upper mould can enhance the magnetic field density.Under the electromagnetic force, the mould-filling process of sheet casings has been studied by physical simulation method.The difference in filling capability between gravity casting and travelling magnetic field casting has been studied.The electromagnetic force can enhance the filling process, but it also brings a problem.With an increase in the magnetic field density, the surface quality of the aluminum alloy sheet castings becomes poor.The reason is discussed. | Su Yanqing Xu Yanjin Zhao Lei Zhang Tiejun Wu Shiping Guo Jingjie | 2010 | China Foundry2010，7，3： | 3 |
| 15 | Correlation between changes of central neurotransmitter expression and stress response in mice A restraint time-course analysis显示文摘BACKGROUND: Changes in central neurotransmitter expression play an important role in stress response and forms the basis for stress-induced psychological and behavior changes. OBJECTIVE: To observe the effects of different restraint stress intervals on brain monoamine neurotransmitter expression,and to investigate the correlation between stress response and neurotransmitter levels. DESIGN: Randomized controlled animal study. SETTING: Chinese Herb and Natural Medicine Institute,Pharmacological College of Jinan University. MATERIALS: Sixty 7-week-old male Kunming mice of clean grade,weighing 18-22 g,were provided by the Guangdong Medical Experimental Animal Center. The experiment was in accordance with animal ethics standards. METHODS: This study was performed at the Chinese Herb and Natural Medicine Institute,Pharmacological College of Jinan University from June 2006 to May 2007. A restraint device for mice was constructed according to published reports. Experimental mice were adaptively fed for 1 week and randomly divided into a control group (n = 10) and an experimental group (n = 50). The experimental group was sub-divided into five restraint intervals: 4,8,12,18,and 24 hours (n = 10 mice per time point). Animals in the experimental group were not allowed to eat or drink during the restraint period. Mice in the control group did not undergo restraint,but had identical food and water restrictions. Cerebral cortex and hypothalamus were separated based on observational times and protein was extracted using perchloric acid. Central monoamine neurotransmitter levels were measured using high performance liquid chromatography with electrochemical detection. MAIN OUTCOME MEASURES: Levels of norepinephrine (NE),dopamine hydrochloride (DA),3,4-dihydroxyphen-ylanetic acid (DOPAC),homovanillic acid (HVA),5-hydroxytryptamine (5-HT),and 5-hydroxyindoleac-etic acid (5-HIAA) in the cerebral cortex and hypothalamus of mice. RESULTS: Sixty mice were included in the final analysis. ① NE levels in the cerebral cortex,hypothalamus,and plasma: four hours after restraint,NE levels in the cerebral cortex and hypothalamus ere significantly lower than control levels (P < 0.05). After 12 hours of restraint,NE levels in the experimental group were significantly higher than in the control group (P < 0.05). At 18 hours of restraint,there was no significant difference in NE levels in the cerebral cortex between the experimental group and the control group (P > 0.05). In addition,NE levels in the plasma gradually increased with longer restraint time,which was significant between experimental groups and the control group (P < 0.05-0.01). ② Levels of DA,DOPAC,and HVA in the cerebral cortex and hypothalamus: there were significant differences in DA levels in the cerebral cortex and hypothalamus after 18 and 24 hours of restraint compared to control animals (P < 0.05). DOPAC and HVA levels in the cerebral cortex were enhanced with longer restraint time,and there was significant difference in all restraint groups compared to control levels (P < 0.01),except for DOPAC levels after 4 hours of restraint. Moreover,DOPAC and HVA levels in the hypothalamus were enhanced with increasing restraint time. Levels of 5-HT and 5-HIAA in the cerebral cortex and hypothalamus: after short restraint periods and in the control group,5-HT was not detectable. However,it was quantitatively detected at 12 hours after restraint. The 5-HT levels in the cerebral cortex and hypothalamus reached peak levels at 12 and 18 hours of restraint. 5-HIAA levels in the cerebral cortex and hypothalamus showed a similar tendency to increase with restraint time. 5-HIAA levels at 4-8 hours after restraint were significantly higher than control levels (P < 0.01). The 5-HIAA levels decreased at 12 hours after restraint,but remained significantly higher than the control group (P < 0.05). CONCLUSION: Restraint stress affects the hypothalamic-pituitary-adrenal (HPA) axis and causes changes in monoamine neurotransmitters in brain tissues,which suggests stress status could be improved by adjusting HPA axis and neurotransmitter levels in the brain. | Li Bao Xinsheng Yao Liang Zhao Yanqing Lü Hiroshi Kurihara | 2008 | Neural Regeneration Research2008，3，2： | 2 |
| 16 | Coarsening Manner and Microstructure Evolution of Al-In Hypermonotectic Alloy during Rapidly Cooling Process显示文摘A numerical model reflecting the real physical processes well has been developed to predict the coarsening manner of the second phase droplets and the microstructural evolution under the common action of nucleation, diffusional growth, colliding coagulation during rapid cooling Al-ln hypermonotectic alloys. The model reflects the real physical processes well and is also applicable to other immiscible alloys. | Yuan LIU, Jingjie GUO, Jun JIA, Yanqing SU, Hongsheng DING, Jiuzhou ZHAO and Xiang XUESchool of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China | 2002 | Journal of Materials Science & Technology2002，18，3： | 2 |
| 17 | The recent development of soft x-ray interference lithography in SSRF显示文摘This paper introduces the recent progress in methodologies and their related applications based on the soft x-ray interference lithography beamline in the Shanghai synchrotron radiation facility.Dual-beam,multibeam interference lithography and Talbot lithography have been adopted as basic methods in the beamline.To improve the experimental performance,a precise real-time vibration evaluation system has been established;and the lithography stability has been greatly improved.In order to meet the demands for higher resolution and practical application,novel experimental methods have been developed,such as high-order diffraction interference exposure,high-aspect-ratio and large-area stitching exposure,and parallel direct writing achromatic Talbot lithography.As of now,a 25 nm half-pitch pattern has been obtained;and a cm2 exposure area has been achieved in practical samples.The above methods have been applied to extreme ultraviolet photoresist evaluation,photonic crystal and surface plasmonic effect research,and so on. | Jun Zhao Shumin Yang Chaofan Xue Liansheng Wang Zhaofeng Liang Lei Zhang Yong Wang Yanqing Wu Renzhong Tai | 2020 | International Journal of Extreme Manufacturing2020，2，1： | 2 |
| 18 | Solid–liquid Interdiffusion Bonding of Cu/Sn/Ni Micro-joints with the Assistance of Temperature Gradient显示文摘A novel solid-liquid interdiffusion(SLID)bonding method with the assistance of temperature gradient(TG)was carried out to bonding Cu and Ni substrates with Sn as interlayer.The element distribution and grain morphology of interfacial intermetallic compound(IMC)in Cu/Sn/Ni micro-joints during both SLID and TG-SLID bonding and in the final Cu/(Cu,Ni)_(6)Sn_(5)/Ni full IMC micro-joints were analyzed.Under the effect of Cu-Ni cross-interaction,interfacial(Cu,Ni)_(6)Sn_(5) dominated the IMC growth at all the interfaces.The morphology of the(Cu,Ni)_(6)Sn_(5) grains was closely related to Ni content with three levels of low,medium and high.The full IMC micro-joints consisted of L-(Cu,Ni)_(6) Sn_(5),M-(Cu,Ni)_(6)Sn_(5) and H-(Cu,Ni)_(6)Sn_(5) grains after SLID bonding or TG-SLID bonding with Ni as hot end,while only L-(Cu,Ni)_(6)Sn_(5) grains after TG-SLID bonding with Cu as hot end,showing that the direction of TG had a remarkably effect on the growth and morphology of the interfacial(Cu,Ni)_(6)Sn_(5) during TG-SLID bonding.Thermodynamic analysis revealed the key molar latent heat and critical Ni content between fine-rounded-like(Cu,Ni)_(6)Sn_(5) and block-like(Cu,Ni)_(6)Sn_(5) were 17,725.4 J and 11.0 at.%at 260℃,respectively.Moreover,the growth kinetic of the interfacial IMC was analyzed in detail during bonding with and without TG.Under the combination of TG and Cu-Ni cross-interaction,void-free full IMC micro-joints were fast formed by TG-SLID bonding with Cu as hot end.This bonding method may present a feasible solution to solve the problems of low formation efficiency and inevitable Cu_(3) Sn growth of full IMC joints for 3 D packaging applications. | Yanqing Lai Shi Chen Xiaolei Ren Yuanyuan Qiao Ning Zhao | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，11： | 2 |
| 19 | Biocompatible chitosan/polyethylene glycol/multi-walled carbon nanotube composite scaffolds for neural tissue engineering显示文摘Carbon nanotube(CNT)composite materials are very attractive for use in neural tissue engineering and biosensor coatings.CNT scaffolds are excellent mimics of extracellular matrix due to their hydrophilicity,viscosity,and biocompatibility.CNTs can also impart conductivity to other insulating materials improve mechanical stability guide neuronal cell behavior and trigger axon regeneration.The performance of chitosan(CS)/polyethylene glycol(PEG)composite scaffolds could be optimized by introducing multi-walled CNTs(MWCNTs).CS/PEG/CNT composite scaffolds with CNT content of 1%,3%,and 5%(1%=0.01 g/mL)were prepared by freeze-drying.Their physical and chemical properties and biocompatibility were evaluated.Scanning electron microscopy(SEM)showed that the composite scaffolds had a highly connected porous structure.Transmission electron microscope(TEM)and Raman spectroscopy proved that the CNTs were well dispersed in the CS/PEG matrix and combined with the CS/PEG nanofiber bundles.MWCNTs enhanced the elastic modulus of the scaffold.The porosity of the scaffolds ranged from 83%to 96%.They reached a stable water swelling state within 24 h,and swelling decreased with increasing MWCNT concentration.The electrical conductivity and cell adhesion rate of the scaffolds increased with increasing MWCNT content.Immunofluorescence showed that rat pheochromocytoma(PC12)cells grown in the scaffolds had characteristics similar to nerve cells.We measured changes in the expression of nerve cell markers by quantitative real-time polymerase chain reaction(qRT-PCR),and found that PC12 cells cultured in the scaffolds expressed growth-associated protein 43(GAP43),nerve growth factor receptor(NGFR),and class IIIβ-tubulin(TUBB3)proteins.Preliminary research showed that the prepared CS/PEG/CNT scaffold has good biocompatibility and can be further applied to neural tissue engineering research. | Shengbo SANG Rong CHENG Yanyan CAO Yayun YAN Zhizhong SHEN Yajing ZHAO Yanqing HAN | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，1： | 2 |
| 20 | Detection of Hydrazine at MXene/ZIF-8 Nanocomposite Modified Electrode显示文摘ZIF-8 with excellent chemical and physical properties is a promising material for the field of electrochemical sensing.However,the poor electrical conductivity of ZIF-8 severely limits its electrochemical performance.Here,we report a method that can significantly improve the conductivity of ZIF-8 by intercalating Ti_(3)C_(2)T_(x) MXene as a conductive platform.Benefiting from higher conductivity and unique electrocatalytic activity,the obtained MXene/ZIF-8 nanocomposite presented the worthy analytical performance for hydrazine sensing.The successful fabrication of MXene/ZIF-8 holds great promise for the design of electrochemical sensors,and it is a promising material to promote the development of new electrode materials. | Yanqing Yao Xuhui Han Xuanhe Yang Jia Zhao Chunpeng Chai | 2021 | Chinese Journal of Chemistry2021，39，2： | 1 |
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