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| 1 | MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1显示文摘MicroRNAs (miRNAs ) 由抑制最近在 carcinogenesis 和转移在我们 non-protein-coding RNA 的角色的理解带给卓见的 posttranscriptional 施加功能。在这研究,我们在 CRC 在 colorectal 癌症(CRC ) 和它的潜在的临床的应用程序描述了函数和 miR-139-5p 的分子的机制。我们发现 miR-139-5p 是显著地, CRC 与邻近的 noncancerous 纸巾(NCT ) 相比取样的在 73.8% 的 downregulated,和减少的 miR-139-5p 与穷人被联系预后。功能的分析证明 miR-139-5p 的那个宫外的表达式在 vivo 在 vitro 和转移压制了 CRC 房间移植和侵略。机械学的调查表明 miR-139-5p 由指向 AMFR 和 NOTCH1 压制 CRC 房间侵略和转移。二基因 phenocopied 击倒 CRC 上的 miR-139-5p 的禁止的效果转移。而且,二基因的蛋白质层次与 NCT 相比是在 CRC 样品的 upregulated,并且相反地与 miR-139-5p 表示相关。增加的 NOTCH1 蛋白质表示与 CRC 病人的差的预后被相关。一起,我们的数据显示 miR-139-5p 为 CRC 是潜在的肿瘤 suppressor 和预示的因素,并且指向 miR-139-5p 可以镇压 CRC 的转移并且改善幸存。 | Mingxu Song Yuan Yin Jiwei Zhang Binbin Zhang Zehua Bian Chao Quan Leyuan Zhou Yaling Hu Qifeng Wang Shujuan Ni Bojian Fei Weili Wang Xiang Du Dong Hua Zhaohui Huang | 2014 | Protein & Cell2014，5，11： | 14 |
| 2 | Icosahedral quasicrystalline phase in an as-cast Mg-Zn-Er alloy显示文摘The microstructure of an as-cast Mg-Zn-Er alloy was investigated through scanning electron microscopy (SEM) and transmission electron microscopy (TEM) equipped with energy dispersive spectroscopy (EDS). The results indicate that two different second phases, one with eutectoid-lamellar morphology and the other with granular shape, distribute in the α-Mg matrix. The coexistence of the face-centered icosahedral quasicrystalline phase (I-phase) and W-phase with the face-centered cubic structure is found in the as-cast alloy. The coexistence of I-phase and W-phase in the Mg-Zn-Er alloy is because the W-phase is the primary phase and the I-phase forms by peritectic reaction during solidification. | LI Jianhui DU Wenbo LI Shubo WANG Zhaohui | 2009 | Rare Metals2009，28，3： | 13 |
| 3 | Chalcogenide glass photonic integration for improved 2μm optical interconnection显示文摘In this work,on-chip chalcogenide glass photonic integrations with several fundamental photonic building blocks are designed and fabricated based on the As2 S3 platform for improved 2μm optical interconnection,achieving a broadened wavelength bandwidth and improved fabrication tolerance.A 600 nm thick As2 S3 strip waveguide has low propagation loss of 1.447 dB/cm at 2μm.Broadband vertical coupling is realized by a grating coupler with 4.3 dB coupling loss.A Bragg grating filter,power splitter,Mach–Zander interferometer,and mode converter for on-chip mode division multiplexing(MDM)are also reported at 2μm with reliable performances.Finally,a record high MDM optical interconnection capacity of 3×80 Gbps at 2μm is experimentally demonstrated based on the proposed As2 S3 chip,drawing promising prospects for future photonic integration and high-speed interconnection at the 2μm waveband. | WEIHONG SHEN PINGYANG ZENG ZELIN YANG DI XIA JIANGBING DU BIN ZHANG KE XU ZUYUAN HE AND ZHAOHUI LI | 2020 | Photonics Research2020，8，9： | 10 |
| 4 | Ultra-broadband on-chip twisted light emitter for optical communications显示文摘On-chip twisted light emitters are essential components of orbital angular momentum(OAM)communication devices1,2.These devices address the growing demand for high-capacity communication systems by providing an additional degree of freedom for wavelength/frequency division multiplexing(WDM/FDM).Although whispering-gallery-mode-enabled OAM emitters have been shown to possess some advantages3–5,such as compactness and phase accuracy,their inherent narrow bandwidths prevent them from being compatible with WDM/FDM techniques.Here,we demonstrate an ultra-broadband multiplexed OAM emitter that utilizes a novel joint path-resonance phase control concept.The emitter has a micron-sized radius and nanometer-sized features.Coaxial OAM beams are emitted across the entire telecommunication band from 1,450 to 1,650 nm.We applied the emitter to an OAM communication with a data rate of 1.2 Tbit/s assisted by 30-channel optical frequency combs(OFCs).The emitter provides a new solution to further increase capacity in the OFC communication scenario. | Zhenwei Xie Ting Lei Fan Li Haodong Qiu Zecen Zhang Hong Wang Changjun Min Luping Du Zhaohui Li Xiaocong Yuan | 2018 | Light(Science & Applications)2018，7，1： | 7 |
| 5 | Effect of microstructure evolution on mechanical property of extruded Mg-12Gd-2Er-1Zn-0.6Zr alloys显示文摘The microstructure evolution of as-cast,as-extruded and peak-aged Mg-12Gd-2Er-1Zn-0.6Zr alloys were investigated by Optical Microscope(OM),X-ray Diffraction(XRD),Scanning Electron Microscope(SEM)and Transmission Electron Microscope(TEM).The mechanical performance was also tested by tensile test at room temperature in the present study.The results indicated that the lamellar 14H-LPSO structure formed during the solid solution process at 793 K for 24 h,and also existed after hot extrusion process.The dynamic recrystallization(DRX)occurred during hot extrusion.The DRXed fine grain size was∼5μm.Meanwhile,some un-DRXed grains contained LPSO structure had a roughly orientation along the extrusion direction.The tensile test result showed that the as-extruded alloy had a better elongation of 14%due to fine DRXed grain and fiber-like un-DRXed with LPSO structure attributed to the high elongation.Because of the precipitation of theβ′-phase,the ultimate tensile strength(UTS)and yield tensile strength(YTS)increased up to 415 MPa(UTS)and 374 MPa(YTS),respectively. | Kai Wen Ke Liu Zhaohui Wang Shubo Li Wenbo Du | 2015 | Journal of Magnesium and Alloys2015，3，1： | 7 |
| 6 | Influence of various volute designs on volute overall performance显示文摘This paper discusses the influence of various volute designs on volute overall performance for a certain centrifugal compressor with both vaned and vaneless diffuser. Firstly, based on a free vortex flow pattern and the assumption of a circumferentially uniform flow at the design condition, a corrected method for volute design is adopted. By means of this method, corresponding to five geometric parameters affecting the volute overall performance, ten volute cases are designed. Secondly, the numerical simulation is employed and the detailed flow field and losses in different volutes with different geometric parameters are analyzed. The numerical investigation reveals that in all of the five geometric parameters, the radial location of the cross-section has the strongest influence on the performance of the volute. The non-uniform volute inlet formed by the upward vaned diffuser outlet flow is another important factor. Finally a relatively better value of D4/D2 is concluded. | Xiaoqing Qiang Jinfang Teng Zhaohui Du | 2010 | Journal of Thermal Science2010，19，6： | 7 |
| 7 | Optical observations of LIGO source GW 170817 by the Antarctic Survey Telescopes at Dome A,Antarctica显示文摘The LIGO detection of gravitational waves(GW) from merging black holes in 2015 marked the beginning of a new era in observational astronomy. The detection of an electromagnetic signal from a GW source is the critical next step to explore in detail the physics involved. The Antarctic Survey Telescopes(AST3),located at Dome A, Antarctica, is uniquely situated for rapid response time-domain astronomy with its continuous night-time coverage during the austral winter. We report optical observations of the GW source(GW 170817) in the nearby galaxy NGC 4993 using AST3. The data show a rapidly fading transient at around 1 day after the GW trigger, with the i-band magnitude declining from 17:23 ± 0:13 magnitude to 17:72 ± 0:09 magnitude in ~1:8 h. The brightness and time evolution of the optical transient associated with GW 170817 are broadly consistent with the predictions of models involving merging binary neutron stars. We infer from our data that the merging process ejected about ~10^(-2) solar mass of radioactive material at a speed of up to 30% the speed of light. | lei hu xuefeng wu igor andreoni michael c.b.ashley jeff cooke xiangqun cui fujia du zigao dai bozhong gu yi hu haiping lu xiaoyan li zhengyang li ensi liang liangduan liu bin ma zhaohui shang tianrui sun n.b.suntzeff charling tao syed a.uddin lifan wang xiaofeng wang haikun wen di xiao jin xu ji yang shihai yang xiangyan yuan hongyan zhou hui zhang jilin zhou zonghong zhu | 2017 | Science Bulletin2017，62，21： | 6 |
| 8 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 9 | Microscopic examination of intracellular organisms in bronchoalveolar lavage fluid for the diagnosis of ventilator-associated pneumonia:a prospective multi-center study显示文摘 | Liu Chang Du Zhaohui Zhou Qing Hu Bo Li Zhifeng Yu Li Xu Tao Fan Xuepeng Yang Junhui Li Jianguo | 2014 | Chinese Medical Journal2014，，10： | 6 |
| 10 | EXPERIMENTAL INVESTIGATION OF TIP CLEARANCE FLOW FOR AN AXIAL FLOW FAN ROTOR显示文摘在一个轴的通风迷的尖端区域的流动域与在设计的系统调节的粒子图象速度计(PIV ) 被调查。有三个不同尖端清理的流动地分别地在三架不同环绕的飞机上被调查。锁 Thephase 的平均方法被用来调查产生和一个尖端漏旋涡的发展。从 PIV 系统的结果从一张粒子动力学风速表(PDA ) 与那相比是系统。两个数据在好同意,为转子的尖端漏旋涡的结构被说明。一个漏旋涡的特征在速度向量和旋涡的轮廓被描述。漏旋涡的摇摆和旋涡的位置详细被调查,它解释在数字模拟之间的差异, PDAexperimental 结果到某个程度。在不同时间的尖端漏旋涡的中心 loci 和漏旋涡的吝啬的中心 loci 特别地被显示。最后,当适当地解释了时,由试验性的测量的尖端漏旋涡的轨道与从为高速度和高压的压缩机和汽轮机的存在模型的预言相比。一个好协议被获得。 | GUO Qiang ZHU Xiaocheng DU Zhaohui | 2006 | Chinese Journal of Mechanical Engineering2006，19，3： | 5 |
| 11 | COMPUTATIONAL AND EXPERI-MENTAL STUDY ON TIP LEAKAGE VORTEX OF CIRCUMFERENTIAL SKEWED BLADES显示文摘In the steady operation condition,the experiments and the numerical simulations are used to investigate the tip leakage flow fields in three low pressure axial flow fans with three kinds of circumferential skewed rotors,including the radial rotor,the forward-skewed rotor and the back-ward-skewed rotor. The three-dimensional viscous flow fields of the fans are computed. In the ex-periments,the two-dimensional plane particle image velocimetry (PIV) system is used to measure the flow fields in the tip region of three different pitchwise positions of each fan. The results show that the computational results agree well with the experimental data in the flow field of the tip region of each fan. The tip leakage vortex core segments based on method of the eigenmode analysis can dis-play clearly some characteristics of the tip leakage vortex,such as the origination position of tip leak-age vortex,the development of vortex strength,and so on. Compared with the radial rotor,the other two skewed rotors can increase the stability of the tip leakage vortex and the increment in the for-ward-skewed rotor is more than that in the backward-skewed one. Among the tip leakage vortices of the three rotors,the velocity of the vortex in the forward-skewed rotor is the highest in the circumfer-ential direction and the lowest in the axial direction. | LI Yang OUYANG Hua DU Zhaohui | 2007 | Chinese Journal of Mechanical Engineering2007，20，2： | 4 |
| 12 | Microstructure and strengthening mechanisms of Mg-6Al-6Nd alloy显示文摘The microstructure and strengthening mechanisms of as-cast Mg-6Al-6Nd alloy were studied. The results show that the addition of 6 wt.% Nd into Mg-6Al alloy leads to the precipitation of Al11Nd3 and Al2Nd phases and decrease in the content of Al solid soluted in Mg-Al matrix. The volume fractions of Al11Nd3 and Al2Nd phases are 3.64% and 0.34%, respectively. Compared with Mg-6Al alloy, the ultimate strength, yielding strength, and elongation of Mg-6Al-6Nd alloy at room temperature and 175°C are enhanced in some degrees. The strengthening mechanisms of Mg-6Al-6Nd alloy are mainly composed of solid solution strengthening of Al solid soluted in Mg-Al matrix and grain refinement strengthening, dispersion strengthening, and composite strengthening brought by the precipitation of Al11Nd3 phase. The composite strengthening includes the load transfer from the matrix to Al11Nd3 phase and the enhancement of dislocation density due to the geometrical mismatch and thermal mismatch between the matrix and Al11Nd3 phase. | WU Yufeng DU Wenbo YAN Zhenjie WANG Zhaohui ZUO Tieyong | 2010 | Rare Metals2010，29，1： | 3 |
| 13 | Cholecystokinin octapeptide antagonizes apoptosis in human retinal pigment epithelial cells显示文摘Although cholecystokinin octapeptide-8 is important for neurological function, its neuroprotective properties remain unclear. We speculated that cholecystokinin octapeptide-8 can protect human retinal pigment epithelial cells against oxidative injury. In this study, retinal pigment epithelial cells were treated with peroxynitrite to induce oxidative stress. Peroxynitrite triggered apoptosis in these cells, and increased the expression of Fas-associated death domain, Bax, caspase-8 and Bcl-2. These changes were suppressed by treatment with cholecystokinin octapeptide-8. These results suggest that cholecystokinin octapeptide-8 can protect human retinal pigment epithelial cells against apoptosis induced by peroxynitrite. | Yuan Liu Yueling Zhang Zhaohui Gu Lina Hao Juan Du Qian Yang Suping Li Liying Wang Shilei Gong | 2014 | Neural Regeneration Research2014，9，14： | 2 |
| 14 | Highly efficient and stable solar-powered desalination by tungsten carbide nanoarray film with sandwich wettability显示文摘Solar-powered desalination is a promising way to resolve the worldwide water crisis for its low con- sumption and simple facility. Considering the fragility and aggregations of traditional materials, which may decrease efficiency, we herein introduce a robust tungsten carbide (WC) nanoarray film as a stable and efficient photothermal material, whose absorption is over 97.5% throughout almost the whole solar spectrum range (220–2200 nm) due to nanoarray structure and thus enhanced localized surface plasmon resonance. Besides, for the first time, we modified the film with sandwich wettability. It accelerates evap- oration by reducing water’s reflection of light, enlarging hydrophobic-hydrophilic boundaries, and depressing heat dissipation. Combining high absorption with unique wettability, the WC nanoarray film offers high solar-to-vapor efficiency of 90.8% and produces drinking water at the rate of (1.06 ± 0.10) kg m^(-2)h^(-1)from man-made seawater and (0.98 ± 0.18) kg m^(-2)h^(-1)from heavy metal sewage under one sun (AM 1.5) while 98% performance remains after 1 h×100 times’ reutilization. | Nana Han Kai Liu Xinping Zhang Meng Wang Pan Du Zhaohui Huang Daojin Zhou Qian Zhang Tengfei Gao Yin Jia Liang Luo Jianjun Wang Xiaoming Sun | 2019 | Science Bulletin2019，64，6： | 2 |
| 15 | Full Length Article Effect of trace addition of al on microstructure,texture and tensile ductility of Mg-6Zn-0.5Er alloy显示文摘The effects of trace addition of Al on the microstructure and mechanical properties of the as-extruded Mg-6Zn-0.5Er alloy were investigated in the present investigation.The results showed that the trace addition of Al affected the mechanical properties significantly.The elongation of the extruded alloy was improved markedly from 17 to 25%with the trace addition of Al.It is suggested that the improvement of ductility was mainly attributed to the modification of basal texture of the as-extruded alloy,resulting from the complete dynamic recrystallization due to the trace addition of Al.In addition,the existence of the complete dynamic recrystallization led to an obvious increase in the number fraction of high angle grain boundaries,the average misorientation angle and Schmid factors for the(0001)1120 slip,which also have contributed to the improvement of ductility. | Xiaobing Zheng Wenbo Du Ke Liu Zhaohui Wang Shubo Li | 2016 | Journal of Magnesium and Alloys2016，4，2： | 2 |
| 16 | Effects of trace Ca/Sn addition on corrosion behaviors of biodegradable Mg-4Zn-0.2Mn alloy显示文摘The effects of alloying elements of Ca/Sn on corrosion behaviors of the as-cast Mg-4Zn-0.2Mn alloy were investigated by immersion tests and electrochemical methods.The results indicated that the average corrosion rate value of the Mg-4Zn-0.2Mn-Ca alloy was∼0.31 mm/year in Hank’s physiological solution for 40 days,and corrosion resistance increased for the specimens containing Ca element rather than that containing Sn because of the higher breakdown potential value,lower current density and deactivated corrosion rate,which was ascribed to a formation of the uniformly distributed Mg-Zn-Ca ternary phase. | Wenbo Du Ke Liu Ke Ma Zhaohui Wang Shubo Li | 2018 | Journal of Magnesium and Alloys2018，6，1： | 2 |
| 17 | Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China显示文摘 | Baoli Cheng Guohao Xie ShangLong Yao Xinmin Wu Qulian Guo Miaoning Gu Qiang Fang Qiuping Xu Dongxin Wang Yuhong Jin ShiYing Yuan Junlu Wang Zhaohui Du Yunbo Sun XiangMing Fang | 2007 | Critical Care Medicine2007，，11： | 2 |
| 18 | Impact of crizotinib on long-term survival of ALK-positive advanced non-small-cell lung cancer: A Chinese multicenter cohort study显示文摘Objective: Crizotinib has demonstrated promising efficacy in patients with anaplastic lymphoma kinase(ALK)-positive non-small-cell lung cancer(NSCLC) in clinical trials. We conducted this retrospective multicenter study to assess the outcomes of crizotinib therapy in, to our knowledge, a large sample cohort of patients with ALKpositive advanced NSCLC.Methods: We reviewed the medical records of 484 unselected ALK-positive NSCLC patients treated with crizotinib at 5 cancer centers in China from January 2013 to November 2017. Clinical data were collected from the initiation of crizotinib therapy to Response Evaluation Criteria in Solid Tumors(RECIST)-defined progressive disease(PD).Results: A total of 428 eligible ALK-positive NSCLC patients were enrolled, 273(63.8%) of whom received crizotinib as first-line treatment. The median progression-free survival(PFS) and overall survival(OS) from the initiation of crizotinib treatment were 14.4 [95% confidence interval(95% CI), 12.4-16.4] months and 53.4(95%CI, 33.7-73.1) months, respectively. In subgroup analyses, patients who received crizotinib as first-line treatment showed a higher disease control rate(DCR) and a longer median OS compared with second-/later-line crizotinib treatment(94.8% and OS not reached vs. 89.0% and 40.5 months, respectively). For 261 patients with RECISTdefined PD, multivariate Cox analysis revealed that in patients who received first-line crizotinib therapy, continued crizotinib beyond progressive disease(CBPD) and next-generation ALK inhibitors after crizotinib failure were associated with improved survival.Conclusions: This study has demonstrated the clinically meaningful benefit of crizotinib treatment in a large cohort of Chinese ALK-positive NSCLC patients. CBPD and next-generation ALK inhibitor treatment may provide improved survival after RECIST-defined progression on crizotinib. | Puyuan Xing Di Ma Qiang Wang Xuezhi Hao Mengzhao Wang Yan Wang Li Shan Tao Xin Li Liang Hongge Liang Yang Du Zhaohui Zhang Junling Li | 2019 | Chinese Journal of Cancer Research2019，31，3： | 2 |
| 19 | MiR-421 is a functional marker of circulating tumor cells in gastric cancer patients显示文摘 | Hui Zhou Bingxiu Xiao Fei Zhou Hongxia Deng Xinjun Zhang Yanru Lou Zhaohui Gong Caigan Du Junming Guo | 2012 | Biomarkers2012，，2： | 2 |
| 20 | EXPERIMENTAL INVESTIGATION FOR THE EFFECT OF ROTATION ON THREE-DIMENSIONAL FLOW FIELD IN FILM-COOLED TURBINE显示文摘An experimental investigation of three-dimensional flow field in a film-cooled turbine model is carried out by using particle image velocimeter (PIV) in a low-speed wind tunnel. The effects of different blowing ratios (M=1.5, 2) on the flow field are studied. The experimental results reveal the classical phenomena of the formation of kidney vortex pair and secondary flow in wake region behind the jet hole. And the changes of the kidney vortex pair and the wake at different locations away from the hole on the suction and pressure sides are also studied. Compared with the flow field in stationary cascade, there are centrifugal force and Coriolis force existing in the flow field of rotating turbine, and these forces bring the radial velocity in the jet flow. The effect of rotation on the flow field of the pressure side is more distinct than that on the suction side from the measured flow fields in Y-Z plane and radial velocity contours. The increase of blowing ratio makes the kidney vortex pair and the secondary flow in the wake region stronger and makes the range of the wake region enlarged. | YUAN Feng ZHU Xiaocheng DU Zhaohui | 2007 | Chinese Journal of Mechanical Engineering2007，20，1： | 2 |
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