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| 1 | Type 1 CD8^+ T Cells are Superior to Type 2 CD8^+ T Cells in Tumor Immunotherapy due to Their Efficient Cytotoxicity,Prolonged Survival and Type 1 Immune Modulation显示文摘CD8+ cytotoxic T(Tc) cells play a crucial role in host immune responses to cancer,and in this context,adoptive CD8+ Tc cell therapy has been studied in numerous animal tumor models. Its antitumor efficacy is,to a large extent,determined by the ability of Tc cells to survive and infiltrate tumors. In clinical trials,such in vitro-activated T cells often die within hours to days,and this greatly limits their therapeutic efficacy. CD8+ Tc cells fall into two subpopulations based upon their differential cytokine secretion. In this study,we in vitro generated that ovalbumin(OVA) -pulsed dendritic cell(DCOVA) -activated CD8+ type 1 Tc(Tc1) cells secreting IFN-γ,and CD8+ type 2 Tc(Tc2) cells secreting IL-4,IL-5 and IL-10,which were derived from OVA-specific T cell receptor(TCR) transgenic OT I mice. We then systemically investigated the in vitro and in vivo effector function and survival of Tc1 and Tc2 cells,and then assessed their survival kinetics after adoptively transferred into C57BL/6 mice,respectively. We demonstrated that,when compared to CD8+ Tc2,Tc1 cells were significantly more effective in perforin-mediated cytotoxicity to tumor cells,had a significantly higher capacity for in vivo survival after the adoptive T cell transfer,and had a significantly stronger therapeutic effect on eradication of well-established tumors expressing OVA in animal models. In addition,CD8+ Tc1 and Tc2 cells skewed the phenotype of CD4+ T cells toward Th1 and Th2 type,respectively. Therefore,the information regarding the differential effector function,survival and immune modulation of CD8+ Tc1 and Tc2 cells may provide useful information when preparing in vitro DC-activated CD8+ T cells for adoptive T cell therapy of cancer. | Zhenmin Ye Chaoke Tang Shulin Xu Bei Zhang Xueshu Zhang Terence Moyana Jicheng Yang Jim Xiang | 2007 | Cellular & Molecular Immunology2007，4，4： | 8 |
| 2 | Circular RNA circStag1 promotes bone regeneration by interacting with HuR显示文摘Postmenopausal osteoporosis is a common bone metabolic disorder characterized by deterioration of the bone microarchitecture,leading to an increased risk of fractures.Recently,circular RNAs(circ RNAs)have been demonstrated to play pivotal roles in regulating bone metabolism.However,the underlying functions of circ RNAs in bone metabolism in postmenopausal osteoporosis remain obscure.Here,we report that circ Stag1 is a critical osteoporosis-related circ RNA that shows significantly downregulated expression in osteoporotic bone marrow mesenchymal stem cells(BMSCs)and clinical bone tissue samples from patients with osteoporosis.Overexpression of circ Stag1 significantly promoted the osteogenic capability of BMSCs.Mechanistically,we found that circ Stag1 interacts with human antigen R(Hu R),an RNA-binding protein,and promotes the translocation of Hu R into the cytoplasm.A high cytoplasmic level of Hu R led to the activation of the Wnt signaling pathway by stabilizing and enhancing low-density lipoprotein receptor-related protein 5/6(Lrp5/6)andβ-catenin expression,thereby stimulating the osteogenic differentiation of BMSCs.Furthermore,overexpression of circ Stag1 in vivo by circ Stag1-loaded adeno-associated virus(circ Stag1-AAV)promoted new bone formation,thereby preventing bone loss in ovariectomized rats.Collectively,we show that circ Stag1 plays a pivotal role in promoting the regeneration of bone tissue via Hu R/Wnt signaling,which may provide new strategies to prevent bone metabolic disorders such as postmenopausal osteoporosis. | Gaoyang Chen Canling Long Shang Wang Zhenmin Wang Xin Chen Wanze Tang Xiaoqin He Zhiteng Bao Baoyu Tan Jin Zhao Yongheng Xie Zhizhong Li Dazhi Yang Guozhi Xiao Songlin Peng | 2022 | Bone Research2022，10，3： | 7 |
| 3 | New Layered SOA-Based Architecture for Multi-robots Cooperative Online SLAM显示文摘A new layered multi-robots architecture for cooperative online simultaneous localization and mapping based on Service-oriented architecture(SOA) is proposed. This architecture is constructed by the concepts of service-oriented and loosely coupled center scheduling.These methods make robots' underlying function realization be transparent in cooperation and avoid the impact affected by robot heterogeneous characteristics, which will be beneficial to the system construction, expansion, restructuring and maintenance. All data packages follow the SOA unified data format, which can avoid the impact affected by sensor heterogeneous characteristics. The point to point serving model reduces the path of data transmission which can improve the timeliness of the system. All of these features can satisfy the requirements of multi-robots cooperative online SLAM. The simulation results show the feasibility, applicability and practicability of this architecture. | CAI Yunfei TANG Zhenmin ZHAO Chunxia | 2014 | Chinese Journal of Electronics2014，23，1： | 5 |
| 4 | Multi-robots Cooperative Online FastSLAM显示文摘 | CAI Yunfei TANG Zhenmin ZHAO Chunxia | 2011 | Chinese Journal of Electronics2011，20，2： | 3 |
| 5 | Nearest-neighbor classifier motivated marginal discriminant projections for face recognition显示文摘边缘的菲希尔分析(MFA ) 是为脸识别的一个代表性的基于边缘的学习算法。在 MFA 的一个主要问题是怎么选择适当参数, k 1 并且 k 2,构造各自内在并且惩罚图。在这份报纸,我们建议一个新奇方法打电话近邻居(NN ) 分类器激发了边缘的判别式设计(NN-MDP ) 。由 NN 分类器激发了, NN-MDP 寻求一些设计向量阻止数据样品错误地被分类。象 MFA 一样, NN-MDP 能同时描绘样品的紧密和可分性。而且与 MFA 相对照,没有未知参数, NN-MDP 能活跃地构造内在的图和惩罚图。ORL,耶鲁,和 FERET 脸数据库上的试验性的结果显示出那 NN-MDP 不仅避免邻居参数选择的难驾驭,和高开销,而且也是更适用的比另外的方法面对识别 NN 分类器。 | Pu HUANG Zhenmin TANG Caikou CHEN Xintian CHENG | 2011 | Frontiers of Computer Science2011，5，4： | 3 |
| 6 | Minimum cost attribute reduction in decision-theoretic rough set models显示文摘 | Xiuyi Jia Wenhe Liao Zhenmin Tang Lin Shang | 2013 | Information Sciences2013，，： | 2 |
| 7 | A Novel Dynamic Obstacle Avoidance Algorithm Based on Collision Time Histogram显示文摘Robot path planning in uncertain dynamic environment is a hot issue in the field of Unmanned ground vehicle(UGV).Starting from the practical demands of UGV,we propose a novel dynamic obstacle avoidance algorithm based on Collision time histogram(CTH).Given current steering angle,an effective collision check model,which is called Collision check circles(CCC),is firstly calculated.The local environment information is then combined with CCC to generate the proposed CTH.The nonholonomic nature of the vehicle is embedded in this process.Finally,the proposed algorithm calculates the executing steering angle by considering both the CTH and the target point.Extensive experiments and comparisons are conducted to evaluate the performance of the proposed algorithm.Simulation experiments are firstly conducted to verify its feasibility.Furthermore,real-world experiment is conducted to verify its effectiveness.Experimental results demonstrate the practical value of the proposed algorithm. | ZHUGE Chengchen CAI Yunfei TANG Zhenmin | 2017 | Chinese Journal of Electronics2017，26，3： | 2 |
| 8 | Speaker Identification Using Multi-Step Clustering Algorithm with Transformation-Based GMM显示文摘 | Limin Xu Zhenmin Tang | 2007 | Automatic Control and Computer Science2007，41，： | 1 |
| 9 | Straight line feature based image distortion correction显示文摘An image distortion correction method is proposed, which uses the straight line features. Many parallel lines of different direction from different images were extracted, and then were used to optimize the distortion parameters by nonlinear least square. The thought of step by step was added when the optimization method working. 3D world coordination is not need to know, and the method is easy to implement. The experiment result shows its high accuracy. | Zhang Haofeng Zhao Chunxia Lu Jianfeng Tang Zhenmin Yang Jingyu | 2008 | Engineering Sciences2008，6，2： | 1 |
| 10 | QMOR: QoS-aware multi-sink opportunistic routing for wireless multimedia sensor networks 显示文摘 | Shen Hang Bai Guangwei Tang Zhenmin | 2013 | Wireless Personal Communications2013，72，4： | 1 |
| 11 | An adap- tive opportunistic network coding mechanism in wireless mul- timedia sensor networks显示文摘 | Shen Hang Bai Guangwei Zhao Lu Tang Zhenmin | 2012 | International Journal of Distribut- ed Sensor Networks2012，2012，1： | 1 |
| 12 | A theorem on the uneorrelated optimal discriminant vectors显示文摘 | Jin Zhong Yang Jingyu Tang Zhenmin | 2001 | Pattern Rec- ognition2001，34，10： | 1 |
| 13 | QMOR : QoS-aware multi-sink opportunistic routing for wireless multimedia sensor networks显示文摘 | Shen Hang Bai Guangwei Tang Zhenmin | 2013 | Wireless Personal Communications2013，72，4： | 1 |
| 14 | Theory and Application of Multi-robot Service-oriented Architecture显示文摘In order to solve the problem of heterogeneity in multi-robot cooperation, a new service-oriented architecture is proposed for multi-robot cooperation. Service provision and energy consumption are the basic cooperative behaviors. A set of basic concepts of robot service are proposed. A layered multi-robot service-oriented architecture is designed. Finally, the experiments illustrate the superiority of the proposed architecture which makes robot's underlying functional components be transparently encapsulated and the services in upper layer be transparently invoked, which will effectively avoid the impact of heterogeneous characteristics in multi-robot cooperation and facilitate the system construction, expansion, restructuring and maintenance. | Yunfei Cai Zhenmin Tang Yuhua Ding Bin Qian | 2016 | IEEE/CAA Journal of Automatica Sinica2016，3，1： | 1 |
| 15 | On an opti-mization representation of decision-theoretic rough set mod-el 显示文摘 | Jia Xiuyi Tang Zhenmin Liao Wenhe | 2014 | International Journal of Approximate Reasoning2014，55，1： | 1 |
| 16 | Identification of a Distant Speaker and Its Robustness显示文摘 | JIANG Ye TANG Zhenmin WANG Longbiao | 2011 | Chinese Journal of Electronics2011，20，2： | 1 |
| 17 | Net- work coding based reliable multi-path routing in wireless sensor network 显示文摘 | Zhao Wei Tang Zhenmin T Yang Yuwang | 2013 | TELKOMNIKA Indonesian Journal of Electrical Engineering2013，11，12： | 1 |
| 18 | Research of vowel mapping theory for speaker identification of Chinese mandarin 显示文摘 | LI Yanping TANG Zhenmin QIAN Bo | 2008 | International Journal of Computer Processing of Oriental Languages2008，21，3： | 1 |
| 19 | Local Maximal Margin Discriminant Embedding for Face Recognition显示文摘 | Huang Pu Tang Zhenmin Chen Caikou | 2014 | Journal of Visual Communication&Image Representation2014，25，2： | 1 |
| 20 | Modified particle filter-based infrared pedestrian tracking显示文摘 | Xin Wang Zhenmin Tang | 2010 | Infrared Physics & Technology2010，10，3： | 1 |
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