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| 1 | Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients显示文摘Human infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and there is no cure currently.The 3CL protease(3CLpro)is a highly conserved protease which is indispensable for CoVs replication,and is a promising target for development of broad-spectrum antiviral drugs.In this study we investigated the anti-SARS-CoV-2 potential of Shuanghuanglian preparation,a Chinese traditional patent medicine with a long history for treating respiratory tract infection in China.We showed that either the oral liquid of Shuanghuanglian,the lyophilized powder of Shuanghuanglian for injection or their bioactive components dose-dependently inhibited SARS-CoV-23CLpro as well as the replication of SARS-CoV-2 in Vero E6 cells.Baicalin and baicalein,two ingredients of Shuanghuanglian,were characterized as the first noncovalent,nonpeptidomimetic inhibitors of SARS-CoV-23CLpro and exhibited potent antiviral activities in a cell-based system.Remarkably,the binding mode of baicalein with SARS-CoV-23CLpro determined by X-ray protein crystallography was distinctly different from those of known 3CLpro inhibitors.Baicalein was productively ensconced in the core of the substrate-binding pocket by interacting with two catalytic residues,the crucial S1/S2 subsites and the oxyanion loop,acting as a“shield”in front of the catalytic dyad to effectively prevent substrate access to the catalytic dyad within the active site.Overall,this study provides an example for exploring the in vitro potency of Chinese traditional patent medicines and effectively identifying bioactive ingredients toward a specific target,and gains evidence supporting the in vivo studies of Shuanghuanglian oral liquid as well as two natural products for COVID-19 treatment. | Hai-xia Su Sheng Yao Wen-feng Zhao Min-jun Li Jia Liu Wei-juan Shang Hang Xie Chang-qiang Ke Hang-chen Hu Mei-na Gao Kun-qian Yu Hong Liu Jing-shan Shen Wei Tang Lei-ke Zhang Geng-fu Xiao Li Ni Dao-wen Wang Jian-ping Zuo Hua-liang Jiang Fang Bai Yan Wu Yang Ye Ye-chun Xu | 2020 | Acta Pharmacologica Sinica2020，41，9： | 32 |
| 2 | Photo-curing 3D printing technique and its challenges显示文摘In recent ten years,3D printing technology has been developed rapidly.As an advanced technology,3D printing has been used to fabricate complex and high-precision objects in many fields.3D printing has several technologies.Among these technologies,photo-curing 3D printing was the earliest and most mature technology.In 1988,the first 3D printing machine which was based on photo-curing and called Stereo lithography Appearance(SLA)technology was produced by 3D system Corp.After 30 years of development,many new technologies based on photocuring mechanism emerged.Based on the different principle of pattern formation and character of printing technology,numerous photocuring 3D printing techniques,such as SLA,DLP,LCD,CLIP,MJP,twophoton 3D printing,holographic 3D printing and so on,have been developed.Photo-curing 3D printing has many advantages,such as high precision,smooth surface of printing objects,rapid printing speed and so on.Here,we would introduce five industrial photocuring 3D printing technologies,which are SLA,DLP,LCD,CLIP and MJP.The characters of the materials and the progress of the application of the technique in the biomedical field is also overviewed.At last,the difficulties and challenges of photo-curing 3D printing are also discussed. | Haoyuan Quan Ting Zhang Hang Xu Shen Luo Jun Nie Xiaoqun Zhu | 2020 | Bioactive Materials2020，5，1： | 33 |
| 3 | Effect of Substructure on Toughness of Lath Martensite/Bainite Mixed Structure in Low-Carbon Steels显示文摘The quantitative analysis of substructure in the martensite/bainite mixed structure, which is obtained from low-carbon NiCrMoV steels under different cooling conditions, was made by means of optical microscope (OM), scanning electron microscope (SEM), electron backscatter diffraction (EBSD), and transmission electron microscope (TEM), in order to research the effect on toughness. The test results indicate that the toughness of the steel is enhanced with the decrease in the packet and block size under the condition of the same prior austenite grain size mixed with different ratios of martensite and bainite while the lath width is about 0.38 μm. The calculation shows that both the packet and block boundaries have the same hindering effect on crack extension. Furthermore, the effect of the block width on impact energy is much larger than that of the packet. Therefore, the block can be used as microstructural substructure to affect the toughness in low-carbon martensite steels, suggesting that the block size is 'the effective grain size' for controlling toughness. | LUO Zhi-jun SHEN Jun-chang SU Hang DING Yue-hua YANG Cai-fu ZHU Xing | 2010 | Journal of Iron and Steel Research(International)2010，17，11： | 24 |
| 4 | Influences of enteral nutrition combined with probiotics on gut microflora and barrier function of rats with abdominal infection显示文摘瞄准:为了调查肠内的的、非肠道的营养和专业版的影响,生命学与腹的感染在肠的微生态学,上皮的紧密的连接,免疫者和老鼠的障碍功能上由内脏交付了。方法:与盲肠的结扎和穿孔方法建立的老鼠腹的感染模型,被划分成三个组:非肠道的营养(PN 组, n = 7 ) , PN+enteral 营养(在组, n = 7 ) 并且在 + 职业人员生命学的 PN +( 职业人员生命学组, n = 7 ) 经由为五天的针空肠造口术和颈静脉。三个组的全部的营养的补充是 isonitrogenic 和 isocaloric。Probiotics 被空肠造口术交付 10 mL/d (1 x 10 (8 ) cfu/mL ) 。老鼠在第六天被打死。在盲肠的排汇物为厌氧的细菌的生长是有教养的并且与随机的放大多态的 DNA 与细菌的组 DNA 指纹侧面分析了。transmembrane 绑定蛋白质(occludin ) 和在在冒号和终端回肠的肠上皮的浆细胞的 IgA 水平被一个免疫组织化学方法测量。在冒号和小肠的肠的上皮的紧密的连接的超微结构被电子显微镜学观察。维纳腔血和肝,肺和 mes 伤寒淋巴结的 homogenated 织物是有教养的决定细菌的 translocations,并且在从门静脉的血的内毒素被检测。结果:(1 ) 内脏种类在的细菌的数量在组和职业人员,关於生命的组在 PN 是比那高级的组。DNA 侧面在在组和职业人员,关於生命的组类似于正常老鼠的。在职业人员生命学组的 DNA 侧面的数字在 PN 组并且在组是多于那的大部分。而且,在 PN 有奇怪的条纹组。( 2 ) occludin 和 IgA 在的表示小并且大肠在在组( 2.309 +/- 0.336 , 15.440 +/- 2.383 )并且专业版关於生命的组( 2.938 +/- 0.515 , 16.230 +/- 3.183 )作为与 PN 组相比被改进( 1.207 +/- 0.587 , P <
0.05 , 11.189 +/- 2.108 , P <
0.01 )。在专业版的 occludin 的表达式关於生命的组(肠:2.93 +/- 0.515;盲肠:3.40 +/- 0.617 ) 比那高在在组(肠:2.309 +/- 0.336;盲肠:2.076 +/- 0.670;P <
0.05 ) 。IgA 的表示,在特别在组(肠:15.440 +/- 2.383 ) 并且在组关於生命的专业版(大肠:12.516 +/- 1.542 ) 显著地作为与 PN 组相比增加了(肠:11.189 +/- 2.108;盲肠:10.160 +/- 1.643;P<0.01 ) 。肠的上皮的紧密的连接和职业人员的微绒毛关於生命的组是比在 PN 组的那些更未经触动的。( 3 )在内毒素的血,肝,肺和 mes 伤寒淋巴节点,和层次的细菌的 translocations 显著地在专业版被减少关於生命( 0.082 +/- 0.029 )并且在( 0.125 +/- 0.040 )作为与 PN 组相比组织( 0.403 +/- 0.181 , P <
0.05 )。结论:申请在与专业版生命学结合了能改进 transmembrane 绑定蛋白质(occludin ) 和 IgA 的表达式,改正肠内菌丛骚乱,维持内脏障碍函数和紧密的连接,并且减少出现毁坏细菌的易位。 | Tong-Yi Shen Huan-Long Qin Zhi-Guang Gao Xiao-Bing Fan Xiao-Ming Hang Yan-Qun Jiang | 2006 | World Journal of Gastroenterology2006，12，27： | 22 |
| 5 | The second natural gas hydrate production test in the South China Sea显示文摘Clayey silt reservoirs bearing natural gas hydrates(NGH)are considered to be the hydrate-bearing reservoirs that boast the highest reserves but tend to be the most difficult to exploit.They are proved to be exploitable by the first NGH production test conducted in the South China Sea in 2017.Based on the understanding of the first production test,the China Geological Survey determined the optimal target NGH reservoirs for production test and conducted a detailed assessment,numerical and experimental simulation,and onshore testing of the reservoirs.After that,it conducted the second offshore NGH production test in 1225 m deep Shenhu Area,South China Sea(also referred to as the second production test)from October 2019 to April 2020.During the second production test,a series of technical challenges of drilling horizontal wells in shallow soft strata in deep sea were met,including wellhead stability,directional drilling of a horizontal well,reservoir stimulation and sand control,and accurate depressurization.As a result,30 days of continuous gas production was achieved,with a cumulative gas production of 86.14×104 m3.Thus,the average daily gas production is 2.87×10^4 m^3,which is 5.57 times as much as that obtained in the first production test.Therefore,both the cumulative gas production and the daily gas production were highly improved compared to the first production test.As indicated by the monitoring results of the second production test,there was no anomaly in methane content in the seafloor,seawater,and atmosphere throughout the whole production test.This successful production test further indicates that safe and effective NGH exploitation is feasible in clayey silt NGH reservoirs.The industrialization of hydrates consists of five stages in general,namely theoretical research and simulation experiments,exploratory production test,experimental production test,productive production test,and commercial production.The second production test serves as an important step from the exploratory production test to experimental production test. | Jian-liang Ye Xu-wen Qin Wen-wei Xie Hai-long Lu Bao-jin Ma Hai-jun Qiu Jin-qiang Liang Jing-an Lu Zeng-gui Kuang Cheng Lu Qian-yong Liang Shi-peng Wei Yan-jiang Yu Chunsheng Liu Bin Li Kai-xiang Shen Hao-xian Shi Qiu-ping Lu Jing Li Bei-bei Kou Gang Song Bo Li He-en Zhang Hong-feng Lu Chao Ma Yi-fei Dong Hang Bian | 2020 | China Geology2020，3，2： | 22 |
| 6 | Manufacturing Technology and Application Trends of Titanium Clad Steel Plates显示文摘Some of the major manufacturing processes and corresponding mechanical properties of titanium clad steel plates were analyzed, and the consequences of research, manufacturing, and application of titanium clad steel plates in both markets of China and overseas were also summarized. As an economical and environmentally friendly technology, the roll bonding process is expected to become the next-generation mainstream process for the manufacturing of titanium clad steel plate. Some of the crucial and most important technical problems of this particular process, including vacuum sealing technology, surface treatment process technology, application of a transition layer, and rolling process, were discussed along with the advantageous mechanical properties and life-cycle economy of these plates processed by this technology. Finally, the market needs, application trends, and requirements of titanium clad steel plate were also considered from industries of petrochemical, shipbuilding, marine, and electric power. | Hang SU Xiao-bing LUO Feng CHAI Jun-chang SHEN Xin-jun SUN Feng LU | 2015 | Journal of Iron and Steel Research(International)2015，22，11： | 18 |
| 7 | Incidence trends and age distribution of colorectal cancer by subsite in Guangzhou,2000-2011显示文摘Introduction:Colorectal cancer(CRC) is the third most common cancer in China.The incidence of CRC has been increasing in recent years.The aim of this study was to explore the incidence trends and the age distribution of CRC by subsite in Guangzhou between 2000 and 2011.Methods:A total of 22,432 incident cases of CRC between 2000 and 2011 from Guangzhou Cancer Registry were identified.Crude incidence and age-standardized rates(ASRs),using the Segi’s world standard population,were calculated for CRC and CRC subsites.The incidence trend was analyzed and the annual percentage change(APC) in incidence was calculated by using JoinPoint software.Results:The crude incidence increased significantly from 23.4/10~5 in 2000 to 37.4/10~5 in 2011 for males and from20.9/10~5 to 30.5/10~5 for females.The ASRs of CRC incidence stabilized during the period of 2000-2011 for both males and females.The ages at the onset of CRC for both males and females during 2010-2011 were significantly higher compared with those during 2000-2002(males:f = 1.95,P = 0.05;females:f = 6.03,P < 0.01).For males aged50-64 years,the CRC incidence increased by 8.50%annually(P = 0.04) during 2000-2004 and by 1.68%annually(P = 0.03) during 2005-2011.For females aged 65 years and older,the CRC incidence increased by 5.77%annually(P = 0.03) during 2000-2004.There were no significant changes for the CRC incidences in males aged 49 and younger and 65 years and older and females aged 64 years and younger during 2000-2004,or for those in all females as well as males aged 49 years and younger and 65 years and older during 2005-2011.The percentage of colon cancer in all CRCs increased significantly for both males and females between the periods of 2000-2002 and 2010-2011.The ASRs of descending colon and sigmoid colon cancer incidences increased significantly for females during 2005-2011(APC,5.51%and 1.08%,respectively,both P < 0.05).Conclusions:The crude incidence of CRC increased significantly between 2000 and 2011 because of the aging,whereas the ASRs kept stable.The percentage of colon cancer in all CRCs increased significantly.Further surveillance,research,and intervention are needed to identify the causes of these changes and to reduce the incidence and mortality of CRC. | Qin Zhou Ke Li Guo-Zhen Lin Ji-Chuan Shen Hang Dong Yu-Ting Gu Hua-Zhang Liu | 2015 | Chinese Journal of Cancer2015，34，8： | 17 |
| 8 | Effect of active oxygen on the performance of Pt/CeO2 catalysts for CO oxidation显示文摘This study was focused on the influence of active oxygen on the performance of Pt/CeO_2 catalysts for CO oxidation. A series of CeO_2 supports with different contents of active oxygen were obtained by adding surfactant at different synthesis steps. 0.25 wt% Pt was loaded on these CeO_2 supports by incipientwetness impregnation methods. The catalysts were characterized by N2 adsorption, X-ray diffraction(XRD), high-resolution transmission electron microscopy(HRTEM), H_2 temperature-programmed reduction(H_2-TPR), dynamic oxygen storage capacity(DOSC) and in-situ DRIFTS technologies. For S-f supports, the surfactant was added into the solution before spray-drying in the synthesis process, which facilitates more active oxygen formation on the surface of CeO_2. After loading Pt, the more active oxygen on CeO_2 contributes to dispersing Pt species and enhancing the CO oxidation activity. As for the aged samples,Pt-R-h shows the highest activity above 190 ℃ because of the presence of more partly oxidized Pt^(δ+) species. Thus the activity is also influenced by the states of Pt and the Pt^(δ+) species may contribute to the high activity at elevated temperature. | Anbin Zhou Jun Wang Hui Wang Hang Li Jianqiang Wang Meiqing Shen | 2018 | Journal of Rare Earths2018，36，3： | 16 |
| 9 | Pancreaticoduodenectomy for borderline resectable pancreatic head cancer with a modified artery-first approach technique显示文摘BACKGROUND: The treatment of borderline resectable pancreatic head cancer(BRPHC) is still controversial and challenging. The artery-first approaches are described to be the important options for the early determination. Whether these approaches can achieve an increase R0 rate, better bleeding control and increasing long-term survival for BRPHC are still controversial. We compared a previously reported technique, a modified artery-first approach(MAFA), with conventional techniques for the surgical treatment of BRPHC.METHODS: A total of 117 patients with BRPHC undergone pancreaticoduodenectomy(PD) from January 2013 to June 2015 were included. They were divided into an MAFA group(n=78) and a conventional-technique group(n=39). Background characteristics, operative data and complications were compared between the two groups.RESULTS: Mean operation time was significantly shorter in the MAFA group than that in the conventional-technique group(313 vs 384 min; P=0.014); mean volume of intraoperative blood loss was significantly lower in the MAFA group than that in the conventional-technique group(534 vs 756 m L; P=0.043); and mean rate of venous resection was significantly higher in the conventional-technique group than that in the MAFA group(61.5% vs 35.9%; P=0.014). Pathologic data, early mortality and morbidity were not different significantly between the two groups.CONCLUSIONS: MAFA is safe, simple, less time-consuming, less intraoperative blood loss and less venous resection, and therefore, may become a standard surgical approach to PD for BRPHC with the superior mesenteric vein-portal vein involvement but without superior mesenteric artery invasion. | Min Wang Hang Zhang Feng Zhu Feng Peng Xin Wang Ming Shen Ren-Yi Qin | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，2： | 8 |
| 10 | Association between Plasma Metal Levels and Diabetes Risk: a Case-control Study in China显示文摘Objective Many metals, some of which have been classified as environmental endocrine disruptors, are used extensively in everyday consumer products and are ubiquitous in our living environment. In the present study, we aimed to explore the associations between the prevalence risk of type 2 diabetes and plasma levels of 20 trace elements as well as those of heavy metals in a Han Chinese population. Methods We conducted a case-control study to investigate the associations between plasma concentrations of 20 metals and diabetes in Jiangsu province. A total of 122 newly diagnosed cases of type 2 diabetes and 429 matched controls were recruited from community physical examinations in Suzhou City of Jiangsu Province. Plasma metal levels were measured by inductively-coupled plasma mass spectrometry. Results After adjusting for confounders, plasma vanadium, chromium, manganese, copper, zinc, arsenic, selenium, strontium, palladium, cadmium, cesium, and barium were associated with diabetes risk(P < 0.05). The adjusted OR increased with increasing concentration of vanadium, manganese, copper, zinc, and cesium. Conclusion Many metals, including manganese, copper, zinc, arsenic, selenium, and cadmium in plasma, are associated with the morbidity of diabetes. Monitoring of environmental metal levels and further studies are urgently needed. | LI Xiu Ting YU Peng Fei GAO Yan GUO Wen Hui WANG Jun LIU Xin GU Ai Hua JI Gui Xiang DONG Qiu WANG Bo Shen CAO Ying ZHU Bao Li XIAO Hang | 2017 | Biomedical and Environmental Sciences2017，30，7： | 8 |
| 11 | Active manganese oxide on MnOx-CeO2 catalysts for low-temperature NO oxidation:Characterization and kinetics study显示文摘MnO_x-CeO_2 catalysts were synthesized to investigate the active sites for NO oxidation by varying the calcination temperature. XRD and TEM results showed that cubic CeO_2 and amorphous MnO_x existed in MnO_x-CeO_2 catalysts. High temperature calcination caused the sintering of amorphous MnO_x and transforming to bulk crystalline Mn_2O_3, H_2-TPR and XPS results suggested the valence of Mn in MnO_x-CeO_2 was higher than pure MnO_x, and decreased with the increasing calcination temperature, The turnover frequency(TOF) was calculated based on the initial reducibility according to H_2-TPR quantitation and kinetic study. The TOF results indicated that the initial reducibility of amorphous MnO_x with high valence manganese ions was equivalent to the active sites for NO oxidation. It can be inferred that the amorphous MnO_x plays a key role in low-temperature NO oxidation. | Lingkun Meng Jun Wang Zhihui Sun Jinxin Zhu Hang Li Jianqiang Wang Meiqing Shen | 2018 | Journal of Rare Earths2018，36，2： | 7 |
| 12 | Activation of mitogen-activated protein kinases in satellite glial cells of the trigeminal ganglion contributes to substance P-mediated inflammatory pain显示文摘Inflammatory orofacial pain,in which substance P (SP) plays an important role,is closely related to the cross-talk between trigeminal ganglion (TG) neurons and satellite glial cells (SGCs).SGC activation is emerging as the key mechanism underlying inflammatory pain through different signalling mechanisms,including glial fibrillary acidic protein (GFAP) activation,phosphorylation of mitogen-activated protein kinase (MAPK) signalling pathways,and cytokine upregulation.However,in the TG,the mechanism underlying SP-mediated orofacial pain generated by SGCs is largely unknown.In this study,we investigated whether SP is involved in inflammatory orofacial pain by upregulating interleukin (IL)-1β and tumour necrosis factor (TNF)-α from SGCs,and we explored whether MAPK signalling pathways mediate the pain process.In the present study,complete Freund’s adjuvant (CFA) was injected into the whisker pad of rats to induce an inflammatory model in vivo.SP was administered to SGC cultures in vitro to confirm the effect of SP.Facial expression analysis showed that pre-injection of L703,606 (an NK-1 receptor antagonist),U0126 (an inhibitor of MAPK/extracellular signal-regulated kinase [ERK] kinase [MEK] 1/2),and SB203580 (an inhibitor of P38) into the TG to induce targeted prevention of the activation of the NK-1 receptor and the phosphorylation of MAPKs significantly suppressed CFA-induced inflammatory allodynia.In addition,SP promoted SGC activation,which was proven by increased GFAP,p-MAPKs,IL-1β and TNF-α in SGCs under inflammatory conditions.Moreover,the increase in IL-1β and TNF-α was suppressed by L703,606,U0126 and SB203580 in vivo and in vitro.These present findings suggested that SP,released from TG neurons,activated SGCs through the ERK1/2 and P38 pathways and promoted the production of IL-1β and TNF-α from SGCs,contributing to inflammatory orofacial pain associated with peripheral sensitization. | Yanyan Zhang Ning Song Fei Liu Jiu Lin Mengke Liu Chaolan Huang Daqing Liao Cheng Zhou Hang Wang Jiefei Shen | 2019 | International Journal of Oral Science2019，11，3： | 6 |
| 13 | Association of gestational anemia with pregnancy conditions and outcomes: A nested case-control study显示文摘BACKGROUND Gestational anemia is a serious public health problem that affects pregnant women worldwide.Pregnancy conditions and outcomes might be associated with the presence of gestational anemia.This study investigated the association of pregnancy characteristics with anemia,exploring the potential etiology of the disease.AIM To assess the association of pregnancy parameters with gestational anemia.METHODS A nested case-control study was conducted based on the Chinese Pregnant Women Cohort Study-Peking Union Medical College Project(CPWCS-PUMC).A total of 3172 women were included.Patient characteristics and gestational anemia occurrence were extracted,and univariable and multivariable logistic regression models were used to analyze the association of pregnancy parameters with gestational anemia.RESULTS Among the 3172 women,14.0% were anemic,46.4% were 25-30 years of age,21.9%resided in eastern,15.7%in middle,12.4%in western 18.0% in southern and 32.0%in northern regions of China.Most women(65.0%)had a normal prepregnancy body mass index.Multivariable analysis found that the occurrence of gestational anemia was lower in the middle and western regions than that in the eastern region[odds ratio(OR)=0.406,95%confidence interval(CI):0.309-0.533,P<0.001],higher in the northern than in the southern region(OR=7.169,95% CI:5.139-10.003,P<0.001),lower in full-term than in premature births(OR=0.491,95% CI:0.316-0.763,P=0.002),and higher in cases with premature membrane rupture(OR=1.404,95% CI:1.051-1.876,P=0.02).CONCLUSION Gestational anemia continues to be a health problem in China,and geographical factors may contribute to the situation.Premature birth and premature membrane rupture may be associated with gestational anemia.Therefore,we should vigorously promote local policy reformation to adapt to the demographic characteristics of at-risk pregnant women,which would potentially reduce the occurrence of gestational anemia. | Yin Sun Zhong-Zhou Shen Fei-Ling Huang Yu Jiang Ya-Wen Wang Su-Han Zhang Shuai Ma Jun-Tao Liu Yong-Le Zhan Hang Lin Yun-Li Chen Ying-Jie Shi Liang-Kun Ma | 2021 | World Journal of Clinical Cases2021，9，27： | 5 |
| 14 | The combination of chidamide with the CHOEP regimen in previously untreated patients with peripheral T-cell lymphoma: a prospective, multicenter, single arm, phase 1b/2 study显示文摘Objective:To assess the efficacy and safety of the novel histone deacetylase inhibitor,chidamide,in combination with cyclophosphamide,doxorubicin,vincristine,etoposide,and prednisone(Chi-CHOEP)for untreated peripheral T-cell lymphoma(PTCL).Methods:A prospective,multicenter,single arm,phase 1 b/2 study was conducted.A total of 128 patients with untreated PTCL(18–70 years of age)were enrolled between March 2016 and November 2019,and treated with up to 6 cycles with the Chi-CHOEP regimen.In the phase 1 b study,3 dose levels of chidamide were evaluated and the primary endpoint was determination of the maximumtolerated dose and recommended phase 2 dose(RP2 D).The primary endpoint of the phase 2 study was 2-year progression-free survival(PFS).Results:Fifteen patients were enrolled in the phase 1 b study and the RP2 D for chidamide was determined to be 20 mg,twice a week.A total of 113 patients were treated at the RP2 D in the phase 2 study,and the overall response rate was 60.2%,with a complete response rate of 40.7%.At a median follow-up of 36 months,the median PFS was 10.7 months,with 1-,2-,and 3-year PFS rates of 49.9%,38.0%,and 32.8%,respectively.The Chi-CHOEP regimen was well-tolerated,with grade 3/4 neutropenia occurring in approximately two-thirds of the patients.No unexpected adverse events(AEs)were reported and the observed AEs were manageable.Conclusions:This large cohort phase 1 b/2 study showed that Chi-CHOEP was well-tolerated with modest efficacy in previously untreated PTCL patients. | Wei Zhang Liping Su Lihong Liu Yuhuan Gao Quanshun Wang Hang Su Yuhuan Song Huilai Zhang Jing Shen Hongmei Jing Shuye Wang Xinan Cen Hui Liu Aichun Liu Zengjun Li Jianmin Luo Jianxia He Jingwen Wang O.A.O’Connor Daobin Zhou | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 15 | The oncoprotein HBXIP promotes human breast cancer growth through down-regulating p53 via miR-18b/MDM2 and pAKT/MDM2 pathways显示文摘 | Hang Li Zhen Wang Mian Jiang Run-ping Fang Hui Shi Yu Shen Xiao-li Cai Qian Liu Kai Ye Sai-jun Fan Wei-ying Zhang Li-hong Ye | 2018 | Acta Pharmacologica Sinica2018，39，11： | 4 |
| 16 | Effect of calcium citrate on bone integration in a rabbit femur defect model显示文摘Objective:To explore effect of calcium citrate on bone integration in a rabbit femur defect model, and to compare the bone formation with different sizes by radiological and histological study. Methods:Twenty-four male Japanese white rabbits were randomly divided into three groups (Group A.B.C)in this study.Under anesthesia,defects of four sizes(1.2,1.5,2.0 and 2.5 mm) were created in each of the rabbits.Commercially pure calcium citrate powder was placed inside the medullary compartment of the femur(Experimental),while in the contralateral femur(Control) nothing was implanted.The defects were analyzed using radiography and histological analysis by using Imagepro-Plus 6.0 software after animal was sacrificed at 4th(Group A),6th(Group B) and 8th(Group C) weeks postoperatively.Four samples were analyzed for each size of defect and each healing period.Results:The histological and the radiologic evaluation were performed after sacrification of all rabbits on postoperative 4th and 6th weeks,It showed significant difference between the experimental group and the control group when these defects were less than or equal to 2.0 mm.No statistical difference was observed when these defects were larger than 2.0 mm at all healing periods except at the 4th week.Conclusions:Calcium citrate affects the early periods of hone defects healing mechanism in Japanese white rabbits positively,especially when the defect is not too large,We suggest further studies on calcium citrate to determine the effects of various dosages,administration ways and the experimental time on the bone defects. | Wei Zhang Wei Wang Qing-Yu Chen Zhong-Qin Lin Shao-Wen Cheng Dong-Quan Kou Xiao-Zhou Ying Yue Shen Xiao-Jie Cheng Peng-Fei Nie Xiu-Cui Li Ferdinand An Rompis Hang Huang Hua Zhang Zhong-Lin Mu Lei Peng | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 3 |
| 17 | Nitrous Oxide Emissions from a Masson Pine Forest Soil in Subtropical Central China显示文摘The forest ecosystem plays a pivotal role in contributing greenhouse gases to the atmosphere.In order to characterize the temporal pattern of nitrous oxide(N_2O) emissions and identify the key factors affecting N_2O emissions from a Masson pine forest in a hilly red-soil region in subtropical central China,we measured the N_2O emissions in Jinjing of Hunan Province using the static chambergas chromatographic method for 3 years(2010-2012) and analyzed the relationships between the N_2O fluxes and the environmental variables.Our results revealed that the N_2O fluxes over the 3 years varied from-36.0 to 296.7 μg N m^(-2) h^(-1),averaging 18.4±5.6 μg N m^(-2) h^(-1)(n=3).The average annual N_2O emissions were estimated to be 1.6±0.3 kg N ha^(-1) year^(-1).The N_2O fluxes exhibited clear intra-annual(seasonal) variations as they were higher in summers and lower in winters.Compared with other forest observations in the subtropics,N_2O emissions at our site were relatively high,possibly due to the high local dry/wet N deposition,and were mostly sensitive to variations in precipitation and soil ammonium N content.In this work,a multiple linear regression model was developed to determine the influence of environmental factors on N_2O emissions,in which a category predictor of 'Season' was intentionally used to account for the seasonal variation of the N_2O fluxes.Such a model explained almost 40%of the total variation in daily N_2O emissions from the Masson pine forest soil studied(P<0.001). | CHEN Dan FU Xiao-Qing WANG Cong LIU Xin-Liang LI Hang SHEN Jian-Lin WANG Yi LI Yong WU Jin-Shui | 2015 | Pedosphere2015，25，2： | 3 |
| 18 | Controlled fabrication and microwave absorbing mechanism of hollow Fe3O4@C microspheres显示文摘Uniform core-shell SiO2@Fe_3O_4@C microspheres were prepared by a one-step hydrothermal method with SiO_2 microspheres as the template, and the hollow Fe_3O_4@C(HFC) microspheres were achieved via etching SiO_2 template. By changing the sizes of SiO_2 microspheres, a series of HFC microspheres with variable cavity sizes were obtained to study the relationship between cavity size and microwave absorbing(MA) performance for the first time. The morphology and structure of samples were characterized in detail. The results showed that the MA performance of HFC sample depended on its cavity size. In particular, the hollow structure was good for improving MA performance and could make MA move to the high-frequency region. More importantly, as the cavity size increases, the resonance frequency of HFC-i(i=1,2, 3, 4) samples moved to a low frequency, and the optimal matching thickness of HFC-i samples was increasing. Among all HFC-i samples, HFC-3 showed the most excellent MA performance,which could be mainly explained by the quarter-wavelength matching model, intrinsical magnetic and dielectric loss. Furthermore,the MA performance of HFC mixture blended by the equal mass fraction of HFC-2, HFC-3 and HFC-4 was the comprehensive results of three HFC-i samples. All the above suggested that the cavity size in HFC sample had a great influence on the MA performance. | Yanhui Hou Huili Yuan Hang Chen Junhai Shen Liangchao Li | 2017 | Science China Chemistry2017，60，6： | 3 |
| 19 | New advances in the diagnosis of primary aldosteronism显示文摘Primary aldosteronism (PA) is a common form of endocrine hypertension. The diagnostic process of PA includes a screening test, confirmatory test, and subtype classification. In this review, we have summarized the latest advances in the diagnosis of PA with regard to screening and confirmatory tests and provided some recommendations to improve clinical practice. | Shen Hang Xu Zhi-Xin Li Qi-Fu | 2020 | Chronic Diseases and Translational Medicine2020，6，1： | 3 |
| 20 | Spinal CCL2 Promotes Pain Sensitization by Rapid Enhancement of NMDA-Induced Currents Through the ERK-GluN2B Pathway in Mouse Lamina Ⅱ Neurons显示文摘Previous studies have shown that CCL2(C-C motif chemokine ligand 2)induces chronic pain,but the exact mechanisms are still unknown.Here,we established models to explore the potential mechanisms.Behavioral experiments revealed that an antagonist of extracellular signal-regulated kinase(ERK)inhibited not only CCL2-induced inflammatory pain,but also pain responses induced by complete Freund’s adjuvant.We posed the question of the intracellular signaling cascade involved.Subsequent experiments showed that CCL2 up-regulated the expression of phosphorylated ERK(pERK)and N-methyl D-aspartate receptor[NMDAR]subtype 2B(GluN2B);meanwhile,antagonists of CCR2 and ERK effectively reversed these phenomena.Whole-cell patchclamp recordings revealed that CCL2 enhanced the NMDAR-induced currents via activating the pERK pathway,which was blocked by antagonists of GluN2B and ERK.In summary,we demonstrate that CCL2 directly interacts with CCR2 to enhance NMDAR-induced currents,eventually leading to inflammatory pain mainly through the CCL2-CCR2-pERK-GluN2B pathway. | Hui Zhang Sui-Bin Ma Yong-Jing Gao Jun-Ling Xing Hang Xian Zhen-Zhen Li Shu-Ning Shen Sheng-Xi Wu Ceng Luo Rou-Gang Xie | 2020 | Neuroscience Bulletin2020，36，11： | 3 |
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