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| 1 | Degradation of lipid droplets by chimeric autophagy-tethering compounds显示文摘Degrading pathogenic proteins by degrader technologies such as PROTACs(proteolysis-targeting chimeras)provides promising therapeutic strategies,but selective degradation of non-protein pathogenic biomolecules has been challenging. | Yuhua Fu Ningxie Chen Ziying Wang Shouqing Luo Yu Ding Boxun Lu | 2021 | Cell Research2021，31，9： | 5 |
| 2 | Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models显示文摘 | Meng Yu Yuhua Fu Yijian Liang Haikun Song Yao Yao Peng Wu Yuwei Yao Yuyin Pan Xue Wen Lixiang Ma Saiyin Hexige Yu Ding Shouqing Luo Boxun Lu | 2017 | Cell Research2017，27，12： | 5 |
| 3 | Auditory characteristics of noise-exposed memberscrossing age-related groups显示文摘Objective: To report audiological characteristics in a group of noise-exposed crew members on board ships.Methods and materials: Clinical and audiological measurements including pure-tone thresholds, acoustic immittance results and tinnitus questionnaires were collected from both the ship crew members(study subjects) and their land based colleagues(controls).Results: 1) Noise exposed crew members showed not only high frequency, but also low frequency hearing loss; 2) Hearing impairment increased with age, with 65.5% of crew members younger than 50 years showing normal hearing while only 14.9% of those older than 50 years had normal hearing; 3)hearing loss gradually increased with the extension of on board career time; and 4) Most study subjects reported high pitch tinnitus, significantly more than the control group although not significantly different among different age groups.Conclusion: Noise induced hearing impairment from working on board ships shows specific frequency and age characteristics. Understanding these characteristics is important for advancing relevant studies and for effective prevention of noise-induced hearing loss in ship crew members. | Liu Chenqing Ding Daxiong Zhu Yuhua Wang Hongyang Cheng Xiaoting Zhao Zhenhua Cao Juyang Zhai Suoqiang Yu Ning | 2018 | Journal of Otology2018，13，2： | 3 |
| 4 | Superhydro phobic fabrics from hybrid silica sol-gel coatings: struc rural effect of precursors on wettability and washing du rability显示文摘 | Hongxia Wang Jie Ding Yuhua Xue | 2010 | J ournal of Materials Research2010，25，7： | 1 |
| 5 | Co-metabolic degradation of bensulfuron-methyl in laboratory condi- tions显示文摘 | Wei Luo Yuhua Zhao Haitao Ding | 2008 | Journal of Hazardous Materials2008，158，： | 1 |
| 6 | Effect of Helicobacter pylori on cyclooxygenase-2 and inducible nitricoxide synthase in patients with gastric precancerous lesions and its clinicalsignificance显示文摘 | Hui Zhang Chunsheng Ding Zhimin Suo Yuhua Kang | 2015 | Experimental and Therapeutic Medicine2015，，6： | 1 |
| 7 | Rapid determination of water- and fat-soluble vitamins with microemulsion electrokinetic chromatography显示文摘 | YIN Changna CAO Yuhua DING Shaodong | 2008 | J Chromatogr: A2008，1193，12： | 1 |
| 8 | Factors Affecting Transformation Temperatures in Fe-Mn-Si-Cr-Ni Shape Memory Alloy显示文摘The effects of prestrain and annealing temperature on phase transformation temperatures in Fe14Mn5Si8Cr4Ni shape memory alloy have been Studied. The results showed that when the annealing temperature was 673 K, both the Af and the Ms temperatures increased appreciably as the prestrain increased, the A. temperature increased slightly with increasing prestrain; the resistivity difference at 303 K between the heating and cooling curve also increased with increasing prestrain, which agreed with the recovery strain. The shape memory effect in Fe-Mn-Si-Cr-Ni shape memory alloy is caused by the stress-inducedγ→ε martensite transformation and its reverse transformation. When the prestrain was 10%, the Ms temperature decreased remarkably as the annealing temperature increased. | Yuhua WEN+, ding LI and Mingjing TU (Department of Materials Shaping and Controlling Engineering, Sichuan University, Chengdu 610065, China) | 2000 | Journal of Materials Science & Technology2000，16，5： | 1 |
| 9 | Reversal of diabetes in mice by intrahepatic injection of bone-derived GFP-mu- rine mesenchymal stem cells infected with the recombinant retrovirus-carrying human insulin gene显示文摘 | Xu Jian Lu Yuhua Ding Fei | 2007 | World J Surg2007，31，9： | 1 |
| 10 | Crystal structure and optical performance analysis of a new type of persistent luminescence material with multi-functional application prospects显示文摘Persistent luminescence (PersL) materials,as environmentally friendly and energy-saving materials,have broad application prospects in many fields such as lighting,chemistry and even biomedicine.However,studies on the types,performances and mechanism of PersL materials are still insufficient,which significantly restricts their development and application.Under this consideration,we successfully synthesized a yellow PersL material CaSrGa_(4)O_(8)(CSG).The crystal structure was studied in detail through Rotation Electron Diffraction (RED) and Powder X-ray Diffraction (PXRD).What’s more,by co-doping Mn^(2+) and Yb^(3+),the afterglow brightness of CSG could be increased by nearly 20 times,and the afterglow duration could reach more than 6 h.It is worth mentioning that the samples also have excellent performances in mechanical luminescence (ML),photostimulated luminescence (PSL) and cathodoluminescence (CL),which was also investigated systematically.Finally,an anti-counterfeiting label was designed by the samples to reveal the potential of their application in anti-counterfeiting.The results showed that our research not only provided a new candidate PersL material for multifunctional applications,but also gave good help for studying the physical and chemical properties of CSG. | Songsong Ding Pohua Chen Haijie Guo Peng Feng Yunpeng Zhou Yuhua Wang Junliang Sun | 2022 | Journal of Energy Chemistry2022，31，6： | 1 |
| 11 | Theory and Application of Multi-robot Service-oriented Architecture显示文摘In order to solve the problem of heterogeneity in multi-robot cooperation, a new service-oriented architecture is proposed for multi-robot cooperation. Service provision and energy consumption are the basic cooperative behaviors. A set of basic concepts of robot service are proposed. A layered multi-robot service-oriented architecture is designed. Finally, the experiments illustrate the superiority of the proposed architecture which makes robot's underlying functional components be transparently encapsulated and the services in upper layer be transparently invoked, which will effectively avoid the impact of heterogeneous characteristics in multi-robot cooperation and facilitate the system construction, expansion, restructuring and maintenance. | Yunfei Cai Zhenmin Tang Yuhua Ding Bin Qian | 2016 | IEEE/CAA Journal of Automatica Sinica2016，3，1： | 1 |
| 12 | Mapping of de novo mutations in primary biliary cholangitis to a disease-specific co-expression network underlying homeostasis and metabolism显示文摘Primary biliary cholangitis(PBC) is an autoimmune disease involving dysregulation of a broad array of homeostatic and metabolic processes. Although considerable single-nucleotide polymorphisms have been unveiled, a large fraction of risk factors remains enigmatic. Candidate genes with rare mutations that tend to confer more deleterious effects need to be identified. To help pinpoint cellular and developmental mechanisms beyond common noncoding variants, we integrate whole exome sequencing with integrative network analysis to investigate genes harboring de novo mutations. Prominent convergence has been revealed on a network of disease-specific co-expression comprised of 55 genes associated with homeostasis and metabolism. The transcription factor gene MEF2 D and the DNA repair gene PARP2 are highlighted as hub genes and identified to be up-and down-regulated, respectively, in peripheral blood data set. Enrichment analysis demonstrates that altered expression of MEF2 D and PARP2 may trigger a series of molecular and cellular processes with pivotal roles in PBC pathophysiology. Our study identifies genes with de novo mutations in PBC and suggests that a subset of genes in homeostasis and metabolism tend to act in synergy through converging on co-expression network, providing novel insights into the etiology of PBC and expanding the pool of molecular candidates for discovering clinically actionable biomarkers. | Lu Wang Jinchen Li Chan Wang Ruqi Tang Jialong Liang Yuhua Gong Yaping Dai Ningling Ding Jian Wu Na Dai Lei Liu Yi Zhao Youlin Shao Weifeng Zhao Peng Jiang Xingjuan Shi Weichang Chen Ye Tian Xiangdong Liu Xiong Ma Zhongsheng Sun | 2022 | Journal of Genetics and Genomics2022，49，2： | 1 |
| 13 | Identification of differentially expressed genes in leaf and root between wheat hybrid and its parental inbreds using PCR-based cDNA subtraction显示文摘 | Yingyin Yao Zhongfu Ni Yinhong Zhang Yan Chen Yuhua Ding Zongfu Han Zhiyong Liu Qixin Sun | 2005 | Plant Molecular Biology2005，，3： | 1 |
| 14 | The improved radial basis function neural network and its application 显示文摘 | Wang Xudong Ding Yuhua Shao Huihe | 1998 | ArtifLife Robotics1998，2，： | 1 |
| 15 | Artemin对胰腺癌细胞系MIA PaCa-2浸润能力的研究(英文)显示文摘Objective:The aim of this study was to analyze the capacity of Artemin promoting the motility and invasiveness of MIA PaCa-2 pancreatic cancer (PAC) cells.Methods:The PAC cell line MIA PaCa-2 was cultured in vitro and studied using Transwell chamber analysis.The motility and invasiveness ability affected by different concentrations of Artemin and its receptor GFRα3 were determined.Expression level of matrix metalloproteinase-2 (MMP-2),epithelial cadherin (E-cadherin) were quantitative analysis using RT-PCR and Western blot in MIA PaCa-2 cells stimulated with Artemin and receptor GFRα3.Results:MIA PaCa-2 PAC cell motility and invasiveness was significantly increased with Artemin and its receptor GFRα3 increasing concentrations than control (P<0.01).150 ng/mL was the best of both the role of concentration.MMP-2 was increased significantly (t=6.35,t=7.32),while E-cadherin was significantly lower (t=4.27,t=5.61),after affected by the 150 ng/mL Artemin and GFRα3,respectively.The difference was statistically significant compared with the control group (P<0.01).Conclusion:Artemin and its receptor GFRα3 can promote PAC cell motility and invasiveness ability and contribute to the aggressive behavior.The mechanism may be related to increased expression of MMP-2 molecule and E-cadherin down-regulation expression. | Lingxin Meng Yuhua Chi Xiangxu Wang Zhaojun Ding Ling Mou Wen Cui Yingjie Xue | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，4： | 0 |
| 16 | A 1.8-V 240-MHz 2.19-mW Four-Stage CMOS OTA with a Segmenting Frequency Compensation Technique显示文摘A four-stage Operational transconductance amplifier(OTA)used in an infrared temperature sensor adopting the proposed Feed-forward Gm-stage and segmenting nested Miller compensation technique is presented.The purpose of the proposed segment compensation is primarily to make more amplifier stages concatenated.The circuit linked several transconductance stages to form a segment,and linked several segments to form a large multistage amplifier.For example,a twostage amplifier linked with a three-stage amplifier can realize a five-stage amplifier,two three-stage amplifiers linked can realize a six-stage amplifier.A four-stage amplifier in the form of 2+2(two stages and two stages)was used as an example to verify this compensation method.The proposed OTA is designed in the 180 nm complementary metal oxide semiconductor process.It consists of two parts which ensure the stability and improve the bandwidth performance.The first part is a feedforward transconductance stage,and the second part is the two-segment transconductance stages with the Miller compensation techniques employed within and between the two segments.Based on the small-signal model,stability analysis and theoretical derivation are performed in theory.On condition of a 2-pF load capacitance,a direct current gain of 109 dB and a gain-bandwidth of 240 MHz with a phase margin of 50°can be achieved.The proposed design consumes 2.19 mW in a 1.8-V supply voltage.The transient simulation indicates that the settling time of the output is 19 ns with the settling error being 1%,and the slew rate is 114 V/μs. | LIANG Yuhua ZHENG Zirui LIU Shubin LI Dengquan DING Ruixue ZHU Zhangming | 2021 | Chinese Journal of Electronics2021，30，5： | 0 |
| 17 | Abnormal expression of inducible nitric oxide synthase in Duchenne muscular dystrophy muscles显示文摘Duchenne muscular dystrophy (DMD) is a fatal genetic disease for the youth and children. 8 biopsies of DMD patients were determined and demonstrated that the membrane_binding nitric oxide synthase was enriched in normal skeletal muscles and was little in DMD muscles. The results from Western blot and immunohistochemistry showed that inducible nitric oxide synthase (iNOS) was overexpressed in DMD muscle fibers, while a small amount of highly localized iNOS can be found in normal fibers. Based on these findings, it is proposed that the mechanism of progressive injury in DMD muscle might be associated with the abnormal expression of iNOS. | Minsheng Zhu Yuhua Fan Xiangyu Xu Gang Wang Yue Shen Ying Pan Shubiao Ding | 1998 | Chinese Science Bulletin1998，43，10： | 0 |
| 18 | Image compression algorithm of floral canopy based on mask hybrid coding for ROI显示文摘To achieve high-quality image compression of a floral canopy,a region of interest(ROI)mask of the wavelet domain was generated through the automatic identification of the canopy ROI and lifting the bit-plane of the ROI to obtain priority of coding for the ROI-set partitioning in hierarchical trees(ROI-SPIHT)coding.The embedded zerotree wavelet(EZW)coding was conducted for the background(BG)region of the image and a relatively more low-frequency wavelet coefficient was obtained using a relatively small amount of coding.Through the weighing factor r of the ROI coding amount,the proportion of the ROI and BG coding amount was dynamically adjusted to generate embedded,truncatable bit streams.Despite the location of truncation,the image information and ROI mask information required by the decoder can be guaranteed to achieve high-quality compression and reconstruction of the image ROI.The results indicated that under the same bit rate,the larger the r value is,the larger the peak-signal-to-noise ratio(PSNR)for the ROI reconstructed image and the smaller the PSNR for the BG reconstructed image.In the range of 0.07-1.09 bpp,the PSNR of the ROI reconstructed image was 42.65%higher on average than that of the BG reconstructed image,43.95%higher on average than that of the composite image of the ROI and BG(ALL),and 16.84%higher on average than that of the standard SPIHT reconstructed image.Additionally,the mean square error of the quality evaluation index and similarity for the ROI reconstructed image were both better than those for the BG,ALL,and standard SPIHT reconstructed images.The texture distortion of the ALL image was smaller than that of the SPIHT reconstructed image,indicating that the image compression algorithm based on the mask hybrid coding for ROI(ROI-MHC)is capable of improving the reconstruction quality of an ROI image.When the weighing factor r is a fixed value,as the proportion of ROI(a)increases,the quality of ROI image reconstruction gradually decreases.Therefore,upon the application of the ROI-MHC image compression algorithm,high-quality reconstruction of the ROI image can be achieved through dynamically configuring r according to a.Under the same bit rate,the quality of the ROI-MHC image compression is higher than that of current compression algorithms of same classes and offers promising application opportunities. | Sun Guoxiang Wang Xiaochan Ding Yongqian Li Yuhua Zhang Baohua Li Yongbo Zhang Yu | 2017 | International Journal of Agricultural and Biological Engineering2017，10，5： | 0 |
| 19 | AlScN films prepared by alloy targets and SAW device characteristics显示文摘In this paper,we reported a surface acoustic wave(SAW)device prepared and optimized by piezoelectric films containing AIN,AIScN(Sc-20 at%)and AIScN(Sc-30 at%)by reactive magnetron sputtering using Al and AISc alloy targets.We calculated the material intrinsic electromechanical coupling coefficient k_(t)^(2) of AlScN(Sc-20 at%)and AlScN(Sc-30 at%)which are much better than AIN.It can be explained by the lattice softening.Furtherly,the results were confirmed by transmission electron microscopy(TEM)observation of the microstructure.Then the SAW devices based on three thin films were tested by vector network analysis obtaining the device equivalent electro mechanical coupling coefficient k_(eff)^(2).The value of AIScN(Sc-20 at%)k_(eff)^(2),which equals to 1.94%,is higher than that of AIN and AIScN(Sc-30 at%)while the value of AIScN(Sc-30 at%)k_(t)^(2) is higher than that of others.It is shown in our study that the crystallinity and orientation of the material still have a greater impact on k_(eff)^(2) but it does not have influence on k_(t)^(2) in the actual device preparation process. | Kuo Men Hao Liu Xingquan Wang Qian Jia Zhaochong Ding Huating Wu Daogao Wu Yuhua Xiong | 2023 | Journal of Rare Earths2023，41，3： | 0 |
| 20 | Self-assembled multiepitope nanovaccine based on NoV P particles induces effective and lasting protection against H3N2 influenza virus显示文摘Current seasonal influenza vaccines confer only limited coverage of virus strains due to the frequent genetic and antigenic variability of influenza virus(IV).Epitope vaccines that accurately target conserved domains provide a promising approach to increase the breadth of protection;however,poor immunogenicity greatly hinders their application.The protruding(P)domain of the norovirus(NoV),which can self-assemble into a 24-mer particle called the NoV P particle,offers an ideal antigen presentation platform.In this study,a multiepitope nanovaccine displaying influenza epitopes(HMN-PP)was constructed based on the NoV P particle nanoplatform.Large amounts of HMN-PP were easily expressed in Escherichia coli in soluble form.Animal experiments showed that the adjuvanted HMN-PP nanovaccine induced epitope-specific antibodies and haemagglutinin(HA)-specific neutralizing antibodies,the antibodies could persist for at least three months after the last immunization.Furthermore,HMN-PP induced matrix protein 2 extracellular domain(M2e)-specific antibody-dependent cell-mediated cytotoxicity,CD4^(+)and CD8^(+)T-cell responses,a nucleoprotein(NP)-specific cytotoxic T lymphocyte(CTL)response.These results indicated that the combination of a multiepitope vaccine and self-assembled NoV P particles may be an ideal and effective vaccine strategy for highly variable viruses such as IV and SARS-CoV-2. | Jiaojiao Nie Qingyu Wang Shenghui Jin Xin Yao Lipeng Xu Yaotian Chang Fan Ding Zeyu Li Lulu Sun Yuhua Shi Yaming Shan | 2023 | Nano Research2023，16，5： | 0 |
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