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| 1 | Multimodality treatment in hepatocellular carcinoma patients with tumor thrombi in portal vein显示文摘AIM To compare the therapeutic effect andsignificances of multimodality treatment forhepatocellular carcinoma (HCC) with tumorthrombi in portal vein (PVTT).METHODS HCC patients (n = 147) with tumortrombi in the main portal vein or the first branchof portal vein were divided into four groups bythe several therapeutic methods. There wereconservative treatment group in 18 out ofpatients (group A); and hepatic artery ligation(HAL) and/or hepatic artery infusion (HAl)group in 18 patients (group B), in whompostoberative chemoembolization was doneperiodically; group of removal of HCC with PVTTin 79 (group C) and group of transcatheterhepatic arterial chemoembolization (TACE) orHAl and/or portal vein infusion (PVI) afteroperation in 32 (group D).RESULTS The median survival period was 12months in our series and the 1-, 3-, and 5-yearsurvival rates were 44.3%, 24.5% and 15.2%,respectively. The median survival times were 2,5, 12 and 16 months in group A, B, C and D,respectively. The 1-, 3- and 5-year survival rateswere 5.6%, 0% and 0% in group A; 22.2%,5.6% and 0% in group B; 53.9%, 26.9% and16.6% in group C; 79.3%, 38.9% and 26.8% ingroup D, respectively. Significant differenceappeared in the survival rates among the groups(P<0.05).CONCLUSION Hepatic resection with removalof tumor thrombi and HCC should increase thecurative effects and be encouraged for theprolongation of life span and quality of life forHCC patients with PVTT, whereas the besttherapeutic method for HCC with PVTT is withregional hepatic chemotherapy orchemoemblization after hepatic resection withremoval of tumor thrombi. | Jia Fan Zhi Quan Wu Zhao You Tang Jian Zhou Shuang Jian Qiu Zeng Chen Ma Xin Da Zhou Sheng Long Ye Liver Cancer Institute, Zhongshan Hospital, Fudan University Medical Center (Former Shanghai University), 136 Yixueyuan Road, Shanghai 200032, China | 2001 | World Journal of Gastroenterology2001，7，1： | 80 |
| 2 | Soil Heavy Metal Pollution Around the Dabaoshan Mine,Guangdong Province,China显示文摘在 Dabaoshan 矿的附近的土壤污染,广东省,中国,通过全部的集中的决心和有毒的金属, Cu, Zn, Cd,和 Pb 的化学种形成被学习,用诱导地联合的血浆质谱法。结果证明在过去的十年,公害被 Cu, Zn, Cd,和 Pb 的联合引起,与跟踪和是的酸矿排水影响土壤的主要污染来源。显著地高级(P ≤ 0.05 ) 作为与稻,花园,和控制土壤相比在跟踪 Cu, Zn, Cd,和 Pb 被发现,与一般水准 1 486, 2 516, 6.42,和 429 mg kg ? 1 分别地。这些金属连续地从跟踪和废水下游地被驱散,并且因此他们在水稻土的集中象 567 一样高, 1 140 , 2.48 ,和 191 mg kg ? 1 ,分别地显著地更高( P ≤ 0.05 )作为与那些相比在花园土壤。从所有土壤类形的上述金属的顺序的抽取的结果证明剩余部分是主导的形式。然而, Fe-Mn 氧化物和有机物一定的金属的数量比那些跳到在可交换的形式存在的碳酸盐或那些相对高。当金属能从一个惰性的状态被转变到一个活跃状态,潜在的环境风险将与时间由于这些金属增加。 | ZHOU Jian-Min DANG Zhi CAI Mei-Fang LIU Cong-Qiang | 2007 | Pedosphere2007，17，5： | 66 |
| 3 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 4 | Mantle xenoliths from Late Cretaceous basalt in eastern Shandong Province: New constraint on the timing of lithospheric thinning in eastern China显示文摘The age of the alkali basalt from Daxizhuang in Jiaozhou, eastern Shandong, was determined to be 73.5±0.3 Ma by 40Ar-39Ar technique. The basalt gave high eNd(t) values of +7.5 and +7.6, suggesting that the primitive magma was derived from depleted asthenospheric mantle with a formation depth of about 65—95 km. Spinel-lherzolite xenoliths have been discovered in the basalt. The Fo values of olivine from the xenoliths range from 88 to 89. The estimated equilibrium P-T conditions of spinel-lherzolite xenoliths are about 2.0 GPa and 1010—1140℃, suggesting an equilibrium depth of about 65 km. Geochemical characteristics of the Late Mesozoic (125—115 Ma) mantle-derived rocks in Shandong Province suggest an enriched lithospheric mantle along the southern margin of the North China block. However, geochemical characteristics of the Late Cretaceous basalts in Daxizhuang and the equilibrium P-T condition estimated from the xenoliths suggest that the lithosphere at 73 Ma ago was as thick as that of the Cenozoic in the region. Additionally, the xenoliths are rich in basaltic-component, suggesting a derivation from a newly-formed lithosphere. Therefor, lithospheric thinning took place at a time interval between about 120 and 73 Ma along the southern margin of the North China block. | YAN Jun, CHEN Jiangfeng, XIE Zhi & ZHOU Taixi School of Earth and Space Sciences, University of Science and Technology of China, Hefei 230026, China | 2003 | Chinese Science Bulletin2003，48，19： | 59 |
| 5 | Review of Key Problems Related to Integrated Energy Distribution Systems显示文摘Integrated energy distribution system(IEDS)is one of the integrated energy and power system forms,which involves electricity/gas/cold/heat and other various energy forms.The energy coupling relationship is close and complex.IEDS is the focus of regional energy internet research and development at home and abroad.Compared with the traditional power distribution system,IEDS through the multi-energy coupling link comprehensive utilization,effectively improve the distribution system economy,safety,reliability,flexibility and toughness,but also to ease the regional energy system environmental pressure.IEDS is an important direction for the future development of energy systems,and its related research and practice on China’s energy system development also has important practical and strategic significance.This paper summarizes the related researches of the IEDS and explores the energy operation characteristics and coupling mechanisms.What’s more,the integrated model of IEDS is summarized.On these bases,this paper discusses and prospects some key issues such as joint planning,optimization control and security analysis,state estimation and situational awareness and generalized demand side management. | Dan Wang Liu Liu Hongjie Jia Weiliang Wang Yunqiang Zhi Zhengji Meng Bingyu Zhou | 2018 | CSEE Journal of Power and Energy Systems2018，4，2： | 43 |
| 6 | Ability of Agrogyron elongatum to accumulate the single metal of cadmium, copper, nickel and lead and root exudation of organic acids显示文摘Agrogyron elongatum were grown in nutrient solution containing moderate to high amounts of separate heavy metal of Cd, Cu, Ni and Pb in a greenhouse for a 9-day. Cd, Cu, Ni and Pb generally led to decrease in the elongation of roots although the length of seedlings exposed to Cd and Pb at 0.05 and 0 5 mg/L showed to be slightly greater than that of controls. Of the four metals in the experiment, Pb was absorbed and accumulated to the highest level, with the concentrations of 92754 mg/kg dry weight (DW) in roots and 11683 mg/kg DW in shoots. Cd was moderately accumulated in Agrogyron elongatum, but the maximum bioaccumulation coefficients (BCs) for roots and shoots were observed. The patterns for Cu and Ni uptake and distribution in plants differed from those of Pb and Cd, as it was showed that the shoot accumulation of Cu and Ni was significantly higher than in roots. A. elongatum had the highest Ni concentration in shoots (30261 mg/kg DW) at the external concentration of 250 mg/L. Cu ranked second, with a shoot concentration of 12230 mg/kg DW when 50 mg/L Cu in solution was applied. For the four trace elements tested, the highest concentrations in shoots decreased by the order of Ni>Cu>Pb>Cd (mg/kg DW), and those in roots were Pb>Cd>Ni>Cu (mg/kg DW). Malic, oxalic and citric acids exuded by roots exposed to 1 and 50 mg/L of the metals were detected. Release of organic acids from plants significantly differed among the metal treatments. Cu was most effectively in inducing root exudation of the three types of organic acids. Cd, and Ni were also the inducers of secretion of malic and oxalic acids. With reference of Pb, a small amounts of malic and oxalic acids were detected in the root exudates, but few quantities of citric acid were found. However, no correlation between alternations in root exudation of organic acids and metal accumulation could be established. | YANG Hong 1, Jongathan W.C.Wong 2, YANG Zhi min\+1, ZHOU Li xiang 1(1. College of Science, Nanjing Agricultural University, Nanjing\ 210095, China. 2. Department of Biology, Hong Kong Baptist University, China) | 2001 | Journal of Environmental Sciences2001，13，3： | 26 |
| 7 | Single-incision vs three-port laparoscopic cholecystectomy:Prospective randomized study显示文摘AIM:To compare the clinical outcome of single-inci-sion laparoscopic cholecystectomy(SILC)with threeport laparoscopic cholecystectomy(TPLC). METHODS:Between 2009 and 2011,one hundred and two patients with symptomatic benign gallbladder diseases were randomized to SILC(n=49)or TPLC (n=53).The primary end point was post operative pain score(at 6 h and 7 d).Secondary end points were blood loss,operation duration,overall complications,postoperative analgesic requirements,length of hospital stay,cosmetic result and total cost.Surgical techniques were standardized and all operations were performed by one experienced surgeon,who had performed more than 500 laparoscopic cholecystectomies. RESULTS:One patient in the SILC group required conversion to two-port LC.There were no open conversions or major complications in either treatment groups.There were no differences in terms of esti-mated blood loss(mean±SD,14±6.0 mL vs 15±4.0 mL),operation duration(mean±SD,41.8±17.0 min vs 38.5±22.0 min),port-site complications(contusion at incision:5 cases vs 4 cases and hematoma at inci- sion:2 cases vs 1 case),total cost(mean±SD,12 075 ±1047 RMB vs 11 982±1153 RMB)and hospital stay (mean±SD,1.0±0.5 d vs 1.0±0.2 d),respectively. TPLC had a significantly worse visual analogue pain score at 8 h after surgery(mean±SD,3.5±1.6 vs 2.0 ±1.5),however,the scores were similar on day 7(mean ±SD,2.5±1.4 vs 2.0±1.3).Cosmetic satisfaction, as determined by a survey at 2 mo follow-up favored SILC(mean±SD,8±0.4 vs 6±0.2). CONCLUSION:SILC is a safe and feasible approach in selected patients.The main advantages are a better cosmetic result and less pain. | Ming-Xin Pan Ze-Sheng Jiang Yuan Cheng Xiao-Ping Xu Zhi Zhang Jia-Sheng Qin Guo-Lin He Ting-Cheng Xu Chen-Jie Zhou Hai-Yan Liu Yi Gao | 2013 | World Journal of Gastroenterology2013，19，3： | 24 |
| 8 | Deep Learning and Its Applications in Biomedicine显示文摘Advances in biological and medical technologies have been providing us explosive volumes of biological and physiological data,such as medical images,electroencephalography,genomic and protein sequences.Learning from these data facilitates the understanding of human health and disease.Developed from arti?cial neural networks,deep learning-based algorithms show great promise in extracting features and learning patterns from complex data.The aim of this paper is to provide an overview of deep learning techniques and some of the state-of-the-art applications in the biomedical?eld.We?rst introduce the development of arti?cial neural network and deep learning.We then describe two main components of deep learning,i.e.,deep learning architectures and model optimization.Subsequently,some examples are demonstrated for deep learningapplications,including medical image classi?cation,genomic sequence analysis,as well as protein structure classi?cation and prediction.Finally,we offer our perspectives for the future directions in the?eld of deep learning. | Chensi Cao Feng Liu Hai Tan Deshou Song Wenjie Shu Weizhong Li Yiming Zhou Xiaochen Bo Zhi Xie | 2018 | Genomics, Proteomics & Bioinformatics2018，16，1： | 22 |
| 9 | 3D printing of bone tissue engineering scaffolds显示文摘Tissue engineering is promising in realizing successful treatments of human body tissue loss that current methods cannot treat well or achieve satisfactory clinical outcomes.In scaffold-based bone tissue engineering,a high performance scaffold underpins the success of a bone tissue engineering strategy and a major direction in the field is to produce bone tissue engineering scaffolds with desirable shape,structural,physical,chemical and biological features for enhanced biological performance and for regenerating complex bone tissues.Three-dimensional(3D)printing can produce customized scaffolds that are highly desirable for bone tissue engineering.The enormous interest in 3D printing and 3D printed objects by the science,engineering and medical communities has led to various developments of the 3D printing technology and wide investigations of 3D printed products in many industries,including biomedical engineering,over the past decade.It is now possible to create novel bone tissue engineering scaffolds with customized shape,architecture,favorable macro-micro structure,wettability,mechanical strength and cellular responses.This article provides a concise review of recent advances in the R&D of 3D printing of bone tissue engineering scaffolds.It also presents our philosophy and research in the designing and fabrication of bone tissue engineering scaffolds through 3D printing. | Chong Wang Wei Huang Yu Zhou Libing He Zhi He Ziling Chen Xiao He Shuo Tian Jiaming Liao Bingheng Lu Yen Wei Min Wang | 2020 | Bioactive Materials2020，5，1： | 20 |
| 10 | 污水中抗生素抗性菌及抗性基因的去除技术显示文摘环境中抗性细菌(ARB)及抗性基因(ARG)的污染严重威胁着人类的健康与生态安全,而城镇污水是抗性菌和抗性基因主要的'汇'和'源',常规的污水处理工艺并不能有效去除抗性菌和抗性基因,因此寻求高效的抗性菌和抗性基因的去除技术是控制环境中抗性基因的污染与传播的重要途径。通过综述近年污水中抗性菌及抗性基因去除技术的研究进展,可为完善污水厂现有的处理工艺以及研发高效的抗性菌及抗性基因的去除技术提供一定的思路。污水中抗生素抗性菌及抗性基因控制技术主要包括生物处理工艺、消毒工艺及高级氧化处理技术等。污水厂的生物处理工艺对抗性菌和抗性基因的消除具有一定的作用,但是污泥中富集了大量的抗性菌和抗性基因,直接排放或再利用将产生二次污染。氯消毒、紫外消毒和臭氧消毒工艺对抗性菌的去除效果很好,但只有在很高剂量时才对抗性基因产生显著的去除作用。同时,生物处理和消毒工艺都会增加抗性基因传播的风险。高级氧化处理技术,包括TiO2光催化、UV/H2O2、Fenton等不仅能高效去除抗性菌和抗性基因,而且能有效控制抗性基因的传播,将是今后发展与应用的重要方向。今后仍需深入研究生物处理工艺中污泥的有效处置以及水力、水质参数对抗性基因转移的影响与机制;开发组合型的消毒工艺;研究TiO2的固定化工艺、电化学高级氧化、硫酸根自由基氧化等技术以及多工艺的联合处理技术,以高效去除抗性菌和抗性基因,同时尽可能地减少抗性基因的传播。 | 陈蕾 George (Zhi) ZHOU | 2018 | 生态环境学报2018，27，11： | 19 |
| 11 | Effects of plant species coexistence on soil enzyme activities and soil microbial community structure under Cd and Pb combined pollution显示文摘The relationship between plant species coexistence and soil microbial communities under heavy metal pollution has attracted much attention in ecology.However,whether plant species coexistence could offset the impacts of heavy metal combined pollution on soil microbial community structure and soil enzymes activities is not well studied.The modified ecological dose model and PCR-RAPD method were used to assess the effects of two plant species coexistence on soil microbial community and enzymes activities subjected to Cd and Pb combined stress.The results indicated that monoculture and mixed culture would increased microbe populations under Cd and Pb combined stress,and the order of sensitivity of microbial community responding to heavy metal stress was:actinomycetes > bacteria > fungi.The respirations were significantly higher in planted soil than that in unplanted soil.The plant species coexistence could enhance soil enzyme activities under Cd and Pb combined.Furthermore,planted soil would be helpful to enhance soil genetic polymorphisms,but Cd and Pb pollution would cause a decrease on soil genetic polymorphisms.Mixed culture would increase the ecological dose 50%(ED50) values,and the ED50 values for soil enzyme activities decreased with increasing culture time.The dehydrogenase was most sensitive to metal addition and easily loses activity under low dose of heavy metal.However,it was difficult to fully inhibit the phoshpatase activity,and urease responded similarly with phosphatase. | Yang Gao Pei Zhou Liang Mao Yueer Zhi Chunhua Zhang Wanjun Shi | 2010 | Journal of Environmental Sciences2010，22，7： | 19 |
| 12 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 13 | Simultaneous changes in seed size, oil content and protein content driven by selection of SM/EEIhomologues during soybean domestication显示文摘Soybean accounts for more than half of the global production of oilseed and more than a quarter of the protein used globally for human food and animal feed.Soybean domestication involved parallel increases in seed size and oil content,and a concomitant decrease in protein content.However,science has not yet discovered whether these effects were due to selective pressure on a single gene or multiple genes.Here,re-sequencing data from>800 genotypes revealed a strong selection during soybean domestication on GmSWEETlOa.The selection of GmSWEETlOa conferred simultaneous increases in soybean-seed size and oil content as well as a reduction in the protein content.The result was validated using both near-isogenic lines carrying substitution of haplotype chromosomal segments and transgenic soybeans.Moreover,GmSWEETlOb was found to be functionally redundant with its homologue GmSWEETlOa and to be undergoing selection in current breeding,leading the the elite allele GrnSWEETlOb,a potential target for present-day soybean breeding.Both GmSWEETlOa and GmSWEETlOb were shown to transport sucrose and hexose,contributing to sugar allocation from seed coat to embryo,which consequently determines oil and protein contents and seed size in soybean.We conclude that past selection of optimal GmSWEETlOa alleles drove the initial domestication of multiple soybean-seed traits and that targeted selection of the elite allele GmSWEETlOb may further improve the yield and seed quality of modern soybean cultivars. | Shoudong Wang Shulin Liu Jie Wang Kengo Yokosho Bin Zhou Ya-Chi Yu Zhi Liu Wolf BFrommer Jian Feng Ma Li-Qing Chen Yuefeng Guan Huixia Shou Zhixi Tian | 2020 | National Science Review2020，7，11： | 17 |
| 14 | Combined Influence of Insulin Resistance and Inflammatory Biomarkers on Type 2 Diabetes:A Population-based Prospective Cohort Study of Inner Mongolians in China显示文摘This prospective study was designed to examine the combined influence of insulin resistance(IR)and inflammatory biomarker levels on type 2 diabetes mellitus(T2DM)among 1,903Inner Mongolians.During follow-up,205(10.77%)participants developed T2DM,and the incidence | QIU Qiao Yan ZHANG Bei Lei ZHANG Ming Zhi WU Jia Hui ZHOU Jing Wen LIANG Zhu ZHANG Yong Hong ZHANG Shao Yan | 2018 | Biomedical and Environmental Sciences2018，31，4： | 15 |
| 15 | Long-term outcomes of choledochoduodenostomy for hepatolithiasis显示文摘背景 Oddi 括约肌在阻止倒流胆管炎起一个重要作用。在那里存在在 hepatolithiasis 管理的 choledochoduodenostomy 的申请上的争吵。现在的学习瞄准了为 hepatolithiasis.Methods 的治疗评估 choledochoduodenostomy 的长期的结果 hepatolithiasis 的 46 个连续盒子经历了 choledochoduodenostomy 的人,回顾地被分析。pre- 和周期性的胆管炎和尖锐胆管炎的手术后的率严重类型被比较。配对的 chi 平方测试是 applied.Results 吝啬的后续时间是与 97.8% 的后续率(45/46 ) 从 1.6 ~ 40 年的 17.3 年。残余石头的高率(39.1% , 18/46 ) ,周期性的石头(31.1% , 14/45 ) ,未改正的苛评(85% , 17/20 ) ,并且死亡(24.4% , 11/45 ) 在这个组被观察。进通过吻合的胆汁的道的食物碎片和十二指肠的内容的流回被观察。周期性的胆管炎的率等于外科手术前的时期(93.3% , 42/45 ) 。尖锐胆管炎的率在 choledochoduodenostomy 以后的严重类型(46.7%, 21/45 )显著地增加了( P < 0.01 )什么时候与外科手术前的时期相比(20.0%, 9/45 ) .Conclusions Choledochoduodenostomy 完全没达到石头的清理的目标,苛评的修正,并且由自己 hepatobiliary 损害搬迁。没有 cholangioplasty 的 Choledochoduodenostomy 由于 Oddi 的括约肌的反倒流功能的损失导致了严重倒流胆管炎的增加。因此, choledochoduodenostomy 不是一条理想的途径在 hepatolithiasis 减少胆管炎并且不是在 hepatolithiasis 的管理的最好的选择。 | LING Xiao-feng XU Zhi WANG Li-xin HOU Chun-sheng XIU Dian-rong ZHANG Tong-lin ZHOU Xiao-si | 2010 | Chinese Medical Journal2010，，2： | 15 |
| 16 | A preliminary study on ras protein expression in human esophageal cancer and precancerous lesions显示文摘INTRODUCTIONThe esophageal carcinoma is a common malignanttumor in Linzhou City (Linxian) of Henan Provincein northern China.Although the etiology andnatural history of csophageal carcinoma are notclear,a substantial amount of evidence has beenprovided to suggest that the development of humanesophageal squamous cell carcinomas (SCC) is amultistage progressive process.An | Jian Li Chang Wei Feng Zhi Guo Zhao Qi Zhou Li Dong Wang | 2000 | World Journal of Gastroenterology2000，6，2： | 15 |
| 17 | Exploration and research progress of shale gas in China显示文摘There are three types of shale gas resources in China.The resources are present in large amounts and are widely distributed.Marine facies,transitional facies and continental facies resources each account for a third.Based on resource distributions,there are many wells penetrated into the Sinian,Cambrian, Ordovieian,Silurian,Devonian,Carboniferous and Permian strata of the Yangtze plate and its periphery, the North China Craton and the Tarim Basin.Many years of exploration have indicated that the marine Silurian Longmaxi shale gas is widely distributed in south China and has been industrialized in its production in the Siehuan basin.The shale gas from the Cambrian Niutitang Formation and the Sinian Doushantuo Formation are important discoveries in Yichang,Hub ei and Zhenba,Shanxi.There are also shale gas resources found within transitional facies and continental facies in different areas in China.The 'two element enrichment theory'has been summarized during the exploration process of Silurian marine shale gas in the Sichuan Basin.In addition,horizontal drilling and fracturing technologies up to 3500 m in depth have been developed.Based on the understanding of shale gas accumulation in a complex tectonic zone outside the Sichnan basin,a preliminary summary of the formation of the 'converse fault syneline control reservoir'and 'paleo uplift control reservoir'model has been constructed.The dominant theory of 'Trinity'shale gas enrichment and the high yield of the 'deep water Lu Pengxiang sedimentary facies belt, structural preservation conditions and overpressure'is summarized.Guided by the above theories.Anyel well in Guizhou and Eyangyel well in Hubei were drilled.'Four storey'oil and shale 'gas is found in the Permian Qixia group,the Silurian Shiniulan Formation,the Longmaxi Formation and the Ordovician Baota Formation in Anyel well.Good shale gas has been gound in the Cambrian Niutitang formation inian Doushantuo formation in Eyangye lwell.This paper aims to summarize and review the main progress,theoretical technology and problems of shale gas exploration and development in recent years in China,and predicts the future exploration and development direction for shale gas and possible exploration areas. | Gang-yi Zhai Yu-fang Wang Zhi Zhou Shu-fang Yu Xiang-lin Chen Yun-xiao Zhang | 2018 | China Geology2018，1，2： | 15 |
| 18 | Proximal gastrectomy with jejunal interposition and TGRY anastomosis for proximal gastric cancer显示文摘AIM: To compare the short-term outcomes of patients who underwent proximal gastrectomy with jejunal interposition(PGJI) with those undergoing total gastrectomy with Roux-en-Y anastomosis(TGRY).METHODS: From January 2009 to January 2011, thirty-five patients underwent PGJI, and forty-one patients underwent TGRY. The surgical efficacy and short-term follow-up outcomes were compared between the two groups.RESULTS: There were no differences in the demographic and clinicopathological characteristics. The mean operation duration and postoperative hospital stay in the PGJI group were statistically longer than those in the TGRY group(P = 0.00). No anastomosis leakage was observed in two groups. No statistically significant difference was found in endoscopic findings, Visick grade or serum albumin level. The single-meal food intake in the PGJI group was more than that in the TGRY group(P = 0.00). The PG group showed significantly better hemoglobin levels in the second year(P = 0.02). The twoyear survival rate was not significantly different(PGJI vsTGRY, 93.55% vs 92.5%, P = 1.0).CONCLUSION: PGJI is a safe, radical surgical method for proximal gastric cancer and leads to better outcomes in terms of the single-meal food intake and hemoglobin level, compared with TGRY in the short term. | Ping Zhao Shuo-Meng Xiao Ling-Chao Tang Zhi Ding Xiang Zhou Xiao-Dong Chen | 2014 | World Journal of Gastroenterology2014，20，25： | 15 |
| 19 | miR-181b functions as an oncomiR in colorectal cancer by targeting PDCDZ显示文摘 | Yanqing Liu Uzair-ur-Rehman Yu Guo Hongwei Liang Rongjie Cheng Fei Yang Yeting Hong Chihao Zhao Minghui Liu Mengchao Yu Xinyan Zhou Kai Yin Jiangning Chen Junfeng Zhang Chen-Yu Zhang Feng Zhi Xi Chen | 2016 | Protein & Cell2016，7，10： | 14 |
| 20 | β_1肾上腺素受体与CYP2D6基因多态性对美托洛尔抗高血压治疗的药代动力学和药效学影响(英文)显示文摘背景:美托洛尔是临床常用的抗高血压药物,它经由CYP2D6代谢。CYP2D6*10降低CYP2D6活性,是中国人群中最为常见的多态性。β1肾上腺素受体为美托洛尔的作用靶标,Ser49Gly与Gly389Arg多态性显著改变受体功能。CYP2D6与β1肾上腺素受体遗传多态性对美托洛尔降压疗效的联合影响仍属未知。目的:发现与美托洛尔药代动力学与药效动力学相关的基因多态性位点。为提高高血压病的疗效和减少不良反应提供实验依据。方法:符合WHO/ISH高血压诊断标准的轻、中度高血压患者125例,服用美托洛尔单药治疗12周,每四周检测血压。在临床观察疗效的同时,应用PCR-RFLP方法对患者进行CYP2D6*10与β1肾上腺素受体Ser49Gly和Gly389Arg基因型分析。同时抽取静脉血5mL,高效液相色谱-荧光检测法测定患者美托洛尔谷浓度。结果:美托洛尔谷浓度与CYP2D610基因型显著相关,并呈基因剂量效应。但高血压患者血压降低程度在CYP2D6*1*1、1*10与CYP2D6*10*10组间无差异。Gly49携带者服用美托洛尔后收缩压与舒张压的降低显著大于Ser49Ser纯合子;与Gly389携带者相比,Arg389Arg服用美托洛尔后收缩压与舒张压的降低更为显著,表明Gly49与Arg389型受体对美托洛尔治疗有较好的敏感性。结论:CYP2D6*10突变显著改变美托洛尔的药代动力学,但对美托洛尔的降压效果无显著性影响。β1肾上腺素受体遗传多态性与β受体阻滞药的降压敏感性有一定相关性。 | HU Jie HU Zhao-qian HU Ying-zi TAN Zhi-rong HU Dong-li LI Zhi WANG Dan ZHANG Wei ZHOU Hong-hao | 2007 | 中国临床药理学与治疗学2007，12，10： | 13 |
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