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| 1 | Effect of sintering temperature in argon atmosphere on microstructure and properties of 3D printed alumina ceramic cores显示文摘Alumina ceramics with different sintering temperatures in argon atmosphere were obtained using stereolithography-based 3D printing.The effects of sintering temperature on microstructure and physical and mechanical properties were investigated.The results show that the average particle size,shrinkage,bulk density,crystallite size,flexural strength,Vickers hardness,and nanoindentation hardness increased with the increase in sintering temperature,whereas the open porosity decreased with increasing sintering temperature.No change was observed in phase composition,chemical bond,atomic ratio,and surface roughness.For the sintered samples,the shrinkage in Z direction is much greater than that in X or Y direction.The optimum sintering temperature in argon atmosphere is 1350℃with a shrinkage of 3.0%,3.2%,and 5.5%in X,Y,and Z directions,respectively,flexural strength of 26.7 MPa,Vickers hardness of 198.5 HV,nanoindentation hardness of 33.1 GPa,bulk density of 2.5 g/cm^3,and open porosity of 33.8%.The optimum sintering temperature was 70℃higher than that sintering in air atmosphere when achieved the similar properties. | He LI Yongsheng LIU Yansong LIU Qingfeng ZENG Kehui HU Zhigang LU Jingjing LIANG | 2020 | Journal of Advanced Ceramics2020，9，2： | 13 |
| 2 | OsMADS16 Genetically Interacts with OsMADS3 and OsMADS58 in Specifying Floral Patterning ~in Rice显示文摘瑞斯(Oryza sativa ) 有贡献谷物产量的唯一的花的模式。然而,在米饭位于花的机关身份的说明下面的分子的机制,特别地在花的 homeotic 基因之中的相互作用,遗体糟糕理解。这里,我们证明花的 homeotic 基因 OsMADS16 (也叫的 SUPERWOMAN1, SPW1, B 班基因) 和在指定花的机关 patterning 的米饭 C 班基因 OsMADS3 和 OsMADS58 的行为。OsMADS16 和二 C 班基因在第三个锭盘创始人房间有一个重叠表示模式。与单个异种相比, spw1-1 osmads3-4 和 spw1-1 osmads58 加倍异种在花以内展出像颖的机关的另外的锭盘,特别地,六像颖的结构的额外的锭盘在野类型的雄蕊的位置形成了。这些宫外的像颖的结构被显示用标记基因通过细胞的观察并且在 situ 杂交分析有 palea 身份。我们的结果建议 B 班和 C 班基因在在花的分裂组织以内压制不确定的生长起一个关键作用,特别地 whorl-3 primordia。我们也假设那,与以前的假设相对照,在米饭的专业化小穗状花小穗机关, palea,在 eudicots 的萼片的对应物,和词根对苞相应。 | Dapeng Yun Wanqi Liang Ludovico Dreni Changsong Yin Zhigang Zhou Martin M. Kater Dabing Zhang | 2013 | Molecular Plant2013，6，3： | 11 |
| 3 | Safety and efficacy of tenecteplase versus alteplase in patients with acute ischaemic stroke (TRACE): a multicentre, randomised, open label, blinded-endpoint (PROBE) controlled phase II study显示文摘Background Tenecteplase(TNK)possesses several pharmacological characteristics superior to conventional alteplase(rt-PA),with well-established safety and efficacy profile in Caucasians.There exists controversy over the optimal dose of intravenous rt-PA for East Asians with acute ischaemic stroke(AIS).Current study aimed to determine the safety dose range of recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)for patients with AIS in China.Methods This multicentre,prospective,randomised,open-label,blinded end-point,phase II study compared three tiers of 0.1,0.25,0.32 mg/kg rhTNK-tPA(to a maximum of 40 mg)with standard 0.9 mg/kg rt-PA(to a maximum of 90 mg)in patients who were eligible for intravenous thrombolysis.The safety outcome were symptomatic intracranial haemorrhage(sICH)within 36 hours.Results Between May 2018 and February 2020,240 patients were randomly assigned to four group,4 of whom did not receive study treatment.The intention-to-treat analysis included 236 patients.There was no difference in the improvement on National Institutes of Health Stroke Scale at day 14 in the 3 tiers and control group(63.3%,77.2%,66.7%vs 62.7%).The number of sICH was 3 of 60(5.0%)in the 0.1 mg/kg group,none in the 0.25 mg/kg group,2 of 60(3.3%)in the 0.32 mg/kg group and 1(1.7%)of 59 in the rt-PA group.There were no significant between-group differences in severe adverse events.Conclusions Similar to the Caucasians,rhTNK-tPA was well tolerated in Chinese patients with AIS at all doses administered within 3 hours of symptom onset.The dose-efficacy profile of rhTNK-tPA needs to be established with future investigations. | Shuya Li Yuesong Pan Ziran Wang Zhigang Liang Huisheng Chen Dong Wang Yi Sui Xingquan Zhao Yilong Wang WanLiang Du Huaguang Zheng Yongjun Wang | 2022 | Stroke & Vascular Neurology2022，7，1： | 9 |
| 4 | Interaction of strong converging shock wave with SF6gas bubble显示文摘Interaction of a strong converging shock wave with an SF6 gas bubble is studied, focusing on the effects of shock intensity and shock shape on interface evolution. Experimentally, the converging shock wave is generated by shock dynamics theory and the gas bubble is created by soap film technique. The post-shock flow field is captured by a schlieren photography combined with a high-speed video camera. Besides, a three-dimensional program is adopted to provide more details of flow field. After the strong converging shock wave impact, a wide and pronged outward jet, which differs from that in planar shock or weak converging shock condition, is derived from the downstream interface pole. This specific phenomenon is considered to be closely associated with shock intensity and shock curvature. Disturbed by the gas bubble, the converging shocks approaching the convergence center have polygonal shapes, and the relationship between shock intensity and shock radius verifies the applicability of polygonal converging shock theory. Subsequently, the motion of upstream point is discussed, and a modified nonlinear theory considering rarefaction wave and high amplitude effects is proposed. In addition, the effects of shock shape on interface morphology and interface scales are elucidated. These results indicate that the shape as well as shock strength plays an important role in interface evolution. | Yu Liang ZhiGang Zhai XiSheng Luo | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，6： | 8 |
| 5 | Adipocyte-derived SFRP5 inhibits breast cancer cells migration and invasion through Wnt and epithelial-mesenchymal transition signaling pathways显示文摘Objective:Obesity is closely associated with metastasis in breast cancer patients.Secreted frizzled-related protein 5(SFRP5),one of the novel adipokines with anti-inflammatory properties,is associated with obesity.This study aims to study the role of SFRP5 in the crosstalk between obesity and breast cancer metastasis and identify the underlying mechanism.Methods:3T3-L1 pre-adipocytes were differentiated to mature adipocytes and a hypertrophic adipocyte model was induced with palmitic acid(PA).Cell motility was measured in MDA-MB-231 and MCF-7 breast cancer cells co-cultured with adipocytes conditioned medium(CM)with or without SFRP5 protein.Wnt and epithelialmesenchymal transition(EMT)signal pathways were investigated by western blot.Circulating SFRP5 level in 218 breast cancer patients and the association with clinicopathologic characteristics of breast cancer were further determined.Online databases ENCORI and PREDICT Plus were used to exam the link between SFRP5 and prognosis.Results:Reduced SFRP5 level was detected in the hypertrophic adipocyte model.Recombinant SFRP5 protein inhibited MDA-MB-231 and MCF-7 cells invasion and migration induced by PA-treated adipocyte CM,and SFRP5 inhibition by specific antibody reversed the effect of SFRP5.Furthermore,SFRP5 significantly inhibited Wnt and downstream EMT in breast cancer cells.Low circulating SFRP5 level correlated with body mass index(BMI),lymph node(LN)metastasis,TNM stage and high Ki67 expression in breast cancer patients.Increased SFRP5 level was associated with favorable predicted survival.Kaplan-Meier curves showed high SFRP5 level in tumor tissue was associated with better outcome of breast cancer patients.Conclusions:Our findings demonstrated SFRP5 is a vital adipokine that mediates the crosslink between obesity and the metastatic potential of breast cancer.Promotion of SFRP5 expression in the adipose microenvironment may represent a novel approach for preventing breast cancer metastasis. | Wenzhong Zhou Chunmiao Ye Liang Li Liyuan Liu Fei Wang Lixiang Yu Fei Zhou Yujuan Xiang Yongjiu Wang Gengshen Yin Zhongbing Ma Qinye Fu Qiang Zhang Dezong Gao Shuya Huang Zhigang Yu | 2020 | Chinese Journal of Cancer Research2020，32，3： | 5 |
| 6 | Senegenin promotes in vitro proliferation of human neural progenitor cells显示文摘Senegenin,an effective component of Polygala tenuifolia root extract,promotes proliferation and differentiation of neural progenitor cells in the hippocampus.However,the effects of senegenin on mesencephalon-derived neural progenitor cells remain poorly understood.Cells from a ventral mesencephalon neural progenitor cell line(ReNcell VM) were utilized as models for pharmaceutical screening.The effects of various senegenin concentrations on cell proliferation were analyzed,demonstrating that high senegenin concentrations(5,10,50,and 100 μmo/L),particularly 50 μmol/L,significantly promoted proliferation of ReNcell VM cells.In the mitogen-activated protein kinase signal transduction pathway,senegenin significantly increased phosphorylation levels of extracellular signal-regulated kinases.Moreover,cell proliferation was suppressed by extracellular signal-regulated kinase inhibitors.Results suggested that senegenin contributed to in vitro proliferation of human neural progenitor cells by upregulating phosphorylation of extracellular signal-regulated kinase. | Shi, Fang Liang, Zhigang Guo, Zixuan Li, Ran Yu, Fen Zhang, Zhanjun Wang, Xuan Wang, Xiaomin | 2011 | Neural Regeneration Research2011，6，3： | 5 |
| 7 | Mechanisms leading to the frequent occurrences of hypoxia and a preliminary analysis of the associated acidification off the Changiiang estuary in summer显示文摘Based on literature data and shipboard observations,this study investigated the main environmental characteristics of the seafloor topography,current field,front,and upwelling that are closely related to hypoxia occurrence off the Changjiang estuary.The physical processes of the plume front and upwelling off the Changjiang estuary in summer were coupled.The vertical distribution pattern of the plume front was closely related to the upwelling.By reviewing and analyzing the historical summer hypoxia events off the Changjiang estuary,we statistically demonstrated the spatial structure of the horizontal distribution of the hypoxic zone and investigated the location of occurrence zone of the hypoxia.We found that the dissolved oxygen(DO)concentration on the inner continental shelf off the estuary showed a'V'shape in relation to station depth.Therefore,we noted that the hypoxic water on the inner continental shelf mostly occurred on the slopes with steep seafloor topography.Base on the current understanding of the hypoxic mechanisms off the Changjiang estuary,we analyzed the biogeochemical mechanisms that could cause the steep terrain off the Changjiang estuary to become the main areas prone to summer hypoxia and explained the internal relations between the location of the hypoxic zone on the slopes and the plume front and upwelling.The plume front and upwelling off the Changjiang estuary and their coupling were important driving forces of summer hypoxia.The continuous supply of nutrients affected by the interaction of the plume front extension of the Changjiang Diluted Water(CDW)and upwelling and the favorable light conditions were important mechanisms causing the phytoplankton blooms and benthic hypoxia off the Changjiang estuary in summer.By analyzing oxygen utilization,organic carbon mineralization,and nutrient regeneration in the hypoxic zone,we observed that the significant oxygen utilization process off the Changjiang estuary in summer also mainly occurred near the steep slopes with front and upwelling features and confirmed the apparent nutrient loss in the benthic hypoxic zone.Meanwhile,our analysis revealed that the sediment resuspension in the benthic boundary layer in the mud areas off the Changjiang estuary could also affect the oxygen utilization and mineralization of organic carbon and nutrient recycling and regeneration.This study also demonstrated that the steep terrain off the Changjiang estuary was the main location for summer acidification,and the coupling between the plume front and upwelling on the steep slopes was an important physical driving force inducing summer benthic acidification.Finally,we discussed issues to address in future studies of the hypoxic zone and water acidification off the Changjiang estuary. | WEI QinSheng WANG BaoDong YU ZhiGang CHEN JianFang XUE Liang | 2017 | Science China Earth Sciences2017，60，2： | 5 |
| 8 | Expression of reconstructive hF Ⅷ in the hrDNA by using hrDNA targeting vector显示文摘Our lab has constructed a new nonviral vec-tor—hrDNA targeting vector(pHrneo). pHrneo is a human derived vector that can target gene into human ribosomal DNA(hrDNA) locus. In this study, we inserted expression cassette of reconstructive hF Ⅷ (hFVIII-BDDAK39) to pHrneo to construct targeting vector: pHrneo-BDDAK39. Through electroporation of pHrneo-BDDAK39 into HT1080 cells, we identified the homologous recombinants by PCR and Southen blotting, and tested the expression of hFVIII- BDDAK39 in the hrDNA locus. The hFⅧ-BDDAK39 was successfully targeted into hrDNA locus of HT-1080 by pHrneo-BDDAK39, and the efficiency of site-specific inte-gration was 2.0×10?5. hFⅧ-BDDAK39 in hrDNA locus of HT-1080 is found to be able to express efficiently (32±5 ng·106 cells?1·24 h?1). Targeting vector pHrneo-BDDAK39 can find use in gene therapy for hemophilia. | LIU Xionghao LIU Mujun SHE Hua WEN Lu XUE Zhigang LIANG Desheng CAI Fang PAN Qian LONG Zhigao WU Lingqian DAI Heping XIA Kun XlA Jiahui | 2005 | Chinese Science Bulletin2005，50，19： | 5 |
| 9 | Study on the Soy Protein-Based Adhesive Cross-Linked by Glyoxal显示文摘Based on the ESI-MS and ^(13)C-NMR analysis of the forms of glyoxal in acidic and alkaline solutions,the soy-based adhesive cross-linked by glyoxal was prepared in this work.The results showed that glyoxal existed in water in different forms at different pH levels.Under alkaline conditions,glyoxal transformed to glycolate through the intramolecular disproportionation reaction.Under acidic conditions,although some of glyoxal transformed to glycolate as what happened under alkaline conditions,most of glyoxal molecules existed in the form of fiveor six-membered cyclic ether structure.No ethylene tetraol or free aldehyde group was actually detected under these conditions.Although glyoxal reacted with soy protein under both acidic and alkaline conditions,alkaline conditions were more favorable for the improvement of mechanical performance and water resistance of soybased adhesives than acid conditions. | Zhigang Wu Jiankun Liang Hong Lei Bengang Zhang Xuedong Xi Lifen Li | 2021 | Journal of Renewable Materials2021，9，2： | 5 |
| 10 | Balancing flexural strength and porosity in DLP-3D printing Al_(2)O_(3)cores for hollow turbine blades显示文摘High porosity and high strength are usually mutually exclusive in the preparation of ceramic materials.However,high porosity and flexural strength are required for the preparation of complex ceramic cores for hollow turbine blades.In this study,Al_(2)O_(3)cores with high porosity and high flexural strength were successfully prepared using digital light processing(DLP)3 D printing technology.The influence of sintering temperature on the microstructure,pore evolution,and flexural strength of the cores were investigated.With an increase in the sintering temperature,the porosity of the ceramic cores first increased and then decreased,reaching a maximum value of 35%at 1400℃.The flexural strength increased with the increase in sintering temperature,but at 1400℃the incremental enhancement of flexural strength was greatest.Combined with the core service requirements and core performance,this study selected 1400℃(open porosity of 35.1%and flexural strength of 20.3 MPa)as the optimal sintering temperature for the DLP-3 D printed Al_(2)O_(3)core. | Qiaolei Li Xiaolong An Jingjing Liang Yongsheng Liu Kehui Hu Zhigang Lu Xinyan Yue Jinguo Li Yizhou Zhou Xiaofeng Sun | 2022 | Journal of Materials Science & Technology2022，，9： | 4 |
| 11 | Size,morphology,and composition of lunar samples returned by Chang'E-5 mission显示文摘This study focuses on the physical and chemical properties of surficial lunar regolith(LR)samples returned from the Moon by the Chang’E-5(CE-5)mission.Insights regarding the effect of a new sampling geological site on the surficial lunar sample CE5 C0400 were illustrated using nondestructive techniques such as laser diffractometry coupled with image analysis,X-ray computed tomography,and field emission scanning electron microscopy equipped with energy dispersive spectroscopy,and Xray diffraction combined with Rietveld refinement.From the characterization analyses,the CE-5 sampling site in the northeastern Oceanus Procellarum on the Moon yields a unique collection of relatively regular-shaped and fine basalt-dominated particles.The median grain size D_(50) is(55.24±0.96)μm,falling within the relatively low end of the range of the Apollo lunar returned samples.The coefficient of uniformity C_(u)of 15.1 and the coefficient of curvature C_(c)of 1.7 could classify CE5 C0400 to be well-graded.The minerals in CE5 C0400 comprise approximately 44.5%pyroxene,30.4%plagioclase,3.6%olivine,and6.0%ilmenite.There is a relatively low content of approximately 15.5%glass phase in the CE-5 lunar sample.From the results,we deduce that the CE-5 LR structure could have mainly resulted from micrometeoroid impacts to achieve such a high level of maturity. | Hui Zhang Xian Zhang Guang Zhang Keqi Dong Xiangjin Deng Xiaosong Gao Yaodong Yang Yuan Xiao Xiao Bai Kaixin Liang Yiwei Liu Wenbin Ma Shaofan Zhao Ce Zhang Xiaojing Zhang Jian Song Wei Yao Hong Chen Weihua Wang Zhigang Zou Mengfei Yang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，2： | 4 |
| 12 | Effect of electrode Pt-loading and cathode flow-field plate type on the degradation of PEMFC显示文摘The electrode Pt-loading has an effect on the number of active sites and the thickness of catalyst layer,which has huge influence on the mass transfer and water management during dynamic process in PEMFCs. In this study, membrane electrode assemblies with different Pt-loadings were prepared, and PEMFCs were assembled using those membrane electrode assemblies with traditional solid plate and water transport plate as cathode flow-field plates, respectively. The performance and electrochemical surface area of cells were characterized to evaluate the membrane electrode assemblies degradation after rapid currentvariation cycles. Scanning electron microscope and transmission electron microscope were used to investigate the decay of catalyst layers and Pt/C catalyst. With the increase of Pt-loading, the performance degradation of membrane electrode assemblies will be mitigated. But higher Pt-loading means thicker catalyst layer, which leads to a longer pathway of mass transfer, and it may result in carbon material corrosion in membrane electrode assemblies. The decay of Pt/C catalyst in cathode is mainly caused by the corrosion of carbon support, and the degradation of anode Pt/C catalyst is a consequence of migration and aggregation of Pt particles. And using water transport plate is beneficial to alleviating the age of cathode Pt/C catalyst. | Lijuan Qu Zhiqiang Wang Xiaoqian Guo Wei Song Feng Xie Liang He Zhigang Shao Baolian Yi | 2019 | Journal of Energy Chemistry2019，28，8： | 4 |
| 13 | Pt/WO_3/C nanocomposite with parallel WO_3 nanorods as cathode catalyst for proton exchange membrane fuel cells显示文摘Pt/WO3/C nanocomposites with parallel WO3 nanorods were synthesized and applied as the cathode catalyst for proton exchange membrane fuel cells(PEMFCs). Electrochemical results and single cell tests show that an enhanced activity for the oxygen reduction reaction(ORR) is obtained for the Pt/WO3/C catalyst compared with Pt/C. The higher catalytic activity might be ascribed to the improved Pt dispersion with smaller particle sizes. The Pt/WO3/C catalyst also exhibits a good electrochemical stability under potential cycling. Thus, the Pt/WO3/C catalyst can be used as a potential PEMFC cathode catalyst. | Meiling Dou Ming Hou Zhilin Li Feng Wang Dong Liang Zhigang Shao Baolian Yi | 2015 | Journal of Energy Chemistry2015，24，1： | 4 |
| 14 | Qualitative and quantitative assessment of related substances in the Compound Ketoconazole and Clobetasol Propionate Cream by HPLC-TOF-MS and HPLC显示文摘Related substances in pharmaceutical formulations are associated with their safety, efficacy and stability. However, there is no overall study already published on the assessment of related substances in the Compound Ketoconazole and Clobetasol Propionate Cream. In this work, a reliable HPLC-TOF-MS qualitative method was developed for the analysis of related substances in this preparation with a quick and easy extraction procedure. Besides the active pharmaceutical ingredients, two compounds named ketoconazole impurity B′ optical isomer and ketoconazole impurity E were identified. Furthermore, a new HPLC method for qualitative and quantitative assessment on related substances and degradation products, which were found in the stability test, was established and validated. The single standard to determine multi-components method was applied in the quantitative analysis, which was an effective way for reducing cost and improving accuracy. This study can provide a creative idea for routine analysis of quality control of the Compound Ketoconazole and Clobetasol Propionate Cream. | Wenling Yang Xiaomei Yang Fanghua Shi Zhigang Liao Yongkun Liang Liangzhong Yu Ruixun Wang Qing Li Kaishun Bi | 2019 | Journal of Pharmaceutical Analysis2019，9，3： | 4 |
| 15 | Establishment of novel rat models for premalignant breast disease显示文摘 | Wang Feng Ma Zhongbing Wang Fei Fu Qinye Fang Yunzhi Zhang Qiang Gao Dezong Li Yuyang Li Liang Yu Lixiang Yu Zhigang | 2014 | Chinese Medical Journal2014，，11： | 4 |
| 16 | Bt protein expression in the transgenic insect-resistant cotton in China显示文摘According to statistics of International Service for the Acquisition of Agri-biotech Applications(ISAAA),18million farmers in 28 countries planted more than 181million hectares of genetically modified(GM)crops in2014,at an annual growth rate of between 3%–4%,with6.3 million ha more than 2013[1].Among these counties,China ranks the sixth with 3.9 million ha.Globally,27kinds of transgenic crops have been approved.The four main food groups for which GM varieties are | Guoqing Sun Dongling Zhang Rui Zhang Yuan Wang Zhigang Meng Tao Zhou Chenzhen Liang Tao Zhu Sandui Guo | 2016 | Science Bulletin2016，61，20： | 3 |
| 17 | Investigation on Flow Accelerated Corrosion Mitigation for Secondary Circuit Piping of the Third Qinshan Nuclear Power Plant显示文摘Flow accelerated corrosion(FAC) is the main failure cause of the secondary circuit carbon steel piping in nuclear power plants.The piping failures caused by FAC have resulted in numerous unplanned outages and tragic fatalities.The existing researches focus on the main factors contributing to FAC,which include metallurgical factors,environmental factors and hydrodynamic factors. Some effective FAC management methods and programs with long term monitoring and inspection data analysis are recommended.But a comprehensive FAC management system should be developed in order to mitigate and manage FAC systematically.In this paper,the FAC influencing factors are analyzed in combination with the operating conditions of the secondary circuit piping in the Third Qinshan Nuclear Power Plant(TQNPP),China(Third Qinshan Nuclear Power Company Limited,China).A comprehensive FAC mitigation and management system is developed for TQNPP secondary circuit piping.The system is composed of five processes,viz.materials substitution,water chemical optimization,long-term monitor strategy for the susceptible piping,integrity evaluation of the local thinning defects,and repair or replacement.With the implementation of the five processes,the material of FAC sensitive pipe fittings are modified from carbon steel to stainless steel,N_2H_4 and NH_3 are finally selected as the water chemical regulator of secondary circuit,the secondary circuit pips are classified according to FAC susceptibility in order to conduct long term monitoring strategy,and an integrity evaluation flow for local thinning caused by FAC in carbon steel piping is developed.If the component with local thinning defects is not fit-for-service,corresponding repair or replacement should be conducted.The comprehensive FAC mitigation and management system with five interrelated processes would be a cost-effective method of increasing personnel safety,plant safety and availability. | ZHAO Liang HU Jianqun WU Zhigang WANG Kin | 2011 | Chinese Journal of Mechanical Engineering2011，24，2： | 3 |
| 18 | Chemical composition and antimicrobial activity of essential oil isolated from the cultured mycelia of Ganoderma japonicum显示文摘Objective:To explore a new natural antibiotic. Methods:The chemical composition of the essential oil from Ganoderma japonicum (G. japonicum) mycelia was analyzed by gas chromatography-mass spectrometry(GC-MS). The antimicrobial activity of the oil was evaluated against eighteen microorganisms,including bacteria,mildew and yeast by using a disc diffusion method. Furthermore,the minimum inhibitory concentrations(MIC) and the minimum bactericidal concentrations(MBC) of the essential oil against twelve clinical pathogens were determined. Results:The main components of the oil were nerolidol,decadienal,linalool and benzyl alcohol. The antimicrobial results indicated that the oil inhibited all the tested bacterium,especially Methicillin-resistant Staphylococcus aureus (MRSA) in which the antibacterial activity exhibited a MBC of 1.03 mg/ml. Conclusion:The essential oil of G. japonicum mycelium has significant inhibitory activity. It is a potential medicinal resource that can be used as a natural antibiotic. | Dandan Liu Zheng Hu Zhigang Liu Bo Yang Wenjuan Tu Liang Li | 2009 | Journal of Nanjing Medical University2009，23，3： | 3 |
| 19 | The influences of biotic and abiotic factors on the occurrence and severity of poplar canker disease in Qingfeng County, China and the management implications显示文摘Landscape pathology is a research approach that can provide validation of the effectiveness of regional controls of forest disease at a landscape scale. In this paper,we analyzed the effects of stand features, management approaches, and geographical locations on poplar canker disease incidence(DI) and disease severity index(DSI) of individual trees at a 10 km ×10 km mesoscale landscape in Qingfeng County, China. DI varied significantly with stand age, tree densities, and the degree of canopy closure.DI in stands younger than 4 years old was significantly lower than that in the stands over 6 years old and reached the highest value at a stand age of 8–10 years. Overall, DI was positively correlated with stand age, stand density, and the degree of canopy closure. DI was significantly lower in agro-forest stand patches than in other three patch types,i.e. isolated patch, pure stand patch, and mixed stand patch.Poplar plantations distributed around and near to villages exhibited significantly higher DI mainly due to human activities and herbivores. Fragmentation or connectivity in this mesoscale landscape seemed not impact disease occurrence. DSI was not significantly correlated with stand density, but varied significantly with tree varieties and trees ages. DSI was highest in stands of 10–12 year trees for all poplar varieties we studied here. Plantation density and plantation age were thus critical factors in determining DI and DSI. A logistic predictive model of disease occurrence was developed for the study area, considering varieties,age, height, density, canopy cover, stand types, patch types,management status, and stand geographical locations. Our study here shows that adjustment of stand density by thinning at different plantation ages is an effective approach controlling the occurrence canker disease in short-rotation poplar plantations at the landscape scale. | Zhigang Ma Jingle Zhu Zhiqiang Sun Jun Liang Zhaoxin Zhang Limin Zhang Lijuan Sun Wenjuan Li | 2015 | Journal of Forestry Research2015，26，4： | 3 |
| 20 | Increased lateral root formation by CRISPR/Cas9-mediated editing of arginase genes in cotton显示文摘Dear Editor,Proper development of plant roots is critical for primary physiological functions,including water and nutrient absorption and uptake,physical support,and carbohydrate storage(Zhang et al.,2010).Crop root systems act as the key organ for sensing and response to abiotic and biotic stresses.Previous studies of crop root system development suggest that increased lateral root formation(LRF)could | Yanling Wang Zhigang Meng Chengzhen Liang Zhaohong Meng Yuan Wang Guoqing Sun Tao Zhu Yongping Cai Sandui Guo Rui Zhang Yi Lin | 2017 | Science China(Life Sciences)2017，60，5： | 3 |
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