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| 1 | The spreading frontiers of avian-human influenza described by the free boundary显示文摘In this paper,a reaction-diffusion system is proposed to investigate avian-human influenza.Two free boundaries are introduced to describe the spreading frontiers of the avian influenza.The basic reproduction numbers rF0(t)and RF0(t)are defined for the bird with the avian influenza and for the human with the mutant avian influenza of the free boundary problem,respectively.Properties of these two time-dependent basic reproduction numbers are obtained.Sufficient conditions both for spreading and for vanishing of the avian influenza are given.It is shown that if rF0(0)<1 and the initial number of the infected birds is small,the avian influenza vanishes in the bird world.Furthermore,if rF0(0)<1 and RF0(0)<1,the avian influenza vanishes in the bird and human worlds.In the case that rF0(0)<1 and RF0(0)>1,spreading of the mutant avian influenza in the human world is possible.It is also shown that if rF0(t0)>1 for any t0>0,the avian influenza spreads in the bird world. | LEI ChengXia KIM KwangIk LIN ZhiGui | 2014 | Science China Mathematics2014，57，5： | 5 |
| 2 | Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics显示文摘Colorectal cancer(CRC), a malignant tumor worldwide consists of microsatellite instability(MSI) and stable(MSS) phenotypes. Although SHP2 is a hopeful target for cancer therapy, its relationship with innate immunosuppression remains elusive. To address that, single-cell RNA sequencing wasperformed to explore the role of SHP2 in all cell types of tumor microenvironment(TME) from murine MC38 xenografts. Intratumoral cells were found to be functionally heterogeneous and responded significantly to SHP099, a SHP2 allosteric inhibitor. The malignant evolution of tumor cells was remarkably arrested by SHP099. Mechanistically, STING-TBK1-IRF3-mediated type I interferon signaling was highly activated by SHP099 in infiltrated myeloid cells. Notably, CRC patients with MSS phenotype exhibited greater macrophage infiltration and more potent SHP2 phosphorylation in CD68;macrophages than MSI-high phenotypes, suggesting the potential role of macrophagic SHP2 in TME. Collectively,our data reveals a mechanism of innate immunosuppression mediated by SHP2, suggesting that SHP2 is a promising target for colon cancer immunotherapy. | Jian Gao Zhigui Wu Mingxia Zhao Rui Zhang Manru Li Dongdong Sun Haibo Cheng Xianjia Qi Yuxian Shen Qiang Xu Hongqi Chen Dijun Chen Yang Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 5 |
| 3 | Spreading and vanishing in a West Nile virus model with expanding fronts显示文摘We study a simplified version of a West Nile virus(WNv) model discussed by Lewis et al.(2006),which was considered as a first approximation for the spatial spread of WNv. The basic reproduction number R_0 for the non-spatial epidemic model is defined and a threshold parameter R_0~D for the corresponding problem with null Dirichlet boundary condition is introduced. We consider a free boundary problem with a coupled system, which describes the diffusion of birds by a PDE and the movement of mosquitoes by an ODE. The risk index R_0~F(t) associated with the disease in spatial setting is represented. Sufficient conditions for the WNv to eradicate or to spread are given. The asymptotic behavior of the solution to the system when the spreading occurs is considered. It is shown that the initial number of infected populations, the diffusion rate of birds and the length of initial habitat exhibit important impacts on the vanishing or spreading of the virus. Numerical simulations are presented to illustrate the analytical results. | TARBOUSH Abdelrazig K. LIN ZhiGui ZHANG MengYun | 2017 | Science China Mathematics2017，60，5： | 4 |
| 4 | Malaria Deaths—China,2011–2020显示文摘Introduction:The malaria deaths(MDs)caused by imported Plasmodium falciparum has become a great challenge.This article analyzed MDs in China in 2011−2020 to provide evidence-based data for further strategies and interventions adjustment.Methods:Individual data via the National Notifiable Disease Reporting System(NNDRS)in 2011−2020 were collected.The Plasmodium species,case classification,temporal and spatial distribution,and source of MDs were analyzed to explore MD characteristics.The Parasitic Diseases Information Reporting Management System(PDIRMS)of MDs in 2013−2020 which explored clinical symptom and treatment was also collected and analyzed.Results:A total of 165 MDs with a mortality rate of 0.5%were recorded in the NNDRS from 2011 to 2020.Among them,164(99.4%)died due to imported malaria cases,1(0.6%)died of indigenous case reported in Yunnan in 2013.The number of MDs showed a decreasing trend from 2011(n=30)to 2020(n=6).The MDs consisted of 160(97.0%)P.falciparum cases,1(0.6%)mixed infection case,and 4(2.4%)clinical diagnosed cases.The MDs were mainly reported in Guangdong(n=18,10.9%),Sichuan(n=17,10.3%),Beijing(n=15,9.1%)and Henan(n=15,9.1%).The PDIRMS had reported 121 MDs from 2013−2020,and 46.3%(n=56)of MDs exhibited severe brain damage,and most of the patients(n=95,78.5%)were administrated by artemisinin combination therapy injection form.Conclusions:The total MDs decreased in China,and a delay in diagnosis and treatment is the main causes of MDs.Therefore,two actions are needed to prevent MDs,including improving health education for key populations such as migrant workers who come to and return from endemic regions and maintaining malaria diagnosis and treatment capabilities of clinicians in medical facilities. | Li Zhang Hong Tu Shuisen Zhou Zhigui Xia Jun Feng | 2021 | China CDC weekly2021，3，17： | 4 |
| 5 | Genome architecture and tetrasomic inheritance of autotetraploid potato显示文摘Potato(Solanum tuberosum)is the most consumed non-cereal food crop.Most commercial potato cultivars are autotetraploids with highly heterozygous genomes,severely hampering genetic analyses and improvement.By leveraging the state-of-the-art sequencing technologies and polyploid graph binning,we achieved a chromosome-scale,haplotype-resolved genome assembly of a cultivated potato,Cooperation-88(C88).lntra-haplotype comparative analyses revealed extensive sequence and expression differences in this tetraploid genome.We identified haplotype-specific pericentromeres on chromosomes,suggesting a distinct evolutionary trajectory of potato homologous centromeres.Furthermore,we detected double reduction events that are unevenly distributed on haplotypes in 1021 of 1034 selfing progeny,a feature of autopolyploid inheritance.By distinguishing maternal and paternal haplotype sets in C88,we simulated the origin of heterosis in cultivated tetraploid with a survey of 3110 tetra-allelic loci with deleterious mutations,which were masked in the heterozygous condition bytwo parents.This study provides insights into the genomic architecture of autopolyploids and will guide their breeding. | Zhigui Bao Canhui Li Guangcun Li Pei Wang Zhen Peng Lin Cheng Hongbo Li Zhiyang Zhang Yuying Li Wu Huang Mingwang Ye Daofeng Dong Zhukuan Cheng Peter VanderZaag Evert Jacobsen Christian W.B.Bachem Suomeng Dong Chunzhi Zhang Sanwen Huang Qian Zhou | 2022 | Molecular Plant2022，15，7： | 4 |
| 6 | LIX1-like protein promotes liver cancer progression via miR-21-3p-mediated inhibition of fructose-1,6-bisphosphatase显示文摘Limb and CNS expressed 1 like(LIX1L) is over-expressed in several types of tumors.However,the function of LIX1L in glucose metabolism and hepatocellular carcinoma(HCC) progression remains elusive.Here we report that LIX1L is over-expressed in human HCC tissues,which predicts unfavorable prognosis.LIX1L deficiency in vivo significantly attenuated liver cancer initiation in mice.Functional studies indicated that LIX1L overexpression elevated proliferation,migratory,invasive capacities of HCC cells in vitro,and promoted liver cancer growth and metastasis in vivo.LIX1L knockdown up-regulated fructose-1,6-bisphosphatase(FBP1) expression to reduce glucose consumption as well as lactate production.Mechanistically,LIX1L increased miR-21-3p expression,which targeted and suppressed FBP1,thereby promoting HCC growth and metastasis.MiR-21-3p inhibitor could abrogate LIX1L induced enhancement of cell migration,invasion,and glucose metabolism.Inhibition of miR-21-3p suppressed tumor growth in an orthotopic tumor model.Our results establish LIX1L as a critical driver of hepatocarcinogenesis and HCC progression,with implications for prognosis and treatment. | Jie Zou Xiaoyun Zhu Dejuan Xiang Yanqiu Zhang Jie Li Zhigui Su Lingyi Kong Hao Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 4 |
| 7 | Imported Malaria Cases--China,2012–2018显示文摘Introduction:In 2017,no indigenous malaria cases were reported in China,but imported malaria was a challenge for the elimination program.This study analyzed the status and trends of imported malaria in China from 2012 to 2018 to provide evidence for further strategies and adjustments to current interventions.Methods:Data on individuals were collected from the Parasitic Diseases Information Reporting Management System(PDIRMS)from 2012 to 2018.Plasmodium species,case classification,temporal distribution,spatial distribution,and source of imported cases were analyzed to investigate imported malaria characteristics.Results:In total,21,376 malaria cases were recorded in the PDIRMS from 2012 to 2018.Among them,20,938(98.0%)cases were imported malaria cases(IMCs).The number and proportion of IMCs increased from 2012(n=2,474,91.0%)to 2018(n=2,511,99.7%).IMCs consisted of 13,510(64.5%)P.falciparum,4,803(22.9%)P.vivax,1,725(8.2%)P.ovale,376(1.8%)P.malariae,2(0.01%)P.knowlesi,348(1.7%)mixed infections,and 174(0.8%)clinically-diagnosed cases.The proportion of imported P.falciparum cases increased from 2012(n=1403,57.4%)to 2018(n=1655,66.0%),while imported P.vivax cases showed a decreasing trend from 2012(n=901,43.7%)to 2018(n=352,14.0%).IMCs were mainly reported in Yunnan(n=2,922,14.0%),Guangxi(n=2,827,13.5%),and Jiangsu(2,067,9.9%).IMCs were reported throughout the entire year,and the highest number of IMCs was reported in June 2013.IMCs originated from 67 countries from 4 continents,and the largest proportion were from Myanmar(n=3,081,14.7%)and Ghana(n=2,704,12.9%).Conclusion and Implications for Public Health Practice:The total number of IMCs increased in China.Therefore,two actions are needed to continue the elimination of malaria in China:prevent reestablishment caused by imported P.vivax because Anopheles sinensis is still widely distributed;and ensure timely diagnosis and appropriate treatment to avoid fatal cases caused by imported P.falciparum. | Jun Feng Hong Tu Li Zhang Zhigui Xia Shuisen Zhou | 2020 | China CDC weekly2020，2，17： | 4 |
| 8 | Modelling-based evaluation of the effect of quarantine control by the Chinese government in the coronavirus disease 2019 outbreak显示文摘Dear Editor,The recent outbreak of novel coronavirus disease 2019(COVID-19)has already become a global-scale epidemic.Since the case from China was reported on Dec 30th,2019(Huang et al.,2020;Li et al.,2020),the pathogen was soon identified as a new coronavirus on Jan 7th. | Xinkai Zhou Zhigui Wu Ranran Yu Shanni Cao Wen Fang Zhen Jiang Fang Yuan Chao Yan Dijun Chen | 2020 | Science China(Life Sciences)2020，63，8： | 3 |
| 9 | The Blow-up Rate for a System of Heat Equations with Neumann Boundary Conditions | Zhigui Lin Department of Mathematics,Yangzhou University,Yangzhou 225002,P.R.China E-mail:zglin68@hotmail.comChunhong Xie Department of Mathematics,Nanjing University,Nanjing 210093,P.R. China E-mail:algebra@nju.edu.cn | 1999 | Acta Mathematica Sinica,English Series1999，15，4： | 3 |
| 10 | Blowup behaviors for diffusion system coupled through nonlinear boundary conditions in a half space显示文摘This paper deals with the blowup estimates near the blowup time for the system of heat equations in a half space coupled through nonlinear boundary conditions. The upper and lower bounds of blowup rate are established. The uniqueness and nonuniqueness results for the system with vanishing initial value are given. | LIN Zhigui | 2004 | Science China Mathematics2004，47，1： | 3 |
| 11 | A novel control method for turboshaft engine with variable rotor speed based on the Ngdot estimator through LQG/LTR and rotor predicted torque feedforward显示文摘In order to compensate for the disturbance of wide variation in rotor demanded torque on power turbine speed and realize the fast response control of turboshaft engine during variable rotor speed,a cascade PID control method based on the acceleration estimator of gas turbine speed(Ngdot)and rotor predicted torque feedforward is proposed.Firstly,a two-speed Dual Clutch Transmission(DCT)model is applied in the integrated rotor/turboshaft engine system to achieve variable rotor speed.Then,an online estimation method of Ngdot based on the Linear Quadratic Gaussian with Loop Transfer Recovery(LQG/LTR)is proposed for power turbine speed cascade control.Finally,according to the cascade PID controller based on Ngdot estimator,a rotor demanded torque predicted method based on the Min-batch Gradient Descent-Neural Network(MGD-NN)is put forward to compromise the influence of rotor torque interference.The simulation results show that compared with cascade PID controller based on Ngdot estimator and the one combined with collective pitch feedforward control,the novel control method proposed can reduce the overshoot of power turbine speed by more than 20%,which possesses faster response,superior dynamic effect and satisfactory robustness performance.The control method proposed can realize the fast response control of turboshaft engine with variable rotor speed better. | Yong WANG Qian’gang ZHENG Zhigui XU Haibo ZHANG | 2020 | Chinese Journal of Aeronautics2020，33，7： | 3 |
| 12 | Global fast and slow solutions of a localized problem with free boundary显示文摘In this paper,we consider a localized problem with free boundary for the heat equation in higher space dimensions and heterogeneous environment.For simplicity,we assume that the environment and solution are radially symmetric.First,by using the contraction mapping theorem,we prove that the local solution exists and is unique.Then,some sufficient conditions are given under which the solution will blow up in finite time.Our results indicate that the blowup occurs if the initial data are sufficiently large.Finally,the long time behavior of the global solution is discussed.It is shown that the global fast solution does exist if the initial data are sufficiently small,while the global slow solution is possible if the initial data are suitably large. | ZHOU Peng LIN ZhiGui | 2012 | Science China Mathematics2012，55，9： | 3 |
| 13 | Coexistence in a mutualistic model with cross-diffusion in a heterogeneous environment显示文摘 | Badradeen Adam Zhigui Lin Abdelrazig K. Tarboush | 2018 | International Journal of Biomathematics2018，11，6： | 2 |
| 14 | Malaria Diagnosis and Verification--China,2017–2018显示文摘What is already known about this topic?Prompt,accurate diagnosis is an essential part of malaria elimination strategies.Insufficient malaria diagnosis capacity will be a potential risk for malaria reintroduction.What is added by this report?Health facilities at the county and prefectural levels were the most concentrated facilities for initial diagnosis of malaria(68.2%)and confirmation(76.4%).More than 65%of cases could not be diagnosed within 1 day of onset,and only 89.4%of laboratory-confirmed cases were accurate.What are the implications for public health practice?Malaria health education should be strengthened to improve public awareness and health professionals’vigilance of malaria,thereby shortening the diagnostic intervals.In addition,the capacity of malaria diagnosis,especially Plasmodium speciation,should be improved to ensure accurate diagnosis and appropriate treatment. | Jianhai Yin Li Zhang Jun Feng Shuisen Zhou Zhigui Xia | 2020 | China CDC weekly2020，2，17： | 2 |
| 15 | Approaching Malaria Elimination in China显示文摘Malaria has been one of the most important public health problems over China and world.When dated back to the mid-20th century,malaria seriously affected the health of Chinese people with widespread epidemics.About 30 million malaria cases with an estimated 1%mortality rate were recorded in China each year in the 1940s,which caused an extremely high disease burden and a toll on the labor force(1–2).Even as recently as the 1970s,a peak in the incidence of malaria was recorded with 24.1 million cases(1–2). | Ning Xiao Qiuli Xu Jun Feng Zhigui Xia Lei Duan Duoquan Wang Yayi Guan Xiao-nong Zhou | 2020 | China CDC weekly2020，2，17： | 2 |
| 16 | Stability in a diffusive food-chain model with Michaelis–Menten functional response显示文摘 | Zhigui Lin Michael Pedersen | 2004 | Nonlinear Analysis2004，，3： | 2 |
| 17 | Integrated phenotypic,phylogenomic,and evolutionary analyses indicate the earlier domestication of Geng upland rice in China显示文摘Dear Editor,Ensuring food security with finite resources and environmental impacts is a new challenge in sustainable agriculture(Yu et al.,2022).It is therefore essential to develop suitable rice varieties for resource-saving and environmentally friendly cultivation(Luo et al.,2019;Yu et al.,2022).Upland rice,which evolves many green characters for rice sustainable cultivation(e.g.,drought resistance,the usage efficiency of nitrate,the good capacity of direct seeding,etc.),is therefore an important germplasm in rice breeding(Luo et al.,2019).However,the origination and evolution of upland rice,as well as its green genetic resource,remain mysterious(Xia et al.,2019). | Zhi Luo Hui Xia Zhigui Bao Lei Wang Yu Feng Ting Zhang Jie Xiong Liang Chen Lijun Luo | 2022 | Molecular Plant2022，15，10： | 2 |
| 18 | Strategy in a diffusive food-chain model with Michaelis-Menten functional response显示文摘 | Pedersen M | 2004 | Chaos Solitans and Fractals2004，，57： | 1 |
| 19 | Coupled diffusion systems with localized nonlinear reactions显示文摘 | Pedersen M LIN Zhigui | 2001 | Computers and Mathematics with Applications2001，42，： | 1 |
| 20 | Asymptotic periodicity in a diffusive West Nile virus model in a heterogeneous environment显示文摘 | Abdelrazig K. Tarboush Jing Ge Zhigui Lin | 2017 | International Journal of Biomathematics2017，10，8： | 1 |
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