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| 1 | TRPV1 activation improves exercise endurance and energy metabolism through PGC-1α upregulation in mice显示文摘 | Zhidan Luo Liqun Ma Zhigang Zhao Hongbo He Dachun Yang Xiaoli Feng Shuangtao Ma Xiaoping Chen Tianqi Zhu Tingbing Cao Daoyan Liu Bernd Nilius Yu Huang Zhencheng Yan Zhiming Zhu | 2012 | Cell Research2012，22，3： | 18 |
| 2 | Association of KIR Genotypes and Haplotypes with Susceptibility to Chronic Hepatitis B Virus Infection in Chinese Han Population显示文摘Killer immunoglobulin-like receptor (KIR) genes can regulate the activation of NK and T cells upon interaction with HLA class I molecules. Hepatitis B virus (HBV) infection has been regarded as a multi-factorial disorder disease. Previous studies revealed that KIRs were involved in HCV and HIV infection or clearance. The aim of this study was to explore the possibility of the inheritance of KIR genotypes and haplotypes as a candidate for susceptibility to persistent HBV infection or HBV clearance. The sequence specific primer polymerase chain reaction (SSP-PCR) was employed to identify the KIR genes and pseudogenes in 150 chronic hepatitis B (CHB) patients, 251 spontaneously recovered (SR) controls, and 412 healthy controls. The frequencies of genotype G, M, FZ1 increased in CHB patients compared with healthy control subjects. The frequency of genotype AH was higher in SR controls than that in both CHB patients and healthy controls. The carriage frequencies of genotype G and AH were higher; while, the frequencies of AF and AJ were lower in SR controls than those in healthy control subjects. The frequency of A haplotype was lower, whereas, the frequency of B haplotype was higher in CHB patients and SR controls than those in healthy controls. In healthy controls, haplotype 4 was found lower compared with that in CHB patients and SR controls and the frequency of haplotype 5 was higher in SR controls than that in other two groups. Based on these findings, it seems that the genotypes M and FZ1 are HBV susceptive genotypes; AH, on the other hand, may be protective genotypes that facilitate the clearance of HBV. It appears that the haplotype 4 is HBV susceptive haplotype, whereas, haplotype 5 may be the protective haplotype that facilitates the clearance of HBV. | Zhiming Lu Bingchang Zhang Shijun Chen Zhongtao Gai Zhaolei Feng Xiangdong Liu Yiqing Liu Xin Wen Li Li Yulian Jiao Chunyan Ma Song Shao Xiangfa Cui Guojian Chen Jianfeng Li Yneran Zhao | 2008 | Cellular & Molecular Immunology2008，5，6： | 13 |
| 3 | Complexity of software trustworthiness and its dynamical statistical analysis methods显示文摘Developing trusted softwares has become an important trend and a natural choice in the development of software technology and applications. At present,the method of measurement and assessment of software trustworthiness cannot guarantee safe and reliable operations of software systems completely and effectively. Based on the dynamical system study,this paper interprets the characteristics of behaviors of software systems and the basic scientific problems of software trustworthiness complexity,analyzes the characteristics of complexity of software trustworthiness,and proposes to study the software trustworthiness measurement in terms of the complexity of software trustworthiness. Using the dynamical statistical analysis methods,the paper advances an invariant-measure based assessment method of software trustworthiness by statistical indices,and hereby provides a dynamical criterion for the untrustworthiness of software systems. By an example,the feasibility of the proposed dynamical statistical analysis method in software trustworthiness measurement is demonstrated using numerical simulations and theoretical analysis. | ZHENG ZhiMing MA ShiLong LI Wei JIANG Xin WEI Wei MA LiLi TANG ShaoTing | 2009 | Science in China(Series F)2009，52，9： | 11 |
| 4 | Dynamical characteristics of software trustworthiness and their evolutionary complexity显示文摘Developing trusted softwares has become an important trend and a natural choice in the development of software technology and applications, and software trustworthiness modeling has become a prerequisite and necessary means. To discuss and explain the basic scientific problems in software trustworthiness and to establish theoretical foundations for software trustworthiness measurement, combining the ideas of dynamical system study, this paper studies evolutionary laws of software trustworthiness and the dynamical mechanism under the effect of various internal and external factors, and proposes dynamical models for software trustworthiness, thus, software trustworthiness can be considered as the statistical characteristics of behaviors of software systems in the dynamical and open environment. By analyzing two simple examples, the paper explains the relationship between the limit evolutionary behaviors of software trustworthiness attributes and dynamical system characteristics, and interprets the dynamical characteristics of software trustworthiness and their evolutionary complexity. | ZHENG ZhiMing MA ShiLong LI Wei WEI Wei JIANG Xin ZHANG ZhanLi GUO BingHui | 2009 | Science in China(Series F)2009，52，8： | 8 |
| 5 | Metabolic hypertension:concept and practice显示文摘Hypertension is a serious public health problem worldwide.More than 60%of the risk factors for hypertension are associated with metabolic disturbances.Metabolic abnormalities increase the risk for hypertension and cause high blood pressure.Improving metabolic disturbances is beneficial for hypertension treatment.Due to the importance of metabolic abnormalities in the pathogenesis of hypertension,we propose a concept of metabolic hypertension.In this review,we discuss and review the clinical types,pathogenesis,risk evaluation and management of metabolic hypertension.Elucidation of the mechanism of metabolic hypertension should facilitate the design of novel pharmacotherapeutics and dedicated antihypertensive manipulations. | Zhiming Zhu Peijian Wang Shuangtao Ma | 2013 | Frontiers of Medicine2013，7，2： | 5 |
| 6 | Minimizing chemical interference errors for the determination of lithium in brines by flame atomic absorption spectroscopy analysis显示文摘Chemical interferences (ionization and oxide/hydroxide formation) on the atomic absorbance signal of lithium in FAAS analysis of brine samples are elaborated in this article. It is suggested that inadequate or overaddition of deionization buffers can lead to loss of sensitivities under particular operating conditions. In the analysis of brine samples, signal en-hancing and oxide/hydroxide formation inducing signal reduction resulting from overaddition of deionization buffers can be seen with varying amounts of chemical buffers. Based on experimental results, the authors have arrived at the optimized operating conditions for the detection of lithium, under which both ionization and stable compound formation can be sup-pressed. This is a simplified and quick method with adequate accuracy and precision for the determination of lithium in rou-tine brine samples from chemical plants or R&D laboratories, which contain comparable amounts of lithium with some other components. | WEN Xianming MA Peihua ZHU Geqin WU Zhiming | 2006 | Rare Metals2006，25，4： | 4 |
| 7 | Correlation Between Microstructure and Corrosion Behavior of Two 90Cu10Ni Alloy Tubes显示文摘Two kinds of 90Cu10 Ni tubes with different service lives(more than 3 years and only 1 year,respectively)under identical working conditions were studied by an immersion test in a 3.5 wt% NaCl solution and the electron backscattered diffraction(EBSD) technique.The morphology after immersion showed severer corrosion attack at the grain boundaries of the tube with shorter service life compared with the tube with longer service life.The grain boundary characterization distributions(GBCDs) of the two tubes obtained by EBSD revealed more Σ3 boundaries and twins,and larger random boundary meshes in the tube with longer service life.A short immersion test in a modified Livingston's solution was conducted to evaluate the tendency to corrosion attack of different types of the grain boundaries.SEM and AFM were used to characterize the corrosion morphologies of the boundaries.A strong correlation between varying depths of corrosion grooves and types of the grain boundaries was obtained.The influence of deviation angle of low Σ boundaries on corrosion resistance of the grain boundaries was also discussed.It is concluded that a special ‘‘grain boundary engineering''(GBE) treatment has been performed on the tube with longer service life.It is proposed that the optimized GBCD is responsible for the better service performance of the tube. | Aili Ma Shengli Jiang Yugui Zheng Zhiming Yao Wei Ke Shuang Xia | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，4： | 4 |
| 8 | The evolution of microstructure and texture of AZ80 Mg alloy cup-shaped pieces processed by rotating backward extrusion显示文摘This study proposed an effective plastic deformation technique,rotating backward extrusion(RBE),for producing high performance AZ80 magnesium alloy cup-shaped pieces.The RBE process was carried on the Gleeble-3500 test machine at 653 K,and the conventional backward extrusion(CBE)was also conducted for comparison.A detailed microstructure analysis was performed using the optical microscopy(OM)and electron back-scatter diffraction(EBSD).The results shown that the equivalent strain and deformation uniformity of the cup pieces could be substantially increased by the RBE process compared with the CBE process.Furthermore,the RBE process could significantly improve the grain refining capacity and the proportion of dynamic recrystallization(DRX),of which the maximum reduction of grain size was 88.60%,and the maximum increase of DRX proportion was 55.30%in the cup bottom.The main deformation mechanism of the RBE process was the discontinuous DRX(DDRX),while the continuous DRX(CDRX)was also occurred in the cup transition.Compared with the CBE sample,the texture of the cup bottom was weakened for the RBE sample.The microhardness value of the RBE sample was higher than that of the CBE sample,which can be attributed to the grain refinement strengthening. | Xin Che Qiang Wang Beibei Dong Mu Meng Zhi Gao Kai Liu Jin Ma Fulai Yang Zhiming Zhang | 2021 | Journal of Magnesium and Alloys2021，9，5： | 4 |
| 9 | Preparation and analysis of active rat model of rheumatoid arthritis with features of TCM toxic heat-stasis painful obstruction显示文摘Objective:To establish a collagen type II-induced rat model of rheumatoid arthritis(RA)presenting characteristics of the human form of the traditional Chinese syndrome pattern of toxic heat-stasis painful obstruction(bi zheng;arthromyodynia)as well as pathologic features of active RA.The Chinese herbal medicine Tengmei decoction was used to validate the animal model.Methods:Ninety specific pathogen free Sprague-Dawley rats were randomly divided into a normal group of 6 rats and a model group of 84 rats.To establish the rat model of collageninduced arthritis(CIA),bovine type II collagen in complete Freund’s adjuvant was injected into the model group rats as a priming dose(Day 0)and boosting dose(Day 9).Changes in arthritic index(AI)scores,including limb swelling,were monitored.Thereafter,24 successfullyestablished CIA rats were randomly assigned to 4 groups with 6 animals each:model,positive control drug,high-dose traditional Chinese herbal medicine,and traditional Chinese herbal medicine.A blank control group of 6 rats was included.After 12 weeks of intervention with Tengmei decoction,articular synovial tissue and serum specimens were collected to detect interleukin-2(IL-2)and IL-17 transcription and protein expression levels. | Yanan Wang Yan Lu Jie Wang Zhiming Shen Hui Liu Weiguo Ma Jisheng Zhang Xuehong Ma Kang Wang Fengxian Meng | 2015 | Journal of Traditional Chinese Medical Sciences2015，2，3： | 3 |
| 10 | History of and suggestions for China’s biosafety legislation显示文摘Biosafety has attracted an unprecedented amount of attention from the global community as an important element in national security.All biosafety issues are related to laws and therefore must be regulated accordingly.A preliminary biosafety legislation system based on and suitable for China’s actual conditions has been established.The provisions of numerous laws have provided legislative tools to manage biosafety issues.The State Council and relevant ministries have also exercised their respective functions and drafted codes and regulations concerning biosafety protection.These laws and regulations play important roles,but our nation still lacks a law solely dedicated to biosafety regulation,and the supervisory system is incomplete.To remedy this situation,relevant biotechnologies must be developed,issues related to biosafety must be thoroughly examined,and the best practices of other nations should be introduced,all of which will improve biosafety legislation in China. | Liang Huigang Xiang Xiaowei Ma Haixia Yuan Zhiming | 2019 | Journal of Biosafety and Biosecurity2019，1，2： | 3 |
| 11 | Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity显示文摘Brown adipose tissue(BAT)is an energy-expending organ that produces heat.Expansion or activation of BAT prevents obesity and diabetes.Chronic cold exposure enhances thermogenesis in BAT through uncoupling protein 1(UCP1)activation triggered via a b-adrenergic pathway.Here,we report that the cold-sensing transient receptor potential melastatin 8(TRPM8)is functionally present in mouse BAT.Challenging brown adipocytes with menthol,a TRPM8 agonist,up-regulates UCP1 expression and requires protein kinase A activation.Upon mimicking long-term cold exposure with chronic dietary menthol application,menthol significantly increased the core temperatures and locomotor activity in wild-type mice;these effects were absent in both TRPM82/2 and UCP12/2 mice.Dietary obesity and glucose abnormalities were also prevented by menthol treatment.Our results reveal a previously unrecognized role for TRPM8,suggesting that stimulation of this channel mediates BAT thermogenesis,which could constitute a promising way to treat obesity. | Shuangtao Ma Hao Yu Zhigang Zhao Zhidan Luo Jing Chen Yinxing Ni Rongbing Jin Liqun Ma Peijian Wang Zhenyu Zhu Li Li Jian Zhong Daoyan Liu Bernd Nilius Zhiming Zhu | 2012 | Journal of Molecular Cell Biology2012，4，2： | 2 |
| 12 | Aortic heterogeneity across segments and under high fat/salt/glucose conditions at the single-cell level显示文摘The aorta,with ascending,arch,thoracic and abdominal segments,responds to the heartbeat,senses metabolites and distributes blood to all parts of the body.However,the heterogeneity across aortic segments and how metabolic pathologies change it are not known.Here,a total of 216612 individual cells from the ascending aorta,aortic arch,and thoracic and abdominal segments of mouse aortas under normal conditions or with high blood glucose levels,high dietary salt,or high fat intake were profiled using single-cell RNA sequencing.We generated a compendium of 10 distinct cell types,mainly endothelial(EC),smooth muscle(SMC),stromal and immune cells.The distributions of the different cells and their intercommunication were influenced by the hemodynamic microenvironment across anatomical segments,and the spatial heterogeneity of ECs and SMCs may contribute to differential vascular dilation and constriction that were measured by wire myography.Importantly,the composition of aortic cells,their gene expression profiles and their regulatory intercellular networks broadly changed in response to high fat/salt/glucose conditions.Notably,the abdominal aorta showed the most dramatic changes in cellular composition,particularly involving ECs,fibroblasts and myeloid cells with cardiovascular risk factor-related regulons and gene expression networks.Our study elucidates the nature and range of aortic cell diversity,with implications for the treatment of metabolic pathologies. | Dongxu He Aiqin Mao Chang-Bo Zheng Hao Kan Ka Zhang Zhiming Zhang Lei Feng Xin Ma | 2020 | National Science Review2020，7，5： | 2 |
| 13 | The small GTPase RABA2a recruits SNARE proteins to regulate the secretory pathway in parallel with the exocyst complex in Arabidopsis显示文摘Delivery of proteins to the plasma membrane occurs via secretion,which requires tethering,docking,priming,and fusion of vesicles.In yeast and mammalian cells,an evolutionarily conserved RAB GTPase activation cascade functions together with the exocyst and SNARE proteins to coordinate vesicle transport with fusion at the plasma membrane.However,it is unclear whether this is the case in plants.In this study,we show that the small GTPase RABA2a recruits and interacts with the VAMP721/722-SYP121-SNAP33 SNARE ternary complex for membrane fusion.Through immunoprecipitation coupled with mass spectrometry analysis followed by the validatation with a series of biochemical assays,we identified the SNARE proteins VAMP721 and SYP121 as the interactors and downstream effectors of RABA2a.Further expreiments showed that RABA2a interacts with all members of the SNARE complex in its GTP-bound form and modulates the assembly of the VAMP721/722-SYP121-SNAP33 SNARE ternary complex.Intriguingly,we did not observe the interaction of the exocyst subunits with either RABA2a or theSNARE proteins in several different experiments.Neither RABA2a inactivation affects the subcellular localization or assembly of the exocystnor the exocyst subunit mutant exo84b shows the disrupted RABA2a-SNARE association or SNARE assembly,suggesting that the RABA2a-SNARE-and exocyst-mediated secretory pathways are largely independent.Consistently,our live imaging experiments reveal that the two sets of proteins follow non-overlapping trafficking routes,and genetic and cell biologyanalyses indicate that the two pathways select different cargos.Finally,we demonstrate that the plant-specific RABA2a-SNARE pathway is essential for the maintenance of potassium homeostasis in Arabisopsis seedlings.Collectively,our findings imply that higher plants might have generated different endomembrane sorting pathways during evolution and may enable the highly conserved endomembrane proteins to participate in plant-specific trafficking mechanisms for adaptation to the changing environment. | Lei Pang Zhiming Ma Xi Zhang Yuanzhi Huang Ruili Li Yansong Miao Ruixi Li | 2022 | Molecular Plant2022，15，3： | 2 |
| 14 | Activation of the bitter taste sensor TRPM5 prevents high saltinduced cardiovascular dysfunction显示文摘High salt intake is a known risk factor of cardiovascular diseases. Our recent study demonstrated that long-term high salt intake impairs transient receptor potential channel M5(TRPM5)-mediated aversion to high salt concentrations, consequently promoting high salt intake and hypertension;however, it remains unknown whether TRPM5 activation ameliorates cardiovascular dysfunction. Herein we found that bitter melon extract(BME) and cucurbitacin E(CuE), a major compound in BME, lowered high salt-induced hypertension. Long-term BME intake significantly enhanced the aversion to high salt concentrations by upregulating TRPM5 expression and function, eventually decreasing excessive salt consumption in mice. Moreover, dietary BME ameliorated high salt-induced cardiovascular dysfunction and angiotensin II-induced hypertension in vivo. The mechanistic evidence demonstrated that dietary BME inhibited high salt-induced RhoA/Rho kinase pathway overactivation, leading to reduced phosphorylation levels of myosin light chain kinase and myosin phosphatase targeting subunit 1. Furthermore, CuE inhibited vasoconstriction by attenuating L-type Ca^(2+) channel-induced Ca^(2+) influx in vascular smooth muscle cells. To summarize, our findings indicate that dietary BME has a beneficial role in antagonizing excessive salt consumption and thus appears promising for the prevention of high salt-induced cardiovascular dysfunction. | Hao Wu Yuanting Cui Chengkang He Peng Gao Qiang Li Hexuan Zhang Yanli Jiang Yingru Hu Xiao Wei Zongshi Lu Tianyi Ma Daoyan Liu Zhiming Zhu | 2020 | Science China(Life Sciences)2020，63，11： | 2 |
| 15 | “Extreme utilization”development of deep shale gas in southern Sichuan Basin,SW China显示文摘To efficiently develop deep shale gas in southern Sichuan Basin,under the guidance of“extreme utilization”theory,a basic idea and solutions for deep shale gas development are put forward and applied in practice.In view of multiple influencing factors of shale gas development,low single-well production and marginal profit of wells in this region,the basic idea is to establish“transparent geological body”of the block in concern,evaluate the factors affecting shale gas development through integrated geological-engineering research and optimize the shale gas development of wells in their whole life cycle to balance the relationship between production objectives and development costs.The solutions are as follows:(1)calculate the gold target index and pinpoint the location of horizontal well drilling target,and shale reservoirs are depicted accurately by geophysical and other means to build underground transparent geological body;(2)optimize the drilling and completion process,improve the adaptability of key tools by cooling,reducing density and optimizing the performance of drilling fluid,the“man-made gas reservoir”is built by comprehensively considering the characteristics of in-situ stress and fractures after the development well is drilled;(3)through efficient management,establishment of learning curve and optimization of drainage and production regime,the development quality and efficiency of the well are improved across its whole life cycle,to fulfil“extreme utilization”development of shale gas.The practice shows that the estimated ultimate recovery of single wells in southern Sichuan Basin increase by 10%-20%than last year. | MA Xinhua WANG Hongyan ZHAO Qun LIU Yong ZHOU Shangwen HU Zhiming XIAO Yufeng | 2022 | Petroleum Exploration and Development2022，49，6： | 2 |
| 16 | Organic matter enrichment in the first member of the Xiagou formation of the lower Cretaceous in the Jiuquan Basin, China显示文摘The sources and enrichment of organic matter in a sediment core in the first member of the Xiagou Formation(K_1g^1) from the Chang 2-2 borehole of the Jiuquan Basin,NW China,have been examined using Rock-Eval,maceral,carbon isotopes and biomarker data.This data indicates that highly variable organic matter sources and preservation conditions in response to climate change.TOC content,HI,and δ^(13)C value were strongly correlated with the abundance of gammacerane,woody organic matter content,steranes/hopanes ratio,and C_(29) sterane content.This correlation demonstrates the importance that the control of the salinity of the depositional environment and organic matter sources can have upon the enrichment,type,and carbon isotopic composition of organic matter.In the Jiuquan Basin's relatively high temperature and arid climate,high salinity lakes with high primary productivity of algae,planktons,and bacteria,and good organic matter preservation conditions(anoxic bottom water) resulted in the enrichment of isotopically-light algae-bacterial organic matter.In the Jiuquan Basin's regions with a relatively low temperature and wet climate,fresh lakes with low primary productivity of algae,planktons,and bacteria received significant terrigenous high plants input,resulting in the deposition of a low abundance of isotopically heavier terrestrial organic matter. | Lixin Pei Gang Gao Wenzhe Gang Zhilong Huang Guofu Ma Zhiming Yang Jianjun Chen | 2016 | Acta Geochimica2016，35，1： | 2 |
| 17 | A simple kriging method incorporating multiscale measurements in geochemical survey显示文摘 | Changjiang Li Zhiming Lu Tuhua Ma | 2009 | Journal of Geochemical Exploration2009，101，2： | 1 |
| 18 | Homoclinic orbits for second order self-adjoint difference equations显示文摘 | Manjun Ma Zhiming Guo | 2006 | Journal of Mathematical Analysis and Applications2006，323，： | 1 |
| 19 | Studies on developing a safe-management standard system for Chinese biosafety laboratories显示文摘Standardization management is one of the key prerequisites to guarantee the effective and safe functioning of high-level biosafety laboratories.Since the outbreak of SARS,increasing numbers of biosafety laboratory levels have been established in China.Therefore,creating a specialized and standardized management system for biosafety laboratories has become necessary and is a core concern.This paper describes the current status of Chinese standards for biosafety management and analyzes its relation to other laboratory biosafety standard systems in developed countries.Based on the analysis on developing a biosafety laboratory,a laboratory biosafety standard system framework was developed,and a policy environment for building the system was suggested with the aim of promoting the promulgation of specific biosafety standards and securing the effective functioning of high-level biosafety laboratories. | Feng W Haixia Ma Amei Deng ZongSheng C Zhiming Y | 2019 | Journal of Biosafety and Biosecurity2019，1，1： | 1 |
| 20 | Direct oxidation of methyl radicals in OCM process deduced from correlation of product selectivities显示文摘Selectivity of hydrogen in reaction of oxidative coupling of methane (OCM) was evaluated over the MxOy-BaCO3 (MxOy: La2O3, Sm2O3, MgO, CaO) catalysts. Correlation of product selectivities was thus discussed. From the correlation of product selectivities, it is revealed that the carbon oxides (CO and CO2) were most probably formed from the direct oxidation of methyl radicals under the conditions adopted in the present work. This is also in accordance with the OCM mechanism proposed in literature. | Zhiming Gao Yuanyuan Ma | 2010 | Journal of Natural Gas Chemistry2010，19，5： | 1 |
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