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| 1 | Magmatic Event at the End of the Archean in Eastern Hebei Province and Its Geological Implication显示文摘By using the SHRIMP U-Pb and single zircon stepwise evaporation methods, the authors have obtained some results for granitoids from eastern Hebei Province. The Yuhuzhai hyperthene tonalitic granite was formed 2550 Ma ago, the Qingyangshu gabbroic gneiss 2536 Ma, the Yinmahe granodioritic gneiss near Lücao, Lulong County, 2533 Ma, the gabbro-dioritic gneiss near Longwan, Qianxi County, 2518?2515 Ma, the Qiuhuayu trondjemitic gneiss at Zunhua 2515 Ma, the Xiaoguanzhuang tonalitic gneiss at Zunhua 2495 Ma, and the Cuizhangzi gneiss in Qianxi County 2492 Ma. These geochronilogical data demonstrate that, though diverse in composition, type and origin, the granitic gneisses in eastern Hebei Province were emplaced and crystallized in a rather short period of magmatic activity. The formation of such a great amount of gneisses in this small time gap suggests that it was a critical crust accretion stage at the end of Neoarchean. The fact that granitoids of various types occurred at the same time implies a large-scale underplating (mantle plume) activity, which was then responsible for the crust accretion. | GENG Yuansheng LIU Fulai YANG Chonghui | 2006 | Acta Geologica Sinica(English Edition)2006，80，6： | 87 |
| 2 | Protolith ages and timing of peak and retrograde metamorphism of the high-pressure granulites in the Shandong Peninsula,eastern North China Craton显示文摘高压(HP ) granulites 广泛地在 tonalite-trondhjemite-granodiorite (TTG ) 以内作为被外国领地包围的土地发生在山东半岛的早前寒武纪的变形地下室的片麻岩,北方中国 Craton (NCC ) 的东南部分。基于阴极射线发光(CL ) ,激光拉曼光谱学并且在原处标明日期的 U-Pb,我们从 HP granulites 描绘锆石并且组织他们进三种主要类型:继承(magmatic ) 锆石, HP 变形锆石并且后退锆石。有清楚或弱定义的 magmatic zoning 的继承锆石包含 29152890 妈和 27632510 妈的磷灰石,和 207Pb/206Pb 年龄的包括,与在太古代地下室的二个 magmatic 事件相关。同类的 HP 变形锆石包括石榴石, clinopyroxene,斜长石,石英,金红石和磷灰石包含高压的变态的索引矿物质,并且产出在 1900 和 1850 妈之间的 207Pb/206Pb 年龄,标记预定山峰 HP granulite 外形变态。retrograde 锆石包含 orthopyroxene,斜长石,石英,磷灰石和闪石的包括,并且在三个组之中产出 18401820 妈的最年轻的 207Pb/206Pb 年龄,我们它相关到媒介到低压的 granulite 外形后退变态。数据在这研究介绍了建议中央的 subduction -- 并且降低他们在 Palaeoproterozoic (19001850 妈) 期间受到 HP granulite 外形变态的外壳深度的 Neoarchean magmatic protoliths。随后, HP granulites 是到上面的外壳层次的 exhumated,并且被媒介套印到低压的 granulite 和角闪岩外形后退在 ca 的事件。1840820 妈。 | Pinghua Liu Fulai Liu Hong Yang Fang Wang Jianhui Liu | 2012 | Geoscience Frontiers2012，3，6： | 19 |
| 3 | High- and Ultrahigh-pressure Metamorphism and Retrogressive Textures of Gneiss in the Donghai Area——Evidence from gneisses in drillhole ZK2304显示文摘In the gneisses from the drillhole ZK2304 of the Donghai area, there have been preserved high- and ultrahigh-pressure metamorphic mineral assemblages, a series of complicated retrogressive textures and relevant metamorphic reactions. In addition to garnet, jadeititic-clinopyroxene and rutile, other peak stage (M2) minerals in some gneisses include phengite, aragonite and coesite or quartz pseudomorphs after coesite. The typical peak-stage mineral assemblages in gneisses are characterized by garnet + jadeitic-clinopyroxene + rutile + coesite, garnet + jadeitic-clinopyroxene + phengite + rutile ± coesite and garnet + jadeitic-clinopyroxene + aragonite + rutile ± coesite. The grossular content (Gro) in garnet is high and may reach 50. 1 mol%. The SiO2 content of phengite ranges from 54.37% to 54.84% with 3.54-3.57 p.f.u. Quartz pseudomorphs after coesite occur as inclusions in garnet.The gneisses of the Donghai area have been subjected to multistage recrystallization and exhibit a closewise P-T | LIU Fulai, XU Zhiqin, XU Huifen and YANG Jingsui Institute of Geology, CAGS, 26 Baiwanzhuang Rd., Beijing 100037 Zhu Xiling | 1999 | Acta Geologica Sinica(English Edition)1999，73，3： | 12 |
| 4 | Mineral inclusions of zircon and UHP metamorphic evidence from paragneiss and orthogneiss of pre-pilot drill-hole CCSD-PP2 in north Jiangsu Province,China显示文摘Coesite inclusions, together with omphacite, jadeite, garnet and phengite inclusions, were identified in zircons separates from almost all gneissic core samples of pre-pilot drillhole CCSD-PP2 by the Laser Raman spectros-copy and the cathodoluminescence method. These data indicate that gneissic rocks consisting of paragneisses and or-thogneisses ubiquitously experienced UHP metamorphism. This research may be of great significance for an in-depth study of the subduction-exhumation mechanism of the Sulu UHP metamorphic belt and selecting the drilling site for the Chinese Continental Scientific Drilling Project. | LIU Fulai XU Zhiqin YANG Jingsui S Maruyama J.G.Liou I.Katayama H.Masago | 2001 | Chinese Science Bulletin2001，46，12： | 12 |
| 5 | Microstructure, biodegradation, antibacterial and mechanical properties of ZK60-Cu alloys prepared by selective laser melting technique显示文摘Magnesium(Mg) alloys are receiving increasing attention for body implants owing to their good biocompatibility and biodegradability. However, they often suffer from bacterial infections on account of their insufficient antibacterial ability. In this study, ZK60-x Cu(x = 0, 0.2, 0.4, 0.6 and 0.8 wt%) alloys were prepared by selective laser melting(SLM) with alloying copper(Cu) to enhance their antibacterial ability.Results showed that ZK60-Cu alloys exhibited strong antibacterial ability due to combination of release of Cu ions and alkaline environment which could kill bacteria by destroying cellular membrane structure,denaturing enzymes and inhibiting deoxyribonucleic acid(DNA) replication. In addition, their compressive strength increased due to grain refinement and uniformly dispersing of short-bar shaped MgZnCu phases. Moreover, ZK60-Cu alloys also exhibited good cytocompatibility. In summary, ZK60-Cu alloys with antibacterial ability may be promising implants for biomedical applications. | Cijun Shuai Long Liu Mingchun Zhao Pei Feng Youwen Yang Wang Guo Chengde Gao Fulai Yuan | 2018 | Journal of Materials Science & Technology2018，34，10： | 12 |
| 6 | Synthesis and Characterization of a Hydroxyethyl Derivative of Chitosan and Evaluation of Its Biosafety显示文摘Hydroxyethyl chitosan(HE-chitosan) is a water-soluble derivative of chitosan with many apparent biological properties. For example, it is non-toxic and rapidly biodegradable. Moreover, HE-chitosan has advantages in water-solubility, moisture retention and gelling property due to its hydroxyethyl group. However, the biocompatibility and biodegradability of this multifunctional derivative have rarely been documented although they are critical for its application in biomedical and clinical treatments. The purpose of this work was to evaluate the biosafety of HE-chitosan, and draw important clues for its diverse applications. HE-chitosan was synthesized and characterized its chemical structure with FTIR. Its molecular weight(MW) was determined by gel permeation chromatography(GPC), and its deacetylation degree(DD) was investigated through potentiometric analysis. The cytotoxicity of HE-chitosan on mouse fibroblast cell L929 was tested. The biocompatibility and biodegradability of HE-chitosan in rat and rabbit were evaluated. The FTIR results indicated that the hydroxyethyl groups were linked to C6 of chitosan. The GPC analysis confirmed that its Mw was about 90.01 k Da. It was also demonstrated that HE-chitosan had excellent biocompatibility and biodegradability in vivo and had no cytotoxicity on L929. These findings indicated that HE-chitosan can potentially be applied as a biomaterial in tissue engineering, drug delivery, and other biomedical fields. | SHAO Kai HAN Baoqin GAO Jinning SONG Fulai YANG Yan LIU Wanshun | 2015 | Journal of Ocean University of China2015，14，4： | 5 |
| 7 | A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor显示文摘Glucagon-like peptides(GLP-1 and GLP-2)are two proglucagon-derived intestinal hormones that mediate distinct physiological functions through two related receptors(GLP-1R and GLP-2R)which are important drug targets for metabolic disorders and Crohn's disease,respectively.Despite great progress in GLP-1 R structure determination,our understanding on the differences of peptide binding and signal transduction between these two receptors remains elusive.Here we report the electron microscopy structure of the human GLP-2R in complex with GLP-2 and a Gs heterotrimer.To accommodate GLP-2 rather than GLP-1,GLP-2R fine-tunes the conformations of the extracellular parts of transmembrane helices(TMs)1,5,7 and extracellular loop 1(ECL1).In contrast to GLP-1,the N-terminal histidine of GLP-2 penetrates into the receptor core with a unique orientation.The middle region of GLP-2 engages with TM1 and TM7 more extensively than with ECL2,and the GLP-2 C-terminus closely attaches to ECL1,which is the most protruded among 9 class B G protein-coupled receptors(GPCRs).Functional studies revealed that the above three segments of GLP-2 are essential for GLP-2 recognition and receptor activation,especially the middle region.These results provide new insights into the molecular basis of ligand specificity in class B GPCRs and may facilitate the development of more specific therapeutics. | Wen Sun Li-Nan Chen Qingtong Zhou Li-Hua Zhao Dehua Yang Huibing Zhang Zhaotong Cong Dan-Dan Shen Fenghui Zhao Fulai Zhou Xiaoqing Cai Yan Chen Yan Zhou Sarina Gadgaard Wijnand JCvan der Velden Suwen Zhao Yi Jiang Mette MRosenkilde HEric Xu Yan Zhang Ming-Wei Wang | 2020 | Cell Research2020，30，12： | 4 |
| 8 | The evolution of microstructure and texture of AZ80 Mg alloy cup-shaped pieces processed by rotating backward extrusion显示文摘This study proposed an effective plastic deformation technique,rotating backward extrusion(RBE),for producing high performance AZ80 magnesium alloy cup-shaped pieces.The RBE process was carried on the Gleeble-3500 test machine at 653 K,and the conventional backward extrusion(CBE)was also conducted for comparison.A detailed microstructure analysis was performed using the optical microscopy(OM)and electron back-scatter diffraction(EBSD).The results shown that the equivalent strain and deformation uniformity of the cup pieces could be substantially increased by the RBE process compared with the CBE process.Furthermore,the RBE process could significantly improve the grain refining capacity and the proportion of dynamic recrystallization(DRX),of which the maximum reduction of grain size was 88.60%,and the maximum increase of DRX proportion was 55.30%in the cup bottom.The main deformation mechanism of the RBE process was the discontinuous DRX(DDRX),while the continuous DRX(CDRX)was also occurred in the cup transition.Compared with the CBE sample,the texture of the cup bottom was weakened for the RBE sample.The microhardness value of the RBE sample was higher than that of the CBE sample,which can be attributed to the grain refinement strengthening. | Xin Che Qiang Wang Beibei Dong Mu Meng Zhi Gao Kai Liu Jin Ma Fulai Yang Zhiming Zhang | 2021 | Journal of Magnesium and Alloys2021，9，5： | 4 |
| 9 | Mineral inclusions in zircon domains and geological significance of SHRIMP U-Pb dating for coesite-bearing zircons of paragneiss in Sulu terrane, eastern China显示文摘Laser Raman spectroscopy and cathodoluminescence (CL) image reveal that zircons separated from paragneisses in the southwestern Sulu terrane (eastern China) preserve multi-stage mineral assemblages in different zircon domains. In the same paragneiss zircon sample, some zircon grains retain inherited (detrital) cores with abundant low-pressure mineral inclusions of Qtz + Phe + Ap + impurities and Qtz + Phe + impurities. The ultrahigh-pressure (UHP) metamorphic overgrowths mantles of these zircons preserve Coe, Coe + Phe and other UHP mineral inclusions, indicating that these inherited (detrital) zircons from protoliths experienced metamorphic recrystallization during the Sulu UHP metamorphic event. However, other zircon grains preserve UHP mineral inclusions of Coe, Coe + Ap and Coe + Phe in the cores and mantles, whereas the outmost rims contain quartz (Qtz) and other low-pressure mineral inclusions. These phenomena prove that the second group zircons were crystallized at UHP metamorphic stage and overprinted by the late retrogressive metamorphism related to the Sulu terrane exhumation. SHRIMP U-Pb dating reveals that zircons separated from the paragneisses recorded complicated geochronological traces. Some zircons retain inherited cores with the 206Pb/238U ages of 284-754 Ma, indicating the complexity of the detrital zircons in protoliths. Coesite-bearing zircon domains recorded 238-266 Ma (with the average age of 245(14 Ma) for the UHP metamorphic event. The retrogressive rims of zircons recorded 213-223 Ma (with the average age of 217(15 Ma) for the late-stage amphibolite facies metamorphic event, indicating that the rapid exhumation time for the Sulu UHP terrane is about 220 Ma. | LIU Fulai YANG Jingsui XU Zhiqin | 2005 | Science China Earth Sciences2005，48，2： | 3 |
| 10 | Micro-area Chemical Composition and Preserved P-T Evolution Trace of Phengite in Albite Gneiss from the Donghai Ultrahigh-Pressure Metamorphic Area,East China显示文摘Study of micro-area chemical compositions indicates that phengite in albite gneiss from hole ZK2304 of the Donghai region has evident compositional zoning. SiO2 and tetrahedrally coordinated Si contents decrease, and Al2O3, AlIV and AlVI contents increase gradually from core to rim. However, K2O, MgO and FeO contents basically remain unchanged from core to rim. According to P-T estimates obtained from geothermometers and barometers, combined with previous experimental data, the core belt (micro-area I) of phengite was formed at T=637-672℃ and P=1.55-1.73 GPa, and the transitional belt (micro-area II) of the phengite were formed at r=594-654℃ and P=1.35-1.45 GPa. Towards the rim belt (micro-area III), the temperature decreased slightly, but the pressure decreased rapidly with r=542-630℃ and P=1.12-1.19 GPa. The P-T evolution path recorded by the compositional zoning of phengite is characterized by significant near-isothermal decompression, revealing that the gneiss has. undergone | LIU Fulai ZHANG Zeming XU Zhiqin YANG Jingsui XU Huifen | 2000 | Acta Geologica Sinica(English Edition)2000，74，2： | 2 |
| 11 | Lithofacies and Pore Structure of Fine-grained Sedimentary Rocks of Qing-1 Member of Cretaceous in the Southern Songliao Basin显示文摘Fine-grained sedimentary rocks often contain hydrocarbon and mineral resources.Compared with coarse-grained sedimentary rocks,fine-grained sedimentary rocks are less studied.To elucidate the lithofacies and pore structure of lacustrine fine-grained rocks,the 340.6 m continuous core of Cretaceous Qing-1 Member from five wells in the southern central depression of the Songliao Basin was analyzed using X-ray diffraction,Rock-Eval pyrolysis,low-temperature nitrogen adsorption,high-pressure mercury injection,argon ion polishing-field emission scanning electron microscopy,and laser scanning confocal microscopy.Based on mineral compositions,organic matter abundance and sedimentary structure,lacustrine fine-grained rocks in the study area were divided into ten lithofacies,with their spatial distributions mainly influenced by tectonic cycle,climate cycle and provenance.Furthermore,pore structure characteristics of different lithofacies are summarized.(1)The siliceous mudstone lithofacies with low TOC content and the laminated/layered claybearing siliceous mudstone lithofacies with medium TOC content have the highest proportion of first-class pores(diameter>100 nm),making it the most favourable lithofacies for the accumulation of shale oil and shale gas.(2)The massive claybearing siliceous mudstone lithofacies with low TOC content has the highest proportion of second-class pores(diameter ranges from 10 to 100 nm),making it a favourable lithofacies for the enrichment of shale gas.(3)The massive clay-bearing siliceous mudstone lithofacies with high TOC content has the highest proportion of third-class pores(diameter<10 nm),making it intermediate in gas storage and flow.Laser confocal oil analysis shows that the heavy component of oil is mainly distributed in the clay lamina,while the light part with higher mobility is mainly concentrated in the silty lamina. | LIN Lamei LIU Su XU Yang LI Fulai | 2021 | Acta Geologica Sinica(English Edition)2021，95，2： | 1 |
| 12 | Molecular basis of ligand recognition and activation of human V2 vasopressin receptor显示文摘Dear Editor,Vasopressin type 2 receptor(V2R)belongs to the vasopressin(VP)/oxytocin(OT)receptor subfamily of G protein-coupled receptors(GPCRs),which comprises at least four closely related receptor subtypes:V1aR,V1bR,V2R,and OTR. | Fulai Zhou Chenyu Ye Xiaomin Ma Wanchao Yin Tristan I.Croll Qingtong Zhou Xinheng He Xiaokang Zhang Dehua Yang Peiyi Wang H.Eric Xu Ming-Wei Wang Yi Jiang | 2021 | Cell Research2021，31，8： | 1 |
| 13 | Exhumation structure and mechanism of the Sulu ultrahigh-pressure metamorphic belt central China显示文摘 | Xu Zhiqin Zhang Zemin Liu Fulai Yang Jingsui Li Haibing Yang Tiannan Qiu Haijun Li Tianfu Meng Fanchong Chen Shizhong Tang Zemin and Chen Fangyuan | | ACTA GEOLOGICA SINICA(CHINESE EDITION)0，，： | 1 |
| 14 | Scientific objectives of the Hot Universe Baryon Surveyor(HUBS) mission显示文摘The Hot Universe Baryon Surveyor(HUBS) is a proposed space-based X-ray telescope for detecting X-ray emissions from the hot gas content in our universe. With its unprecedented spatially-resolved high-resolution spectroscopy and large field of view,the HUBS mission will be uniquely qualified to measure the physical and chemical properties of the hot gas in the interstellar medium, the circumgalactic medium, the intergalactic medium, and the intracluster medium. These measurements will be valuable for two key scientific goals of HUBS, namely to unravel the AGN and stellar feedback physics that governs the formation and evolution of galaxies, and to probe the baryon budget and multi-phase states from galactic to cosmological scales. In addition to these two goals, the HUBS mission will also help us solve some problems in the fields of galaxy clusters, AGNs, difuse X-ray backgrounds, supernova remnants, and compact objects. This paper discusses the perspective of advancing these fields using the HUBS telescope. | Joel Bregman Renyue Cen Yang Chen Wei Cui Taotao Fang Fulai Guo Edmund Hodges-Kluck Rui Huang Luis C.Ho Li Ji Suoqing Ji Xi Kang Xiaoyu Lai Hui Li Jiangtao Li Miao Li Xiangdong Li Yuan Li Zhaosheng Li Guiyun Liang Helei Liu Wenhao Liu Fangjun Lu Junjie Mao Gabriele Ponti Zhijie Qu Chenxi Shan Lijing Shao Fangzheng Shi Xinwen Shu Lei Sun Mouyuan Sun Hao Tong Junfeng Wang Junxian Wang Q.Daniel Wang Song Wang Tinggui Wang Weiyang Wang Zhongxiang Wang Dandan Xu Haiguang Xu Heng Xu Renxin Xu Xiaojie Xu Yongquan Xue Hang Yang Feng Yuan Shuinai Zhang Yuning Zhang Zhongli Zhang Yuanyuan Zhao Enping Zhou Ping Zhou | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，9： | 1 |
| 15 | Robust Fuzzy Clustering-based Image Segmentation显示文摘 | Zhang Yang Chung Fulai Wang Shitong | 2009 | Applied Soft Computing2009，9，1： | 1 |
| 16 | Robust fuzzy clustering-based image segmentation 显示文摘 | Zhang Yang Fulai Chung Wang Shitong | 2009 | Applied Soft Computing2009，9，： | 1 |
| 17 | Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification显示文摘 | Minjia Tan Hao Luo Sangkyu Lee Fulai Jin Jeong Soo Yang Emilie Montellier Thierry Buchou Zhongyi Cheng Sophie Rousseaux Nisha Rajagopal Zhike Lu Zhen Ye Qin Zhu Joanna Wysocka Yang Ye Saadi Khochbin Bing Ren Yingming Zhao | 2011 | Cell2011，，： | 1 |
| 18 | Catalytic C-N Bond Alkynylation of N-Benzylic Sulfonamides with Terminal Alkynes显示文摘A new cross-coupling reaction of N-benzylic sulfonamides with terminal alkynes for the synthesis of internal alkynes is reported.In the presence of 5 mol%of(Tf)_(2)NH/Bi(OTf)_(3)(1∶1),a broad range of N-benzylic sulfona-mides react smoothly with arylacetylenes to afford structurally diverse internal alkynes in moderate to excellent yields.We reasoned that vinyl cations could be formed by the regioselective attack of terminal alkynes with benzyl cations generated in situ from N-benzylic sulfonamides under acidic conditions,which then eliminated to form a carbon-carbon triple bond. | Congrong Liu Fulai Yang Tingting Wang | 2014 | Chinese Journal of Chemistry2014，32，5： | 0 |
| 19 | An Efficient Prins Cyclization for Stereoselective Synthesis of Tetrahydropyran from Imines and Homoallyl Alcohols显示文摘An unprecedented protocol has been developed for the efficient synthesis of substituted tetrahydropyrans via a bismuth-promoted Prins cyclization of imines with homoallyl alcohols.In the presence of 40 mol%BiCl_(3),a wide variety of imines react smoothly with homoallyl alcohols at room temperature to give the corresponding 4-chlorotetrahydropyran derivatives in good to excellent yields. | Congrong Liu Daojuan Cheng Fulai Yang | 2014 | Chinese Journal of Chemistry2014，32，11： | 0 |
| 20 | Metal-Free Synthesis of β-Bromoalkenyl Sulfides via Deoxygenative Bromination/Olefination/Sulfenylation of Ketones with SulfonylHydrazides and Pyridinium Tribromide显示文摘A novel metal-free method for synthesis of β-bromoalkenyl sulfides via deoxygenative bromination/olefination/sulfenylation process usingcommercially available ketones, sulfonyl hydrazides and pyridinium tribromide as starting materials has been developed. In this reaction, pyridiniumtribromide plays the role of oxidant and substrate, wherein water and molecular nitrogen are generated as environmentally benign by-products. Prelimi-nary investigation revealed that vinyl bromides were critical intermediate. Importantly, this protocol not only obviates the use of alkynes and traditionalsulfenylating agents, but also reveals that ketones can be used as precursors of vinyl bromides. | Yishu Bao Lingyu Zhong Qiaodan Hou Qingfa Zhou Fulai Yang | 2018 | Chinese Journal of Chemistry2018，36，11： | 0 |
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