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| 1 | Leachate treatment using a demonstration aged refuse biofilter显示文摘Approximately 7000 m3 of aged refuse(AR) with a placement of over eight years was excavated from Shanghai Refuse Landfill,the largest landfill in China,and used for the construction of a two-stage bioreactor(AR biofilter) media for the biological treatment of 100 m3 of refuse landfill leachate.It was found that over 64% of COD,96.9%-99.8% of NH4+-N,and 95.8%-99.8% of BOD5 could be removed by the AR biofilter,when the leachate with initial COD,BOD5,and NH4+-N concentrations were 986-4128 mg/L,264-959 mg/L,and 538-1583 mg/L,respectively.The corresponding concentrations in the effluent were reduced to below 300-400 mg/L,2-12 mg/L,and 10-20 mg/L,respectively.The effluent was clear and pale yellow with suspended solid below 150 mg/L and color below 150 Pt/Co degree.Meanwhile,the total nitrogen removal was only 49%-63%,indicating a relative poor denitrification capacity of AR biofilter.The effluent pH was neutral and the population of Escherichia coli was less than 10-1 CFU/mL.Hence,it was considered that the demonstration project can work well for the effective treatment of leachate. | Hongjiang Li Yingying Gu Youcai Zhao Zhiping Wen | 2010 | Journal of Environmental Sciences2010，22，7： | 6 |
| 2 | Osteogenic and antibacterial dual functions of a novel levofloxacin loaded mesoporous silica microspheres/nano-hydroxyapatite/ polyurethane composite scaffold显示文摘Lev/MSNs/n-HA/PU has been proved to be a novel scaffold material to treat bone defect caused by chronic osteomyelitis.We have previously identified that this material can effectively treat chronic osteomyelitis caused by Staphylococcus aureus in vivo.However,the potential mechanisms of antibacterial and osteogenic induction properties remain unclear.Thus,for osteogenesis property,immunohistochemistry,PCR,and Western blot were performed to detect the expression of osteogenic markers.Furthermore,flow cytometry and TUNEL were applied to analyze MC3T3-E1 proliferation and apoptosis.For antibacterial property,the material was co-cultivated with bacteria,bacterial colony forming units was counted and the release time of the effective levofloxacin was assayed by agar disc-diffusion test.Moreover,scanning electron microscope was applied to observe adhesion of bacteria.In terms of osteogenic induction,we found BMSCs adherently grew more prominently on Lev/MSNs/n-HA/PU.Lev/MSNs/n-HA/PU also enhanced the expression of osteogenic markers including OCN and COL1a1,as well as effectively promoted the transition from G1 phase to G2 phase.Furthermore,Lev/MSNs/n-HA/PU could reduce apoptosis of MC3T3-E1.Besides,both Lev/MSNs/n-HA/PU and n-HA/PU materials could inhibit bacterial colonies,while Lev/MSNs/n-HA/PU possessed a stronger antibacterial activities,and lower bacterial adhesion than n-HA/PU.These results illustrated that Lev/MSNs/n-HA/PU composite scaffold possess favorable compatibility in vitro,which induce osteogenic differentiation of MSCs,promote proliferation and differentiation of MC3T3-E1,and inhibit apoptosis.Moreover,clear in vitro antibacterial effect of Lev/MSNs/n-HA/PU was also observed.In summary,this study replenishes the potential of Lev/MSNs/n-HA/PU composite scaffold possess dual functions of anti-infection and enhanced osteogenesis for future clinical application. | Zhiping Kuang Guangming Dai Ruijie Wan Dongli Zhang Chen Zhao Cheng Chen Jidong Li Hongchen Gu Wei Huang | 2021 | Genes & Diseases2021，8，2： | 4 |
| 3 | Purification and characterization of the acetyl-CoA synthetase from Mycobacterium tuberculosis显示文摘Acetyl-CoA (AcCoA ) 合成酶(交流) 催化醋酸盐的变换进 AcCoA,它涉及许多分解代谢、 anabolism 的小径。尽管这酶在许多有机体被学习许多年了, Mycobacterium 肺结核交流和它的活动的规定的性质仍然保持未知。这里, M 的通常认为的交流基因。肺结核 H37Rv (山交流) 与 6 牥潭敲 ? 被表示为熔化蛋白质 ? 呓 ? 汰祡摥愠 ? 湩楨楢潴祲爠汯? 湡 ? 潣汵? ?灰敲獳??? | Ru Li Jing Gu Peng Chen Zhiping Zhang Jiaoyu Deng XianEn Zhang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，11： | 4 |
| 4 | The pilot test of Pt-Pd and Pt-Rh feeds extracted and separated with a new sulfoxide extractant显示文摘Platinum, palladium and rhodium of the raw feeds extracted and separated with a new sulfoxide extractant (MSO) were studied in the paper. The pilot test results showed that the percentage extractions are more than 99% for platinum and palladium in Pt-Pd feed, and the percentage strippings are 100% and 99.2% with HCl and ammonia, respectively. The ratio of palladium to platinum is 0.0016 in stripping platinum solution, and the ratio of platinum to palladium is 0.0020 in strip- ping palladium solution. The percentage extraction of platinum is 99% in Pt-Rh feed, and the percentage stripping is 100%. The ratio of rhodium to platinum is 0.0002 in stripping platinum solution. Therefore, platinum, palladium, and rhodium feeds are separated effectively with MSO. | ZHU Ping GU Guobang QU Zhiping HUANG Yanfei YAO Wenxue | 2006 | Rare Metals2006，25，2： | 3 |
| 5 | New Algorithm Rules Out Acute-on-chronic Liver Failure Development within 28 Days from Acute Decompensation of Cirrhosis显示文摘Background and Aims:Approximately 10%of patients with acute decompensated(AD)cirrhosis develop acute-on-chronic liver failure(ACLF)within 28 days.Such cases have high mortality and are difficult to predict.Therefore,we aimed to establish and validate an algorithm to identify these patients on hospitalization.Methods:Hospitalized patients with AD who developed ACLF within 28 days were considered pre-ACLF.Organ dysfunction was defined accord-ing to the chronic liver failure-sequential organ failure as-sessment(CLIF-SOFA)criteria,and proven bacterial infec-tion was taken to indicate immune system dysfunction.A retrospective multicenter cohort and prospective one were used to derive and to validate the potential algorithm,re-spectively.A miss rate of<5%was acceptable for the calcu-lating algorithm to rule out pre-ACLF.Results:In the deri-vation cohort(n=673),46 patients developed ACLF within 28 days.Serum total bilirubin,creatinine,international normalized ratio,and present proven bacterial infection at admission were associated with the development of ACLF.AD patients with≥2 organ dysfunctions had a higher risk for pre-ACLF patients[odds ratio=16.58195%confidence interval:(4.271-64.363),p<0.001].In the derivation co-hort,67.5%of patients(454/673)had≤1 organ dysfunction and two patients(0.4%)were pre-ACLF,with a miss rate of 4.3%(missed/total,2/46).In the validation cohort,65.9%of patients(914/1388)had≤1 organ dysfunction,and four(0.3%)of them were pre-ACLF,with a miss rate of 3.4%(missed/total,4/117).Conclusions:AD patients with≤1 organ dysfunction had a significantly lower risk of developing ACLF within 28 days of admission and could be safely ruled out with a pre-ACLF miss rate of<5%. | Xiaoting Tang Hai Li Guohong Deng Xin Zheng Xianbo Wang Yan Huang Yanhang Gao Zhongji Meng Zhiping Qian Feng Liu Xiaobo Lu Yu Shi Beiling Li Wenyi Gu Xiaomei Xiang Yan Xiong Yixin Hou Jun Chen Na Gao Sen Luo Liujuan Ji Jing Li Rongjiong Zheng Haotang Ren Jinjun Chen | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 1 |
| 6 | Pollen-like self-supported FeIr alloy for improved hydrogen evolution reaction in acid electrolyte显示文摘Ir is recognized as efficient catalyst for hydrogen evolution reaction(HER).The high price,however,has hindered its application in the production of hydrogen.In this work,we prepared the self-supported FeIr alloy nanoparticles,taking advantage of solid-state synthesis method.The as-prepared FeIr alloy possesses a novel morphology of pollen,which is consist of smaller FeIr nanoparticles.DFT calculations reveal that the change of the free Gibbs for Ir is negative after the adsorption of active H,while it is positive for the case of Fe.Thus,the alloying of Fe and Ir not only effectively reduces the cost,but also can achieve more adequate adsorption of active H species.Benefitting from this,the as-prepared FeIr alloy nanoparticle exhibits superior HER performance with an overpotential of 19 m V at a current density of 10 m V/cm^(2)and a Tafel slope of 32 m V/dec,when tested in 0.5 M H_(2)SO_(4),better than pure Ir and Pt/C.This work paves the way to the exploration of efficient alloy electrocatalysts for HER. | Shengyu Ma Jun Deng Yaping Xu Weiying Tao Xiaoqi Wang Zhiping Lin Qinghua Zhang Lin Gu Wenwu Zhong | 2022 | Journal of Energy Chemistry2022，31，3： | 1 |
| 7 | Transient response analysis of large scale rotor-bearing system with strong nonlinear elements by a transfer matrix-newmark formulation itegration method显示文摘 | Zhiping Gu Xizhe Zhi Guang Meng Tong Fang | 2003 | Journal of Sound and Vibration2003，259，3： | 1 |
| 8 | Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals显示文摘 | Benjamin R. Carone Lucas Fauquier Naomi Habib Jeremy M. Shea Caroline E. Hart Ruowang Li Christoph Bock Chengjian Li Hongcang Gu Phillip D. Zamore Alexander Meissner Zhiping Weng Hans A. Hofmann Nir Friedman Oliver J. Rando | 2010 | Cell2010，，7： | 1 |
| 9 | Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex显示文摘 | Huang Ying Wu Zhiping Riwanto Meliana Gao Shengqiang Levison Bruce S Gu Xiaodong Fu Xiaoming Wagner Matthew A Besler Christian Gerstenecker Gary Zhang Renliang Li Xin-Min DiDonato Anthony J Gogonea Valentin Tang W H Wilson Smith Jonathan D | 2013 | Journal of Clinical Investigation2013，，9： | 1 |
| 10 | Concurrent chemoradiotherapy in locally advanced nasopharyngeal carcinoma: A treatment paradigm also applicable to patients in Southeast Asia显示文摘 | Heming Lu Luxing Peng Xianbin Yuan Yanrong Hao Zhiping Lu Jiaxin Chen Jinjian Cheng Shan Deng Junzhao Gu Qiang Pang Jian Qin | 2009 | Cancer Treatment Reviews2009，，4： | 1 |
| 11 | Effect of the filler structure of carbon nanomaterials on the electrical, thermal, and rheological properties of epoxy composites显示文摘 | Zhiping He Xiaohua Zhang Minghai Chen Min Li Yizhuo Gu Zuoguang Zhang Qingwen Li | 2013 | J Appl Polym Sci2013，，6： | 1 |
| 12 | Shape separation of colloidal gold nanoparticles through salt-triggered selective precipitation显示文摘 | Guo, Zhirui Fan, Xu Xu, Lina Lu, Xiang Gu, Chunrong Bian, Zhiping Gu, Ning Zhang, Jinan Yang, Di | 2011 | 南京医科大学学报(自然科学版)2011，31，6： | 1 |
| 13 | Experimental re- search of reservoir physical changes Induced by CO2 flooding显示文摘 | Gu Libing Li Zhiping Hou Xinlin | 2007 | Journal of Oil and Gas Technology2007，29，3： | 1 |
| 14 | Effects of Matrine on Proliferation and Apoptosis in Gallbladder Carcinoma Cells (GBC‐SD)显示文摘 | Zhiping Zhang Xuefeng Wang Wenguang Wu Jianwei Wang Yong Wang Xiangsong Wu Xiaozhou Fei Songgang Li Jie Zhang Ping Dong Jun Gu Yingbin Liu | 2011 | Phytother Res2011，，6： | 1 |
| 15 | Atomic-level correlation between the electrochemical performance of an oxygen-evolving catalyst and the effects of CeO_(2) functionalization显示文摘Herein,we prepared a bimetallic layered double hydroxide(FeCo LDH)featuring a dandelion-like structure.Anchoring of CeO_(2)onto FeCo LDH produced interfaces between the functionalizing CeO_(2)and the parent LDH.Comparative electrochemical studies were carried out.Onset potential,overpotential,and Tafel slope point to the superior oxygen-evolving performance of CeO_(2)-FeCo LDH with respect to FeCo LDH,therefore,demonstrating the merits of CeO_(2)functionalization.The electronic structures of Fe,Co,and Ce were analyzed by X-ray photoelectron spectroscopy(XPS)and electron energy loss spectroscopy(EELS)from which the increase of Co^(3+)and the concurrent lowering of Ce^(4+)were established.With the use of CeO_(2)-FeCo LDH,accelerated formation at a sizably reduced potential of Co-OOH,one of the key intermediates preceding the release of O_(2)was observed by in situ Raman spectroscopy.We now have the atomic-level and location-specific evidence,the increase of the active Co^(3+)across the interface to correlate the enhanced catalytic performance with CeO_(2)functionalization. | Yanyan Li Wen Luo Duojie Wu Qi Wang Jie Yin Pinxian Xi Yongquan Qu Meng Gu Xinyu Zhang Zhouguang Lu Zhiping Zheng | 2022 | Nano Research2022，15，4： | 1 |
| 16 | Achieving high-purity colloidal gold nanoprisms and their application as biosensing platforms显示文摘 | Zhirui Guo Xu Fan Lianke Liu Zhiping Bian Chunrong Gu Yu Zhang Ning Gu Di Yang Jinan Zhang | 2010 | Journal of Colloid And Interface Science2010，，1： | 1 |
| 17 | Concurrent chemoradiotherapy in locally advanced nasopharyngeal carcinoma: A treatment paradigm also applicable to patients in Southeast Asia显示文摘 | Heming Lu Luxing Peng Xianbin Yuan Yanrong Hao Zhiping Lu Jiaxin Chen Jinjian Cheng Shan Deng Junzhao Gu Qiang Pang Jian Qin | 2009 | Cancer Treatment Reviews2009，，： | 1 |
| 18 | INTERVAL PARAMETER PERTURBATION METHOD FOR EVALUATING THE BOUNDS ON NATURAL FREQUENCIES OF STRUCTURES WITH INTERVAL PARAMETERS显示文摘For structural parameters with uncertainties,interval mathematics can,in the casewhere the probabilistic distribution density of uncertain variables is unavailable,deal with the influ-ence of uncertainties in structural parameters on the response of structures.In order to evaluate the re-gion containing natural frequencies of structures with interval parameters,the interval parameter per-turbation method is presented in this paper.The advantage of the present method is its computationalefficiency in evaluating the region containing natural frequencies.A numerical example is used to il-lustrate the efficiency of the method proposed. | Qiu Zhiping Gu Yuanxian | 1998 | Acta Mechanica Solida Sinica1998，11，1： | 0 |
| 19 | A cell transcriptomic profile p ovides insights into adipocytes of porcine mammary gland across development显示文摘Background Studying the composition and developmental mechanisms in mammary gland is crucial for healthy growth of newborns. The mammary gland is inherently heterogeneous, and its physiological function dependents on the gene expression of multiple cell types. Most studies focused on epithelial cells, disregarding the role of neighboring adipocytes.Results Here, we constructed the largest transcriptomic dataset of porcine mammary gland cells thus far. The dataset captured 126,829 high-quality nuclei from physiological mammary glands across five developmental stages(d 90 of gestation, G90;d 0 after lactation, L0;d 20 after lactation, L20;2 d post natural involution, PI2;7 d post natural involution, PI7). Seven cell types were identified, including epithelial cells, adipocytes, endothelial cells, fibroblasts cells, immune cells, myoepithelial cells and precursor cells. Our data indicate that mammary glands at different developmental stages have distinct phenotypic and transcriptional signatures. During late gestation(G90), the differentiation and proliferation of adipocytes were inhibited. Meanwhile, partly epithelial cells were completely differentiated. Pseudo-time analysis showed that epithelial cells undergo three stages to achieve lactation, including cellular differentiation, hormone sensing, and metabolic activation. During lactation(L0 and L20), adipocytes area accounts for less than 0.5% of mammary glands. To maintain their own survival, the adipocyte exhibited a poorly differentiated state and a proliferative capacity. Epithelial cells initiate lactation upon hormonal stimulation. After fulfilling lactation mission, their undergo physiological death under high intensity lactation. Interestingly, the physiological dead cells seem to be actively cleared by immune cells via CCL21-ACKR4 pathway. This biological process may be an important mechanism for maintaining homeostasis of the mammary gland. During natural involution(PI2 and PI7), epithelial cell populations dedifferentiate into mesenchymal stem cells to maintain the lactation potential of mammary glands for the next lactation cycle.Conclusion The molecular mechanisms of dedifferentiation, proliferation and redifferentiation of adipocytes and epithelial cells were revealed from late pregnancy to natural involution. This cell transcriptomic profile constitutes an essential reference for future studies in the development and remodeling of the mammary gland at different stages. | Yongliang Fan Long Jin Zhiping He Tiantian Wei Tingting Luo Jiaman Zhang Can Liu Changjiu Dai Chao A Yan Liang Xuan Tao Xuebin Lv Yiren Gu Mingzhou Li | 2024 | Journal of Animal Science and Biotechnology2024，15，1： | 0 |
| 20 | A Direct Toolpath Constructive Design Method for Controllable Porous Structure Configuration with a TSP-based Sequence Planning Determination显示文摘The inherent capabilities of additive manufacturing(AM)to fabricate porous lattice structures with controllable structural and functional properties have raised interest in the design methods for the production of extremely in-tricate internal geometries.Current popular methods of porous lattice structure design still follow the traditional flow,which mainly consists of computer-aided design(CAD)model construction,STereoLithography(STL)model conversion,slicing model acquisition,and toolpath configuration,which causes a loss of accuracy and manufac-turability uncertainty in AM preparation stages.Moreover,toolpath configuration relies on a knowledge-based approach summarized by expert systems.In this process,geometrical construction information is always ignored when a CAD model is created or constructed.To fully use this geometrical information,avoid accuracy loss and ensure qualified manufacturability of porous lattice structures,this paper proposes a novel toolpath-based con-structive design method to directly generate toolpath printing file of parametric and controllable porous lattice structures to facilitate model data exchange during the AM preparation stages.To optimize the laser jumping route between lattice cells,we use a hybrid travelling salesman problem(TSP)solver to determine the laser jumping points on contour scans.Four kinds of laser jumping orders are calculated and compared to select a minimal laser jumping route for sequence planning inside lattice cells.Hence,the proposed method can achieve high-precision lattice printing and avoid computational consumption in model conversion stages from a geomet-rical view.The optical metallographic images show that the shape accuracy of lattice patterns can be guaranteed.The existence of“grain boundaries”brought about by the multi-contour scanning strategy may lead to different mechanical properties. | Zhiping Wang Yicha Zhang Donghua Dai Dongdong Gu Chaoyue Chen Di Wang Alain Bernard | 2023 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2023，2，1： | 0 |
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